Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

Tierschutzbeauftragte/r (m/w/d)15. Oct. 2025
Postdoc position on studying intrinsically disordered proteins in clathrin-mediated endocytosis (f/m/d)25. Sep. 2025

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Aktuelle Publikationen

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Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Enrica Bordignon; Oleg Sitsel; Daniel Roderer; Daniel Prumbaum; Stefan Raunser; Min Dong; Claus Arthur Martin Seidel; Peter Njenga Ng'ang'a; Julian Folz; Svetlana Kucher; Ying Xu; Alexander Belyy; Ralf Kühnemuth; Tufa Enver Assafa

Science Advances 2025

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C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek

Computational and Structural Biotechnology Journal 2025

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Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

  • Felix Schöpf; Gian L. Marongiu; Klaudia Milaj; Thiemo Sprink; Judith Kikhney; Annette Moter; Daniel Roderer

Nature Communications 2025

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Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Sarah Lampe; Björn Hanf; Jeremy A. M. Morgan; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler

Nature Chemistry 2025

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Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

  • Kun‐Han Lin; Mrinalini Ranjan; Noa Lipstein; Nils Brose; Erwin Neher; Holger Taschenberger

The Journal of Physiology 2025

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PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections

  • Kaixuan Liu; Yang Liu; Qinghua Wang; Marc Nazaré; Leilei Zhang; Xiandao Pan; Hai-Yu Hu

Journal of Medicinal Chemistry 2025

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Characterization of the direct and indirect inhibition of apoptosis by full-length recombinant Bcl-xL monomers

  • Christina Elsner; Ludovica M. Epasto; Adeline Cieren; Dominik Gendreizig; Svetlana Kucher; Daniel Roderer; Enrica Bordignon
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Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

  • Rosa Planells-Cases; Viktoriia Vorobeva; Sumanta Kar; Franziska W. Schmitt; Uwe Schulte; Marina Schrecker; Richard K. Hite; Bernd Fakler; Thomas J. Jentsch

Nature Communications 2025

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Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension

  • Ekaterina Legchenko; Philippe Chouvarine; Klea Hysko; Fatimunnisa Qadri; Radoslaw Wesolowski; Edgar Specker; Silke Glage; Martin Meier; Katharina Schwarz; Joerg Heineke; Gerhard Pohlmann; Mehmet Ramazanoglu; Michael Bader; Georg Hansmann

American Journal of Respiratory Cell and Molecular Biology 2025

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Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69

  • Mark McHugh; Charity N. Njeshi; Nathaniel Smith; Sudhanva S. Kashyap; Real Datta; Han Sun; Alan P. Robertson; Richard J. Martin

PLOS Pathogens 2025

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Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Felix Schöpf; Andreas Oder; Jens Peter von Kries; Daniel Roderer

Proceedings of the National Academy of Sciences 2025

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Death, taxes, and rhomboids: Understanding the ubiquitous roles of the rhomboid protein superfamily

  • Henry Sawczyc; Spyridon Kosteletos; Adam Lange

Journal of Biological Chemistry 2025

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Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

  • Souvik Ghosh; Ramona Birke; Ashwin Karthick Natarajan; Johannes Broichhagen

Journal of Peptide Science 2025

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Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

  • Anton F. Ketzel; Yang Hu; Xiao‐Lu Li; Jiaqian Li; Xinxiang Lei; Han Sun

Magnetic Resonance in Chemistry 2025

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MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants

  • Aqfan Jamaluddin; Rachael A. Wyatt; Johannes Broichhagen; Joshua Levitz; Caroline M. Gorvin
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Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

  • Gaga Kochlamazashvili; Aarti Swaminathan; Alexander Stumpf; Amit Kumar; York Posor; Dietmar Schmitz; Volker Haucke; Marijn Kuijpers

Proceedings of the National Academy of Sciences 2025

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Chemisch spaltbare Sonden zur Visualisierung ko-internalisierter Rezeptoren

  • Johannes Broichhagen

BIOspektrum 2025

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Unsaturated phosphorus electrophiles to probe protein tyrosine phosphatases

  • Eleftheria Poulou; Max Ruwolt; Christian Stieger; Kristin Kemnitz-Hassanin; Christian Hackenberger
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Development of a human RPE In vitro model with AMD-like features reveals blue light-induced modulation of the endocannabinoid system.

  • Di Meo C; Tisi A; Lizzi AR; Palaniappan S; Pulcini F; Cinque B; Delle Monache S; Nazarè M; Hsu E; Rapino C; Maccarrone M

Biochemical and biophysical research communications 2025

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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.

  • Borrega-Roman L; Hoare BL; Kosar M; Sarott RC; Patej KJ; Bouma J; Scott-Dennis M; Koers EJ; Gazzi T; Mach L; Barrondo S; Sallés J; Guba W; Kusznir E; Veprintsev DB

Frontiers in pharmacology 2025

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Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization.

  • Sowa ST; Kücükdisli M; Mostinski Y; Schaller DA; Vinagreiro CS; Cirillo D; Bosetti C; Brinch SA; van Laar K; Wegert A; Leenders RGG; Krauss S; Nazaré M

Journal of medicinal chemistry 2025

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Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis.

  • Horatscheck A; Krauß M; Bulut H; Chambon V; Zadah MS; Dransart E; Peloza K; Santos KF; Robertson MJ; Prichard K; Miksche S; Radetzki S; von Kries JP; Nazaré M

Structure (London, England : 1993) 2025

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Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research.

  • Hentsch A; Guberman M; Radetzki S; Kaushik S; Huizenga M; He Y; Contzen J; Kuhn B; Benz J; Schippers M; Paul J; Leibrock L; Collin L; Wittwer M; Nazaré M

Journal of the American Chemical Society 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

  • Hentsch A; Guberman M; Radetzki S; Kaushik S; Huizenga M; Paul J; Schippers M; Benz J; Kuhn B; Heer D; Topp A; Esteves Gloria L; Walter A; Nazaré M

Angewandte Chemie (International ed. in English) 2025

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Chemical Probes for Investigating the Endocannabinoid System.

  • Hanske A; Nazaré M; Grether U

Current topics in behavioral neurosciences 2025

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Quantitative analysis of inhibitor-induced assembly disruption in human UDP-GlcNAc 2-epimerase using mass photometry

  • Nico Boback; Jacob Gorenflos López; Christian P. R. Hackenberger; Santiago Di Lella; Daniel C. Lauster
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Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

  • Reza Asadollahi; Aisha Ahmad; Paranchai Boonsawat; Jasmine Shahanoor Hinzen; Mareike Lohse; Boris Bouazza-Arostegui; Siqi Sun; Tillmann Utesch; Jonas D. Sommer; Dragana Ilic; Murugesh Padmanarayana; Kati Fischermanns; Mrinalini Ranjan; Moritz Boll; Chandran Ka; Amélie Piton; Francesca Mattioli; Bertrand Isidor; Katrin Õunap; Karit Reinson; Monica H. Wojcik; Christian R. Marshall; Saadet Mercimek-Andrews; Naomichi Matsumoto; Noriko Miyake; Bruno de Oliveira Stephan; Rachel Sayuri Honjo; Debora R. Bertola; Chong Ae Kim; Roman Yusupov; Heather C. Mefford; John Christodoulou; Joy Lee; Oliver Heath; Natasha J. Brown; Naomi Baker; Zornitza Stark; Martin Delatycki; Nicole J. Lake; Shimriet Zeidler; Linda Zuurbier; Saskia M. Maas; Chris C. de Kruiff; Farrah Rajabi; Lance H. Rodan; Stephanie A. Coury; Konrad Platzer; Henry Oppermann; Rami Abou Jamra; Skadi Beblo; Caroline Maxton

Nature Genetics 2025

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Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

  • Reza Asadollahi; Aisha Ahmad; Paranchai Boonsawat; Jasmine Shahanoor Hinzen; Mareike Lohse; Boris Bouazza-Arostegui; Siqi Sun; Tillmann Utesch; Jonas D. Sommer; Dragana Ilic; Murugesh Padmanarayana; Kati Fischermanns; Mrinalini Ranjan; Moritz Boll; Chandran Ka; Amélie Piton; Francesca Mattioli; Bertrand Isidor; Katrin Õunap; Karit Reinson; Monica H. Wojcik; Christian R. Marshall; Saadet Mercimek-Andrews; Naomichi Matsumoto; Noriko Miyake; Bruno de Oliveira Stephan; Rachel Sayuri Honjo; Debora R. Bertola; Chong Ae Kim; Roman Yusupov; Heather C. Mefford; John Christodoulou; Joy Lee; Oliver Heath; Natasha J. Brown; Naomi Baker; Zornitza Stark; Martin Delatycki; Nicole J. Lake; Shimriet Zeidler; Linda Zuurbier; Saskia M. Maas; Chris C. de Kruiff; Farrah Rajabi; Lance H. Rodan; Stephanie A. Coury; Konrad Platzer; Henry Oppermann; Rami Abou Jamra; Skadi Beblo; Caroline Maxton

Nature Genetics 2025

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Polyfluoroalkyl-Tagged Cell-Penetrating Peptide Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

  • Sarah Hansen; Hana Zupan; Ferhat Mutlu; Jan Vincent Arafiles; Ruben Cruz; Kenichi Ataka; Martin Lehmann; Bettina Keller; Joachim Heberle; Christian Hackenberger
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Biogenesis and reformation of synaptic vesicles

  • Svenja Bolz; Volker Haucke

The Journal of Physiology 2025

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Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie International Edition 2025

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Blobby is a synaptic active zone assembly protein required for memory in Drosophila

  • J. Lützkendorf; T. Matkovic-Rachid; S. Liu; T. Götz; L. Gao; O. Turrel; M. Maglione; M. Grieger; S. Putignano; N. Ramesh; T. Ghelani; A. Neumann; N. Gimber; J. Schmoranzer; A. Stawrakakis; B. Brence; D. Baum; Kai Ludwig; M. Heine; T. Mielke; F. Liu; A. M. Walter; M. C. Wahl; S. J. Sigrist

Nature Communications 2025

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Selectivity and Safety Characterization of a Xanthine–Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis

  • Radoslaw Wesolowski; Anja Schütz; Michael Lisurek; Marc Nazaré; Udo Heinemann; Dirk Pleimes; Michael Bader; Edgar Specker

ACS Pharmacology & Translational Science 2025

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Selectivity and Safety Characterization of a Xanthine–Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis

  • Radoslaw Wesolowski; Anja Schütz; Michael Lisurek; Marc Nazaré; Udo Heinemann; Dirk Pleimes; Michael Bader; Edgar Specker

ACS Pharmacology & Translational Science 2025

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Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

  • Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen

RSC Chemical Biology 2025

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Impact of dispersion correction in DFT-enhanced anisotropic NMR for stereochemical elucidation of flexible marine natural products

  • Lu-Ping Chi; Xiao-Lu Li; Anton F. Ketzel; Armando Navarro-Vázquez; Caspar J. Schattenberg; Xiao-Ming Li; Xin Li; Han Sun; Bin-Gui Wang

Marine Life Science & Technology 2025

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Morphological profiling data resource enables prediction of chemical compound properties

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied

iScience 2025

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Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR

  • Lisa Gerland; Anne Diehl; Natalja Erdmann; Matthias Hiller; Christina Lang; Christian Teutloff; Jon Hughes; Hartmut Oschkinat

Chemistry – A European Journal 2025

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Pore-Opening and Ion-Conduction Mechanism in Channelrhodopsins C1C2, ChR2, and iChloC by Computational Electrophysiology and Constant-pH Simulations

  • Songhwan Hwang; Tillmann Utesch; Caspar Schattenberg; Johannes Vierock; Han Sun

Journal of Chemical Information and Modeling 2025

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Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method

  • Xue Bessie Su; Valeria Fedeli; Guizhen Liu; Meike Marie Amma; Paraskevi Boulasiki; Jingyi Wang; Mariano Bizzarri; Henning Jacob Jessen; Dorothea Fiedler; Antonella Riccio; Adolfo Saiardi

Biochemical Journal 2025

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Proximity labelling reveals the compartmental proteome of murine sensory neurons

  • Julia R Sondermann; Allison M Barry; Feng Xian; Thomas Haberl; David Gomez-Varela; Fritz Benseler; Dietmar Schreiner; Nils Brose; Noa Lipstein; Manuela Schmidt
online lesen

Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

online lesen

Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

online lesen

Structural Transition from Closed to Open for the Influenza A M2 Proton Channel as Observed by Proton-Detected Solid-State NMR

  • Swantje Mohr; Caspar Schattenberg; Tillmann Utesch; Henry Sawczyc; Veniamin Chevelkov; Sascha Lange; Jacek Kozuch; Han Sun; Adam Lange

Journal of the American Chemical Society 2025

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Structural Transition from Closed to Open for the Influenza A M2 Proton Channel as Observed by Proton-Detected Solid-State NMR

  • Swantje Mohr; Caspar Schattenberg; Tillmann Utesch; Henry Sawczyc; Veniamin Chevelkov; Sascha Lange; Jacek Kozuch; Han Sun; Adam Lange

Journal of the American Chemical Society 2025

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Carbazole‐Based Thin Microporous Polymer Films for Photocatalytic Hydrogen Evolution

  • Veit Dippold; Hüseyin Küçükkeçeci; Eugenia Bosler; Johannes Schmidt; Samrat Ghosh; Gregor Michl; Islam E. Khalil; Lisa Gerland; Adam Lange; Dirk Oberschmidt; Arne Thomas

Advanced Materials 2025

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Ena/VASP-EVH1 inhibition prevents chemotaxis and metastasis by blocking the EVH1–WAVE2 interaction

  • Matthias Müller; Matthias Barone; Maarten van Dinther; Kathrin Motzny; Jiang Ren; Jenny Eichhorst; Dominik Albat; Slim Chiha; Martin Lehmann; Rudolf Volkmer; Hartmut Oschkinat; Hans-Günther Schmalz; Peter ten Dijke; Ronald Kühne

Proceedings of the National Academy of Sciences 2025

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Aminopeptidase-Responsive NIR Photosensitizer for Precision Targeting and Eradication of Pseudomonas aeruginosa Biofilms

  • Yang Liu; Kaixuan Liu; Ling lei; Qinghua Wang; Xiang Wang; Xiangchuan Meng; Qian Liu; Jiacheng Du; Leilei Zhang; Marc Nazaré; Hai-Yu Hu

ACS Applied Materials & Interfaces 2025

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Chemical probes for imaging cellular compartmentalization

  • Margret H. Bülow; Johannes Broichhagen

Trends in Biochemical Sciences 2025

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Liste der Publikationen