Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

Ph.D. students in Biophysics/Structural Biology (m/f/d)24. Sep. 2026
Leitung der Massenspektrometrie-Core Facility02. Sep. 2026

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Aktuelle Publikationen

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Halogen…π Interactions as Important Contributors to Binding Affinity in Medicinal Chemistry

  • Marc Nazaré
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Use of substituted heterocyclic compounds for treating disease associated with genotoxic stress-induced I kappa B kinase/nuclear factor kappa-light-chain-enhancer of activated B cells activation which is cancer

  • Marc Nazaré
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Use of substituted heterocyclic compounds for treating a subject afflicted by hyperthyroidism or thyroid disease including Grave's disease, Grave's ophthalmopathy, Grave's dermopathy or thyroid cancer

  • Marc Nazaré
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CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45

  • Marc Nazaré
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Composition to identify compound of interest comprises fluorescent-labeled fatty acid whose fatty acid part binds to fatty acid binding compound, and fluorescent part and compound interact to elicit Forster resonance energy transfer effects

  • Marc Nazaré
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New xanthine derivatives are tryptophan hydroxylases inhibitors used to treat e.g. bone diseases, systemic sclerosis, gastrointestinal diseases, cancer, vascular diseases, inflammatory, metabolic diseases and psychiatric diseases

  • Marc Nazaré
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New N-(4-(azaindazol-6-yl)-phenyl)-sulfonamide compound used in treating e.g. diabetes, cardiovascular diseases, fibrosis, inflammation, epilepsy, pain, tumors, cerebral infarctions, osteoarthritis, obesity, dyslipidemia, gout and tinnitus

  • Marc Nazaré
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New substituted triazole derivatives are tankyrase-1 inhibitors useful for treating or preventing e.g. non-regenerative wound healing, viral infection, dermal, renal, liver or myocardial fibrosis, or aberrant systemic glucose metabolism

  • Marc Nazaré
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New xanthine derivatives are tryptophan hydroxylase inhibitor, used to treat serotonin-related diseases or disorders e.g. osteoporosis, osteoporosis pseudoglioma syndrome, osteopenia, diarrhea, emesis, and peripheral artery disease

  • Marc Nazaré
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Cl− Channels and Cl−/H+ Exchangers

  • Thomas J. Jentsch

Encyclopedia of Molecular Pharmacology 512

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HaloTag Ligand and HaloTag Protein engineering for a binary fluorescent turn-on probe

  • Blaise Gatin-Fraudet; Ulrich Pabst; Christina H. Olesen; Bianca C. Baciu; Ramona Birke; Sigrid Milles; Johannes Broichhagen
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Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza

  • Dorothea Fiedler; Maren Schädel; Martina Katharina Ried-Lasi; Verena Gaugler; Gabriel Schaaf; Henning Jacob Jessen; Philipp Gaugler; Michael Harings; Kiran Raj; Guizhen Liu; Mengsi Lu; Charlotte Magdalena Mathilda Grothaus; Ulrike Anna Jochimsen; Athanasios Makris; Simon Maria Bartsch; Anna Maria Frentzen

Science Advances 2026

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Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

  • Sarat Vatsavayai; Peter Penzes; Kuchuan Chen; Euan Parnell; William W. Seeley; Rasheen Powell; Dragana Ilic; Yi Zeng; Noa Lipstein; Aaron D Gitler; Leonard Petrucelli; Caiwei Guo; Tetsuya Akiyama; Chang Liu; Odilia Sianto; Edith Yang; Shannon S Zhen; Mortiz Boll; Georgiana Miller; Juliane Bombosch; Eric Green; Ryan David Morrie; Shila Mekhoubad

Science Translational Medicine 2026

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Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

  • Taoran Xiao; Alexandra Kovinko; Chaowei Shi; Henry Sawczyc; Denis Qoraj; Carl Öster; Thiemo Sprink; Sascha Lange; Spyridon Kosteletos; Han Sun; Daniel Roderer; Shanshuang Chen; Adam Lange
online lesen

Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Jaime A. Isern; Max Ruwolt; Sarah Lampe; Abhirup Majumdar; Fan Liu; David Furkert; Dorothea Fiedler

Nature Communications 2026

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Dynamics of (Hetero)aryl Motifs: An Integrative Approach To Study the Conformational Landscape in Macrocycles

  • Anton F. Ketzel; Matthew Diamandas; Xiao-Lu Li; Yang Daniel Ou; Xinxiang Lei; Andrei K. Yudin; Han Sun

Journal of the American Chemical Society 2026

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Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

  • Xue Bessie Su; Xinjie Zhang; Valeria Fedeli; An-Li Andrea Ko; Jiarui Nicole Fu; Dorothea Fiedler; Adolfo Saiardi

The EMBO Journal 2026

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Discerning protein pools by selective staining with self‐labeling tags

  • Kati Fischermanns; Johannes Broichhagen

FEBS Letters 2026

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Protein Modifications for Cellular Protein Delivery

  • Jan Vincent V. Arafiles; Jonathan Franke; Palina Dubatouka; Luise Franz; Christian P.R. Hackenberger

Chemical Reviews 2026

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The role of adhesins of Fusobacterium nucleatum in colorectal cancer – a structural perspective

  • Felix Schöpf; Gian Luca Marongiu; Daniel Roderer

Gut Microbes 2026

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Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations

  • Denis Qoraj; Swantje Mohr; Yessenbek K. Aldakul; Thiemo Sprink; Carl Öster; Taoran Xiao; Peter Schmieder; Sascha Lange; Tillmann Utesch; Daniel Roderer; Shanshuang Chen; Han Sun; Adam Lange

Nature Communications 2026

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Characterization of the Direct and Indirect Inhibition of Apoptosis by Full‐Length Recombinant Bcl‐xL Monomers

  • Christina Elsner; Ludovica M. Epasto; Adeline Cieren; Dominik Gendreizig; Svetlana Kucher; Daniel Roderer; Enrica Bordignon

ChemBioChem 2026

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Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations

  • Denis Qoraj; Swantje Mohr; Yessenbek K. Aldakul; Thiemo Sprink; Carl Öster; Taoran Xiao; Peter Schmieder; Sascha Lange; Tillmann Utesch; Daniel Roderer; Shanshuang Chen; Han Sun; Adam Lange

Nature Communications 2026

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Species Context Reverses PPIP5K Control of Fungal Morphogenesis and Actin Organization

  • Elisa Koc; Lisa Juhran; Visnja Emmerich; Abel Alcázar-Román; Simon M. Bartsch; Adolfo Saiardi; Lasse van Wijlick; Johannes Postma; Thomas Lenz; Dorothea Fiedler; Michael Feldbrügge; Kai Stühler; Ingrid Span; Ursula Fleig
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Emergence of new function through evolutionary divergence of an intrinsically disordered region

  • Carlos A. Elena-Real; Antonia M. Körber; Blaise Gatin-Fraudet; Alexandra Kovinko; Kathrin Motzny; Arbesa Saiti; Adam Lange; Johannes Broichhagen; Sigrid Milles
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De-Nterm-ining GLP1R signaling bias

  • Johannes Broichhagen; David J. Hodson

Trends in Pharmacological Sciences 2026

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Structural basis for covalent inhibition of sulfatases by sulfamate warheads

  • Charles W.E. Tomlinson; Stefano Elli; Morgan Batiste-Simms; Zongjia Chen; Chris Taylor; Adam Dowle; Edwin A. Yates; Marc Nazaré; Martin A. Fascione; Lianne I. Willems; Spencer J. Williams; Conor J. Crawford; Alan Cartmell
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Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells

  • Meike M. Amma; Laxmikanth Kollipara; Tobias Dürr-Mayer; Josefin Streeck; Peter Schmieder; Adolfo Saiardi; Henning J. Jessen; Sven Heiles; Dorothea Fiedler

ACS Chemical Biology 2026

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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

  • Sarah Lampe; Tanmay Kumar Mohanty; Rashna Bhandari; Dorothea Fiedler

FEBS Letters 2026

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Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

  • László Albert; Samrat Basak; Henrike Körner; Nazar Oleksiievets; Nikolaos Mougios; Elena R. Cotroneo; Michelle S. Frei; Jörg Enderlein; Johannes Broichhagen; Nadja A. Simeth; Roman Tsukanov; Felipe Opazo

ACS Nano 2026

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Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

  • Dagan C. Marx; Alberto J. Gonzalez-Hernandez; Joon Lee; Dirk Siepe; Willem F. Weber; Kevin Huynh; Pamela N. Gallo; Sheida Sharghi Moshtaghin; Anisul Arefin; Johannes Broichhagen; Marian Kalocsay; David Eliezer; Joshua Levitz

Nature Communications 2026

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Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins

  • Dagan C. Marx; Kevin Huynh; Alberto J. Gonzalez-Hernandez; Alexa Strauss; Carlos Rico; Pamela N. Gallo; Sheida Sharghi Moshtaghin; Anisul Arefin; Johannes Broichhagen; David Eliezer; George Khelashvili; Joshua Levitz

Nature Communications 2026

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Site-resolved spatial and structural interactome of a human cell

  • Zehong Zhang; Nanako Yokoyama; Ying Zhu; Julia Ruta; Jiale Cheng; Vini Natalia; Tolga Soykan; Volker Haucke; Fan Liu
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Phosphoinositides and inositol phosphates—functions and cellular dynamics

  • Feng Rao; Volker Haucke

FEBS Letters 2026

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Cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK channels

  • Berke Türkaydin; Valerio Rizzi; Chaimae Benkerdagh; Simon Ghysbrecht; Simone Aureli; Thomas Baukrowitz; Marcus Schewe; Francesco Luigi Gervasio; Han Sun

Nature Communications 2026

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Abnormal ClC-3/TMEM9-mediated endosomal ion transport in CLCN3-associated neurodevelopmental disease.

  • Polovitskaya MM; Tkemaladze T; Jensen L; Kar S; Planells-Cases R; Agolini E; Agrawal PB; Alfieri P; Barakat TS; Bertrand M; Bowman P; Brooks AS; Bruel AL; Cabet S; Chwialkowska K; Colafati GS; Delanne J; Faivre L; Felton C; Grasshoff U; Guerrot AM; Haack TB; Haase C; Helseth AR; Janssens K; Khan A; Koch-Hogrebe M; Mandelberg J; Mangold E; Melikidze E; Meuwissen M; Mičule I; Noble B; Platzer K; Rots D; Sarret C; Schmetz A; Shillington A; Tran-Mau-Them F; Wieczorek D; Lesca G; Bayat A; Jentsch TJ

EMBO molecular medicine 2026

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Microwave-assisted combinatorial synthesis of phalloidin derivatives for optimization of structure–activity-relationship (SAR)

  • Tino Damaszek; Mark A. R. de Geus; Zhanyu He; Guiyang Yao; Christian P. R. Hackenberger; Roderich D. Süssmuth

Chemical Communications 2026

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Drug Delivery Vehicle—Teriflunomide Interactions Affect Treatment and Fluorine Magnetic Resonance in an Animal Model of Multiple Sclerosis

  • Xiang Hu; Nandita Saha; Yinhao Chen; Jason M. Millward; Andreas Oder; Keven Mallow; Stefanie Münchberg; Christian Prinz; Helmar Waiczies; Michael Rothe; Martin Neuenschwander; Marc Nazaré; Friedemann Paul; Thoralf Niendorf; Sonia Waiczies

Pharmaceutics 2026

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Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
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Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
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Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

  • Thiemo Sprink; Adam Lange; Carl Öster; Sascha Lange; Shanshuang Chen; Daniel Roderer; Chaowei Shi; Han Sun; Taoran Xiao; Alexandra Kovinko; Henry Sawczyc; Denis Qoraj; Spyridon Kosteletos; Anton Florian Ketzel

Science Advances 2026

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Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

  • Thiemo Sprink; Adam Lange; Carl Öster; Sascha Lange; Shanshuang Chen; Daniel Roderer; Chaowei Shi; Han Sun; Taoran Xiao; Alexandra Kovinko; Henry Sawczyc; Denis Qoraj; Spyridon Kosteletos; Anton Florian Ketzel

Science Advances 2026

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Induced regulatory B cells stably expressing interleukin-10 reverse central nervous system autoimmunity by targeting myeloid cells

  • Benoît Manfroi; Van Duc Dang; Bui Thi Cuc; Annemarie Jungmann; Sibyline Borzakian; Yanli Tong; Claire Beauvineau; Louise Dupuis; Elena Guffart; Katharina Borst; Ngan Thu Nguyen; Zhiguo Wu; Daniel Alvarez-Simon; Guillaume Chyzak; Simon Schäfer; Roman G. Gerlach; Stefan Frischbutter; Alf Hamann; Layale Salem Wehbe; Mohamed El Behi; Marine Luka; Mickaël Ménager; Luc Jouneau; Pierre Boudinot; Steffen Jung; Thomas H. Winkler; Roland Liblau; Romain Marignier; Hervé Isambert; Marco Prinz; Lukas Simon Amann; Jens Peter von Kries; Edgar Specker; Jörn Walter; Florence Mahuteau-Betzer; Simon Fillatreau

Immunity 2026

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A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

  • Fabian M.B. Thöne; Maya M. Polovitskaya; Uta E. Höpken; Armin Rehm; Thomas J. Jentsch

Journal of Biological Chemistry 2026

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Conservation and Specificity in Bacillus Biofilm Dynamics: On Structure and Function of B. cereus Camelysins

  • Anne Diehl; Florian Lindemann; Nils Cremer; Yvette Roske; Matthias Hiller; Barth van Rossum; Martina Leidert; Kürşad Turgay; Hartmut Oschkinat

Journal of Molecular Biology 2026

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Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

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Supplementary Figure S1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Liste der Publikationen