Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
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Aktuelle Publikationen

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Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
online lesen

Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
online lesen

A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

  • Fabian M.B. Thöne; Maya M. Polovitskaya; Uta E. Höpken; Armin Rehm; Thomas J. Jentsch

Journal of Biological Chemistry 2026

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Conservation and Specificity in Bacillus Biofilm Dynamics: On Structure and Function of B. cereus Camelysins

  • Anne Diehl; Florian Lindemann; Nils Cremer; Yvette Roske; Matthias Hiller; Barth van Rossum; Martina Leidert; Kürşad Turgay; Hartmut Oschkinat

Journal of Molecular Biology 2026

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Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

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Supplementary Figure S1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Methods from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S7 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Data from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S6 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie 2026

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Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2026

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Supplementary Table 4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

LRRC8-Mediated Glutamate Release from Astrocytes Is Not Increased During the Initiation of Experimental Temporal Lobe Epilepsy

  • Kamyab Sarmadi; Linda Gaspar; Peter Bedner; Lukas Henning; Christian Henneberger; Ronald Jabs; Thomas J. Jentsch; Christian Steinhäuser; Gerald Seifert

International Journal of Molecular Sciences 2026

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Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

  • Haoran Liu; Klaus Benndorf; Yessenbek K. Aldakul; Han Sun

Advanced Science 2026

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Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides

  • Niklas Piet Doering; Kristina Puls; Marta Diceglie; Anja Meraner; Axel Hentsch; Siriwat Hongnak; Armin Wurzer; Helmut Schmidhammer; Mariana Spetea; Marc Nazare; Gerhard Wolber

Journal of Medicinal Chemistry 2026

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Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

online lesen

Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Helge Ewers; Volker Haucke; Michael Krauss

Nature Communications 2026

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Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Helge Ewers; Volker Haucke; Michael Krauss

Nature Communications 2026

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Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction

  • Antje Kathrin Huebner; Jean Christopher Hennings; Michael Kiehntopf; Sebastian Bachmann; Tobias Stauber; Thomas J Jentsch; Dominique Eladari; Christian A Hubner; Bernhard Schermer; Keerthana Srinivasa Murthy; Nicolas Picard; Inês Cabrita; David Boehm; Maria Elisabeth Krause; Vandit Shah; Regine Chambrey; Diana Schmerler; Mukhran Khundadze; Christian Franke; Detlef Boeckenhauer; Gregor Jörg Gentsch; Jennifer Baraka-Vidot

Science Translational Medicine 2026

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Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting

  • Christian E. Stieger; Charlotte Völkel; Mathias B. Bertelsen; Michael Lisurek; Jan Vincent V. Arafiles; Jonathan Franke; Leander Crocker; Karl Schuppe; Yunjae Lim; Christiane Groneberg; Mathias Christmann; Han Sun; Christian P. R. Hackenberger

Journal of the American Chemical Society 2026

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Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity and post-tetanic potentiation

  • Erik Mathias Jorgensen; Noa Lipstein; Nils Brose; Erwin Neher; Thomas C Südhof; Holger Taschenberger; Mrinalini Ranjan; Kun-Han Lin; Brian D Mueller; Sonja Melanie Wojcik; Mareike Lohse

Science Advances 2026

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Cellular protein delivery through membrane potential driven water pores

  • Jonathan Franke; Palina Dubatouka; Amin Yourdkhani; Sahil Soni; Tillmann Utesch; Juliana Serrano; Tolga Soykan; Martin Lehmann; Han Sun; Jan Vincent V. Arafiles; Christian P. R. Hackenberger
online lesen

MSReportChecker: Real-Time HRMS Report Validation Directly Inside Your Word Processor

  • Ulrich Pabst; Johannes Broichhagen
online lesen

DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones

  • Nicholas S. O'Brien; Jing Xue; Claudia Bahnik; Martin Neuenschwander; Michael Kraub; Phillip J. Robinson; Volker Haucke; Adam McCluskey

European Journal of Medicinal Chemistry 2026

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Nanobodies equipped with HaloTag variants enable rapid and straightforward one-step immunofluorescence lifetime multiplexing

  • László Albert; Samrat Basak; Henrike Körner; Nazar Oleksiievets; Nikolaos Mougios; Elena R. Cotroneo; Michelle S. Frei; Jörg Enderlein; Johannes Broichhagen; Nadja A. Simeth; Roman Tsukanov; Felipe Opazo
online lesen

Molecular assembly of the KCNQ1–KCNE1–BACE1 complex

  • Alina Martin; Valeska Bienert; Stephanie Haefner; Florian Stockinger; Alexander Möhwald; Melanie Freimuth; Sandra Karch; Johannes Broichhagen; Guillaume Sandoz; Christian Alzheimer; Tobias Huth
online lesen

Direct Observation of Nanometer-Sized Steps of Single Myosin VI Molecules in Living Cells

  • Quang Quan Nguyen; Jiamin Zeng; Truong Son Bui; Kilian Roßmann; Yandong Yin; Johannes Broichhagen; H. Lee Sweeney; Hyokeun Park

Nano Letters 2026

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Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion

  • Lennart Hoffmann; Marlen Duchmann; Katina Lazarow; Yun-Hsuan Huang; Fabian Lukas; Wen-Ting Lo; Regina Feil; Christopher Schmied; Martin Lehmann; John E. Lunn; Ilaria Piazza; Jens P. von Kries; Volker Haucke; Tanja Maritzen

Nature Cell Biology 2026

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Collecting Large Datasets of Unambiguous Structural Restraints for Protein Structure Determination by 4D Proton‐Detected Solid‐State NMR

  • Veniamin Chevelkov; Sascha Lange; Adam Lange

ChemPhysChem 2026

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From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects

  • Nicholas S. O'Brien; Azadeh Ghods; Jing Xue; Mary J. Garson; Ken W. L. Yong; Jennette A. Sakoff; Jayne Glibert; Megan Chircop; Uwe Fink; Volker Haucke; Phillip J. Robinson; Adam McCluskey

RSC Medicinal Chemistry 2026

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Unlocking the Multifaceted Role of CB<sub>1</sub>R in the Endocannabinoid System with Labeled Chemical Probes

  • Leonard Mach; Marc Nazare

CHIMIA 2026

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Selective, genetically induced increase in synaptic vesicle priming

  • Zoltan Nusser; Mohammad Aldahabi; Noa Lipstein; Andrea Lorincz; Flora Balint; Nils Brose

Science Advances 2026

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Isotopic tracing of [13C6]scyllo-inositol uncovers its incorporation into phosphatidylinositols in mammalian cells

  • Meike Marie Amma; Laxmikanth Kollipara; Peter Schmieder; Adolfo Saiardi; Sven Heiles; Dorothea Fiedler
online lesen

A bio-orthogonal and covalent 5 kDa small protein tag

  • Ulrich Pabst; Jana Rossius; Christina Holmboe Olesen; Melissa Birol; Johannes Broichhagen
online lesen

TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma

Molecular Cancer Therapeutics 2026

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Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

  • Sarah Hansen; Hana Zupan; Ferhat Mutlu; Jan Vincent V. Arafiles; Rubén Cruz; Palina Dubatouka; Kenichi Ataka; Martin Lehmann; Bettina G. Keller; Joachim Heberle; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2026

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Polyfluoralkylierte zellpenetrierende Peptid‐Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion

  • Sarah Hansen; Hana Zupan; Ferhat Mutlu; Jan Vincent V. Arafiles; Rubén Cruz; Palina Dubatouka; Kenichi Ataka; Martin Lehmann; Bettina G. Keller; Joachim Heberle; Christian P. R. Hackenberger

Angewandte Chemie 2026

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A cell-permeable nanobody to restore F508del cystic fibrosis transmembrane conductance regulator activity

  • Luise Franz; Tihomir Rubil; Anita Balázs; Marie Overtus; Kristin Kemnitz-Hassanin; Cedric Govaerts; Marcus A. Mall; Christian P. R. Hackenberger

Nature Chemical Biology 2026

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Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Enrica Bordignon; Oleg Sitsel; Daniel Roderer; Daniel Prumbaum; Stefan Raunser; Min Dong; Claus Arthur Martin Seidel; Peter Njenga Ng'ang'a; Julian Folz; Svetlana Kucher; Ying Xu; Alexander Belyy; Ralf Kühnemuth; Tufa Enver Assafa

Science Advances 2025

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C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek

Computational and Structural Biotechnology Journal 2025

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Liste der Publikationen