Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
MEHR

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


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Aktuelle Publikationen

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KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation

  • Dmitry Tsvetkov; Johanna Schleifenbaum; Yibin Wang; Mario Kassmann; Maya M. Polovitskaya; Mohamed Ali; Sebastian Schütze; Michael Rothe; Friedrich C. Luft; Thomas J. Jentsch; Maik Gollasch

Hypertension 2024

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Additional experimental procedures from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

ADC characterization from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Additional experimental procedures from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Data from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 7 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 6 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 6 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 2 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 1 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 1 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary Data from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary Data from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 7 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Data from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Organic synthesis from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Organic synthesis from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

ADC characterization from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 5 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 5 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 4 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 4 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 3 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 3 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
online lesen

Supplementary figure 2 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper
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Absolute Configuration of 12S-Deoxynortryptoquivaline from Ascidian-Derived Fungus Aspergillus clavatus Determined by Anisotropic NMR and Chiroptical Spectroscopy

  • Elisa Doro-Goldsmith; Qi Song; Xiao-Lu Li; Xiao-Ming Li; Xue-Yi Hu; Hong-Lei Li; Hao-Ran Liu; Bin-Gui Wang; Han Sun

Journal of Natural Products 2024

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An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells

  • Carolina Vinagreiro; Qian Liu; Qinghua Wang; Xiang Wang; Hai-Yu Hu; Marc Nazare
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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper

Molecular Cancer Therapeutics 2024

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ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

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Synthesis of Peptides Containing a Combination of Free and 2‐trans‐Cyclooctene Carbamate Protected Lysine Residues

  • W. Doelman; N. A. M. Ligthart; M. A. T. van de Plassche; M. A. R. de Geus; L. Reinalda; M. M. E. Isendoorn; D. V. Filippov; S. I. van Kasteren

ChemBioChem 2024

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Moments of Gaussian Distributions for Small and Large Sample Sizes Revisited

  • Florian Heiser; E W Knapp

Mathematics and Statistics 2024

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses

  • Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
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Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin

  • fulin; Jimin Du; David Furkert; Megan L Shipton; Xiaoqi Liu; Tim Aguirre; Alfred C Chin; Andrew M Riley; Barry V L Potter; Dorothea Fiedler; Xu Zhang; Yi Zhu; Chenglai Fu

Cardiovascular Research 2024

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Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides

  • Arseniy Galashov; Ekaterina Kazakova; Christian E. Stieger; Christian P. R. Hackenberger; Oliver Seitz

Chemical Science 2024

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Revisiting Gauge-Independent Kinetic Energy Densities in Meta-GGAs and Local Hybrid Calculations of Magnetizabilities

  • Caspar J. Schattenberg; Artur Wodyński; Hugo Åström; Dage Matts Börje Sundholm; Martin Prof. Dr. Kaupp; Susi Lehtola

The Journal of Physical Chemistry A 2023

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Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

  • Ann‐Kathrin Rückert; Julia Ast; Annie Hasib; Daniela Nasteska; Katrina Viloria; Johannes Broichhagen; David J. Hodson

Diabetic Medicine 2023

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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

  • Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

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Structure–function relationships in protein homorepeats

  • Carlos A. Elena-Real; Pablo Mier; Nathalie Sibille; Miguel A. Andrade-Navarro; Pau Bernadó

Current Opinion in Structural Biology 2023

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers

  • Joon Lee; Alberto J. Gonzalez-Hernandez; Melanie Kristt; Nohely Abreu; Kilian Roßmann; Anisul Arefin; Dagan C. Marx; Johannes Broichhagen; Joshua Levitz

Science Advances 2023

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Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches

  • Swantje Mohr; Yessenbek K. Aldakul; Han Sun; Henry Sawczyc; Adam Lange

Integrated Structural Biology 2023

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Polyarylisocyanides Derived from an Alkyne-Pd(II) Catalyst as Robust Alignment Media with Excellent Enantiodiscimination

  • Gao-Wei Li; Xiao-Juan Wang; Shuai-Hua Shi; Lan-Tao Liu; Jia-Qian Li; Han Sun; Zong-Quan Wu; Xinxiang Lei

Analytical Chemistry 2023

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Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl−/H+ Exchanger ClC-7

  • Shroddha Bose; Cecilia de Heus; Mary E. Kennedy; Fan Wang; Thomas J. Jentsch; Judith Klumperman; Tobias Stauber

Biomolecules 2023

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Claudin-4 polymerizes after the incorporation of just two extracellular claudin-3 residues

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann
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Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

  • Stephan J Sigrist; Volker Haucke

EMBO reports 2023

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Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

  • Nathaniel Smith; Han Sun

Journal of General Physiology 2023

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Nutrient-regulated control of lysosome function by signaling lipid conversion

  • Michael Ebner; Dmytro Puchkov; Orestes López-Ortega; Pathma Muthukottiappan; Yanwei Su; Christopher Schmied; Silke Zillmann; Iryna Nikonenko; Jochen Koddebusch; Gillian L. Dornan; Max T. Lucht; Vonda Koka; Wonyul Jang; Philipp Alexander Koch; Alexander Wallroth; Martin Lehmann; Britta Brügger; Mario Pende; Dominic Winter; Volker Haucke

Cell 2023

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Liste der Publikationen