Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
MEHR

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


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Aktuelle Publikationen

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Protocol for semisynthesis of histone H4 with site-specific modifications using irreversible sortase-mediated ligation

  • Yihang Xiao; Kun Zou; Mingxuan Wu

STAR Protocols 2025

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Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes

  • Patrick Watermann; Gurleen K. Kalsi; Ralf Dringen; Christian Arend

Neurochemical Research 2025

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Selective photo crosslinking to methylarginine readers by sulfonium peptides

  • Ting Luo; Feng Feng; Kun Zou; Yumo Zhao; Yingxiao Gao; Mingxuan Wu

Bioorganic & Medicinal Chemistry 2025

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Chemical probes for imaging cellular compartmentalization

  • Margret H. Bülow; Johannes Broichhagen

Trends in Biochemical Sciences 2025

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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I

  • Xiaoqi Liu; Zixuan Zhang; Tim Aguirre; Megan L. Shipton; Lin Fu; Jimin Du; David Furkert; Ji Qi; Alfred C. Chin; Andrew M. Riley; Tong Liu; Xu Zhang; Barry V.L. Potter; Dorothea Fiedler; Yi Zhu; Chenglai Fu; Tim Aguirre

Metabolism 2025

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Integrative Molekulardynamiksimulationen entwirren cross‐linking Daten und zeigen Verteilungen von mitochondrialen Proteinen

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie 2025

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Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie International Edition 2025

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Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler

Proceedings of the National Academy of Sciences 2025

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Structural insights into light-gating of potassium-selective channelrhodopsin

  • Takefumi Morizumi; Kyumhyuk Kim; Hai Li; Probal Nag; Tal Dogon; Oleg A. Sineshchekov; Yumei Wang; Leonid S. Brown; Songhwan Hwang; Han Sun; Ana-Nicoleta Bondar; Igor Schapiro; Elena G. Govorunova; John L. Spudich; Oliver P. Ernst

Nature Communications 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

  • Axel Hentsch; Mónica Guberman; Silke Radetzki; Sofia Kaushik; Mirjam Huizenga; Jerome Paul; Maria Schippers; Jörg Benz; Bernd Kuhn; Dominik Heer; Andreas Topp; Ludivine Esteves Gloria; Alexander Walter; Remo Hochstrasser; Matthias B. Wittwer; Jens Peter von Kries; Ludovic Collin; Julie Blaising; Mario van der Stelt; Noa Lipstein; Uwe Grether; Marc Nazaré

Angewandte Chemie International Edition 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

  • Axel Hentsch; Mónica Guberman; Silke Radetzki; Sofia Kaushik; Mirjam Huizenga; Jerome Paul; Maria Schippers; Jörg Benz; Bernd Kuhn; Dominik Heer; Andreas Topp; Ludivine Esteves Gloria; Alexander Walter; Remo Hochstrasser; Matthias B. Wittwer; Jens Peter von Kries; Ludovic Collin; Julie Blaising; Mario van der Stelt; Noa Lipstein; Uwe Grether; Marc Nazaré

Angewandte Chemie 2025

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A silicon rhodamine-fused glibenclamide to label and detect malaria-infected red blood cells

  • Claudia Bastl; Cindy M. Close; Ingo Holtz; Blaise Gatin-Fraudet; Mareike Eis; Michelle Werum; Smilla Konrad; Kilian Roßmann; Christiane Huhn; Souvik Ghosh; Julia Ast; Dorien A. Roosen; Martin Lehmann; Volker Haucke; Luc Reymond; David J. Hodson; Philip Tinnefeld; Kai Johnsson; Viktorija Glembockyte; Nicole Kilian; Johannes Broichhagen
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Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR

  • Lisa Gerland; Anne Diehl; Natalja Erdmann; Matthias Hiller; Christina Lang; Christian Teutloff; Jon Hughes; Hartmut Oschkinat

Chemistry – A European Journal 2025

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Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

  • Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss

Journal of the American Chemical Society 2025

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Aminopeptidase-Responsive NIR Photosensitizer for Precision Targeting and Eradication of Pseudomonas aeruginosa Biofilms

  • Yang Liu; Kaixuan Liu; Ling lei; Qinghua Wang; Xiang Wang; Xiangchuan Meng; Qian Liu; Jiacheng Du; Leilei Zhang; Marc Nazaré; Hai-Yu Hu

ACS Applied Materials & Interfaces 2025

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Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation

  • Anton Florian Ketzel; Xiaolu Li; Martin Kaupp; Han Sun; Caspar Jonas Schattenberg

Journal of Chemical Theory and Computation 2025

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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun

Journal of Chemical Information and Modeling 2025

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Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins

  • Joel I. Badillo‐Gómez; Irene Suarez‐Antuña; Ievgen Mazurenko; Frédéric Biaso; Jacques Pécaut; Elisabeth Lojou; Pascale Delangle; Sarah Hostachy

Chemistry – A European Journal 2025

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Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2PChannels

  • Yessenbek K. Aldakul; Marcus Schewe; Carlos C. Diez; Songhwan Hwang; Thomas Baukrowitz; Han Sun
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IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence

  • Changchang Xing; Linhui Shi; Limei Zhu; Tim Aguirre; Ji Qi; Yuanyuan Chen; Yue Liu; Alfred C. Chin; Hong Zhu; Dorothea Fiedler; Alex F. Chen; Chenglai Fu; Tim Aguirre

Diabetes 2025

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Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG

  • Carl Öster; Veniamin Chevelkov; Adam Lange

Journal of Biomolecular NMR 2025

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Dopaminergic network connectivity alterations are associated with postoperative cognitive dysfunction

  • Florian Lammers-Lietz; Friedrich Borchers; Insa Feinkohl; Cicek Kanar; Henning Krampe; Gregor Lichtner; Jayanth Sreekanth; Janine Wiebach; Martin Weygandt; Claudia Spies; Georg Winterer; friedemann paul; the BioCog consortium; Çiçek Kanar
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Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

  • Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen

RSC Chemical Biology 2025

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Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers

  • Kun Zou; Jinyu Yang; Yingxiao Gao; Feng Feng; Mingxuan Wu

Chemical Science 2025

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Uncovering the potent antimicrobial activity of squaramide based anionophores – chloride transport and membrane disruption

  • Luke E. Brennan; Xuanyang Luo; Farhad Ali Mohammed; Kevin Kavanagh; Robert B. P. Elmes

Chemical Science 2025

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Deuterated oxazines are bright near-infrared fluorophores for mitochondrial imaging and single molecule spectroscopy

  • Blaise Gatin-Fraudet; Julius Seifert; Kris Sarach; Christina Holmboe Olesen; Ramona Birke; Sigrid Milles; Melissa Birol; Martin Lehmann; Johannes Broichhagen

Chemical Communications 2025

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Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

  • Milan Avila Clasen; Max Ruwolt; Cong Wang; Julia Ruta; Boris Bogdanow; Louise U. Kurt; Zehong Zhang; Shuai Wang; Fabio C. Gozzo; Tao Chen; Paulo C. Carvalho; Diogo Borges Lima; Fan Liu

Nature Methods 2024

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Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies

  • Boris Bogdanow; Max Ruwolt; Julia Ruta; Lars Mühlberg; Cong Wang; Wen-feng Zeng; Arne Elofsson; Fan Liu

Molecular Systems Biology 2024

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Dual BACH1 regulation by complementary SCF-type E3 ligases

  • Benedikt Goretzki; Maryam Khoshouei; Martin Schröder; Patrick Penner; Luca Egger; Christine Stephan; Dayana Argoti; Nele Dierlamm; Jimena Maria Rada; Sandra Kapps; Catrin Swantje Müller; Zacharias Thiel; Merve Mutlu; Claude Tschopp; David Furkert; Felix Freuler; Simon Haenni; Laurent Tenaillon; Britta Knapp; Alexandra Hinniger; Philipp Hoppe; Enrico Schmidt; Sascha Gutmann; Mario Iurlaro; Grigory Ryzhakov; César Fernández

Cell 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2024

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ARF1 compartments direct cargo flow via maturation into recycling endosomes

  • Alexander Stockhammer; Petia Adarska; Vini Natalia; Anja Heuhsen; Antonia Klemt; Gresy Bregu; Shelly Harel; Carmen Rodilla-Ramirez; Carissa Spalt; Ece Özsoy; Paula Leupold; Alica Grindel; Eleanor Fox; Joy Orezimena Mejedo; Amin Zehtabian; Helge Ewers; Dmytro Puchkov; Volker Haucke; Francesca Bottanelli

Nature Cell Biology 2024

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Scalable synthesis of sulfonium and selenonium peptides for selective methyllysine reader crosslinking

  • Yingxiao Gao; Feng Feng; Mingxuan Wu

Tetrahedron Letters 2024

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The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

  • Aqfan Jamaluddin; Rachael A. Wyatt; Joon Lee; Georgina K.C. Dowsett; John A. Tadross; Johannes Broichhagen; Giles S.H. Yeo; Joshua Levitz; Caroline M. Gorvin
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Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development

  • Florian Laurent; Caroline Gutjahr; Simon M. Bartsch; Anuj Shukla; Felix Rico-Resendiz; Daniel Couto; Christelle Fuchs; Joël Nicolet; Sylvain Loubéry; Henning J. Jessen; Dorothea Fiedler; Michael Hothorn

PLOS Genetics 2024

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Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

  • Lixiao Zhou; Xingsen Zhao; Jie Sun; Kun Zou; Xiaoli Huang; Liyang Yu; Mingxuan Wu; Yong Wang; Xuekun Li; Wen Yi

Nature Communications 2024

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Energy transfer photoproximity labelling in live cells using an organic cofactor

  • Leander Crocker; Jan Vincent V. Arafiles; Judith M. Müchler; Max Ruwolt; Kristin Kemnitz-Hassanin; Kilian Roßmann; Christian E. Stieger; Fan Liu; Christian P. R. Hackenberger
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Molecular architecture of synaptic vesicles

  • Uljana Kravcenko; Max Ruwolt; Jana Kroll; Artsemi Yushkevich; Martina Zenkner; Julia Ruta; Rowaa Lotfy; Erich Wanker; Christian Rosenmund; Fan Liu; Misha Kudryashev

Proceedings of the National Academy of Sciences 2024

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ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

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Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

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Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network

  • Andromachi Papagiannoula; Ida Marie Vedel; Kathrin Motzny; Maud Tengo; Sigrid Milles
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Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

  • Alice Rossi; Max Ruwolt; Paraskevi Kakouri; Tetiana Kosten; Severine Kunz; Dmytro Puchkov; Jane Reznick; Bettina Purfürst; Damir Omerbašić; Daniel Méndez Aranda; Giorgia Carai; Guido Mastrobuoni; Daniel W. Hart; Michela Carraro; Ludovica Tommasin; Nigel C. Bennett; Valérie Bégay; Katja Faelber; Oliver Daumke; Paolo Bernardi; Thomas J. Park; Stefan Kempa; Fan Liu; Gary R. Lewin
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Biogenesis and reformation of synaptic vesicles

  • Svenja Bolz; Volker Haucke

The Journal of Physiology 2024

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Direct optical measurement of intramolecular distances with angstrom precision

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Michael Weber; Taukeer A. Khan; Christian Brüser; Stefan Jakobs; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell

Science 2024

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Liste der Publikationen