Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
MEHR

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

Fremdsprachensekretär*in / Teamassistenz (w/m/d)04. Sep. 2023
PhD Student17. Aug. 2023
Studentische Hilfskraft (w/m/d)16. Jul. 2023

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Aktuelle Publikationen

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Nuclear magnetic resonance/single molecule fluorescence combinations to study dynamic protein systems

  • Ida Marie Vedel; Andromachi Papagiannoula; Samuel Naudi-Fabra; Sigrid Milles

Current Opinion in Structural Biology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

  • Stephan J Sigrist; Volker Haucke

EMBO reports 2023

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Community-developed checklists for publishing images and image analyses

  • Christopher Schmied; Michael S. Nelson; Sergiy Avilov; Gert-Jan Bakker; Cristina Bertocchi; Johanna Bischof; Ulrike Boehm; Jan Brocher; Mariana T. Carvalho; Catalin Chiritescu; Jana Christopher; Beth A. Cimini; Eduardo Conde-Sousa; Michael Ebner; Rupert Ecker; Kevin Eliceiri; Julia Fernandez-Rodriguez; Nathalie Gaudreault; Laurent Gelman; David Grunwald; Tingting Gu; Nadia Halidi; Mathias Hammer; Matthew Hartley; Marie Held; Florian Jug; Varun Kapoor; Ayse Aslihan Koksoy; Judith Lacoste; Sylvia Le Dévédec; Sylvie Le Guyader; Penghuan Liu; Gabriel G. Martins; Aastha Mathur; Kota Miura; Paula Montero Llopis; Roland Nitschke; Alison North; Adam C. Parslow; Alex Payne-Dwyer; Laure Plantard; Rizwan Ali; Britta Schroth-Diez; Lucas Schütz; Ryan T. Scott; Arne Seitz; Olaf Selchow; Ved P. Sharma; Martin Spitaler; Sathya Srinivasan; Caterina Strambio-De-Castillia; Douglas Taatjes; Christian Tischer; Helena Klara Jambor

Nature Methods 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

  • Ann‐Kathrin Rückert; Julia Ast; Annie Hasib; Daniela Nasteska; Katrina Viloria; Johannes Broichhagen; David J. Hodson

Diabetic Medicine 2023

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Isoform-selective targeting of PI3K: time to consider new opportunities?

  • Davide Cirillo; Marta Diceglie; Marc Nazaré

Trends in Pharmacological Sciences 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Spatially resolved protein map of intact human cytomegalovirus virions

  • Boris Bogdanow; Iris Gruska; Lars Mühlberg; Jonas Protze; Svea Hohensee; Barbara Vetter; Jens B. Bosse; Martin Lehmann; Mohsen Sadeghi; Lüder Wiebusch; Fan Liu

Nature Microbiology 2023

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Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive–compulsive behaviors in mice

  • Dennis Vollweiter; Jasmeet Kaur Shergill; Alexandra Hilse; Gaga Kochlamazashvili; Stefan Paul Koch; Susanne Mueller; Philipp Boehm-Sturm; Volker Haucke; Tanja Maritzen

Proceedings of the National Academy of Sciences 2023

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OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann
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Cryo-EM structures of actin binding proteins as tool for drug discovery

  • Christian Dahlstroem; Themistoklis Paraschiakos; Han Sun; Sabine Windhorst

Biochemical Pharmacology 2023

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The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

  • Claudia Bohg; Carl Öster; Berke Türkaydin; Michael Lisurek; Pascal Sanchez-Carranza; Sascha Lange; Tillmann Utesch; Han Sun; Adam Lange

Science Advances 2023

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OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann
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Addressing persistent challenges in digital image analysis of cancerous tissues

  • Sandhya Prabhakaran; Clarence Yapp; Gregory J. Baker; Johanna Beyer; Young Hwan Chang; Allison Creason; Robert Krueger; Jeremy Muhlich; Nathan Patterson; Kevin Sidak; Damir Sudar; Adam J Taylor; Luke Ternes; Jakob Troidl; Yubin Xie; Artem Sokolov; Darren Tyson; the Cell Imaging Hackathon 2022 Participants (Alphabetical authorship, apart from primary contributors)
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A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses

  • Christoph Ratswohl; Clara Vázquez García; Ata ul Wakeel Ahmad; Hannes Gonschior; Mikhail Lebedin; Casper Ewijn Silvis; Lisa Spatt; Cathrin Gerhard; Martin Lehmann; Leif E. Sander; Florian Kurth; Simon Olsson; Kathrin de la Rosa

European Journal of Immunology 2023

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OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann
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CB2R agonists in the clinics: A treasure chest for treating inflammatory diseases

  • Uwe Grether; Marc Nazaré

Open Access Government 2023

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Direct optical measurement of intra-molecular distances down to the Ångström scale

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Taukeer A. Khan; Michael Weber; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell
online lesen

The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

  • Claudia Bohg; Carl Öster; Berke Türkaydin; Michael Lisurek; Pascal Sanchez-Carranza; Sascha Lange; Tillmann Utesch; Han Sun; Adam Lange

Science Advances 2023

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Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

  • Tim Aguirre; Ellen Teichmann; Florian Q. Römpp; Ruthey Vivier; Cole Bryant; Matthew A. Hulverson; Wesley C. Van Voorhis; Kayode K. Ojo; J. Stone Doggett; Dorothea Fiedler; Stefan Hecht

ACS Chemical Biology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Neuronal endoplasmic reticulum architecture and roles in axonal physiology

  • Klaas Yperman; Marijn Kuijpers

Molecular and Cellular Neuroscience 2023

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Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand

  • Ida M. Vedel; Andreas Prestel; Zhenwei Zhang; Natalia T. Skawinska; Holger Stark; Pernille Harris; Birthe B. Kragelund; Günther H.J. Peters

Structure 2023

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A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

  • Nina A.M. Ligthart; Mark A.R. de Geus; Merel A.T. van de Plassche; Diana Torres García; Marjolein M.E. Isendoorn; Luuk Reinalda; Daniëlle Ofman; Tyrza van Leeuwen; Sander I. van Kasteren

Journal of the American Chemical Society 2023

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ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution

  • Jing Ze Wu; Mariia Zeziulia; Whijin Kwon; Thomas J. Jentsch; Sergio Grinstein; Spencer A. Freeman

Journal of Cell Biology 2023

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(3+2)‐Cyclization Reactions of Unsaturated Phosphonites with Aldehydes and Thioketones

  • Don S. Munasinghe; Marc‐André Kasper; Radomir Jasiński; Karolina Kula; Marcin Palusiak; Małgorzata Celeda; Grzegorz Mlostoń; Christian P. R. Hackenberger

Chemistry – A European Journal 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening

  • Ronja Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch
online lesen

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

  • Joka Pipercevic; Bastian Kohl; Ruta Gerasimaite; Véronique Comte-Miserez; Sarah Hostachy; Thomas Müntener; Elia Agustoni; Henning Jacob Jessen; Dorothea Fiedler; Andreas Mayer; Sebastian Hiller

Nature Communications 2023

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Cesium activates the neurotransmitter receptor for glycine

  • Steffen Fricke; Magnus Harnau; Florian Hetsch; Haoran Liu; Julia Leonhard; Anna Eylmann; Pina Knauff; Han Sun; Marcus Semtner; Jochen C. Meier

Frontiers in Molecular Neuroscience 2023

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The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

  • Laure Papin; Martin Lehmann; Justine Lagisquet; Ghizlane Maarifi; Véronique Robert-Hebmann; Christophe Mariller; Yann Guerardel; Lucile Espert; Volker Haucke; Fabien P. Blanchet

International Journal of Molecular Sciences 2023

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Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

  • Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann

JCI Insight 2023

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Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling

  • Ji Qi; Weiwei Cheng; Zhe Gao; Yuanyuan Chen; Megan L. Shipton; David Furkert; Alfred C. Chin; Andrew M. Riley; Dorothea Fiedler; Barry V.L. Potter; Chenglai Fu

Biomedicine & Pharmacotherapy 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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NMR for Stereochemical Elucidation

  • Xiaolu Li; Xiaoliang Yang; Han Sun

Chiral Separations and Stereochemical Elucidation 2023

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Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1.

  • Elena-Real CA; Urbanek A; Lund XL; Morató A; Sagar A; Fournet A; Estaña A; Bellande T; Allemand F; Cortés J; Sibille N; Melki R; Bernadó P

Structure (London, England : 1993) 2023

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Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
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Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
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Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
online lesen

Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
online lesen

Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
online lesen

TapA acts as specific chaperone in TasA filament formation by strand complementation

  • Yvette Roske; Florian Lindemann; Anne Diehl; Nils Cremer; Victoria A. Higman; Brigitte Schlegel; Martina Leidert; Kristina Driller; Kürşad Turgay; Peter Schmieder; Udo Heinemann; Hartmut Oschkinat

Proceedings of the National Academy of Sciences 2023

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One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP8 Occurs under Cytosolic Conditions

  • Leonie Kurz; Peter Schmieder; Nicolás Veiga; Dorothea Fiedler

Biomolecules 2023

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Discovery of the lanthipeptide curvocidin and structural insights into its trifunctional synthetase CuvL

  • Arnar Sigurdsson; Berta M. Martins; Simon A. Düttmann; Martin Jasyk; Benjamin Dimos-Röhl; Felix Schöpf; Manuel Gemander; Caroline H. Knittel; Romina Schnegotzki; Bianca Schmid; Simone Kosol; Lea Pommerening; María González-Viegas; Maria Seidel; Manuela Hügelland; Silke Leimkühler; Holger Dobbek; Andi Mainz; Roderich Süssmuth

Angewandte Chemie International Edition 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
online lesen

Liste der Publikationen