Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
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FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

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Aktuelle Publikationen

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Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols

  • Mark A. R. de Geus; Christian E. Stieger; Jan Vincent V. Arafiles; Jean-Romain P. J. Lotthé; Peter Schmieder; Kristin Kemnitz-Hassanin; Beate Kindt; Heinrich Leonhardt; Saskia Schmitt; Marcus Gerlach; Dominik Schumacher; Jonas Helma; Marc-André Kasper; Christian P. R. Hackenberger

Journal of the American Chemical Society 2025

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Selectivity and Safety Characterization of a Xanthine–Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis

  • Radoslaw Wesolowski; Anja Schütz; Michael Lisurek; Marc Nazaré; Udo Heinemann; Dirk Pleimes; Michael Bader; Edgar Specker

ACS Pharmacology & Translational Science 2025

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Pore-Opening and Ion-Conduction Mechanism in Channelrhodopsins C1C2, ChR2, and iChloC by Computational Electrophysiology and Constant-pH Simulations

  • Songhwan Hwang; Tillmann Utesch; Caspar Schattenberg; Johannes Vierock; Han Sun

Journal of Chemical Information and Modeling 2025

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Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method

  • Xue Bessie Su; Valeria Fedeli; Guizhen Liu; Meike Marie Amma; Paraskevi Boulasiki; Jingyi Wang; Mariano Bizzarri; Henning Jacob Jessen; Dorothea Fiedler; Antonella Riccio; Adolfo Saiardi

Biochemical Journal 2025

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Proximity labelling reveals the compartmental proteome of murine sensory neurons

  • Julia R Sondermann; Allison M Barry; Feng Xian; Thomas Haberl; David Gomez-Varela; Fritz Benseler; Dietmar Schreiner; Noa Lipstein; Nils Brose; Manuela Schmidt
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Integrative structural interactomics reveals protein organization and structure in a giant virus

  • Lars Mühlberg; Julia Ruta; Vasilii Mikirtumov; Raymond Burton-Smith; Kazuyoshi Murata; Mikhail Kudryashev; Kenta Okamoto; Boris Bogdanow; Fan Liu
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Structural Transition from Closed to Open for the Influenza A M2 Proton Channel as Observed by Proton-Detected Solid-State NMR

  • Swantje Mohr; Caspar Schattenberg; Tillmann Utesch; Henry Sawczyc; Veniamin Chevelkov; Sascha Lange; Jacek Kozuch; Han Sun; Adam Lange

Journal of the American Chemical Society 2025

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Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

  • Souvik Ghosh; Ramona Birke; Ashwin Karthick Natarajan; Johannes Broichhagen

Journal of Peptide Science 2025

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Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

  • Anton F. Ketzel; Yang Hu; Xiao‐Lu Li; Jiaqian Li; Xinxiang Lei; Han Sun

Magnetic Resonance in Chemistry 2025

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Quantitative analysis of inhibitor-induced assembly disruption in human UDP-GlcNAc 2-epimerase using mass photometry

  • Nico Boback; Jacob Gorenflos López; Christian P. R. Hackenberger; Santiago Di Lella; Daniel C. Lauster
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Morphological profiling data resource enables prediction of chemical compound properties

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied

iScience 2025

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Impact of dispersion correction in DFT-enhanced anisotropic NMR for stereochemical elucidation of flexible marine natural products

  • Lu-Ping Chi; Xiao-Lu Li; Anton F. Ketzel; Armando Navarro-Vázquez; Caspar J. Schattenberg; Xiao-Ming Li; Xin Li; Han Sun; Bin-Gui Wang

Marine Life Science & Technology 2025

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A Silicon Rhodamine‐fused Glibenclamide to Label and Detect Malaria‐infected Red Blood Cells

  • Claudia Bastl; Cindy M. Close; Ingo Holtz; Blaise Gatin‐Fraudet; Mareike Eis; Michelle Werum; Smilla Konrad; Laura Kneller; Kilian Roßmann; Christiane Huhn; Souvik Ghosh; Julia Ast; Dorien A. Roosen; Martin Lehmann; Volker Haucke; Luc Reymond; David J. Hodson; Philip Tinnefeld; Kai Johnsson; Viktorija Glembockyte; Nicole Kilian; Johannes Broichhagen

ChemBioChem 2025

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PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections

  • Kaixuan Liu; Yang Liu; Qinghua Wang; Marc Nazaré; Leilei Zhang; Xiandao Pan; Hai-Yu Hu

Journal of Medicinal Chemistry 2025

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Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

  • Rosa Planells-Cases; Viktoriia Vorobeva; Sumanta Kar; Franziska W. Schmitt; Uwe Schulte; Marina Schrecker; Richard K. Hite; Bernd Fakler; Thomas J. Jentsch

Nature Communications 2025

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Cathelicidin-BF: A Potent Antimicrobial Peptide Leveraging Charge and Phospholipid Recruitment against Multidrug-Resistant Clinical Bacterial Isolates

  • Evgeniy Salnikov; Morgane Adélaïde; Francisco Ramos-Martín; Ahmad Saad; Jennifer Schauer; Martina Cremanns; Mariam Rima; Christopher Aisenbrey; Saoussen Oueslati; Thierry Naas; Niels Pfennigwerth; Söeren Gatermann; Catherine Sarazin; Burkhard Bechinger; Nicola D'Amelio

Journal of the American Chemical Society 2025

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Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Felix Schöpf; Andreas Oder; Jens Peter von Kries; Daniel Roderer

Proceedings of the National Academy of Sciences 2025

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Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading

  • Mark Andrew Kreutzberger; Agata Witkowska; Marcelo Ganzella; Julia Preobraschenski; Volker Kiessling; Gudrun Ahnert-Hilger; Reinhard Jahn; Sascha Seibert; Riedel D; Agnieszka Münster-Wandowski; Lukas Tamm; Alex Kreutzberger; Linda H.M. Olsthoorn

Science Advances 2025

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Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

  • Gaga Kochlamazashvili; Aarti Swaminathan; Alexander Stumpf; Amit Kumar; York Posor; Dietmar Schmitz; Volker Haucke; Marijn Kuijpers

Proceedings of the National Academy of Sciences 2025

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Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models

  • Rashi Goel; Kristina Jevdokimenko; Ronja Rehm; Jannik Hentze; Paola Agüi-Gonzalez; Momchil Ninov; Felix Lange; Agata Witkowska; Svenja Bolz; Francesca Pennacchietti; Martina Damenti; Natalie Kaempf; Vladimir Khayenko; Carles Calatayud; Viveka Nand Malviya; Natali L. Chanaday; Emma Scaletti Hutchinson; Hao Liu; Kirsten Weyand; Daniela Ivanova; Tristan P. Wallis; Christopher Small; Hans Michael Maric; Merja Joensuu; Michael A. Cousin; Frédéric A. Meunier; Frederic A. Meunier; Ilaria Testa; Ilaria Testa; Volker Haucke; Stefan Jakobs; Henning Urlaub; Nils Brose; Benjamin H. Cooper; Pål Stenmark; Felipe Opazo; Reinhard Jahn; Silvio O. Rizzoli; Eugenio F. Fornasiero
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Development of a human RPE In vitro model with AMD-like features reveals blue light-induced modulation of the endocannabinoid system.

  • Di Meo C; Tisi A; Lizzi AR; Palaniappan S; Pulcini F; Cinque B; Delle Monache S; Nazarè M; Hsu E; Rapino C; Maccarrone M

Biochemical and biophysical research communications 2025

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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.

  • Borrega-Roman L; Hoare BL; Kosar M; Sarott RC; Patej KJ; Bouma J; Scott-Dennis M; Koers EJ; Gazzi T; Mach L; Barrondo S; Sallés J; Guba W; Kusznir E; Veprintsev DB

Frontiers in pharmacology 2025

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Installation of Site-Specific Inorganic and Organic Phosphate to Peptides and Proteins via Vinylaryl Sulfonium Reagents

  • Qingyun Yang; Kun Zou; Mingxuan Wu

Organic Letters 2025

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Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2

  • Fabián Martínez-Perafán; Anja Fromm; Rozemarijn E. van der Veen; Ayk Waldow; Martin Lehmann; Susanne M. Krug; Dorothee Günzel; Rita Rosenthal; Michael Fromm; Jörg Piontek

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2025

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Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packaging

  • Sarah Harmening; Boris Bogdanow; Karen Wagner; Fan Liu; Martin Messerle; Eva Maria Borst; Anna Ruth Cliffe

Journal of Virology 2025

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Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ+ Cell Ablation in Adult Mice

  • Dila Atak; Erdost Yıldız; Esra Özkan; Mohammadreza Yousefi; Ayşe Özkan; Aysu Bilge Yılmaz; Ali Burak Kızılırmak; Iman Asaad Alnajjar; Çiçek Kanar; Zeynep Lal Caan; Şakir Ümit Zeybek; Cem İsmail Küçükali; Erdem Tüzün; Yasemin Gürsoy‐Özdemir; Atay Vural

Journal of Neurochemistry 2025

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Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

  • Kun‐Han Lin; Mrinalini Ranjan; Noa Lipstein; Nils Brose; Erwin Neher; Holger Taschenberger

The Journal of Physiology 2025

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Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties

  • Arnab Gupta; Bidisha Sinha; Durba Sengupta; Subhendu Kumar Chatterjee; Sumanta Kar; Siddhanta Nikte; Tisha Dash; Saptarshi Maji; Tanmoy Ghosh
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Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization.

  • Sowa ST; Kücükdisli M; Mostinski Y; Schaller DA; Vinagreiro CS; Cirillo D; Bosetti C; Brinch SA; van Laar K; Wegert A; Leenders RGG; Krauss S; Nazaré M

Journal of medicinal chemistry 2025

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Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis.

  • Horatscheck A; Krauß M; Bulut H; Chambon V; Zadah MS; Dransart E; Peloza K; Santos KF; Robertson MJ; Prichard K; Miksche S; Radetzki S; von Kries JP; Nazaré M

Structure (London, England : 1993) 2025

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Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research.

  • Hentsch A; Guberman M; Radetzki S; Kaushik S; Huizenga M; He Y; Contzen J; Kuhn B; Benz J; Schippers M; Paul J; Leibrock L; Collin L; Wittwer M; Nazaré M

Journal of the American Chemical Society 2025

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

online lesen

Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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Protocol for semisynthesis of histone H4 with site-specific modifications using irreversible sortase-mediated ligation

  • Yihang Xiao; Kun Zou; Mingxuan Wu

STAR Protocols 2025

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Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG

  • Carl Öster; Veniamin Chevelkov; Adam Lange

Journal of Biomolecular NMR 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

  • Axel Hentsch; Mónica Guberman; Silke Radetzki; Sofia Kaushik; Mirjam Huizenga; Jerome Paul; Maria Schippers; Jörg Benz; Bernd Kuhn; Dominik Heer; Andreas Topp; Ludivine Esteves Gloria; Alexander Walter; Remo Hochstrasser; Matthias B. Wittwer; Jens Peter von Kries; Ludovic Collin; Julie Blaising; Mario van der Stelt; Noa Lipstein; Uwe Grether; Marc Nazaré

Angewandte Chemie 2025

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Probing the Dynamics of Yersinia Adhesin A (YadA) in Outer Membranes Hints at Requirements for β-Barrel Membrane Insertion

  • Jayasubba Reddy Yarava; Marcella Orwick-Rydmark; David Ryoo; Albert Hofstetter; James C. Gumbart; Michael Habeck; Barth-Jan van Rossum; Dirk Linke; Hartmut Oschkinat

Journal of the American Chemical Society 2025

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Mechanisms and functions of lysosomal lipid homeostasis

  • Michael Ebner; Florian Fröhlich; Volker Haucke

Cell Chemical Biology 2025

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Back Cover: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. Int. Ed. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension

  • Ekaterina Legchenko; Philippe Chouvarine; Klea Hysko; Fatimunnisa Qadri; Radoslaw Wesolowski; Edgar Specker; Silke Glage; Martin Meier; Katharina Schwarz; Joerg Heineke; Gerhard Pohlmann; Mehmet Ramazanoglu; Michael Bader; Georg Hansmannn

American Journal of Respiratory Cell and Molecular Biology 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

  • Hentsch A; Guberman M; Radetzki S; Kaushik S; Huizenga M; Paul J; Schippers M; Benz J; Kuhn B; Heer D; Topp A; Esteves Gloria L; Walter A; Nazaré M

Angewandte Chemie (International ed. in English) 2025

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Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes

  • Patrick Watermann; Gurleen K. Kalsi; Ralf Dringen; Christian Arend

Neurochemical Research 2025

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Selective photo crosslinking to methylarginine readers by sulfonium peptides

  • Ting Luo; Feng Feng; Kun Zou; Yumo Zhao; Yingxiao Gao; Mingxuan Wu

Bioorganic & Medicinal Chemistry 2025

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Chemical probes for imaging cellular compartmentalization

  • Margret H. Bülow; Johannes Broichhagen

Trends in Biochemical Sciences 2025

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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I

  • Xiaoqi Liu; Zixuan Zhang; Tim Aguirre; Megan L. Shipton; Lin Fu; Jimin Du; David Furkert; Ji Qi; Alfred C. Chin; Andrew M. Riley; Tong Liu; Xu Zhang; Barry V.L. Potter; Dorothea Fiedler; Yi Zhu; Chenglai Fu; Tim Aguirre

Metabolism 2025

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Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins

  • Joel I. Badillo‐Gómez; Irene Suarez‐Antuña; Ievgen Mazurenko; Frédéric Biaso; Jacques Pécaut; Elisabeth Lojou; Pascale Delangle; Sarah Hostachy

Chemistry – A European Journal 2025

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Integrative Molekulardynamiksimulationen entwirren cross‐linking Daten und zeigen Verteilungen von mitochondrialen Proteinen

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie 2025

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Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie International Edition 2025

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Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler

Proceedings of the National Academy of Sciences 2025

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Liste der Publikationen