Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
MEHR

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

Technische Assistenz für Elektronenmikroskopie (w/m/d)28. Jan. 2026

all job offers

News

Zum Newsroom

Forschungsgruppen & Technologieplattformen

von 20

Alle Gruppen A-Z

Aktuelle Publikationen

von 50

Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
online lesen

Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
online lesen

A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

  • Fabian M.B. Thöne; Maya M. Polovitskaya; Uta E. Höpken; Armin Rehm; Thomas J. Jentsch

Journal of Biological Chemistry 2026

online lesen

Conservation and Specificity in Bacillus Biofilm Dynamics: On Structure and Function of B. cereus Camelysins

  • Anne Diehl; Florian Lindemann; Nils Cremer; Yvette Roske; Matthias Hiller; Barth van Rossum; Martina Leidert; Kürşad Turgay; Hartmut Oschkinat

Journal of Molecular Biology 2026

online lesen

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

online lesen

Supplementary Figure S1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Methods from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S7 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Data from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Table 1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Supplementary Figure S6 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie 2026

online lesen

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2026

online lesen

Supplementary Table 4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
online lesen

LRRC8-Mediated Glutamate Release from Astrocytes Is Not Increased During the Initiation of Experimental Temporal Lobe Epilepsy

  • Kamyab Sarmadi; Linda Gaspar; Peter Bedner; Lukas Henning; Christian Henneberger; Ronald Jabs; Thomas J. Jentsch; Christian Steinhäuser; Gerald Seifert

International Journal of Molecular Sciences 2026

online lesen

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

  • Haoran Liu; Klaus Benndorf; Yessenbek K. Aldakul; Han Sun

Advanced Science 2026

online lesen

Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides

  • Niklas Piet Doering; Kristina Puls; Marta Diceglie; Anja Meraner; Axel Hentsch; Siriwat Hongnak; Armin Wurzer; Helmut Schmidhammer; Mariana Spetea; Marc Nazare; Gerhard Wolber

Journal of Medicinal Chemistry 2026

online lesen

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

online lesen

Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Helge Ewers; Volker Haucke; Michael Krauss

Nature Communications 2026

online lesen

Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Helge Ewers; Volker Haucke; Michael Krauss

Nature Communications 2026

online lesen

Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction

  • Antje Kathrin Huebner; Jean Christopher Hennings; Michael Kiehntopf; Sebastian Bachmann; Tobias Stauber; Thomas J Jentsch; Dominique Eladari; Christian A Hubner; Bernhard Schermer; Keerthana Srinivasa Murthy; Nicolas Picard; Inês Cabrita; David Boehm; Maria Elisabeth Krause; Vandit Shah; Regine Chambrey; Diana Schmerler; Mukhran Khundadze; Christian Franke; Detlef Boeckenhauer; Gregor Jörg Gentsch; Jennifer Baraka-Vidot

Science Translational Medicine 2026

online lesen

Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting

  • Christian E. Stieger; Charlotte Völkel; Mathias B. Bertelsen; Michael Lisurek; Jan Vincent V. Arafiles; Jonathan Franke; Leander Crocker; Karl Schuppe; Yunjae Lim; Christiane Groneberg; Mathias Christmann; Han Sun; Christian P. R. Hackenberger

Journal of the American Chemical Society 2026

online lesen

Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity and post-tetanic potentiation

  • Erik Mathias Jorgensen; Noa Lipstein; Nils Brose; Erwin Neher; Thomas C Südhof; Holger Taschenberger; Mrinalini Ranjan; Kun-Han Lin; Brian D Mueller; Sonja Melanie Wojcik; Mareike Lohse

Science Advances 2026

online lesen

TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma

Molecular Cancer Therapeutics 2026

online lesen

Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

online lesen

Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Enrica Bordignon; Oleg Sitsel; Daniel Roderer; Daniel Prumbaum; Stefan Raunser; Min Dong; Claus Arthur Martin Seidel; Peter Njenga Ng'ang'a; Julian Folz; Svetlana Kucher; Ying Xu; Alexander Belyy; Ralf Kühnemuth; Tufa Enver Assafa

Science Advances 2025

online lesen

C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek

Computational and Structural Biotechnology Journal 2025

online lesen

Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

  • Felix Schöpf; Gian L. Marongiu; Klaudia Milaj; Thiemo Sprink; Judith Kikhney; Annette Moter; Daniel Roderer

Nature Communications 2025

online lesen

Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Sarah Lampe; Björn Hanf; Jeremy A. M. Morgan; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler

Nature Chemistry 2025

online lesen

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

  • Kun‐Han Lin; Mrinalini Ranjan; Noa Lipstein; Nils Brose; Erwin Neher; Holger Taschenberger

The Journal of Physiology 2025

online lesen

PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections

  • Kaixuan Liu; Yang Liu; Qinghua Wang; Marc Nazaré; Leilei Zhang; Xiandao Pan; Hai-Yu Hu

Journal of Medicinal Chemistry 2025

online lesen

Characterization of the direct and indirect inhibition of apoptosis by full-length recombinant Bcl-xL monomers

  • Christina Elsner; Ludovica M. Epasto; Adeline Cieren; Dominik Gendreizig; Svetlana Kucher; Daniel Roderer; Enrica Bordignon
online lesen

Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

  • Rosa Planells-Cases; Viktoriia Vorobeva; Sumanta Kar; Franziska W. Schmitt; Uwe Schulte; Marina Schrecker; Richard K. Hite; Bernd Fakler; Thomas J. Jentsch

Nature Communications 2025

online lesen

Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension

  • Ekaterina Legchenko; Philippe Chouvarine; Klea Hysko; Fatimunnisa Qadri; Radoslaw Wesolowski; Edgar Specker; Silke Glage; Martin Meier; Katharina Schwarz; Joerg Heineke; Gerhard Pohlmann; Mehmet Ramazanoglu; Michael Bader; Georg Hansmann

American Journal of Respiratory Cell and Molecular Biology 2025

online lesen

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69

  • Mark McHugh; Charity N. Njeshi; Nathaniel Smith; Sudhanva S. Kashyap; Real Datta; Han Sun; Alan P. Robertson; Richard J. Martin

PLOS Pathogens 2025

online lesen

Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Felix Schöpf; Andreas Oder; Jens Peter von Kries; Daniel Roderer

Proceedings of the National Academy of Sciences 2025

online lesen

Death, taxes, and rhomboids: Understanding the ubiquitous roles of the rhomboid protein superfamily

  • Henry Sawczyc; Spyridon Kosteletos; Adam Lange

Journal of Biological Chemistry 2025

online lesen

Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

  • Souvik Ghosh; Ramona Birke; Ashwin Karthick Natarajan; Johannes Broichhagen

Journal of Peptide Science 2025

online lesen

Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

  • Anton F. Ketzel; Yang Hu; Xiao‐Lu Li; Jiaqian Li; Xinxiang Lei; Han Sun

Magnetic Resonance in Chemistry 2025

online lesen

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants

  • Aqfan Jamaluddin; Rachael A. Wyatt; Johannes Broichhagen; Joshua Levitz; Caroline M. Gorvin
online lesen

Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

  • Gaga Kochlamazashvili; Aarti Swaminathan; Alexander Stumpf; Amit Kumar; York Posor; Dietmar Schmitz; Volker Haucke; Marijn Kuijpers

Proceedings of the National Academy of Sciences 2025

online lesen

Chemisch spaltbare Sonden zur Visualisierung ko-internalisierter Rezeptoren

  • Johannes Broichhagen

BIOspektrum 2025

online lesen

Unsaturated phosphorus electrophiles to probe protein tyrosine phosphatases

  • Eleftheria Poulou; Max Ruwolt; Christian Stieger; Kristin Kemnitz-Hassanin; Christian Hackenberger
online lesen

Liste der Publikationen