Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

Wir forschen für die Grundlagen der Medizin von morgen

Was hält uns gesund und was macht uns krank? Wie gelangt ein Medikament an den richtigen Wirkungsort im Körper? Und wie kann man umgekehrt Viren und Bakterien daran hindern in Zellen und Gewebe einzudringen? Um diese Fragen zu beantworten, untersuchen wir biochemische Abläufe in Zellen und Organen und studieren die molekularen Ursachen von Krankheiten. Auf der Basis dieser Erkenntnisse suchen unsere Wissenschaftler:innen gezielt nach Wirkstoffen oder entwickeln neuartige Diagnostika und Therapeutika um so die Grundlage für die Medizin von morgen zu schaffen.
MEHR

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.

ERC-Funded Postdoctoral Positions in Molecular Neuroscience/ Biochemistry in Berlin (f/m/d) (Ref. 15/2024)25. Nov. 2024
PhD student (f/m/d)22. Nov. 2024
PhD student or postdoctoral fellow (f/m/d)31. Oct. 2024

all job offers

News

Zum Newsroom

Forschungsgruppen & Technologieplattformen

von 21

Alle Gruppen A-Z

Aktuelle Publikationen

von 50

Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes

  • Patrick Watermann; Gurleen K. Kalsi; Ralf Dringen; Christian Arend

Neurochemical Research 2025

online lesen

Selective photo crosslinking to methylarginine readers by sulfonium peptides

  • Ting Luo; Feng Feng; Kun Zou; Yumo Zhao; Yingxiao Gao; Mingxuan Wu

Bioorganic & Medicinal Chemistry 2025

online lesen

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I

  • Xiaoqi Liu; Zixuan Zhang; Tim Aguirre; Megan L. Shipton; Lin Fu; Jimin Du; David Furkert; Ji Qi; Alfred C. Chin; Andrew M. Riley; Tong Liu; Xu Zhang; Barry V.L. Potter; Dorothea Fiedler; Yi Zhu; Chenglai Fu

Metabolism 2025

online lesen

Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

  • Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen

RSC Chemical Biology 2025

online lesen

Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

  • Milan Avila Clasen; Max Ruwolt; Cong Wang; Julia Ruta; Boris Bogdanow; Louise U. Kurt; Zehong Zhang; Shuai Wang; Fabio C. Gozzo; Tao Chen; Paulo C. Carvalho; Diogo Borges Lima; Fan Liu

Nature Methods 2024

online lesen

Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies

  • Boris Bogdanow; Max Ruwolt; Julia Ruta; Lars Mühlberg; Cong Wang; Wen-feng Zeng; Arne Elofsson; Fan Liu

Molecular Systems Biology 2024

online lesen

Dual BACH1 regulation by complementary SCF-type E3 ligases

  • Benedikt Goretzki; Maryam Khoshouei; Martin Schröder; Patrick Penner; Luca Egger; Christine Stephan; Dayana Argoti; Nele Dierlamm; Jimena Maria Rada; Sandra Kapps; Catrin Swantje Müller; Zacharias Thiel; Merve Mutlu; Claude Tschopp; David Furkert; Felix Freuler; Simon Haenni; Laurent Tenaillon; Britta Knapp; Alexandra Hinniger; Philipp Hoppe; Enrico Schmidt; Sascha Gutmann; Mario Iurlaro; Grigory Ryzhakov; César Fernández

Cell 2024

online lesen

ARF1 compartments direct cargo flow via maturation into recycling endosomes

  • Alexander Stockhammer; Petia Adarska; Vini Natalia; Anja Heuhsen; Antonia Klemt; Gresy Bregu; Shelly Harel; Carmen Rodilla-Ramirez; Carissa Spalt; Ece Özsoy; Paula Leupold; Alica Grindel; Eleanor Fox; Joy Orezimena Mejedo; Amin Zehtabian; Helge Ewers; Dmytro Puchkov; Volker Haucke; Francesca Bottanelli

Nature Cell Biology 2024

online lesen

Scalable synthesis of sulfonium and selenonium peptides for selective methyllysine reader crosslinking

  • Yingxiao Gao; Feng Feng; Mingxuan Wu

Tetrahedron Letters 2024

online lesen

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

  • Aqfan Jamaluddin; Rachael A. Wyatt; Joon Lee; Georgina K.C. Dowsett; John A. Tadross; Johannes Broichhagen; Giles S.H. Yeo; Joshua Levitz; Caroline M. Gorvin
online lesen

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development

  • Florian Laurent; Caroline Gutjahr; Simon M. Bartsch; Anuj Shukla; Felix Rico-Resendiz; Daniel Couto; Christelle Fuchs; Joël Nicolet; Sylvain Loubéry; Henning J. Jessen; Dorothea Fiedler; Michael Hothorn

PLOS Genetics 2024

online lesen

Structural insights into the opening mechanism of C1C2 channelrhodopsin

  • Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss
online lesen

Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

  • Lixiao Zhou; Xingsen Zhao; Jie Sun; Kun Zou; Xiaoli Huang; Liyang Yu; Mingxuan Wu; Yong Wang; Xuekun Li; Wen Yi

Nature Communications 2024

online lesen

Energy transfer photoproximity labelling in live cells using an organic cofactor

  • Leander Crocker; Jan Vincent V. Arafiles; Judith M. Müchler; Max Ruwolt; Kristin Kemnitz-Hassanin; Kilian Roßmann; Christian E. Stieger; Fan Liu; Christian P. R. Hackenberger
online lesen

Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR

  • Lisa Gerland; Anne Diehl; Natalja Erdmann; Matthias Hiller; Christina Lang; Christian Teutloff; Jon Hughes; Hartmut Oschkinat

Chemistry – A European Journal 2024

online lesen

Molecular architecture of synaptic vesicles

  • Uljana Kravcenko; Max Ruwolt; Jana Kroll; Artsemi Yushkevich; Martina Zenkner; Julia Ruta; Rowaa Lotfy; Erich Wanker; Christian Rosenmund; Fan Liu; Misha Kudryashev

Proceedings of the National Academy of Sciences 2024

online lesen

ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

online lesen

Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

online lesen

Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

online lesen

Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

online lesen

A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

online lesen

A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

online lesen

Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network

  • Andromachi Papagiannoula; Ida Marie Vedel; Kathrin Motzny; Maud Tengo; Sigrid Milles
online lesen

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

  • Alice Rossi; Max Ruwolt; Paraskevi Kakouri; Tetiana Kosten; Severine Kunz; Dmytro Puchkov; Jane Reznick; Bettina Purfürst; Damir Omerbašić; Daniel Méndez Aranda; Giorgia Carai; Guido Mastrobuoni; Daniel W. Hart; Michela Carraro; Ludovica Tommasin; Nigel C. Bennett; Valérie Bégay; Katja Faelber; Oliver Daumke; Paolo Bernardi; Thomas J. Park; Stefan Kempa; Fan Liu; Gary R. Lewin
online lesen

Biogenesis and reformation of synaptic vesicles

  • Svenja Bolz; Volker Haucke

The Journal of Physiology 2024

online lesen

Direct optical measurement of intramolecular distances with angstrom precision

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Michael Weber; Taukeer A. Khan; Christian Brüser; Stefan Jakobs; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell

Science 2024

online lesen

Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

  • Maria Kowald; Sylvestre P. J. T. Bachollet; Fritz Benseler; Maria Steinecker; Sofia Kaushik; Tolga Soykan; Sun Siqi; Ramona Birke; Dragana Ilic; Nils Brose; Hanna Hörnberg; Martin Lehmann; Silvio O. Rizzoli; Johannes Broichhagen; Noa Lipstein
online lesen

NUDIX Hydrolases Target Specific Inositol Pyrophosphates and Regulate Phosphate and Iron Homeostasis, and the Expression of Defense Genes in Arabidopsis

  • Robin Schneider; Klea Lami; Isabel Prucker; Sara Christina Stolze; Annett Strauß; Kevin Langenbach; Marília Kamleitner; Yemisrach Zewdu Belay; Kevin Ritter; David Furkert; Philipp Gaugler; Esther Lange; Natalie Faiß; Julie Marie Schmidt; Michael Harings; Lukas Krusenbaum; Stefanie Wege; Simon Kriescher; Heiko Schoof; Dorothea Fiedler; Hirofumi Nakagami; Ricardo F. H. Giehl; Thomas Lahaye; Henning J. Jessen; Verena Gaugler; Gabriel Schaaf
online lesen

Semi-supervised Contrastive Learning for Bioactivity Prediction using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun
online lesen

Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras

  • Kate Prichard; Ngoc Chau; Jing Xue; Michael Krauss; Jennette A. Sakoff; Jayne Gilbert; Claudia Bahnik; Maria Muehlbauer; Silke Radetzki; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2024

online lesen

Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates

  • Zi Yang; Saori R Yoshii; Yuji Sakai; Jing Zhang; Haruka Chino; Roland L Knorr; Noboru Mizushima

The EMBO Journal 2024

online lesen

Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

online lesen

Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

online lesen

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

online lesen

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler
online lesen

Robust and Irreversible Sortase‐Mediated Ligation by Empolyment of Sarkosyl

  • Yihang Xiao; Mingxuan Wu

Chemistry – A European Journal 2024

online lesen

Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Martin Lehmann; Fan Liu; Weria Pezeshkian
online lesen

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
online lesen

Structural basis for immune cell binding ofFusobacterium nucleatumvia the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Andreas Oder; Jens Peter von Kries; Daniel Roderer
online lesen

A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2knock-down new mouse model

  • Xiao Min Zhang; Urielle François; Maria Florencia Angelo; Stéphane Claverol; Magali Mondin; Christelle Martin; Melissa Deshors; Yann Humeau; Noa Lipstein; Etienne Herzog
online lesen

A Novel Mouse Model Demonstrates In Vivo Replenishment of Central Nervous System Pericytes After Successful Acute Ablation

  • Dila Atak; Erdost Yıldız; Esra Özkan; Mohammadreza Yousefi; Ayşe Özkan; Aysu Bilge Yılmaz; Ali Burak Kızılırmak; Iman Asaad Alnajjar; Çiçek Kanar; Zeynep Lal Caan; Şakir Ümit Zeybek; Cem İsmail Küçükali; Erdem Tüzün; Yasemin Gürsoy-Özdemir; Atay Vural
online lesen

OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó; Rozemarijn Van Der Veen; Volker Haucke; Martin Lehmann

BMC Biology 2024

online lesen

Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment

  • Maria Mendes; Sandra Nunes; Tânia Cova; Francisco Branco; Michael Dyrks; Beate Koksch; Nuno Vale; João Sousa; Alberto Pais; Carla Vitorino

Colloids and Surfaces B: Biointerfaces 2024

online lesen

A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

  • York Posor; Volker Haucke

Journal of Cell Biology 2024

online lesen

An anionic two dimensional covalent organic framework from tetratopic borate centres pillared by lithium ions

  • Darosch Asgari; Julia Grüneberg; Yunkai Luo; Hüseyin Küçükkeçeci; Samrat Ghosh; Veniamin Chevelkov; Sabrina Fischer-Lang; Jérôme Roeser; Adam Lange; Bruce Dunn; Michael Gradzielski; Arne Thomas

Nature Communications 2024

online lesen

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie International Edition 2024

online lesen

HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity

  • Sabrina Montresor; Maria Lucia Pigazzini; Sudarson Baskaran; Mira Sleiman; Govinda Adhikari; Lukas Basilicata; Luca Secker; Natascha Jacob; Yara Ehlert; Anushree Kelkar; Gurleen Kaur Kalsi; Niraj Kulkarni; Paul Spellerberg; Janine Kirstein

Journal of Neurochemistry 2024

online lesen

When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping

  • Alexander Stockhammer; Carissa Spalt; Antonia Klemt; Laila S. Benz; Shelly Harel; Vini Natalia; Lukas Wiench; Christian Freund; Benno Kuropka; Francesca Bottanelli

Journal of Cell Science 2024

online lesen

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

  • Henry Sawczyc; Takashi Tatsuta; Carl Öster; Spyridon Kosteletos; Sascha Lange; Claudia Bohg; Thomas Langer; Adam Lange

Nature Communications 2024

online lesen

Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied
online lesen

Liste der Publikationen