Jens Peter von Kries

Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.

• Specker E; Wesolowski R; Schütz A; Matthes S; Mallow K; Wasinska-Kalwa M; Winkler L; Oder A; Alenina N; Pleimes D; von Kries JP; Heinemann U; Bader M; Nazaré M

Journal of medicinal chemistry 2023

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.

• Yan S; Schöpe PC; Lewis J; Putzker K; Uhrig U; Specker E; von Kries JP; Lindemann P; Omran A; Sanchez-Ibarra HE; Unger A; Zischinsky ML; Klebl B; Stein U

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.

• Aguirre T; Dornan GL; Hostachy S; Neuenschwander M; Seyffarth C; Haucke V; Schütz A; von Kries JP; Fiedler D

eLife 2023

Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.

• Gorenflos López JL; Dornan GL; Boback N; Neuenschwander M; Oder A; Kemnitz-Hassanin K; Schmieder P; Specker E; Asikoglu HC; Oberdanner C; Hackenberger CPR

Chembiochem : a European journal of chemical biology 2023

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.

• Kücükdisli M; Bel-Abed H; Cirillo D; Lo WT; Efrém NL; Horatscheck A; Perepelittchenko L; Prokofeva P; Ehret TAL; Radetzki S; Neuenschwander M; Nazaré M

Journal of medicinal chemistry 2023

7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

• Zink C; Witzinger L; Keller A; Hadamek K; Bothe S; Neuenschwander M; Villmann C; von Kries JP; Schindelin H; Jeanclos E; Gohla A

Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection.

• Mehboob R; von Kries JP; Ehsan K; Almansouri M; Bamaga AK

Frontiers in neurology 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Aguirre T; Dornan GL; Hostachy S; Neuenschwander M; Seyffarth C; Haucke V; Schütz A; von Kries JP; Fiedler D

Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation.

• Renikunta HV; Lazarow K; Gong Y; Shukla PC; Nageswaran V; Giral H; Kratzer A; Opitz L; Engel FB; Haghikia A; Costantino S; Paneni F; von Kries JP; Jakob P

iScience 2023

Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.

• Jordan P; Costa A; Specker E; Popp O; Volkamer A; Piske R; Obrusnik T; Kleissle S; Stuke K; Rex A; Neuenschwander M; von Kries JP; Nazare M; Wolf SA

PloS one 2023

The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.

• Ahmed SM; Ragunathan P; Shin J; Peter S; Kleissle S; Neuenschwander M; Schäfer R; Kries JPV; Grüber G; Dröge P

FEBS letters 2023

Glycolytic flux control by drugging phosphoglycolate phosphatase.

• Jeanclos E; Schlötzer J; Hadamek K; Yuan-Chen N; Alwahsh M; Hollmann R; Fratz S; Yesilyurt-Gerhards D; Frankenbach T; Engelmann D; Keller A; Gohla A

Nature communications 2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.

• Tufan AB; Lazarow K; Kolesnichenko M; Sporbert A; von Kries JP; Scheidereit C

The EMBO journal 2022

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

• Lo WT; Belabed H; Kücükdisli M; Metag J; Roske Y; Prokofeva P; Ohashi Y; Horatscheck A; Cirillo D; Krauss M; Schmied C; Neuenschwander M; Haucke V

Nature chemical biology 2022

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.

• Specker E; Matthes S; Wesolowski R; Schütz A; Grohmann M; Alenina N; Pleimes D; Mallow K; Neuenschwander M; Gogolin A; Weise M; Pfeifer J; Ziebart N; Bader M

Journal of medicinal chemistry 2022

Disruptors of AKAP-Dependent Protein-Protein Interactions.

• Walker-Gray R; Pallien T; Miller DC; Oder A; Neuenschwander M; von Kries JP; Diecke S; Klussmann E

Methods in molecular biology (Clifton, N.J.) 2022

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

• Sandrine Baltzer; Timur Bulatov; Christopher Schmied; Andreas Krämer; Benedict-Tilman Berger; Andreas Oder; Ryan Walker-Gray; Christin Kuschke; Kerstin Zühlke; Jenny Eichhorst; Martin Lehmann; Stefan Knapp; John Weston; Jens Von Kries; Roderich D. Süssmuth; Enno Klussmann

International Journal of Molecular Sciences 2022

TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation

• Tufan AB; Lazarow K; Kolesnichenko M; Sporbert A; von Kries JP; Scheidereit C

Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner.

• Yusenko MV; Biyanee A; Andersson MK; Radetzki S; von Kries JP; Stenman G; Klempnauer KH

Cancer letters 2021

Author Correction: Loss-of-function uORF mutations in human malignancies.

• Schulz J; Mah N; Neuenschwander M; Kischka T; Ratei R; Schlag PM; Castaños-Vélez E; Fichtner I; Tunn PU; Denkert C; Klaas O; Berdel WE; von Kries JP; Wethmar K

Scientific reports 2021

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.

• Ostrop J; Zwiggelaar RT; Terndrup Pedersen M; Gerbe F; Bösl K; Lindholm HT; Díez-Sánchez A; Parmar N; Radetzki S; von Kries JP; Jay P; Jensen KB; Oudhoff MJ

Frontiers in cell and developmental biology 2021

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.

• Bonnekoh H; Vera C; Abad-Perez A; Radetzki S; Neuenschwander M; Specker E; Mahnke NA; Frischbutter S; Latz E; Nazaré M; Kries JV; Maurer M; Scheffel J; Krause K

Clinical and translational allergy 2021

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.

• Ullrich F; Blin S; Lazarow K; Daubitz T; von Kries JP; Jentsch TJ

eLife 2019

Regulation of influenza A virus mRNA splicing by CLK1.

• Artarini A; Meyer M; Shin YJ; Huber K; Hilz N; Bracher F; Eros D; Orfi L; Keri G; Goedert S; Neuenschwander M; von Kries J; Domovich-Eisenberg Y; Karlas A

Antiviral research 2019

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization.

• Kasper MA; Glanz M; Oder A; Schmieder P; von Kries JP; Hackenberger CPR

Chemical science 2019

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.

• Merkert S; Schubert M; Olmer R; Engels L; Radetzki S; Veltman M; Scholte BJ; Zöllner J; Pedemonte N; Galietta LJV; von Kries JP; Martin U

Stem cell reports 2019

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.

• Brennecke P; Rasina D; Aubi O; Herzog K; Landskron J; Cautain B; Vicente F; Quintana J; Mestres J; Stechmann B; Ellinger B; Brea J; Kolanowski JL; Gribbon P

SLAS discovery : advancing life sciences R & D 2019

Identification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels

• Ullrich F; Blin S; Lazarow K; Daubitz T; Kries Jv; Jentsch TJ

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.

• Marcinkowski P; Hoyer I; Specker E; Furkert J; Rutz C; Neuenschwander M; Sobottka S; Sun H; Nazare M; Berchner-Pfannschmidt U; von Kries JP; Krause G

Thyroid : official journal of the American Thyroid Association 2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.

• Klein W; Rutz C; Eckhard J; Provinciael B; Specker E; Neuenschwander M; Kleinau G; Scheerer P; von Kries JP; Nazaré M; Vermeire K; Schülein R

PloS one 2018

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.

• Otten C; Knox J; Boulday G; Eymery M; Haniszewski M; Neuenschwander M; Radetzki S; Vogt I; Hähn K; De Luca C; Cardoso C; Hamad S; Igual Gil C; Roy P; Abdelilah-Seyfried S

EMBO molecular medicine 2018

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

• Liss M; Radke MH; Eckhard J; Neuenschwander M; Dauksaite V; von Kries JP; Gotthardt M

PloS one 2018

Loss-of-function uORF mutations in human malignancies.

• Schulz J; Mah N; Neuenschwander M; Kischka T; Ratei R; Schlag PM; Castaños-Vélez E; Fichtner I; Tunn PU; Denkert C; Klaas O; Berdel WE; von Kries JP; Wethmar K

Scientific reports 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

• Schrade K; Tröger J; Eldahshan A; Zühlke K; Abdul Azeez KR; Elkins JM; Neuenschwander M; Oder A; Elkewedi M; Jaksch S; Andrae K; Li J; Fernandes J; Klussmann E

PloS one 2018

Small Molecules Targeting Human N-Acetylmannosamine Kinase.

• Hinderlich S; Neuenschwander M; Wratil PR; Oder A; Lisurek M; Nguyen LD; von Kries JP; Hackenberger CPR

Chembiochem : a European journal of chemical biology 2017

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

• Anumala UR; Waaler J; Nkizinkiko Y; Ignatev A; Lazarow K; Lindemann P; Olsen PA; Murthy S; Obaji E; Majouga AG; Leonov S; von Kries JP; Lehtiö L; Nazaré M

Journal of medicinal chemistry 2017

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.

• Fetzer C; Korotkov VS; Thänert R; Lee KM; Neuenschwander M; von Kries JP; Medina E; Sieber SA

Angewandte Chemie (International ed. in English) 2017

Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of <i>aqp-8</i> in <i>C. elegans</i>.

• Igual Gil C; Jarius M; von Kries JP; Rohlfing AK

Frontiers in physiology 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

• Juneja M; Kobelt D; Walther W; Voss C; Smith J; Specker E; Neuenschwander M; Gohlke BO; Dahlmann M; Radetzki S; Preissner R; von Kries JP; Schlag PM; Stein U

PLoS biology 2017

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

• Carter DM; Specker E; Przygodda J; Neuenschwander M; von Kries JP; Heinemann U; Nazaré M; Gohlke U

SLAS discovery : advancing life sciences R & D 2017

Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase.

• Bleif S; Hannemann F; Lisurek M; von Kries JP; Zapp J; Dietzen M; Antes I; Bernhardt R

Chembiochem : a European journal of chemical biology 2011

Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

• Waaler J; Machon O; von Kries JP; Wilson SR; Lundenes E; Wedlich D; Gradl D; Paulsen JE; Machonova O; Dembinski JL; Dinh H; Krauss S

Cancer research 2011

Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.

• Timm T; von Kries JP; Li X; Zempel H; Mandelkow E; Mandelkow EM

The Journal of biological chemistry 2011

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

• von Kleist L; Stahlschmidt W; Bulut H; Gromova K; Puchkov D; Robertson MJ; MacGregor KA; Tomilin N; Pechstein A; Chau N; Chircop M; Sakoff J; Haucke V

Cell 2011

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.

• Due AV; Kuper J; Geerlof A; von Kries JP; Wilmanns M

Proceedings of the National Academy of Sciences of the United States of America 2011

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.

• Christian F; Szaszák M; Friedl S; Drewianka S; Lorenz D; Goncalves A; Furkert J; Vargas C; Schmieder P; Götz F; Zühlke K; Moutty M; Göttert H; Klussmann E

The Journal of biological chemistry 2010

The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction.

• Choi M; Eulenberg C; Rolle S; von Kries JP; Luft FC; Kettritz R

Clinical and experimental immunology 2010

A novel DNA gyrase inhibitor rescues Escherichia coli dnaAcos mutant cells from lethal hyperinitiation.

• Johnsen L; Weigel C; von Kries J; Møller M; Skarstad K

The Journal of antimicrobial chemotherapy 2010

Identification of small-molecule scaffolds for p450 inhibitors.

• von Kries JP; Warrier T; Podust LM

Current protocols in microbiology 2010

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.

• Lisurek M; Rupp B; Wichard J; Neuenschwander M; von Kries JP; Frank R; Rademann J; Kühne R

Molecular diversity 2009

Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.

• Podust LM; Ouellet H; von Kries JP; de Montellano PR

The Journal of biological chemistry 2009

Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.

• Fetz V; Knauer SK; Bier C; von Kries JP; Stauber RH

Sensors (Basel, Switzerland) 2009

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

• Konkle ME; Hargrove TY; Kleshchenko YY; von Kries JP; Ridenour W; Uddin MJ; Caprioli RM; Marnett LJ; Nes WD; Villalta F; Waterman MR; Lepesheva GI

Journal of medicinal chemistry 2009