Chemische Biologie

Research groups in Chemical Biology investigate the function of biological systems with the means of chemical methods. The research of this section uses synthetic, high-throughput screening, computational, and analytical approaches to develop chemical tools and molecular probes to study and modulate the cellular function of important pharmacological targets.

Our work embraces peptides, proteins and low molecular weight drug-like molecules, along with the further development of protein analytics, conjugation and delivery techniques. Biochemical, computational and physical methods aid to investigate interactions of substances with important protein structures. High-throughput screening approaches enable the identification of small molecules and the regulation of gene expression at the cellular, pathway, and molecular levels.
Thereby we contribute to a central goal of the institute which is the elucidation of new principles for pharmacological intervention, which may ultimately lead to novel diagnostic and disease treatment strategies.