- Forschung
- Karriere
- Aktuelles
- Institut
- Durchsuchen
- Spachumstellung
- Leichte Sprache
„”
Our research focuses on understanding membrane transport mechanisms at the atomistic scale and rationally designing tool compounds for pharmacological intervention. Biological membranes serve as central barriers that separate the extracellular and intracellular environments, as well as the major compartments within cells. Understanding how ions, substrates, drugs, and delivery systems move across these membranes is not only crucial for elucidating physiological processes and disease mechanisms but also essential for developing drug-like molecules and improving drug delivery strategies. On the theoretical side, our group develops and applies advanced molecular modeling techniques, state-of-the-art molecular dynamics (MD), quantum mechanics/molecular mechanics (QM/MM) simulations, and machine learning. Experimentally, we develop novel solution NMR-based methods to probe the conformational dynamics and molecular interactions of both organic molecules and biomolecules.
[Translate to Deutsch:] K+ permeation in NaK channel. DOI: doi.org/10.1038/s41467-018-03179-y
[Translate to Deutsch:] K+ permeation GluA2 AMPA receptor. DOI: doi.org/10.1073/pnas.201284311.
© Johann Biedermann
MD simulations of ion channels
MD simulations of ion channels
Free energy calculations
NMR for natural products.
MD simulations of ion channels
NMR analysis of cyclic peptides.
MD simulations of membrane transport mechanism.
NMR investigation of natural products
Computational investigation of ion channel modulation.
Cell Painting analysis.
Free energy calculations