Molekulare Physiologie und Zellbiologie

14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells

• Mugabo, Y. et al.

JCI Insight 2022, 7, e156378

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis

• Halland, N. et al.

Journal of Medicinal Chemistry 2022, 65, 1567-1584

Pharmacological tools to investigate inositol polyphosphate kinases - Enzymes of increasing therapeutic relevance

• Kröber, T. et al.

Advances in Biological Regulation 2022, 83, 100836

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

• Li, H. Y. et al.

Advanced Science 2022, 9, e2103249

Phosphoinositides as membrane organizers

• Posor, Y. et al.

Nature Reviews Molecular Cell Biology 2022, early access,

Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents

• Lin, Y. X. et al.

Chemical Science 2022, 13, 5838-5845

Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components

• Dahhan, D. A. et al.

Plant Cell 2022

Proton-gated anion transport governs macropinosome shrinkage

• Zeziulia, M. et al.

Nature Cell Biology 2022

Rapid analytical CEST spectroscopy of competitive host-guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

• Morik, H. et al.

Physical Chemistry Chemical Physics 2022, 24, 12126-12135

Seeing glutamate at central synapses

• Hao, Y., & et al.

Journal of Neuroscience Methods 2022, 375, 109531

Molecular and functional architecture of striatal dopamine release sites

• Banerjee, A. et al.

Neuron 2022, 110, 248-265

Serca Modulation Counteracts Glucocorticoid Resistance in T-All

• Pagliaro, L. et al.

Haematologica 2022, 107, 19-19

Simple, efficient and thorough shotgun proteomic analysis with PatternLab V

• Santos, M. D. M. et al.

Nature Protocols 2022, Online ahead of print,

Site-specific N-glycan profiles of alpha(5)beta(1) integrin from rat liver

• Mirgorodskaya, E. et al.

Biology of the Cell 2022, 114, 160-176

Slow excitatory synaptic currents generated by AMPA receptors

• Pampaloni, N. P., & et al.

Journal of Physiology-London 2022, 600, 217-232

Structural basis of phosphatidylinositol 3-kinase C2 alpha function

• Lo, W. et al.

Nature Structural & Molecular Biology 2022, 29, 218-228

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

• Birke, R. et al.

Organic & Biomolecular Chemistry 2022, Advance Article,

A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

• Jiang, P. L. et al.

Angewandte Chemie International Edition 2022, 61, e202113937

Optimized TMT-Based Quantitative Cross-Linking Mass Spectrometry Strategy for Large-Scale Interactomic Studies

• Ruwolt, M. et al.

Analytical Chemistry 2022, 94, 5265-5272

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

• Azarnia Tehran, D. et al.

Science Advances 2022, 8, eabl5032

Microscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish

• Jordan, J. E. L. et al.

Magnetic Resonance in Medicine 2022, 87, 1435-1445

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

• Lopez-Hernandez, T. et al.

Elife 2022, 11, e71198

Major tail proteins of bacteriophages of the order Caudovirales

• Zinke, M. et al.

Journal of Biological Chemistry 2022, 298, 101472

Advances in tethered photopharmacology for precise optical control of signaling proteins

• Broichhagen('), J., & et al.

Current Opinion in Pharmacology 2022, 63, 102196

An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils

• Ellson, C. D. et al.

Journal of Molecular Biology 2022, 434, 167533

An Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber sigma1 Mediates Stability at Low pH and Preserves Trimeric Organization

• Glorani, G. et al.

Journal of Virology 2022, 96, e0033122

Atomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein

• Sarto, C. et al.

Biological Chemistry 2022, 403, 615-624

Bis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates

• Kasper, M. et al.

European Journal of Organic Chemistry 2022, 2022, e202101389

Ca2+-dependent photocrosslinking in the BK channel intracellular inter-subunit interfaces

• Hernandez, A. J. G. et al.

Biophysical Journal 2022, 121, 502a-502a

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

• Baltzer, S. et al.

International Journal of Molecular Sciences 2022, 23, 763

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

• Gazzi, T. et al.

Chemical Science 2022, 13, 5419-5776

Disruptors of AKAP-Dependent Protein-Protein Interactions

• Walker-Gray, R. et al.

Methods in Molecular Biology , Humana, New York, NY, USA , 2022 117-139

Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

• Liu, G. T. et al.

EMBO Journal 2022, 41, e109352

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

• Wang, C. Y. et al.

Science Advances 2022, 8, eabm3942

Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics

• Jayapaul, J. et al.

Nature Communications 2022, 13, 1708

Improving HyperCEST performance by favorable xenon exchange conditions in liposomal nanocarriers

• Jost, J. O., & et al.

NMR in Biomedicine 2022, e4714

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

• Malek, M. et al.

Journal of Biological Chemistry 2022, 298, 101740

Investigating the Role of Sulfate Groups for the Binding of Gd3+ Ions to Glycosaminoglycans with NMR Relaxometry

• Werner, P. et al.

ChemMedChem 2022, early access, e202100764

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

• Cantrelle, F. et al.

Frontiers in Molecular Neuroscience 2021, 14, 661368

Nonselective cation permeation in an AMPA-type glutamate receptor

• Biedermann, J. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2012843118

Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis

• Stinn, A. et al.

Biosensors-Basel 2021, 11, 60

Pentafluorosulfanyl (SF5) as a Superior (19)F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

• Prinz, C. et al.

ACS Sensors 2021, 6, 3948-3956

Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

• Götz, T. W. B. et al.

Journal of Cell Biology 2021, 220, e202006040

Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

• Lämmle, C. A. et al.

ChemBioChem 2021, 22, 548-556

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

• Gulluni, F. et al.

Science 2021, 374, eabk0410

Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner

• Yusenko, M. V. et al.

Cancer Letters 2021, 520, 132-142

Reagents and models for detecting endogenous GLP1R and GIPR

• Ast, J. et al.

EBioMedicine 2021, 74, 103739

NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi

• D'Andrea, E. D. et al.

Journal of Structural Biology 2021, 213, 107715

Non-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a beta2-arrestin link to the mTOR pathway

• Catar, R. A. et al.

Kidney International 2021, online ahead of print,

Leveraging the partition selection bias to achieve a high-quality clustering of mass spectra

• Silva, A. R. F. et al.

Journal of Proteomics 2021, 245, 104282

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

• Zong, G. et al.

FASEB Journal 2021, 35, e21275

Natural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor

• Guba, W. et al.

New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs , Royal Society of Chemistry 2021

MS Annika: A New Cross-Linking Search Engine

• Pirklbauer, G. J. et al.

Journal of Proteome Research 2021, 20, 2560-2569

Molecular Modelling

• Krause, G. et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

Mechanism of synaptic protein turnover and its regulation by neuronal activity

• Soykan, T. et al.

Current Opinion in Neurobiology 2021, 69, 76-83

Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents

• Kunth, M. et al.

Pharmaceuticals 2021, 14, 79

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier

• Breitkreuz-Korff, O. et al.

Journal of Controlled Release 2021, 338, 137-148

Liquid-like protein assemblies initiate endocytosis

• Witkowska, A., & et al.

Nature Cell Biology 2021, 23, 301-302

Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET

• Sykes, D. A. et al.

Biophysical and Computational Tools in Drug Discovery , Springer , 2021 1-32

ITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

• Riemer, E. et al.

Molecular Plant 2021, 14, 1864-1880

Septin Remodeling During Mammalian Cytokinesis

• Russo, G., & et al.

Frontiers in cell and developmental biology 2021, 9, 768309

Report Structural and compositional diversity in the kainate receptor family

• Selvakumar, P. et al.

Cell Reports 2021, 37, 109891

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

• Koch, P. A. et al.

FEBS Journal 2021, 288, 7025-7042

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

• Kemter, E. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

• Pras, A. et al.

EMBO Journal 2021, 40, e107568

XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications

• Lima, D. B. et al.

Journal of Proteome Research 2021, 20, 1943-1950

Using Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate-Protein Interactions with Surface-Based Biosensors

• Couto, D. et al.

Biochemistry 2021, 60, 2739-2748

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

• Khelashvili, G. et al.

Scientific Reports 2021, 11, 10536

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders

• Duncan, A. R. et al.

American Journal of Human Genetics 2021, 108, 1450-1465

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

• Bonnekoh, H. et al.

Clinical and Translational Allergy 2021, 11, e12045

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

• Ried, M. K. et al.

Nature Communications 2021, 12, 384

The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

• Park, Y. et al.

Chemical Science 2021, 12, 8141-8148

The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

• Willmes, D. M. et al.

JCI Insight 2021, 6, e136083

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis

• Desfougeres, Y. et al.

Advances in Biological Regulation 2021, in press, 100835

The chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata

• Li, X. et al.

Magnetic Resonance in Chemistry 2021, 59, 554-560

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates

• Franz, L. et al.

Methods in Molecular Biology 2021, 2355, 287-299

Similarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation

• Busi, B. et al.

Journal of Physical Chemistry B 2021, 125, 2212-2221

SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

• Schmied, C. et al.

Frontiers in Computer Science 2021, 3, 777837

Structure, gating and interactions of the voltage-dependent anion channel

• Najbauer, E. E. et al.

European Biophysics Journal with Biophysics Letters 2021, 50, 159-172

Structural Plasticity of the Selectivity Filter in Cation Channels

• Hendriks, K. et al.

Frontiers in Physiology 2021, 12, 792958

Structural plasticity of the selectivity filter in a nonselective ion channel

• Roy, R. N. et al.

IUCrJ 2021, 8, 421-430

Structural evidence for visual arrestin priming via complexation of phosphoinositols

• Sander, C. L. et al.

Structure 2021, 30, 1-15

Structural basis of PI3KC2alpha function

• Lo, W. et al.

Nature Structural & Molecular Biology 2021, in press,

Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel

• Hendriks, K. et al.

Journal of Molecular Biology 2021, 433, 167091

SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells

• Olaniru, O. E. et al.

Molecular Metabolism 2021, 53, 101285

Slow AMPA receptors in hippocampal principal cells

• Pampaloni, N. P. et al.

Cell Reports 2021, 36, 109496

Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

• Schwach, J. et al.

ChemBioChem 2021, 22, 1205-1209

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

• Malek, M. et al.

Nature Communications 2021, 12, 2673

Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

• Brandt, R. et al.

Frontiers in Bioengineering and Biotechnology 2021, 8, 614357

Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway

• Pauwels, E. et al.

International Journal of Molecular Sciences 2021, 22, 12007

An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator

• Werner, P. et al.

Scientific Reports 2021, 11, 21731

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

• Bui, T. P. N. et al.

Nature Communications 2021, 12, 4798

Cl(-) channels and Cl(-)/H(+) exchangers

• Ullrich, F., & et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer , 2021 470-477

Chemical Biology Tools To Investigate Malaria Parasites

• Broichhagen, J., & et al.

ChemBioChem 2021, 22, 2219-2236

Characterizing protein conformers by cross-linking mass spectrometry and pattern recognition

• Kurt, L. U. et al.

Bioinformatics 2021, 37, 3035-3037

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

• Schneider, A. F. L. et al.

Nature Chemistry 2021, 13, 530-539

Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells

• Schneider, A. F. L. et al.

Angewandte Chemie International Edition 2021, 60, 22075-22080

Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarized Xe-129

• Kunth, M., & et al.

Chemical Science 2021, 12, 158-169

Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research

• Hauser, A. et al.

Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552

Aptamer BC 007's Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies

• Haberland, A. et al.

Viruses 2021, 13, 932

Analyses of Covalent Modifications in Alpha-Glucans

• Nitschke, F., & et al.

Enzymology of Complex Alpha-Glucans , CRC Press , 2021 34-60

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

• Pigazzini, M. L. et al.

Frontiers in Molecular Neuroscience 2021, 14, 721749

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4

• Kircher, T. et al.

European Journal of Medicinal Chemistry 2021, 209, 112901

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

• Mantilla, B. S. et al.

Molecular Microbiology 2021, 115, 986-1004

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes

• Furkert, D. et al.

STAR Protocols 2021, 2, 100277

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

• Lucey, M. et al.

Molecular Pharmacology 2021, 100, 319-334

A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

• Yan, B. et al.

Organic & Biomolecular Chemistry 2021, 19, 8014-8017

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

• Pauwels, E. et al.

Molecular and Cellular Proteomics 2021, 20, 100144

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

• Rizalar, F. S. et al.

Neuron 2021, 109, 27-41

A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC)-Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

• Jiang, P. et al.

Angewandte Chemie International Edition 2021, Online ahead of print,

A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

• Haucke, V. et al.

Developmental Cell 2021, 56, 1557-1559

A fine-tuned azobenzene for enhanced photopharmacology in vivo

• Gutzeit, V. A. et al.

Cell Chemical Biology 2021, 28, 1648-1663

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy

• Prinz, C. et al.

Theranostics 2021, 11, 2490-2504

A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

• Bohg, C. et al.

Chemical Science 2021, 12, 12754-12762

Crosslinking glutamate receptor ion channels

• Plested, A. J. R., & et al.

Ion Channels: Channel Biochemistry, Reconstitution, and Function , Elsevier , 2021 161-192

Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly

• Ramesh, N. et al.

Current Biology 2021, 31, 1711-1725

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

• Leenders, R. G. G. et al.

Journal of Medicinal Chemistry 2021, 64, 17936-17949

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

• Lan, H. et al.

Nature Communications 2021, 12, 4236

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

• Lazzaretti, C. et al.

International Journal of Molecular Sciences 2021, 22, 151

Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging

• Stieger, C. E. et al.

Angewandte Chemie International Edition 2021, 60, 15359-15364

Identification of extracellular nanoparticle subsets by nuclear magnetic resonance

• Ullah, M. S. et al.

Chemical Science 2021, 12, 8311-8319

Identification of disease-relevant modulators of the SHH pathway in the developing brain

• Mecklenburg, N. et al.

Development 2021, 148, dev199307

Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

• Mancini, C. et al.

Scientific Reports 2021, 11, 19928

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

• Breinlinger, S. et al.

Science 2021, 371, eaax9050

How solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks

• Urbaniak, T. et al.

Polymer 2021, 229, 123986

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

• Klionsky, D. J. et al.

Autophagy 2021, 17, 1-382

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

• Böhme, M. A. et al.

Glia 2021, 69, 1897-1915

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

• Mederos, S. et al.

Nature Neuroscience 2021, 24, 82-92

Functional Imaging Using Fluorine ((19)F) MR - Methods: Basic Concepts

• Waiczies, S. et al.

Methods in Molecular Biology , Springer Nature , 2021 279-299

Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses

• Stadtmueller, M. N. et al.

Journal of Medicinal Chemistry 2021, 64, 12774-12789

Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening

• Liao, G. et al.

Acs Pharmacology & Translational Science 2021, 4, 780-789

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

• Thibado, J. K. et al.

Elife 2021, 10, e67027

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

• Schneider, A. F. L. et al.

RSC Chemical Biology 2021, 2, 1661-1668

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

• Hostachy, S. et al.

Chemical Science 2021, 12, 10696-10702

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

• Brennecke, B. et al.

Bioconjugate Chemistry 2021, 32, 702-712

Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

• Guerrero-Valero, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

• Liang, Y. T. et al.

Cell Reports 2021, 35, 108941

En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes

• Otrin, L. et al.

Nature Communications 2021, 12, 4972

Endothelins

• Oksche, A., & et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

• Carter, D. M. et al.

Journal of Medicinal Chemistry 2021, 64, 14266-14282

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

• Marzook, A. et al.

Biochemical Pharmacology 2021, 190, 114656

Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics

• Dohmen, S. et al.

Chemistry 2020, 26, 3049-3053

pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes

• Gerland, L. et al.

ChemBioChem 2020, 21, 1597-1604

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

• Lauster, D. et al.

Nature Nanotechnology 2020, 15, 373-379

Phosphodiesterase 3A and Arterial Hypertension

• Ercu, M. et al.

Circulation 2020, 142, 133-149

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

• Wang, H. B. et al.

Journal of Biological Chemistry 2020, 295, 1091-1104

Protein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide

• Hoffmann, J. et al.

Magnetic Resonance in Chemistry 2020, 58, 445-465

Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

• Chow, W. Y. et al.

Angewandte Chemie-International Edition 2020, 59, 11937-11942

Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans

• Hecht-Höger, A. M. et al.

Molecular Ecology 2020, 29, 1745-1755

Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules

• Liu, H. et al.

Magnetic Resonance in Chemistry 2020, 58, 404-410

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

• Waaler, J. et al.

Journal of Medicinal Chemistry 2020, 63, 6834-6846

NMR quality control of fragment libraries for screening

• Sreeramulu, S. et al.

Journal of Biomolecular NMR 2020, 74, 555-563

Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity

• Gallrein, C. et al.

Progress in Neurobiology 2020, Online ahead of print, 101907

Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization

• Salazar, H. et al.

Biophysical Journal 2020, 119, 206-218

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

• Kuijpers, M. et al.

Neuron 2020, 109, 1-15

N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

• Kasper, M. A. et al.

ChemBioChem 2020, 21, 113-119

Mussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins

• Kohn, J. M. et al.

Macromolecular Rapid Communications 2020, 41, e1900431

Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations

• Kutle, I. et al.

Journal of Virology 2020, Online ahead of print,

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

• Yusenko, M. V. et al.

Cancer Letters 2020, 479, 61-70

Molecular architecture and assembly of the tight junction backbone

• Piontek, J. et al.

Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183279

Modulating TSH Receptor Signaling for Therapeutic Benefit

• Krause, G. et al.

European Thyroid Journal 2020, 9, 66-77

Modern Peptide and Protein Chemistry: Reaching New Heights

• Hackenberger, C. P. R. et al.

Journal of Organic Chemistry 2020, 85, 1328-1330

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex

• Wang, C. et al.

EMBO Reports 2020, 21, e48833

Megadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

• Verzini, S. et al.

Journal of Molecular Biology 2020, 432, 166689

Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid-Crystalline-Based Medium

• Qin, S. Y. et al.

Angewandte Chemie-International Edition 2020, Online ahead of print,

MAS NMR detection of hydrogen bonds for protein secondary structure characterization

• Friedrich, D. et al.

Journal of Biomolecular NMR 2020, 74, 247-256

Ramping up the autophagy-lysosome system to cope with osmotic stress

• Lopez-Hernandez, T. et al.

Autophagy 2020, 16, 1921-1922

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

• Sawade, L. et al.

Nature Communications 2020, 11, 2835

Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome

• Furkert, D. et al.

Cell Chemical Biology 2020, 27, 1097-1108

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances

• Kobbersmed, J. R. L. et al.

Elife 2020, 9, e51032

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

• Fang, Z. et al.

ACS Pharmacology & Translational Science 2020, 3, 345-360

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

• Schuhmacher, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7729-7738

Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes

• Bertovic, I. et al.

Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

• Pechstein, A. et al.

Cell Reports 2020, 30, 2594-2602

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

• Weinert, S. et al.

EMBO Journal 2020, 39, e103358

Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules

• Maaßen, A. et al.

Angewandte Chemie-International Edition 2020, 59, 5747-5755

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

• Zhou, C. et al.

Immunity 2020, 52, 767-781

Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins

• Winkler, L. et al.

Journal of Cerebral Blood Flow and Metabolism 2020, 271678X20904687

The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30

• Schwiebs, A. et al.

British Journal of Pharmacology 2020, 177, 1424-1433

The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses

• Woitkuhn, J. et al.

Journal of Neurogenetics 2020, 34, 106-114

The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase

• Iburg, M. et al.

Journal of Biological Chemistry 2020, 295, 3064-3079

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

• Liu, H. et al.

Cancer Discovery 2020, 10, 1226-1239

The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha

• Chin, A. C. et al.

Science Advances 2020, 6, eabb8542

The impact of non-ideality of lipid mixing on peptide induced lipid clustering

• Finger, S. et al.

Biochimica et Biophysica Acta - Biomembranes 2020, 1862, 183248

Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading

• Sandhof, C. A. et al.

Autophagy 2020, 16, 878-899

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation

• Heidenreich, S. et al.

Journal of Biological Chemistry 2020, 295, 17158-17168

The axonal endolysosomal and autophagic systems

• Kuijpers, M. et al.

Journal of Neurochemistry 2020, 158, 589-602

The antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes

• Braun, B. C. et al.

Scientific Reports 2020, 10, 3681

Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin

• Piontek, A. et al.

Molecular Oncology 2020, 14, 261-276

Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics

• Hauser, A. et al.

Chemistry 2020, Online ahead of print, 2326-2331

Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions

• Gonzalez-Lozano, M. A. et al.

Science Advances 2020, 6, eaax5783

Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase

• Li, X. L. et al.

Journal of the American Chemical Society 2020, 142, 2301-2309

Splicing-accessible coding 3 ' UTRs control protein stability and interaction networks

• Preussner, M. et al.

Genome Biology 2020, 21, 186

Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

• Pickford, P. et al.

British Journal of Pharmacology 2020, 177, 3905-3923

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

• Nematian-Ardestani, E. et al.

Journal of Biological Chemistry 2020, 295, 610-618

Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content

• Wiglenda, T. et al.

Journal of Molecular Biology 2020, 432, 2080-2098

RIM-binding protein couples synaptic vesicle recruitment to release sites

• Petzoldt, A. G. et al.

Journal of Cell Biology 2020, 219, e201902059

Revealing cytotoxic substructures in molecules using deep learning

• Webel, H. E. et al.

Journal of Computer-Aided Molecular Design 2020, 34, 731-746

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

• Scott-Hewitt, N. et al.

EMBO Journal 2020, 39, e105380

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

• D'Andrea, E. D. et al.

Journal of Structural Biology 2020, 211, 107536

Ligand-specific factors influencing GLP-1R post-endocytic trafficking and degradation

• Fang, Z. et al.

International Journal of Molecular Sciences 2020, 21, 33182425

Aptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins

• Weisshoff, H. et al.

Heliyon 2020, 6, e05421

Cobalt-Exchanged Poly(Heptazine Imides) as Transition Metal-N-x Electrocatalysts for the Oxygen Evolution Reaction

• Ye, M. Y. et al.

Advanced Materials 2020, 32, e1903942

Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations

• Baumann, A. L. et al.

Journal of the American Chemical Society 2020, 142, 9544-9552

Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives

• Schneider, A. F. L. et al.

Nature Chemistry 2020, in press,

Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies

• Göppner, C. et al.

Journal of Biological Chemistry 2020, 296, 100074

Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010

• Brennecke, B. et al.

Pharmaceutical Patent Analyst 2020, 10, 111-163

Biophysics of Membrane Protein Signaling

• Plested, A., & et al.

Biophysical Journal 2020, 118, E01-E01

Binding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe

• Kunth, M., & et al.

Chemical Science 2020, in print,

Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

• Lozza, L. et al.

Scientific Reports 2020, 10, 8640

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

• Stanifer, M. L. et al.

Nature Microbiology 2020, 5, 181-191

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner

• Hempel, C. et al.

Journal of Molecular Biology 2020, 432, 2405-2427

Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes

• Puyskens, A. et al.

Cell Host & Microbe 2020, 27, 238-248

Architecture of the flexible tail tube of bacteriophage SPP1

• Zinke, M. et al.

Nature Communications 2020, 11, 5759

AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells

• Kroll, J. et al.

Journal of Cell Science 2020, 133, jcs236737

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

• Hauser, A. et al.

Chemical Science 2020, 11, doi:10.1039/D0SC03930F

Analysis of Random Migration of Cancer Cells in 3D

• Visweshwaran, S. P., & et al.

Bio-Protocol 2020, 10,

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

• Qiu, D. et al.

Nature Communications 2020, 11, 6035

An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

• Brennecke, B. et al.

Angewandte Chemie-International Edition 2020, 59, 8512-8516

Ambigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp

• Chilczuk, T. et al.

ACS Chemical Biology 2020, 15, 2929-2936

Affinity-enrichment and identification of inositol poly- and pyrophosphate interactomes

• Furkert, D. et al.

STAR Methods 2020, in press,

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7 )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

• Mantilla, B. S. et al.

Molecular Microbiology 2020, Online ahead of print,

A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration

• Polovitskaya, M. M. et al.

American Journal of Human Genetics 2020, 107, 1062-1077

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

• Alsalim, R. et al.

Organic Letters 2020, 22, 7393-7396

A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance

• Clochard, J. et al.

International Journal of Pharmaceutics 2020, 589, 119822

A Golgi-associated lipid kinase controls peripheral nerve myelination

• Posor, Y., & et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875

A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies

• Gericke, B. et al.

Fluids and Barriers of the CNS 2020, 17, 53

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

• Ernst, S. et al.

Science Advances 2020, 6, eaaz8041

Collective exchange processes reveal an active site proton cage in bacteriorhodopsin

• Friedrich, D. et al.

Communications Biology 2020, 3, 4

Alterations of redox and iron metabolism accompany the development of HIV latency

• Shytaj, I. L. (. (. et al.

EMBO Journal 2020, 39, e102209

Control of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling

• Li, X. Y. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 3568-3574

Endocytosis in the adaptation to cellular stress

• Lopez-Hernandez, T. et al.

Cell Stress 2020, 4, 230-247

IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

• Desmarini, D. et al.

mBio 2020, 11,

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

• Bogdanow, B. et al.

Nature Communications 2020, 11, 4845

Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

• Jäpel, M. et al.

Cell Reports 2020, 30, 409-420

Interrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

• Poc, P. et al.

Chemical Science 2020, 11, 7871-7883

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

• Haenig, C. et al.

Cell Reports 2020, 32, 108050

Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association

• Rabouw, H. H. et al.

Nature Microbiology 2020, 5, 1361-1373

Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

• Tu, Z. X. et al.

Advanced Functional Materials 2020, 2000933

Functionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI

• Schnurr, M. et al.

Advanced Biosystems 2020, 4, e1900251

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

• Mostinski, Y. et al.

Journal of Medicinal Chemistry 2020, 63, 14780-14804

Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

• Schnirch, L. et al.

Analytical Chemistry 2020, 92, 10495-10503

Equine Herpesvirus Type 1 Modulates Cytokine and Chemokine Profiles of Mononuclear Cells for Efficient Dissemination to Target Organs

• Pavulraj, S. et al.

Viruses 2020, 12, 999

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

• Gowrisankaran, S. et al.

Nature Communications 2020, 11, 1266

InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

• Sahu, S. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 19245-19253

Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

• Lopez-Hernandez, T. et al.

Nature Cell Biology 2020, 22, 815-827

Development of a pathogenesis-based therapy for peeling skin syndrome type 1

• Valentin, F. et al.

British Journal of Dermatology 2020, 184, 1123-1131

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

• Matthaeus, C. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

• Nakamura, R. et al.

Communications Biology 2020, 3, 240

Delivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide

• Li, M. et al.

Angewandte Chemie-International Edition 2020, 59, 15586-15589

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

• Barone, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690

Deuterated rhodamines for protein labelling in nanoscopy

• Rossmann, K. et al.

bioRxiv 2020, upload on Monday, 17th Aug

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

• Sarott, R. C. et al.

Journal of the American Chemical Society 2020, 142, 16953-16964

Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues

• Xu, S. N. et al.

ACS Sensors 2020, 5, 1650-1656

Dynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter

• Finkenwirth, F. et al.

Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183114

Dynamic palmitoylation events following T-cell receptor signaling

• Morrison, E. et al.

Communications Biology 2020, 3, 368

Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period

• Laezer, I. et al.

Reproduction 2020, 159, 371-382

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

• Dema, A. et al.

Cells 2020, 9, E673

Rapid active zone remodeling consolidates presynaptic potentiation

• Böhme, M. A. et al.

Nature Communications 2019, 10, 1085

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization

• Müller, K. H. et al.

Cell Reports 2019, 27, 3124-3138

Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

• Zhang, Q. Y. et al.

Organic Letters 2019, 21, 2121-2125

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

• Buntz, A. et al.

Nucleic Acids Research 2019, 47, 953-969

Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

• Apel, C. et al.

Organic Letters 2019, 21, 10043-10047

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

• Wallroth, A. et al.

Nature Cell Biology 2019, 21, 1093-1101

Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase

• Milito, A. et al.

Marine Drugs 2019, 17, E650

Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

• Schoene, J. et al.

ChemMedChem 2019, 14, 1514-1527

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

• Pascolutti, R. et al.

Cell Reports 2019, 27, 3049-3061

Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks

• Driller, J. H. et al.

Journal of Cell Science 2019, 132, jcs225151

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

• Fred, S. M. et al.

Journal of Biological Chemistry 2019, 294, 18150-18161

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

• Göppner, C. et al.

Nature Communications 2019, 10, 4678

Nanoscale coupling of endocytic pit growth and stability

• Lehmann, M. et al.

Science Advances 2019, 5, eaax5775

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

• Tiosano, D. et al.

PLoS Genetics 2019, 15, e1008088

Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B27 subtype

• Driller, R. et al.

Journal of Biological Chemistry 2019, 294, 13269-13279

Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5

• Drogen, F. et al.

Journal of Cell Biology 2019, 218, 3117-3133

Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

• Schmidtke, C. et al.

Journal of Biological Chemistry 2019, 294, 9592-9604

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

• Brockmann, M. M. et al.

Elife 2019, 8, e43243

Locally renewing resident synovial macrophages provide a protective barrier for the joint

• Culemann, S. et al.

Nature 2019, 572, 670-675

Regulation of influenza A virus mRNA splicing by CLK1

• Artarini, A. et al.

Antiviral Research 2019, 168, 187-196

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

• Lozza, L. et al.

Scientific Reports 2019, 9, 10878

Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis

• Yang, M. et al.

Journal of Organic Chemistry 2019, 84, 2568-2576

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant

• Bogdanow, B. et al.

Nature Communications 2019, 10, 5518

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

• Ullrich, F. et al.

Elife 2019, 8, e49187

Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells

• Beier, L. S. et al.

International Journal of Molecular Sciences 2019, 20, 4774

Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava

• Wu, Q. H. et al.

Journal of Organic Chemistry 2019, 84, 3083-3092

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

• Zhu, J. et al.

Elife 2019, 8, e43582

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles

• Stengl, A. et al.

Organic & Biomolecular Chemistry 2019, 17, 4964-4969

Tight junction proteins at the blood-brain barrier: far more than claudin-5

• Berndt, P. et al.

Cellular and Molecular Life Sciences 2019, 76, 1987-2002

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

• Marcinkowski, P. et al.

Molecular Pharmacology 2019, 96, 452-462

The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

• Wong, E. L. et al.

Nature Communications 2019, 10, 66

The conduction pathway of potassium channels is water free under physiological conditions

• Öster, C. et al.

Science Advances 2019, 5, eaaw6756

Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates

• Puschmann, R. et al.

Biochemistry 2019, 58, 3927-3932

The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

• Kesten, C. et al.

Nature Communications 2019, 10, 857

The cell adhesion protein CAR is a negative regulator of synaptic transmission

• Wrackmeyer, U. et al.

Scientific Reports 2019, 9, 6768

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

• Schneider, A. F. L. et al.

Bioconjugate Chemistry 2019, 30, 400-404

Structure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR

• Shi, C. W. et al.

Journal of the American Chemical Society 2019, 141, 17314-17321

Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes

• Höfer, C. T. et al.

Biochimica Et Biophysica Acta-Biomembranes 2019, 1861, 1123-1134

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

• Maglione, M. et al.

Scientific Reports 2019, 9, 19616

SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9

• Klose, M. et al.

Journal of Cell Biology 2019, 218, 3039-3059

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

• Plastira, I. et al.

Frontiers in Cellular Neuroscience 2019, 13, 531

In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation

• Nojoumi, S. et al.

International Journal of Molecular Sciences 2019, 20, 2299

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

• Feleciano, D. R. et al.

Frontiers in Aging Neuroscience 2019, 11, 9

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

• Gohlke, S. et al.

Molecular Metabolism 2019, 24, 1-17

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

• Bhukel, A. (. et al.

Nature Communications 2019, 10, 1318

Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo

• Wortmann, L. et al.

Journal of Medicinal Chemistry 2019, 62, 10321-10341

Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR

• Goldberga, I. et al.

RSC Advances 2019, 9, 26686-26690

Delayed allogeneic skin graft rejection in CD26-deficient mice

• Zhao, X. L. et al.

Cellular and Molecular Immunology 2019, 16, 557-567

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations

• Kasper, M. A. et al.

Angewandte Chemie-International Edition 2019, 58, 11625-11630

Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit

• Perez-Rius, C. et al.

Orphanet Journal of Rare Diseases 2019, 14, 268

Comparison of the 3D structures of mouse and human alpha-synuclein fibrils by it solid-state NMR and STEM

• Hwang, S. et al.

Journal of Structural Biology 2019, 206, 43-48

Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke

• Sladojevic, N. et al.

Journal of Neuroscience 2019, 39, 743-757

Characterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations

• Hwang, S. et al.

Journal of Biomolecular NMR 2019, 73, 281-291

Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells

• Binger, K. J. et al.

Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 19983-19988

DNP NMR of biomolecular assemblies

• Jaudzems, K. et al.

Journal of Structural Biology 2019, 206, 90-98

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

• Kreis, P. et al.

Nature Communications 2019, 10, 486

A simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells

• Visweshwaran, S. P., & et al.

Methodsx 2019, 6, 2807-2821

A SEPT1-based scaffold is required for Golgi integrity and function

• Song, K. et al.

Journal of Cell Science 2019, 132, jcs225557

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

• Helbig, I. et al.

American Journal of Human Genetics 2019, 104, 1060-1072

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

• Schewe, M. et al.

Science 2019, 363, 875-880

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

• Marcinkowski, P. et al.

Thyroid 2019, 29, 111-123

A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring

• Le Roux, A. L. et al.

Iscience 2019, 12, 194-203

A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

• König, B. et al.

Elife 2019, 8, e45421

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

• Dejonghe, W. et al.

Nature Chemical Biology 2019, 15, 641-649

Doxorubicin-induced cardiotoxicity involves IFN gamma-mediated metabolic reprogramming in cardiomyocytes

• Ni, C. et al.

Journal of Pathology 2019, 247, 320-332

Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

• Arrey, F. et al.

Frontiers in Immunology 2019, 10, 89

Fish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications

• Horsch, J. et al.

ACS Macro Letters 2019, 8, 724-729

Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

• Moura-Alves, P. et al.

Science 2019, 366, eaaw1629

Homeostatic scaling of active zone scaffolds maintains global synaptic strength

• Goel, P. et al.

Journal of Cell Biology 2019, 218, 1706-1724

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

• Merkert, S. et al.

Stem Cell Reports 2019, 12, 1389-1403

High Exchange Rate Complexes of Xe-129 with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI

• Schnurr, M. et al.

ChemPhysChem 2019, 20, 246-251

Harnessing C-13-labeled myo-inositol to interrogate inositol phosphate messengers by NMR

• Harmel, R. K. et al.

Chemical Science 2019, 10, 5267-5274

Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains

• Sap, K. A. et al.

Molecular & Cellular Proteomics 2019, 18, 1705-1720

Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis

• Poulsen, M. H. et al.

Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 13358-13367

Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking

• Vukicevic, T. et al.

Journal of the American Society of Nephrology 2019, 30, 795-810

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

• Iacobucci, C. et al.

Analytical Chemistry 2019, 91, 6953-6961

Dual Bioorthogonal Labeling of the Amyloid-beta Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products

• Husen, L. S. et al.

Journal of Alzheimers Disease 2019, 72, 537-548

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

• Gerth, F. et al.

Structure 2019, 27, 977-987

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

• Brennecke, P. et al.

Slas Discovery 2019, 24, 398-413

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

• Kasper, M. A. et al.

Angewandte Chemie-International Edition 2019, 58, 11631-11636

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization

• Matthaeus, C. et al.

PLoS One 2019, 14, e0223620

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

• Brinson, R. G. et al.

Mabs 2019, 11, 94-105

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

• Alex, A. et al.

Elife 2019, 8, e48287

Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

• Penkert, M. et al.

Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585

Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells

• Liu, C. P. et al.

Journal of the American Chemical Society 2019, 141, 6812-6816

Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies

• Gupta, R. et al.

Journal of Physical Chemistry B 2019, 123, 5048-5058

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization

• Kasper, M. A. et al.

Chemical Science 2019, 10, 6322-6329