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We conduct basic research on the physiology and cell biology of ion channels and transporters, pre- and postsynaptic membrane proteins, including synaptic vesicles, G-protein-coupled receptors, exoendocytic trafficking, and the permeation properties of epithelia. To study these processes, we employ a broad arsenal of techniques, including biochemistry, molecular and cell biology, biophysics, and imaging (light and electron microscopy), as well as the generation and analysis of transgenic mouse models.
Gruppe(n)
Volker Haucke
Molekulare Pharmakologie und Zellbiologie
Die Forschung im Labor konzentriert sich auf die Visualisierung und Modifikation der endozytischen Maschinerie und der endosomalen…
ForschungseinheitThomas J. Jentsch
Physiologie und Pathologie des Ionentransports
We study ion transport across cellular membranes using techniques of biophysics, cell and molecular biology, and genetically modified mouse…
ForschungseinheitNoa Lipstein
Synapse Biology
In unserem Labor
NachwuchsgruppeMartin Lehmann
Licht- und Elektronenmikroskopie
Wir befassen uns mit biologischen Fragen und nutzen das gesamte Repertoire an lichtmikroskopischen Techniken (konfokale…
TechnologieplattformRalf Schülein
Cell Engineering
Die Cell Engineering Facility setzt modernste CRISPR/Cas-Techniken ein, um Gen-Knock-outs und Knock-ins in Zielzellen zu erzeugen. Andere…
TechnologieplattformNatali Wisbrun
Tierhaltung
Die Technologieplattform Tierhaltung kümmert sich um alle Labortiere. Unser Team arbeitet mit Standards, die auf Richtlinien, Konventionen…
Technologieplattform14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells
JCI Insight 2022, 7, e156378
online lesenRational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis
Journal of Medicinal Chemistry 2022, 65, 1567-1584
online lesenPharmacological tools to investigate inositol polyphosphate kinases - Enzymes of increasing therapeutic relevance
Advances in Biological Regulation 2022, 83, 100836
online lesenPhosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer
Advanced Science 2022, 9, e2103249
online lesenPhosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology 2022, early access,
online lesenProgrammable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents
Chemical Science 2022, 13, 5838-5845
online lesenProteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components
Plant Cell 2022
online lesenProton-gated anion transport governs macropinosome shrinkage
Nature Cell Biology 2022
online lesenRapid analytical CEST spectroscopy of competitive host-guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)
Physical Chemistry Chemical Physics 2022, 24, 12126-12135
online lesenSeeing glutamate at central synapses
Journal of Neuroscience Methods 2022, 375, 109531
online lesenMolecular and functional architecture of striatal dopamine release sites
Neuron 2022, 110, 248-265
online lesenSerca Modulation Counteracts Glucocorticoid Resistance in T-All
Haematologica 2022, 107, 19-19
Simple, efficient and thorough shotgun proteomic analysis with PatternLab V
Nature Protocols 2022, Online ahead of print,
online lesenSite-specific N-glycan profiles of alpha(5)beta(1) integrin from rat liver
Biology of the Cell 2022, 114, 160-176
online lesenSlow excitatory synaptic currents generated by AMPA receptors
Journal of Physiology-London 2022, 600, 217-232
online lesenStructural basis of phosphatidylinositol 3-kinase C2 alpha function
Nature Structural & Molecular Biology 2022, 29, 218-228
online lesenSulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins
Organic & Biomolecular Chemistry 2022, Advance Article,
online lesenA Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry
Angewandte Chemie International Edition 2022, 61, e202113937
online lesenOptimized TMT-Based Quantitative Cross-Linking Mass Spectrometry Strategy for Large-Scale Interactomic Studies
Analytical Chemistry 2022, 94, 5265-5272
online lesenSelective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity
Science Advances 2022, 8, eabl5032
online lesenMicroscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish
Magnetic Resonance in Medicine 2022, 87, 1435-1445
online lesenClathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Elife 2022, 11, e71198
online lesenMajor tail proteins of bacteriophages of the order Caudovirales
Journal of Biological Chemistry 2022, 298, 101472
online lesenAdvances in tethered photopharmacology for precise optical control of signaling proteins
Current Opinion in Pharmacology 2022, 63, 102196
online lesenAn Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils
Journal of Molecular Biology 2022, 434, 167533
online lesenAn Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber sigma1 Mediates Stability at Low pH and Preserves Trimeric Organization
Journal of Virology 2022, 96, e0033122
online lesenAtomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein
Biological Chemistry 2022, 403, 615-624
online lesenBis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates
European Journal of Organic Chemistry 2022, 2022, e202101389
online lesenCa2+-dependent photocrosslinking in the BK channel intracellular inter-subunit interfaces
Biophysical Journal 2022, 121, 502a-502a
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
International Journal of Molecular Sciences 2022, 23, 763
online lesenDetection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Chemical Science 2022, 13, 5419-5776
online lesenDisruptors of AKAP-Dependent Protein-Protein Interactions
Methods in Molecular Biology , Humana, New York, NY, USA , 2022 117-139
online lesenEndosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
EMBO Journal 2022, 41, e109352
online lesenGating choreography and mechanism of the human proton-activated chloride channel ASOR
Science Advances 2022, 8, eabm3942
online lesenHyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics
Nature Communications 2022, 13, 1708
online lesenImproving HyperCEST performance by favorable xenon exchange conditions in liposomal nanocarriers
NMR in Biomedicine 2022, e4714
online lesenInositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3
Journal of Biological Chemistry 2022, 298, 101740
online lesenInvestigating the Role of Sulfate Groups for the Binding of Gd3+ Ions to Glycosaminoglycans with NMR Relaxometry
ChemMedChem 2022, early access, e202100764
online lesenPhosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
Frontiers in Molecular Neuroscience 2021, 14, 661368
online lesenNonselective cation permeation in an AMPA-type glutamate receptor
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2012843118
online lesenNovel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis
Biosensors-Basel 2021, 11, 60
online lesenPentafluorosulfanyl (SF5) as a Superior (19)F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives
ACS Sensors 2021, 6, 3948-3956
online lesenRab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi
Journal of Cell Biology 2021, 220, e202006040
online lesenPhotocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo
ChemBioChem 2021, 22, 548-556
online lesenPI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
Science 2021, 374, eabk0410
online lesenProteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner
Cancer Letters 2021, 520, 132-142
online lesenReagents and models for detecting endogenous GLP1R and GIPR
EBioMedicine 2021, 74, 103739
online lesenNMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi
Journal of Structural Biology 2021, 213, 107715
online lesenNon-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a beta2-arrestin link to the mTOR pathway
Kidney International 2021, online ahead of print,
online lesenLeveraging the partition selection bias to achieve a high-quality clustering of mass spectra
Journal of Proteomics 2021, 245, 104282
online lesenNew structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1
FASEB Journal 2021, 35, e21275
online lesenNatural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor
New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs , Royal Society of Chemistry 2021
online lesenMS Annika: A New Cross-Linking Search Engine
Journal of Proteome Research 2021, 20, 2560-2569
online lesenMolecular Modelling
Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021
online lesenMechanism of synaptic protein turnover and its regulation by neuronal activity
Current Opinion in Neurobiology 2021, 69, 76-83
online lesenMapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents
Pharmaceuticals 2021, 14, 79
online lesenM01 as a novel drug enhancer for specifically targeting the blood-brain barrier
Journal of Controlled Release 2021, 338, 137-148
online lesenLiquid-like protein assemblies initiate endocytosis
Nature Cell Biology 2021, 23, 301-302
online lesenKinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET
Biophysical and Computational Tools in Drug Discovery , Springer , 2021 1-32
online lesenITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis
Molecular Plant 2021, 14, 1864-1880
online lesenSeptin Remodeling During Mammalian Cytokinesis
Frontiers in cell and developmental biology 2021, 9, 768309
online lesenReport Structural and compositional diversity in the kainate receptor family
Cell Reports 2021, 37, 109891
online lesenThe molecular mechanisms mediating class II PI 3-kinase function in cell physiology
FEBS Journal 2021, 288, 7025-7042
online lesenSequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118
online lesenThe cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation
EMBO Journal 2021, 40, e107568
online lesenXlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications
Journal of Proteome Research 2021, 20, 1943-1950
online lesenUsing Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate-Protein Interactions with Surface-Based Biosensors
Biochemistry 2021, 60, 2739-2748
online lesenUnusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin
Scientific Reports 2021, 11, 10536
online lesenUnique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders
American Journal of Human Genetics 2021, 108, 1450-1465
online lesenTopical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Clinical and Translational Allergy 2021, 11, e12045
online lesenInositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
Nature Communications 2021, 12, 384
online lesenThe mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols
Chemical Science 2021, 12, 8141-8148
online lesenThe longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms
JCI Insight 2021, 6, e136083
online lesenThe inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis
Advances in Biological Regulation 2021, in press, 100835
online lesenThe chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata
Magnetic Resonance in Chemistry 2021, 59, 554-560
online lesenTargeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates
Methods in Molecular Biology 2021, 2355, 287-299
online lesenSimilarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation
Journal of Physical Chemistry B 2021, 125, 2212-2221
online lesenSynActJ: Easy-to-Use Automated Analysis of Synaptic Activity
Frontiers in Computer Science 2021, 3, 777837
online lesenStructure, gating and interactions of the voltage-dependent anion channel
European Biophysics Journal with Biophysics Letters 2021, 50, 159-172
online lesenStructural Plasticity of the Selectivity Filter in Cation Channels
Frontiers in Physiology 2021, 12, 792958
online lesenStructural plasticity of the selectivity filter in a nonselective ion channel
IUCrJ 2021, 8, 421-430
online lesenStructural evidence for visual arrestin priming via complexation of phosphoinositols
Structure 2021, 30, 1-15
online lesenStructural basis of PI3KC2alpha function
Nature Structural & Molecular Biology 2021, in press,
Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel
Journal of Molecular Biology 2021, 433, 167091
online lesenSNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells
Molecular Metabolism 2021, 53, 101285
online lesenSlow AMPA receptors in hippocampal principal cells
Cell Reports 2021, 36, 109496
online lesenSite-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
ChemBioChem 2021, 22, 1205-1209
online lesenInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Nature Communications 2021, 12, 2673
online lesenMetabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi
Frontiers in Bioengineering and Biotechnology 2021, 8, 614357
online lesenInhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway
International Journal of Molecular Sciences 2021, 22, 12007
online lesenAn NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator
Scientific Reports 2021, 11, 21731
online lesenConversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
Nature Communications 2021, 12, 4798
online lesenCl(-) channels and Cl(-)/H(+) exchangers
Encyclopedia of Molecular Pharmacology : Third Edition , Springer , 2021 470-477
online lesenChemical Biology Tools To Investigate Malaria Parasites
ChemBioChem 2021, 22, 2219-2236
online lesenCharacterizing protein conformers by cross-linking mass spectrometry and pattern recognition
Bioinformatics 2021, 37, 3035-3037
online lesenCellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
Nature Chemistry 2021, 13, 530-539
online lesenCell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells
Angewandte Chemie International Edition 2021, 60, 22075-22080
online lesenBinding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarized Xe-129
Chemical Science 2021, 12, 158-169
online lesenBeyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research
Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552
online lesenAptamer BC 007's Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies
Viruses 2021, 13, 932
online lesenAnalyses of Covalent Modifications in Alpha-Glucans
Enzymology of Complex Alpha-Glucans , CRC Press , 2021 34-60
An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging
Frontiers in Molecular Neuroscience 2021, 14, 721749
online lesenDesign and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4
European Journal of Medicinal Chemistry 2021, 209, 112901
online lesenAffinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages
Molecular Microbiology 2021, 115, 986-1004
online lesenAffinity enrichment and identification of inositol poly- and pyrophosphate interactomes
STAR Protocols 2021, 2, 100277
online lesenAcylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
Molecular Pharmacology 2021, 100, 319-334
online lesenA silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection
Organic & Biomolecular Chemistry 2021, 19, 8014-8017
online lesenA Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide
Molecular and Cellular Proteomics 2021, 20, 100144
online lesenA Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation
Neuron 2021, 109, 27-41
online lesenA Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC)-Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry
Angewandte Chemie International Edition 2021, Online ahead of print,
online lesenA mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval
Developmental Cell 2021, 56, 1557-1559
online lesenA fine-tuned azobenzene for enhanced photopharmacology in vivo
Cell Chemical Biology 2021, 28, 1648-1663
online lesenIn vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy
Theranostics 2021, 11, 2490-2504
online lesenA combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor
Chemical Science 2021, 12, 12754-12762
online lesenCrosslinking glutamate receptor ion channels
Ion Channels: Channel Biochemistry, Reconstitution, and Function , Elsevier , 2021 161-192
online lesenAntagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly
Current Biology 2021, 31, 1711-1725
online lesenDevelopment of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Journal of Medicinal Chemistry 2021, 64, 17936-17949
online lesenExchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
Nature Communications 2021, 12, 4236
online lesenIdentification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling
International Journal of Molecular Sciences 2021, 22, 151
online lesenDiethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging
Angewandte Chemie International Edition 2021, 60, 15359-15364
online lesenIdentification of extracellular nanoparticle subsets by nuclear magnetic resonance
Chemical Science 2021, 12, 8311-8319
online lesenIdentification of disease-relevant modulators of the SHH pathway in the developing brain
Development 2021, 148, dev199307
online lesenIdentification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways
Scientific Reports 2021, 11, 19928
online lesenHunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy
Science 2021, 371, eaax9050
online lesenHow solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks
Polymer 2021, 229, 123986
online lesenGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021, 17, 1-382
online lesenGlial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glia 2021, 69, 1897-1915
online lesenGABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Nature Neuroscience 2021, 24, 82-92
online lesenFunctional Imaging Using Fluorine ((19)F) MR - Methods: Basic Concepts
Methods in Molecular Biology , Springer Nature , 2021 279-299
online lesenEvaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses
Journal of Medicinal Chemistry 2021, 64, 12774-12789
online lesenIdentification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Acs Pharmacology & Translational Science 2021, 4, 780-789
online lesenDifferences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
Elife 2021, 10, e67027
online lesenDiscovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
RSC Chemical Biology 2021, 2, 1661-1668
online lesenDissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
Chemical Science 2021, 12, 10696-10702
online lesenDOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells
Bioconjugate Chemistry 2021, 32, 702-712
online lesenDysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118
online leseneIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
Cell Reports 2021, 35, 108941
online lesenEn route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes
Nature Communications 2021, 12, 4972
online lesenEndothelins
Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021
online lesenEnhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer
Journal of Medicinal Chemistry 2021, 64, 14266-14282
online lesenEvaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1
Biochemical Pharmacology 2021, 190, 114656
online lesenPd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics
Chemistry 2020, 26, 3049-3053
online lesenpH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes
ChemBioChem 2020, 21, 1597-1604
online lesenPhage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Nature Nanotechnology 2020, 15, 373-379
online lesenPhosphodiesterase 3A and Arterial Hypertension
Circulation 2020, 142, 133-149
online lesenPhosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway
Journal of Biological Chemistry 2020, 295, 1091-1104
online lesenProtein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide
Magnetic Resonance in Chemistry 2020, 58, 445-465
online lesenPigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage
Angewandte Chemie-International Edition 2020, 59, 11937-11942
online lesenPlasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans
Molecular Ecology 2020, 29, 1745-1755
online lesenPractical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules
Magnetic Resonance in Chemistry 2020, 58, 404-410
online lesenPreclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
Journal of Medicinal Chemistry 2020, 63, 6834-6846
online lesenNMR quality control of fragment libraries for screening
Journal of Biomolecular NMR 2020, 74, 555-563
online lesenNovel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
Progress in Neurobiology 2020, Online ahead of print, 101907
online lesenMeasurements of the Timescale and Conformational Space of AMPA Receptor Desensitization
Biophysical Journal 2020, 119, 206-218
online lesenNeuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
Neuron 2020, 109, 1-15
online lesenN-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
ChemBioChem 2020, 21, 113-119
online lesenMussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins
Macromolecular Rapid Communications 2020, 41, e1900431
online lesenMurine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations
Journal of Virology 2020, Online ahead of print,
online lesenMonensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells
Cancer Letters 2020, 479, 61-70
online lesenMolecular architecture and assembly of the tight junction backbone
Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183279
online lesenModulating TSH Receptor Signaling for Therapeutic Benefit
European Thyroid Journal 2020, 9, 66-77
online lesenModern Peptide and Protein Chemistry: Reaching New Heights
Journal of Organic Chemistry 2020, 85, 1328-1330
online lesenMITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex
EMBO Reports 2020, 21, e48833
online lesenMegadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics
Journal of Molecular Biology 2020, 432, 166689
online lesenMeasurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid-Crystalline-Based Medium
Angewandte Chemie-International Edition 2020, Online ahead of print,
online lesenMAS NMR detection of hydrogen bonds for protein secondary structure characterization
Journal of Biomolecular NMR 2020, 74, 247-256
online lesenRamping up the autophagy-lysosome system to cope with osmotic stress
Autophagy 2020, 16, 1921-1922
online lesenRab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
Nature Communications 2020, 11, 2835
online lesenTriplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
Cell Chemical Biology 2020, 27, 1097-1108
online lesenRapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances
Elife 2020, 9, e51032
online lesenThe Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists
ACS Pharmacology & Translational Science 2020, 3, 345-360
online lesenLive-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7729-7738
online lesenVps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772
online lesenVesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports 2020, 30, 2594-2602
online lesenUncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration
EMBO Journal 2020, 39, e103358
online lesenTriple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules
Angewandte Chemie-International Edition 2020, 59, 5747-5755
online lesenTransfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
Immunity 2020, 52, 767-781
online lesenTight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins
Journal of Cerebral Blood Flow and Metabolism 2020, 271678X20904687
online lesenThe virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30
British Journal of Pharmacology 2020, 177, 1424-1433
online lesenThe Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses
Journal of Neurogenetics 2020, 34, 106-114
online lesenThe noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase
Journal of Biological Chemistry 2020, 295, 3064-3079
online lesenThe INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.
Cancer Discovery 2020, 10, 1226-1239
online lesenThe inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha
Science Advances 2020, 6, eabb8542
online lesenThe impact of non-ideality of lipid mixing on peptide induced lipid clustering
Biochimica et Biophysica Acta - Biomembranes 2020, 1862, 183248
online lesenReducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading
Autophagy 2020, 16, 878-899
online lesenThe glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation
Journal of Biological Chemistry 2020, 295, 17158-17168
online lesenThe axonal endolysosomal and autophagic systems
Journal of Neurochemistry 2020, 158, 589-602
online lesenThe antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes
Scientific Reports 2020, 10, 3681
online lesenTargeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin
Molecular Oncology 2020, 14, 261-276
online lesenSynthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics
Chemistry 2020, Online ahead of print, 2326-2331
online lesenStitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Science Advances 2020, 6, eaax5783
online lesenStereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase
Journal of the American Chemical Society 2020, 142, 2301-2309
online lesenSplicing-accessible coding 3 ' UTRs control protein stability and interaction networks
Genome Biology 2020, 21, 186
online lesenSignalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide
British Journal of Pharmacology 2020, 177, 3905-3923
online lesenSelectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
Journal of Biological Chemistry 2020, 295, 610-618
online lesenSclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content
Journal of Molecular Biology 2020, 432, 2080-2098
online lesenRIM-binding protein couples synaptic vesicle recruitment to release sites
Journal of Cell Biology 2020, 219, e201902059
online lesenRevealing cytotoxic substructures in molecules using deep learning
Journal of Computer-Aided Molecular Design 2020, 34, 731-746
online lesenLocal externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
EMBO Journal 2020, 39, e105380
online lesenCrystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi
Journal of Structural Biology 2020, 211, 107536
online lesenLigand-specific factors influencing GLP-1R post-endocytic trafficking and degradation
International Journal of Molecular Sciences 2020, 21, 33182425
online lesenAptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins
Heliyon 2020, 6, e05421
online lesenCobalt-Exchanged Poly(Heptazine Imides) as Transition Metal-N-x Electrocatalysts for the Oxygen Evolution Reaction
Advanced Materials 2020, 32, e1903942
online lesenChemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations
Journal of the American Chemical Society 2020, 142, 9544-9552
online lesenCellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives
Nature Chemistry 2020, in press,
Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies
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online lesenCannabinoid receptor type 2 ligands: an analysis of granted patents since 2010
Pharmaceutical Patent Analyst 2020, 10, 111-163
online lesenBiophysics of Membrane Protein Signaling
Biophysical Journal 2020, 118, E01-E01
online lesenBinding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe
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online lesenAuthor Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Scientific Reports 2020, 10, 8640
online lesenAsymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells
Nature Microbiology 2020, 5, 181-191
online lesenAssembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner
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online lesenAryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
Cell Host & Microbe 2020, 27, 238-248
online lesenArchitecture of the flexible tail tube of bacteriophage SPP1
Nature Communications 2020, 11, 5759
online lesenAP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
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online lesenCombining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
Chemical Science 2020, 11, doi:10.1039/D0SC03930F
online lesenAnalysis of Random Migration of Cancer Cells in 3D
Bio-Protocol 2020, 10,
online lesenAnalysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
Nature Communications 2020, 11, 6035
An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria
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online lesenAmbigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp
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online lesenAffinity-enrichment and identification of inositol poly- and pyrophosphate interactomes
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online lesenA recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration
American Journal of Human Genetics 2020, 107, 1062-1077
online lesenA Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles
Organic Letters 2020, 22, 7393-7396
online lesenA new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance
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online lesenA Golgi-associated lipid kinase controls peripheral nerve myelination
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online lesenA face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies
Fluids and Barriers of the CNS 2020, 17, 53
online lesenLegionella effector AnkX displaces the switch II region for Rab1b phosphocholination
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online lesenCollective exchange processes reveal an active site proton cage in bacteriorhodopsin
Communications Biology 2020, 3, 4
online lesenAlterations of redox and iron metabolism accompany the development of HIV latency
EMBO Journal 2020, 39, e102209
online lesenControl of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 3568-3574
online lesenEndocytosis in the adaptation to cellular stress
Cell Stress 2020, 4, 230-247
online lesenIP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
mBio 2020, 11,
online lesenCross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Nature Communications 2020, 11, 4845
online lesenIntersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission
Cell Reports 2020, 30, 409-420
online lesenInterrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Chemical Science 2020, 11, 7871-7883
online lesenInteractome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
Cell Reports 2020, 32, 108050
online lesenInhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association
Nature Microbiology 2020, 5, 1361-1373
online lesenGraphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance
Advanced Functional Materials 2020, 2000933
online lesenFunctionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI
Advanced Biosystems 2020, 4, e1900251
online lesenFrom Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement
Journal of Medicinal Chemistry 2020, 63, 14780-14804
online lesenExpanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry
Analytical Chemistry 2020, 92, 10495-10503
online lesenEquine Herpesvirus Type 1 Modulates Cytokine and Chemokine Profiles of Mononuclear Cells for Efficient Dissemination to Target Organs
Viruses 2020, 12, 999
online lesenEndophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Nature Communications 2020, 11, 1266
online lesenInsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 19245-19253
online lesenEndocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Nature Cell Biology 2020, 22, 815-827
online lesenDevelopment of a pathogenesis-based therapy for peeling skin syndrome type 1
British Journal of Dermatology 2020, 184, 1123-1131
online lesenEHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481
online lesenCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Communications Biology 2020, 3, 240
online lesenDelivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide
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online lesenDesigned nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690
online lesenDeuterated rhodamines for protein labelling in nanoscopy
bioRxiv 2020, upload on Monday, 17th Aug
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Journal of the American Chemical Society 2020, 142, 16953-16964
online lesenDual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues
ACS Sensors 2020, 5, 1650-1656
online lesenDynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter
Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183114
online lesenDynamic palmitoylation events following T-cell receptor signaling
Communications Biology 2020, 3, 368
online lesenDynamic profile of EVs in porcine oviductal fluid during the periovulatory period
Reproduction 2020, 159, 371-382
online lesenCyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP
Cells 2020, 9, E673
online lesenRapid active zone remodeling consolidates presynaptic potentiation
Nature Communications 2019, 10, 1085
online lesenPoly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Cell Reports 2019, 27, 3124-3138
online lesenRapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen
Organic Letters 2019, 21, 2121-2125
online lesenQuantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression
Nucleic Acids Research 2019, 47, 953-969
online lesenProtein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
Organic Letters 2019, 21, 10043-10047
online lesenProtein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1
Nature Cell Biology 2019, 21, 1093-1101
online lesenProbing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase
Marine Drugs 2019, 17, E650
online lesenProbing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors
ChemMedChem 2019, 14, 1514-1527
online lesenMolecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Cell Reports 2019, 27, 3049-3061
online lesenPhosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks
Journal of Cell Science 2019, 132, jcs225151
online lesenPharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2
Journal of Biological Chemistry 2019, 294, 18150-18161
online lesenPathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism
Nature Communications 2019, 10, 4678
online lesenNanoscale coupling of endocytic pit growth and stability
Science Advances 2019, 5, eaax5775
online lesenMutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction
PLoS Genetics 2019, 15, e1008088
online lesenMetal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B27 subtype
Journal of Biological Chemistry 2019, 294, 13269-13279
online lesenMechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5
Journal of Cell Biology 2019, 218, 3117-3133
online lesenLysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking
Journal of Biological Chemistry 2019, 294, 9592-9604
online lesenRIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses
Elife 2019, 8, e43243
online lesenLocally renewing resident synovial macrophages provide a protective barrier for the joint
Nature 2019, 572, 670-675
online lesenRegulation of influenza A virus mRNA splicing by CLK1
Antiviral Research 2019, 168, 187-196
online lesenThe Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Scientific Reports 2019, 9, 10878
online lesenSarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis
Journal of Organic Chemistry 2019, 84, 2568-2576
online lesenThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
Nature Communications 2019, 10, 5518
online lesenIdentification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Elife 2019, 8, e49187
online lesenUse of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
International Journal of Molecular Sciences 2019, 20, 4774
online lesenUncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava
Journal of Organic Chemistry 2019, 84, 3083-3092
online lesenTwo bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
Elife 2019, 8, e43582
online lesenTuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles
Organic & Biomolecular Chemistry 2019, 17, 4964-4969
online lesenTight junction proteins at the blood-brain barrier: far more than claudin-5
Cellular and Molecular Life Sciences 2019, 76, 1987-2002
online lesenThyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain
Molecular Pharmacology 2019, 96, 452-462
online lesenThe transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
Nature Communications 2019, 10, 66
online lesenThe conduction pathway of potassium channels is water free under physiological conditions
Science Advances 2019, 5, eaaw6756
online lesenScalable Chemoenzymatic Synthesis of Inositol Pyrophosphates
Biochemistry 2019, 58, 3927-3932
online lesenThe companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants
Nature Communications 2019, 10, 857
online lesenThe cell adhesion protein CAR is a negative regulator of synaptic transmission
Scientific Reports 2019, 9, 6768
online lesenTargeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides
Bioconjugate Chemistry 2019, 30, 400-404
online lesenStructure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR
Journal of the American Chemical Society 2019, 141, 17314-17321
online lesenStructural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes
Biochimica Et Biophysica Acta-Biomembranes 2019, 1861, 1123-1134
online lesenSpermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific Reports 2019, 9, 19616
online lesenSNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9
Journal of Cell Biology 2019, 218, 3039-3059
online lesenSmall-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells
Frontiers in Cellular Neuroscience 2019, 13, 531
online lesenIn-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation
International Journal of Molecular Sciences 2019, 20, 2299
online lesenCrosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease
Frontiers in Aging Neuroscience 2019, 11, 9
online lesenIdentification of functional lipid metabolism biomarkers of brown adipose tissue aging
Molecular Metabolism 2019, 24, 1-17
online lesenAutophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
Nature Communications 2019, 10, 1318
online lesenDiscovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo
Journal of Medicinal Chemistry 2019, 62, 10321-10341
online lesenDetection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR
RSC Advances 2019, 9, 26686-26690
online lesenDelayed allogeneic skin graft rejection in CD26-deficient mice
Cellular and Molecular Immunology 2019, 16, 557-567
online lesenCysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations
Angewandte Chemie-International Edition 2019, 58, 11625-11630
online lesenComparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit
Orphanet Journal of Rare Diseases 2019, 14, 268
online lesenComparison of the 3D structures of mouse and human alpha-synuclein fibrils by it solid-state NMR and STEM
Journal of Structural Biology 2019, 206, 43-48
online lesenClaudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke
Journal of Neuroscience 2019, 39, 743-757
online lesenCharacterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations
Journal of Biomolecular NMR 2019, 73, 281-291
online lesenAtp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells
Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 19983-19988
online lesenDNP NMR of biomolecular assemblies
Journal of Structural Biology 2019, 206, 90-98
online lesenATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
Nature Communications 2019, 10, 486
online lesenA simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells
Methodsx 2019, 6, 2807-2821
online lesenA SEPT1-based scaffold is required for Golgi integrity and function
Journal of Cell Science 2019, 132, jcs225557
online lesenA Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy
American Journal of Human Genetics 2019, 104, 1060-1072
online lesenA pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
Science 2019, 363, 875-880
online lesenA New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid 2019, 29, 111-123
online lesenA Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
Iscience 2019, 12, 194-203
online lesenA FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength
Elife 2019, 8, e45421
online lesenDisruption of endocytosis through chemical inhibition of clathrin heavy chain function
Nature Chemical Biology 2019, 15, 641-649
online lesenDoxorubicin-induced cardiotoxicity involves IFN gamma-mediated metabolic reprogramming in cardiomyocytes
Journal of Pathology 2019, 247, 320-332
online lesenHumanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens
Frontiers in Immunology 2019, 10, 89
online lesenFish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications
ACS Macro Letters 2019, 8, 724-729
online lesenHost monitoring of quorum sensing during Pseudomonas aeruginosa infection
Science 2019, 366, eaaw1629
online lesenHomeostatic scaling of active zone scaffolds maintains global synaptic strength
Journal of Cell Biology 2019, 218, 1706-1724
online lesenHigh-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs
Stem Cell Reports 2019, 12, 1389-1403
online lesenHigh Exchange Rate Complexes of Xe-129 with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI
ChemPhysChem 2019, 20, 246-251
online lesenHarnessing C-13-labeled myo-inositol to interrogate inositol phosphate messengers by NMR
Chemical Science 2019, 10, 5267-5274
online lesenGlobal Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains
Molecular & Cellular Proteomics 2019, 18, 1705-1720
online lesenGating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis
Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 13358-13367
online lesenFluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking
Journal of the American Society of Nephrology 2019, 30, 795-810
online lesenFirst Community-Wide, Comparative Cross-Linking Mass Spectrometry Study
Analytical Chemistry 2019, 91, 6953-6961
online lesenDual Bioorthogonal Labeling of the Amyloid-beta Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products
Journal of Alzheimers Disease 2019, 72, 537-548
online lesenExon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain
Structure 2019, 27, 977-987
online lesenEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
Slas Discovery 2019, 24, 398-413
online lesenEthynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates
Angewandte Chemie-International Edition 2019, 58, 11631-11636
online leseneNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
PLoS One 2019, 14, e0223620
online lesenEnabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
Mabs 2019, 11, 94-105
online lesenElectroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology
Elife 2019, 8, e48287
online lesenElectron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations
Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585
online lesenDysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells
Journal of the American Chemical Society 2019, 141, 6812-6816
online lesenDynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies
Journal of Physical Chemistry B 2019, 123, 5048-5058
online lesenVinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization
Chemical Science 2019, 10, 6322-6329
online lesenDas Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) gehört zum Forschungsverbund Berlin e.V. (FVB), einem Zusammenschluss von sieben natur-, lebens- und umweltwissenschaftlichen Instituten in Berlin. Die Einrichtungen sind Mitglieder der Leibniz-Gemeinschaft.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Deutschland