Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler
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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

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Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment

  • Maria Mendes; Sandra Nunes; Tânia Cova; Francisco Branco; Michael Dyrks; Beate Koksch; Nuno Vale; João Sousa; Alberto Pais; Carla Vitorino

Colloids and Surfaces B: Biointerfaces 2024

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A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

  • York Posor; Volker Haucke

Journal of Cell Biology 2024

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An anionic two dimensional covalent organic framework from tetratopic borate centres pillared by lithium ions

  • Darosch Asgari; Julia Grüneberg; Yunkai Luo; Hüseyin Küçükkeçeci; Samrat Ghosh; Veniamin Chevelkov; Sabrina Fischer-Lang; Jérôme Roeser; Adam Lange; Bruce Dunn; Michael Gradzielski; Arne Thomas

Nature Communications 2024

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Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie International Edition 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

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HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity

  • Sabrina Montresor; Maria Lucia Pigazzini; Sudarson Baskaran; Mira Sleiman; Govinda Adhikari; Lukas Basilicata; Luca Secker; Natascha Jacob; Yara Ehlert; Anushree Kelkar; Gurleen Kaur Kalsi; Niraj Kulkarni; Paul Spellerberg; Janine Kirstein

Journal of Neurochemistry 2024

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When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping

  • Alexander Stockhammer; Carissa Spalt; Antonia Klemt; Laila S. Benz; Shelly Harel; Vini Natalia; Lukas Wiench; Christian Freund; Benno Kuropka; Francesca Bottanelli

Journal of Cell Science 2024

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Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

  • Henry Sawczyc; Takashi Tatsuta; Carl Öster; Spyridon Kosteletos; Sascha Lange; Claudia Bohg; Thomas Langer; Adam Lange

Nature Communications 2024

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Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied
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ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons

  • Alessandro Esposito; Sara Pepe; Maria Sabina Cerullo; Katia Cortese; Hanako Tsushima Semini; Silvia Giovedì; Renzo Guerrini; Fabio Benfenati; Antonio Falace; Anna Fassio

Acta Physiologica 2024

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RawVegetable 2.0: Refining XL-MS Data Acquisition through Enhanced Quality Control

  • Louise Ulrich Kurt; Milan Avila Clasen; Ísis Venturi Biembengut; Max Ruwolt; Fan Liu; Fabio Gozzo; Diogo Borges Lima; Paulo Carvalho

Journal of Proteome Research 2024

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Toward the Next Generation of Density Functionals: Escaping the Zero-Sum Game by Using the Exact-Exchange Energy Density

  • Martin Prof. Dr. Kaupp; Artur Wodyński; Alexei V. Arbuznikov; Susanne Fürst; Caspar J. Schattenberg

Accounts of Chemical Research 2024

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Single electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins

  • Mingxuan Wu; Feng Feng; Yingxiao Gao; Qun Zhao; Ting Luo; Qingyun Yang; Nan Zhao; Yihang Xiao; Yusong Han; Jinheng Pan; Shan Feng; Lihua Zhang
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LRRC8/VRAC volume-regulated anion channels are crucial for hearing

  • Deborah A. Knecht; Mariia Zeziulia; Mit B. Bhavsar; Dmytro Puchkov; Hannes Maier; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler
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Melanocortin system activates carotid body arterial chemoreceptors in hypertension

  • Audrys G. Pauza; Pratik Thakkar; Xin Shen; Igor Felippe; Kilian Roßmann; Manami Oya; Kazuhiro Nakamura; Johannes Broichhagen; David J. Hodson; Dainius H. Pauza; David Murphy; Julian F.R. Paton
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Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

  • Saif Mohd; Andreas Oder; Edgar Specker; Martin Neuenschwander; Jens Peter Von Kries; Oliver Daumke

PLOS ONE 2024

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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler
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Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease

  • Maya M. Polovitskaya; Tanushka Rana; Kurt Ullrich; Simona Murko; Tatjana Bierhals; Guido Vogt; Tobias Stauber; Christian Kubisch; René Santer; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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An extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis

  • Samuel Naudi-Fabra; Carlos A. Elena-Real; Ida Marie Vedel; Maud Tengo; Kathrin Motzny; Pin-Lian Jiang; Peter Schmieder; Fan Liu; Sigrid Milles

Nature Communications 2024

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Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

  • Florian Stockinger; Pascal Poc; Alexander Möhwald; Sandra Karch; Stephanie Häfner; Christian Alzheimer; Guillaume Sandoz; Tobias Huth; Johannes Broichhagen

Journal of Medicinal Chemistry 2024

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Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy

  • Evgeny Nimerovsky; Spyridon Kosteletos; Sascha Lange; Stefan Becker; Adam Lange; Loren B. Andreas

The Journal of Physical Chemistry Letters 2024

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Phosphoinositide detection at synapses of fixed murine hippocampal neurons

  • Svenja Bolz; Natalie Kaempf; Maria Muehlbauer; Delia Löwe; Volker Haucke

STAR Protocols 2024

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Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

  • Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

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Patent review of cannabinoid receptor type 2 (CB <sub>2</sub> R) modulators (2016-present)

  • Miroslav Kosar; Leonard Mach; Erick M. Carreira; Marc Nazaré; Pal Pacher; Uwe Grether

Expert Opinion on Therapeutic Patents 2024

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Benzo‐Crown‐Ether functionalized O‐BODIPY Probes for Cations– A Selective Fluorescent Probe for Ba2+

  • Thomas Schwarze; Tobias Sprenger; Marc Nazare; Hans-Jürgen Holdt; Axel Hentsch

Chemistry – A European Journal 2024

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Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

  • Ekaterina Legchenko; Philippe Chouvarine; Fatimunnisa Qadri; Edgar Specker; Marc Nazaré; Radoslaw Wesolowski; Susann Matthes; Michael Bader; Georg Hansmannn

JACC: Basic to Translational Science 2024

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DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue

  • Thais Gazzi; Marina Lesina; Qinghua Wang; Alexandra Berninger; Silke Radetzki; Ihsan Ekin Demir; Larissa Kohlmann; Waldemar Meiser; Sebastian Wilke; Jens Peter von Kries; Hana Algül; Hai-Yu Hu; Marc Nazare

Angewandte Chemie 2024

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Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials.

  • Torsten Bullmann; Kaas T; Ritzau-Jost A; Wöhner A; Toni Kirmann; Filiz Sila Rizalar; Holzer M; Nerlich J; Puchkov D; Christian Geis; Eilers J; Kittel RJ; Arendt T; Haucke V; Stefan Hallermann

The Journal of neuroscience : the official journal of the Society for Neuroscience 2024

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TPT‐004, a Next‐Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats

  • Radoslaw Wesolowski; Dirk Pleimes; Edgar Specker; Michael Bader

Journal of the American Heart Association 2024

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An exploratory research report on brain mineralization in postoperative delirium and cognitive decline

  • Florian Lammers‐Lietz; Friedrich Borchers; Insa Feinkohl; Stefan Hetzer; Cicek Kanar; Frank Konietschke; Gunnar Lachmann; Claudia Chien; Claudia Spies; Georg Winterer; Laszlo Zaborszky; Norman Zacharias; Friedemann Paul

European Journal of Neuroscience 2024

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An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N-Acetylglucosamine Kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler

Journal of the American Chemical Society 2024

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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

  • Berke Türkaydin; Marcus Schewe; Elena Barbara Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun

Nature Communications 2024

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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

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Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies

  • Ying Zhu; Kerem Can Akkaya; Julia Ruta; Nanako Yokoyama; Cong Wang; Max Ruwolt; Diogo Borges Lima; Martin Lehmann; Fan Liu

Nature Communications 2024

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Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase

  • Samira Klössel; Ying Zhu; Lucia Amado; Daniel D Bisinski; Julia Ruta; Fan Liu; Ayelén González Montoro

The EMBO Journal 2024

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Molecular architecture of synaptic vesicles

  • Uljana Kravcenko; Max Ruwolt; Jana Kroll; Artsemi Yushkevich; Martina Zenkner; Julia Ruta; Rowaa Lotfy; Erich E. Wanker; Christian Rosenmund; Fan Liu; Mikhail Kudryashev
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Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

  • Francisco José López-Murcia; Kun-Han Lin; Manon M. M. Berns; Mrinalini Ranjan; Noa Lipstein; Erwin Neher; Nils Brose; Kerstin Reim; Holger Taschenberger

Proceedings of the National Academy of Sciences 2024

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A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

  • Luise Franz; Tihomir Rubil; Anita Balázs; Marie Overtus; Kristin Kemnitz-Hassanin; Cedric Govaerts; Marcus A. Mall; Christian P.R. Hackenberger
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Implementation and First Evaluation of Strong-Correlation-Corrected Local Hybrid Functionals for the Calculation of NMR Shieldings and Shifts

  • Caspar Jonas Schattenberg; Martin Prof. Dr. Kaupp

The Journal of Physical Chemistry A 2024

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

eLife 2024

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List of Publications