Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

  • Souvik Ghosh; Ramona Birke; Ashwin Karthick Natarajan; Johannes Broichhagen

Journal of Peptide Science 2025

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A Silicon Rhodamine‐fused Glibenclamide to Label and Detect Malaria‐infected Red Blood Cells

  • Claudia Bastl; Cindy M. Close; Ingo Holtz; Blaise Gatin‐Fraudet; Mareike Eis; Michelle Werum; Smilla Konrad; Laura Kneller; Kilian Roßmann; Christiane Huhn; Souvik Ghosh; Julia Ast; Dorien A. Roosen; Martin Lehmann; Volker Haucke; Luc Reymond; David J. Hodson; Philip Tinnefeld; Kai Johnsson; Viktorija Glembockyte; Nicole Kilian; Johannes Broichhagen

ChemBioChem 2025

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PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections

  • Kaixuan Liu; Yang Liu; Qinghua Wang; Marc Nazaré; Leilei Zhang; Xiandao Pan; Hai-Yu Hu

Journal of Medicinal Chemistry 2025

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Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

  • Rosa Planells-Cases; Viktoriia Vorobeva; Sumanta Kar; Franziska W. Schmitt; Uwe Schulte; Marina Schrecker; Richard K. Hite; Bernd Fakler; Thomas J. Jentsch

Nature Communications 2025

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Cathelicidin-BF: A Potent Antimicrobial Peptide Leveraging Charge and Phospholipid Recruitment against Multidrug-Resistant Clinical Bacterial Isolates

  • Evgeniy Salnikov; Morgane Adélaïde; Francisco Ramos-Martín; Ahmad Saad; Jennifer Schauer; Martina Cremanns; Mariam Rima; Christopher Aisenbrey; Saoussen Oueslati; Thierry Naas; Niels Pfennigwerth; Söeren Gatermann; Catherine Sarazin; Burkhard Bechinger; Nicola D'Amelio

Journal of the American Chemical Society 2025

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Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Felix Schöpf; Andreas Oder; Jens Peter von Kries; Daniel Roderer

Proceedings of the National Academy of Sciences 2025

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Installation of Site-Specific Inorganic and Organic Phosphate to Peptides and Proteins via Vinylaryl Sulfonium Reagents

  • Qingyun Yang; Kun Zou; Mingxuan Wu

Organic Letters 2025

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Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading

  • Mark Andrew Kreutzberger; Agata Witkowska; Marcelo Ganzella; Julia Preobraschenski; Volker Kiessling; Gudrun Ahnert-Hilger; Reinhard Jahn; Sascha Seibert; Riedel D; Agnieszka Münster-Wandowski; Lukas Tamm; Alex Kreutzberger; Linda H.M. Olsthoorn

Science Advances 2025

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Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

  • Anton Florian Ketzel; Yang Hu; Xiao‐Lu Li; Jiaqian Li; Xinxiang Lei; Han Sun

Magnetic Resonance in Chemistry 2025

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Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

  • Gaga Kochlamazashvili; Aarti Swaminathan; Alexander Stumpf; Amit Kumar; York Posor; Dietmar Schmitz; Volker Haucke; Marijn Kuijpers

Proceedings of the National Academy of Sciences 2025

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Morphological profiling data resource enables prediction of chemical compound properties

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied

iScience 2025

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Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2

  • Fabián Martínez-Perafán; Anja Fromm; Rozemarijn E. van der Veen; Ayk Waldow; Martin Lehmann; Susanne M. Krug; Dorothee Günzel; Rita Rosenthal; Michael Fromm; Jörg Piontek

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2025

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Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packaging

  • Sarah Harmening; Boris Bogdanow; Karen Wagner; Fan Liu; Martin Messerle; Eva Maria Borst; Anna Ruth Cliffe

Journal of Virology 2025

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Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ+ Cell Ablation in Adult Mice

  • Dila Atak; Erdost Yıldız; Esra Özkan; Mohammadreza Yousefi; Ayşe Özkan; Aysu Bilge Yılmaz; Ali Burak Kızılırmak; Iman Asaad Alnajjar; Çiçek Kanar; Zeynep Lal Caan; Şakir Ümit Zeybek; Cem İsmail Küçükali; Erdem Tüzün; Yasemin Gürsoy‐Özdemir; Atay Vural

Journal of Neurochemistry 2025

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Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

  • Kun‐Han Lin; Mrinalini Ranjan; Noa Lipstein; Nils Brose; Erwin Neher; Holger Taschenberger

The Journal of Physiology 2025

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Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties

  • Arnab Gupta; Bidisha Sinha; Durba Sengupta; Subhendu Kumar Chatterjee; Sumanta Kar; Siddhanta Nikte; Tisha Dash; Saptarshi Maji; Tanmoy Ghosh
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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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Protocol for semisynthesis of histone H4 with site-specific modifications using irreversible sortase-mediated ligation

  • Yihang Xiao; Kun Zou; Mingxuan Wu

STAR Protocols 2025

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Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG

  • Carl Öster; Veniamin Chevelkov; Adam Lange

Journal of Biomolecular NMR 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

  • Axel Hentsch; Mónica Guberman; Silke Radetzki; Sofia Kaushik; Mirjam Huizenga; Jerome Paul; Maria Schippers; Jörg Benz; Bernd Kuhn; Dominik Heer; Andreas Topp; Ludivine Esteves Gloria; Alexander Walter; Remo Hochstrasser; Matthias B. Wittwer; Jens Peter von Kries; Ludovic Collin; Julie Blaising; Mario van der Stelt; Noa Lipstein; Uwe Grether; Marc Nazaré

Angewandte Chemie International Edition 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

  • Axel Hentsch; Mónica Guberman; Silke Radetzki; Sofia Kaushik; Mirjam Huizenga; Jerome Paul; Maria Schippers; Jörg Benz; Bernd Kuhn; Dominik Heer; Andreas Topp; Ludivine Esteves Gloria; Alexander Walter; Remo Hochstrasser; Matthias B. Wittwer; Jens Peter von Kries; Ludovic Collin; Julie Blaising; Mario van der Stelt; Noa Lipstein; Uwe Grether; Marc Nazaré

Angewandte Chemie 2025

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Probing the Dynamics of Yersinia Adhesin A (YadA) in Outer Membranes Hints at Requirements for β-Barrel Membrane Insertion

  • Jayasubba Reddy Yarava; Marcella Orwick-Rydmark; David Ryoo; Albert Hofstetter; James C. Gumbart; Michael Habeck; Barth-Jan van Rossum; Dirk Linke; Hartmut Oschkinat

Journal of the American Chemical Society 2025

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Mechanisms and functions of lysosomal lipid homeostasis

  • Michael Ebner; Florian Fröhlich; Volker Haucke

Cell Chemical Biology 2025

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Back Cover: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. Int. Ed. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension

  • Ekaterina Legchenko; Philippe Chouvarine; Klea Hysko; Fatimunnisa Qadri; Radoslaw Wesolowski; Edgar Specker; Silke Glage; Martin Meier; Katharina Schwarz; Joerg Heineke; Gerhard Pohlmann; Mehmet Ramazanoglu; Michael Bader; Georg Hansmannn

American Journal of Respiratory Cell and Molecular Biology 2025

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Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes

  • Patrick Watermann; Gurleen K. Kalsi; Ralf Dringen; Christian Arend

Neurochemical Research 2025

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Selective photo crosslinking to methylarginine readers by sulfonium peptides

  • Ting Luo; Feng Feng; Kun Zou; Yumo Zhao; Yingxiao Gao; Mingxuan Wu

Bioorganic & Medicinal Chemistry 2025

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Chemical probes for imaging cellular compartmentalization

  • Margret H. Bülow; Johannes Broichhagen

Trends in Biochemical Sciences 2025

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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I

  • Xiaoqi Liu; Zixuan Zhang; Tim Aguirre; Megan L. Shipton; Lin Fu; Jimin Du; David Furkert; Ji Qi; Alfred C. Chin; Andrew M. Riley; Tong Liu; Xu Zhang; Barry V.L. Potter; Dorothea Fiedler; Yi Zhu; Chenglai Fu; Tim Aguirre

Metabolism 2025

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Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins

  • Joel I. Badillo‐Gómez; Irene Suarez‐Antuña; Ievgen Mazurenko; Frédéric Biaso; Jacques Pécaut; Elisabeth Lojou; Pascale Delangle; Sarah Hostachy

Chemistry – A European Journal 2025

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Integrative Molekulardynamiksimulationen entwirren cross‐linking Daten und zeigen Verteilungen von mitochondrialen Proteinen

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie 2025

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Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie International Edition 2025

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Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler

Proceedings of the National Academy of Sciences 2025

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Structural insights into light-gating of potassium-selective channelrhodopsin

  • Takefumi Morizumi; Kyumhyuk Kim; Hai Li; Probal Nag; Tal Dogon; Oleg A. Sineshchekov; Yumei Wang; Leonid S. Brown; Songhwan Hwang; Han Sun; Ana-Nicoleta Bondar; Igor Schapiro; Elena G. Govorunova; John L. Spudich; Oliver P. Ernst

Nature Communications 2025

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A silicon rhodamine-fused glibenclamide to label and detect malaria-infected red blood cells

  • Claudia Bastl; Cindy M. Close; Ingo Holtz; Blaise Gatin-Fraudet; Mareike Eis; Michelle Werum; Smilla Konrad; Kilian Roßmann; Christiane Huhn; Souvik Ghosh; Julia Ast; Dorien A. Roosen; Martin Lehmann; Volker Haucke; Luc Reymond; David J. Hodson; Philip Tinnefeld; Kai Johnsson; Viktorija Glembockyte; Nicole Kilian; Johannes Broichhagen
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A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn

Nature Communications 2025

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Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Enrica Bordignon; Oleg Sitsel; Daniel Roderer; Daniel Prumbaum; Stefan Raunser; Min Dong; Claus A.M. Seidel; Ng'ang'a, Peter Njenga; Julian Folz; Svetlana Kucher; ying xu; Alexander Belyy; Ralf Kühnemuth; Tufa Enver Assafa

Science Advances 2025

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Blobby is a synaptic active zone assembly protein required for memory in Drosophila

  • Janine Lützkendorf; T. Matkovic-Rachid; S. Liu; T. Götz; L. Gao; Oriane Turrel; Marta Maglione; M. Grieger; S. Putignano; Niraja Ramesh; Tina Ghelani; A. Neumann; Niclas Gimber; J. Schmoranzer; A. Stawrakakis; B. Brence; Daniel Baum; Kai Ludwig; M. Heine; Thorsten Mielke; Fan Liu; Alexander Matthias Walter; Markus Wahl; Stephan Sigrist

Nature Communications 2025

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Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR

  • Lisa Gerland; Anne Diehl; Natalja Erdmann; Matthias Hiller; Christina Lang; Christian Teutloff; Jon Hughes; Hartmut Oschkinat

Chemistry – A European Journal 2025

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Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

  • Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss

Journal of the American Chemical Society 2025

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Aminopeptidase-Responsive NIR Photosensitizer for Precision Targeting and Eradication of Pseudomonas aeruginosa Biofilms

  • Yang Liu; Kaixuan Liu; Ling lei; Qinghua Wang; Xiang Wang; Xiangchuan Meng; Qian Liu; Jiacheng Du; Leilei Zhang; Marc Nazaré; Hai-Yu Hu

ACS Applied Materials & Interfaces 2025

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Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation

  • Anton Florian Ketzel; Xiaolu Li; Martin Kaupp; Han Sun; Caspar Jonas Schattenberg

Journal of Chemical Theory and Computation 2025

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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun

Journal of Chemical Information and Modeling 2025

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Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2PChannels

  • Yessenbek K. Aldakul; Marcus Schewe; Carlos C. Diez; Songhwan Hwang; Thomas Baukrowitz; Han Sun
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IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence

  • Changchang Xing; Linhui Shi; Limei Zhu; Tim Aguirre; Ji Qi; Yuanyuan Chen; Yue Liu; Alfred C. Chin; Hong Zhu; Dorothea Fiedler; Alex F. Chen; Chenglai Fu; Tim Aguirre

Diabetes 2025

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Dopaminergic network connectivity alterations are associated with postoperative cognitive dysfunction

  • Florian Lammers-Lietz; Friedrich Borchers; Insa Feinkohl; Cicek Kanar; Henning Krampe; Gregor Lichtner; Jayanth Sreekanth; Janine Wiebach; Martin Weygandt; Claudia Spies; Georg Winterer; friedemann paul; the BioCog consortium; Çiçek Kanar
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Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization

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C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek

Computational and Structural Biotechnology Journal 2025

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List of Publications