Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells

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JCI Insight 2022, 7, e156378

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis

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Journal of Medicinal Chemistry 2022, 65, 1567-1584

Pharmacological tools to investigate inositol polyphosphate kinases - Enzymes of increasing therapeutic relevance

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Advances in Biological Regulation 2022, 83, 100836

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

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Advanced Science 2022, 9, e2103249

Phosphoinositides as membrane organizers

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Nature Reviews Molecular Cell Biology 2022, early access,

Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents

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Chemical Science 2022, 13, 5838-5845

Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components

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Plant Cell 2022

Proton-gated anion transport governs macropinosome shrinkage

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Nature Cell Biology 2022

Rapid analytical CEST spectroscopy of competitive host-guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

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Physical Chemistry Chemical Physics 2022, 24, 12126-12135

Seeing glutamate at central synapses

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Journal of Neuroscience Methods 2022, 375, 109531

Molecular and functional architecture of striatal dopamine release sites

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Serca Modulation Counteracts Glucocorticoid Resistance in T-All

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Haematologica 2022, 107, 19-19

Simple, efficient and thorough shotgun proteomic analysis with PatternLab V

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Site-specific N-glycan profiles of alpha(5)beta(1) integrin from rat liver

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Biology of the Cell 2022, 114, 160-176

Slow excitatory synaptic currents generated by AMPA receptors

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Journal of Physiology-London 2022, 600, 217-232

Structural basis of phosphatidylinositol 3-kinase C2 alpha function

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Nature Structural & Molecular Biology 2022, 29, 218-228

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

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Organic & Biomolecular Chemistry 2022, Advance Article,

A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

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Optimized TMT-Based Quantitative Cross-Linking Mass Spectrometry Strategy for Large-Scale Interactomic Studies

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Analytical Chemistry 2022, 94, 5265-5272

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

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Science Advances 2022, 8, eabl5032

Microscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish

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Magnetic Resonance in Medicine 2022, 87, 1435-1445

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

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Elife 2022, 11, e71198

Major tail proteins of bacteriophages of the order Caudovirales

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Journal of Biological Chemistry 2022, 298, 101472

Advances in tethered photopharmacology for precise optical control of signaling proteins

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Current Opinion in Pharmacology 2022, 63, 102196

An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils

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Journal of Molecular Biology 2022, 434, 167533

An Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber sigma1 Mediates Stability at Low pH and Preserves Trimeric Organization

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Journal of Virology 2022, 96, e0033122

Atomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein

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Biological Chemistry 2022, 403, 615-624

Bis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates

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European Journal of Organic Chemistry 2022, 2022, e202101389

Ca2+-dependent photocrosslinking in the BK channel intracellular inter-subunit interfaces

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Biophysical Journal 2022, 121, 502a-502a

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

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International Journal of Molecular Sciences 2022, 23, 763

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

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Chemical Science 2022, 13, 5419-5776

Disruptors of AKAP-Dependent Protein-Protein Interactions

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

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EMBO Journal 2022, 41, e109352

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

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Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics

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Nature Communications 2022, 13, 1708

Improving HyperCEST performance by favorable xenon exchange conditions in liposomal nanocarriers

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NMR in Biomedicine 2022, e4714

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

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Journal of Biological Chemistry 2022, 298, 101740

Investigating the Role of Sulfate Groups for the Binding of Gd3+ Ions to Glycosaminoglycans with NMR Relaxometry

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ChemMedChem 2022, early access, e202100764

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

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Frontiers in Molecular Neuroscience 2021, 14, 661368

Nonselective cation permeation in an AMPA-type glutamate receptor

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Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2012843118

Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis

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Biosensors-Basel 2021, 11, 60

Pentafluorosulfanyl (SF5) as a Superior (19)F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

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ACS Sensors 2021, 6, 3948-3956

Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

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Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

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ChemBioChem 2021, 22, 548-556

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

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Science 2021, 374, eabk0410

Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner

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Reagents and models for detecting endogenous GLP1R and GIPR

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EBioMedicine 2021, 74, 103739

NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi

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Non-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a beta2-arrestin link to the mTOR pathway

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Kidney International 2021, online ahead of print,

Leveraging the partition selection bias to achieve a high-quality clustering of mass spectra

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Journal of Proteomics 2021, 245, 104282

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

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FASEB Journal 2021, 35, e21275

Natural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor

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New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs , Royal Society of Chemistry 2021

MS Annika: A New Cross-Linking Search Engine

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Journal of Proteome Research 2021, 20, 2560-2569

Molecular Modelling

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Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

Mechanism of synaptic protein turnover and its regulation by neuronal activity

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Current Opinion in Neurobiology 2021, 69, 76-83

Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents

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Pharmaceuticals 2021, 14, 79

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier

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Journal of Controlled Release 2021, 338, 137-148

Liquid-like protein assemblies initiate endocytosis

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Nature Cell Biology 2021, 23, 301-302

Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET

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Biophysical and Computational Tools in Drug Discovery , Springer , 2021 1-32

ITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2021, 14, 1864-1880

Septin Remodeling During Mammalian Cytokinesis

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Frontiers in cell and developmental biology 2021, 9, 768309

Report Structural and compositional diversity in the kainate receptor family

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Cell Reports 2021, 37, 109891

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

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FEBS Journal 2021, 288, 7025-7042

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

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Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

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EMBO Journal 2021, 40, e107568

XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications

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Journal of Proteome Research 2021, 20, 1943-1950

Using Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate-Protein Interactions with Surface-Based Biosensors

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Biochemistry 2021, 60, 2739-2748

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

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Scientific Reports 2021, 11, 10536

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders

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American Journal of Human Genetics 2021, 108, 1450-1465

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

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Clinical and Translational Allergy 2021, 11, e12045

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

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Nature Communications 2021, 12, 384

The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

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Chemical Science 2021, 12, 8141-8148

The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

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JCI Insight 2021, 6, e136083

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis

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Advances in Biological Regulation 2021, in press, 100835

The chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata

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Magnetic Resonance in Chemistry 2021, 59, 554-560

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates

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Methods in Molecular Biology 2021, 2355, 287-299

Similarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation

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Journal of Physical Chemistry B 2021, 125, 2212-2221

SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

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Frontiers in Computer Science 2021, 3, 777837

Structure, gating and interactions of the voltage-dependent anion channel

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European Biophysics Journal with Biophysics Letters 2021, 50, 159-172

Structural Plasticity of the Selectivity Filter in Cation Channels

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Frontiers in Physiology 2021, 12, 792958

Structural plasticity of the selectivity filter in a nonselective ion channel

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IUCrJ 2021, 8, 421-430

Structural evidence for visual arrestin priming via complexation of phosphoinositols

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Structure 2021, 30, 1-15

Structural basis of PI3KC2alpha function

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Nature Structural & Molecular Biology 2021, in press,

Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel

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Journal of Molecular Biology 2021, 433, 167091

SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells

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Molecular Metabolism 2021, 53, 101285

Slow AMPA receptors in hippocampal principal cells

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Cell Reports 2021, 36, 109496

Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

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ChemBioChem 2021, 22, 1205-1209

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

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Nature Communications 2021, 12, 2673

Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

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Frontiers in Bioengineering and Biotechnology 2021, 8, 614357

Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway

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International Journal of Molecular Sciences 2021, 22, 12007

An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator

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Scientific Reports 2021, 11, 21731

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

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Nature Communications 2021, 12, 4798

Cl(-) channels and Cl(-)/H(+) exchangers

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Encyclopedia of Molecular Pharmacology : Third Edition , Springer , 2021 470-477

Chemical Biology Tools To Investigate Malaria Parasites

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ChemBioChem 2021, 22, 2219-2236

Characterizing protein conformers by cross-linking mass spectrometry and pattern recognition

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Bioinformatics 2021, 37, 3035-3037

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

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Nature Chemistry 2021, 13, 530-539

Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells

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Angewandte Chemie International Edition 2021, 60, 22075-22080

Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarized Xe-129

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Chemical Science 2021, 12, 158-169

Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research

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Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552

Aptamer BC 007's Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies

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Viruses 2021, 13, 932

Analyses of Covalent Modifications in Alpha-Glucans

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Enzymology of Complex Alpha-Glucans , CRC Press , 2021 34-60

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

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Frontiers in Molecular Neuroscience 2021, 14, 721749

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4

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European Journal of Medicinal Chemistry 2021, 209, 112901

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

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Molecular Microbiology 2021, 115, 986-1004

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes

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STAR Protocols 2021, 2, 100277

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

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Molecular Pharmacology 2021, 100, 319-334

A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

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Organic & Biomolecular Chemistry 2021, 19, 8014-8017

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

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Molecular and Cellular Proteomics 2021, 20, 100144

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

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Neuron 2021, 109, 27-41

A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC)-Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

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Angewandte Chemie International Edition 2021, Online ahead of print,

A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

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Developmental Cell 2021, 56, 1557-1559

A fine-tuned azobenzene for enhanced photopharmacology in vivo

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Cell Chemical Biology 2021, 28, 1648-1663

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy

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Theranostics 2021, 11, 2490-2504

A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

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Chemical Science 2021, 12, 12754-12762

Crosslinking glutamate receptor ion channels

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Ion Channels: Channel Biochemistry, Reconstitution, and Function , Elsevier , 2021 161-192

Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly

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Current Biology 2021, 31, 1711-1725

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

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Journal of Medicinal Chemistry 2021, 64, 17936-17949

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

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Nature Communications 2021, 12, 4236

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

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International Journal of Molecular Sciences 2021, 22, 151

Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging

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Angewandte Chemie International Edition 2021, 60, 15359-15364

Identification of extracellular nanoparticle subsets by nuclear magnetic resonance

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Chemical Science 2021, 12, 8311-8319

Identification of disease-relevant modulators of the SHH pathway in the developing brain

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Development 2021, 148, dev199307

Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

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Scientific Reports 2021, 11, 19928

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

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Science 2021, 371, eaax9050

How solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks

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Polymer 2021, 229, 123986

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

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Autophagy 2021, 17, 1-382

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

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Glia 2021, 69, 1897-1915

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

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Nature Neuroscience 2021, 24, 82-92

Functional Imaging Using Fluorine ((19)F) MR - Methods: Basic Concepts

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Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses

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Journal of Medicinal Chemistry 2021, 64, 12774-12789

Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening

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Acs Pharmacology & Translational Science 2021, 4, 780-789

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

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Elife 2021, 10, e67027

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

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RSC Chemical Biology 2021, 2, 1661-1668

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

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Chemical Science 2021, 12, 10696-10702

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

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Bioconjugate Chemistry 2021, 32, 702-712

Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

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Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

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Cell Reports 2021, 35, 108941

En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes

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Nature Communications 2021, 12, 4972

Endothelins

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Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

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Journal of Medicinal Chemistry 2021, 64, 14266-14282

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

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Biochemical Pharmacology 2021, 190, 114656

Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics

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Chemistry 2020, 26, 3049-3053

pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes

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ChemBioChem 2020, 21, 1597-1604

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

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Nature Nanotechnology 2020, 15, 373-379

Phosphodiesterase 3A and Arterial Hypertension

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Circulation 2020, 142, 133-149

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

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Journal of Biological Chemistry 2020, 295, 1091-1104

Protein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide

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Magnetic Resonance in Chemistry 2020, 58, 445-465

Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

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Angewandte Chemie-International Edition 2020, 59, 11937-11942

Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans

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Molecular Ecology 2020, 29, 1745-1755

Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules

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Magnetic Resonance in Chemistry 2020, 58, 404-410

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

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Journal of Medicinal Chemistry 2020, 63, 6834-6846

NMR quality control of fragment libraries for screening

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Journal of Biomolecular NMR 2020, 74, 555-563

Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity

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Progress in Neurobiology 2020, Online ahead of print, 101907

Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization

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Biophysical Journal 2020, 119, 206-218

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

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Neuron 2020, 109, 1-15

N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

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ChemBioChem 2020, 21, 113-119

Mussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins

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Macromolecular Rapid Communications 2020, 41, e1900431

Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations

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Journal of Virology 2020, Online ahead of print,

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

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Cancer Letters 2020, 479, 61-70

Molecular architecture and assembly of the tight junction backbone

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Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183279

Modulating TSH Receptor Signaling for Therapeutic Benefit

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European Thyroid Journal 2020, 9, 66-77

Modern Peptide and Protein Chemistry: Reaching New Heights

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Journal of Organic Chemistry 2020, 85, 1328-1330

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex

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