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What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.
Thanks to a small group of scientists, Volker Haucke's laboratory has become the first My Green Lab-certified laboratory in Germany with the best sustainable rating of "green".
Here is a short introduction on what to do and who to contact to get new ideas about sustainable laboratory practices.
14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells
JCI Insight 2022, 7, e156378
read onlineRational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis
Journal of Medicinal Chemistry 2022, 65, 1567-1584
read onlinePharmacological tools to investigate inositol polyphosphate kinases - Enzymes of increasing therapeutic relevance
Advances in Biological Regulation 2022, 83, 100836
read onlinePhosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer
Advanced Science 2022, 9, e2103249
read onlinePhosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology 2022, early access,
read onlineProgrammable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents
Chemical Science 2022, 13, 5838-5845
read onlineProteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components
Plant Cell 2022
read onlineProton-gated anion transport governs macropinosome shrinkage
Nature Cell Biology 2022
read onlineRapid analytical CEST spectroscopy of competitive host-guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)
Physical Chemistry Chemical Physics 2022, 24, 12126-12135
read onlineSeeing glutamate at central synapses
Journal of Neuroscience Methods 2022, 375, 109531
read onlineMolecular and functional architecture of striatal dopamine release sites
Neuron 2022, 110, 248-265
read onlineSerca Modulation Counteracts Glucocorticoid Resistance in T-All
Haematologica 2022, 107, 19-19
Simple, efficient and thorough shotgun proteomic analysis with PatternLab V
Nature Protocols 2022, Online ahead of print,
read onlineSite-specific N-glycan profiles of alpha(5)beta(1) integrin from rat liver
Biology of the Cell 2022, 114, 160-176
read onlineSlow excitatory synaptic currents generated by AMPA receptors
Journal of Physiology-London 2022, 600, 217-232
read onlineStructural basis of phosphatidylinositol 3-kinase C2 alpha function
Nature Structural & Molecular Biology 2022, 29, 218-228
read onlineSulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins
Organic & Biomolecular Chemistry 2022, Advance Article,
read onlineA Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry
Angewandte Chemie International Edition 2022, 61, e202113937
read onlineOptimized TMT-Based Quantitative Cross-Linking Mass Spectrometry Strategy for Large-Scale Interactomic Studies
Analytical Chemistry 2022, 94, 5265-5272
read onlineSelective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity
Science Advances 2022, 8, eabl5032
read onlineMicroscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish
Magnetic Resonance in Medicine 2022, 87, 1435-1445
read onlineClathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Elife 2022, 11, e71198
read onlineMajor tail proteins of bacteriophages of the order Caudovirales
Journal of Biological Chemistry 2022, 298, 101472
read onlineAdvances in tethered photopharmacology for precise optical control of signaling proteins
Current Opinion in Pharmacology 2022, 63, 102196
read onlineAn Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils
Journal of Molecular Biology 2022, 434, 167533
read onlineAn Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber sigma1 Mediates Stability at Low pH and Preserves Trimeric Organization
Journal of Virology 2022, 96, e0033122
read onlineAtomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein
Biological Chemistry 2022, 403, 615-624
read onlineBis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates
European Journal of Organic Chemistry 2022, 2022, e202101389
read onlineCa2+-dependent photocrosslinking in the BK channel intracellular inter-subunit interfaces
Biophysical Journal 2022, 121, 502a-502a
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
International Journal of Molecular Sciences 2022, 23, 763
read onlineDetection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Chemical Science 2022, 13, 5419-5776
read onlineDisruptors of AKAP-Dependent Protein-Protein Interactions
Methods in Molecular Biology , Humana, New York, NY, USA , 2022 117-139
read onlineEndosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
EMBO Journal 2022, 41, e109352
read onlineGating choreography and mechanism of the human proton-activated chloride channel ASOR
Science Advances 2022, 8, eabm3942
read onlineHyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics
Nature Communications 2022, 13, 1708
read onlineImproving HyperCEST performance by favorable xenon exchange conditions in liposomal nanocarriers
NMR in Biomedicine 2022, e4714
read onlineInositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3
Journal of Biological Chemistry 2022, 298, 101740
read onlineInvestigating the Role of Sulfate Groups for the Binding of Gd3+ Ions to Glycosaminoglycans with NMR Relaxometry
ChemMedChem 2022, early access, e202100764
read onlinePhosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
Frontiers in Molecular Neuroscience 2021, 14, 661368
read onlineNonselective cation permeation in an AMPA-type glutamate receptor
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2012843118
read onlineNovel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis
Biosensors-Basel 2021, 11, 60
read onlinePentafluorosulfanyl (SF5) as a Superior (19)F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives
ACS Sensors 2021, 6, 3948-3956
read onlineRab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi
Journal of Cell Biology 2021, 220, e202006040
read onlinePhotocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo
ChemBioChem 2021, 22, 548-556
read onlinePI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
Science 2021, 374, eabk0410
read onlineProteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner
Cancer Letters 2021, 520, 132-142
read onlineReagents and models for detecting endogenous GLP1R and GIPR
EBioMedicine 2021, 74, 103739
read onlineNMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi
Journal of Structural Biology 2021, 213, 107715
read onlineNon-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a beta2-arrestin link to the mTOR pathway
Kidney International 2021, online ahead of print,
read onlineLeveraging the partition selection bias to achieve a high-quality clustering of mass spectra
Journal of Proteomics 2021, 245, 104282
read onlineNew structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1
FASEB Journal 2021, 35, e21275
read onlineNatural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor
New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs , Royal Society of Chemistry 2021
read onlineMS Annika: A New Cross-Linking Search Engine
Journal of Proteome Research 2021, 20, 2560-2569
read onlineMolecular Modelling
Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021
read onlineMechanism of synaptic protein turnover and its regulation by neuronal activity
Current Opinion in Neurobiology 2021, 69, 76-83
read onlineMapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents
Pharmaceuticals 2021, 14, 79
read onlineM01 as a novel drug enhancer for specifically targeting the blood-brain barrier
Journal of Controlled Release 2021, 338, 137-148
read onlineLiquid-like protein assemblies initiate endocytosis
Nature Cell Biology 2021, 23, 301-302
read onlineKinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET
Biophysical and Computational Tools in Drug Discovery , Springer , 2021 1-32
read onlineITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis
Molecular Plant 2021, 14, 1864-1880
read onlineSeptin Remodeling During Mammalian Cytokinesis
Frontiers in cell and developmental biology 2021, 9, 768309
read onlineReport Structural and compositional diversity in the kainate receptor family
Cell Reports 2021, 37, 109891
read onlineThe molecular mechanisms mediating class II PI 3-kinase function in cell physiology
FEBS Journal 2021, 288, 7025-7042
read onlineSequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118
read onlineThe cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation
EMBO Journal 2021, 40, e107568
read onlineXlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications
Journal of Proteome Research 2021, 20, 1943-1950
read onlineUsing Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate-Protein Interactions with Surface-Based Biosensors
Biochemistry 2021, 60, 2739-2748
read onlineUnusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin
Scientific Reports 2021, 11, 10536
read onlineUnique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders
American Journal of Human Genetics 2021, 108, 1450-1465
read onlineTopical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Clinical and Translational Allergy 2021, 11, e12045
read onlineInositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
Nature Communications 2021, 12, 384
read onlineThe mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols
Chemical Science 2021, 12, 8141-8148
read onlineThe longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms
JCI Insight 2021, 6, e136083
read onlineThe inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis
Advances in Biological Regulation 2021, in press, 100835
read onlineThe chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata
Magnetic Resonance in Chemistry 2021, 59, 554-560
read onlineTargeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates
Methods in Molecular Biology 2021, 2355, 287-299
read onlineSimilarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation
Journal of Physical Chemistry B 2021, 125, 2212-2221
read onlineSynActJ: Easy-to-Use Automated Analysis of Synaptic Activity
Frontiers in Computer Science 2021, 3, 777837
read onlineStructure, gating and interactions of the voltage-dependent anion channel
European Biophysics Journal with Biophysics Letters 2021, 50, 159-172
read onlineStructural Plasticity of the Selectivity Filter in Cation Channels
Frontiers in Physiology 2021, 12, 792958
read onlineStructural plasticity of the selectivity filter in a nonselective ion channel
IUCrJ 2021, 8, 421-430
read onlineStructural evidence for visual arrestin priming via complexation of phosphoinositols
Structure 2021, 30, 1-15
read onlineStructural basis of PI3KC2alpha function
Nature Structural & Molecular Biology 2021, in press,
Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel
Journal of Molecular Biology 2021, 433, 167091
read onlineSNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells
Molecular Metabolism 2021, 53, 101285
read onlineSlow AMPA receptors in hippocampal principal cells
Cell Reports 2021, 36, 109496
read onlineSite-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
ChemBioChem 2021, 22, 1205-1209
read onlineInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Nature Communications 2021, 12, 2673
read onlineMetabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi
Frontiers in Bioengineering and Biotechnology 2021, 8, 614357
read onlineInhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway
International Journal of Molecular Sciences 2021, 22, 12007
read onlineAn NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator
Scientific Reports 2021, 11, 21731
read onlineConversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
Nature Communications 2021, 12, 4798
read onlineCl(-) channels and Cl(-)/H(+) exchangers
Encyclopedia of Molecular Pharmacology : Third Edition , Springer , 2021 470-477
read onlineChemical Biology Tools To Investigate Malaria Parasites
ChemBioChem 2021, 22, 2219-2236
read onlineCharacterizing protein conformers by cross-linking mass spectrometry and pattern recognition
Bioinformatics 2021, 37, 3035-3037
read onlineCellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
Nature Chemistry 2021, 13, 530-539
read onlineCell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells
Angewandte Chemie International Edition 2021, 60, 22075-22080
read onlineBinding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarized Xe-129
Chemical Science 2021, 12, 158-169
read onlineBeyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research
Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552
read onlineAptamer BC 007's Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies
Viruses 2021, 13, 932
read onlineAnalyses of Covalent Modifications in Alpha-Glucans
Enzymology of Complex Alpha-Glucans , CRC Press , 2021 34-60
An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging
Frontiers in Molecular Neuroscience 2021, 14, 721749
read onlineDesign and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4
European Journal of Medicinal Chemistry 2021, 209, 112901
read onlineAffinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages
Molecular Microbiology 2021, 115, 986-1004
read onlineAffinity enrichment and identification of inositol poly- and pyrophosphate interactomes
STAR Protocols 2021, 2, 100277
read onlineAcylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
Molecular Pharmacology 2021, 100, 319-334
read onlineA silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection
Organic & Biomolecular Chemistry 2021, 19, 8014-8017
read onlineA Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide
Molecular and Cellular Proteomics 2021, 20, 100144
read onlineA Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation
Neuron 2021, 109, 27-41
read onlineA Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC)-Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry
Angewandte Chemie International Edition 2021, Online ahead of print,
read onlineA mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval
Developmental Cell 2021, 56, 1557-1559
read onlineA fine-tuned azobenzene for enhanced photopharmacology in vivo
Cell Chemical Biology 2021, 28, 1648-1663
read onlineIn vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy
Theranostics 2021, 11, 2490-2504
read onlineA combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor
Chemical Science 2021, 12, 12754-12762
read onlineCrosslinking glutamate receptor ion channels
Ion Channels: Channel Biochemistry, Reconstitution, and Function , Elsevier , 2021 161-192
read onlineAntagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly
Current Biology 2021, 31, 1711-1725
read onlineDevelopment of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Journal of Medicinal Chemistry 2021, 64, 17936-17949
read onlineExchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
Nature Communications 2021, 12, 4236
read onlineIdentification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling
International Journal of Molecular Sciences 2021, 22, 151
read onlineDiethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging
Angewandte Chemie International Edition 2021, 60, 15359-15364
read onlineIdentification of extracellular nanoparticle subsets by nuclear magnetic resonance
Chemical Science 2021, 12, 8311-8319
read onlineIdentification of disease-relevant modulators of the SHH pathway in the developing brain
Development 2021, 148, dev199307
read onlineIdentification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways
Scientific Reports 2021, 11, 19928
read onlineHunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy
Science 2021, 371, eaax9050
read onlineHow solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks
Polymer 2021, 229, 123986
read onlineGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021, 17, 1-382
read onlineGlial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glia 2021, 69, 1897-1915
read onlineGABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Nature Neuroscience 2021, 24, 82-92
read onlineFunctional Imaging Using Fluorine ((19)F) MR - Methods: Basic Concepts
Methods in Molecular Biology , Springer Nature , 2021 279-299
read onlineEvaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses
Journal of Medicinal Chemistry 2021, 64, 12774-12789
read onlineIdentification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Acs Pharmacology & Translational Science 2021, 4, 780-789
read onlineDifferences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
Elife 2021, 10, e67027
read onlineDiscovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
RSC Chemical Biology 2021, 2, 1661-1668
read onlineDissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
Chemical Science 2021, 12, 10696-10702
read onlineDOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells
Bioconjugate Chemistry 2021, 32, 702-712
read onlineDysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118
read onlineeIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
Cell Reports 2021, 35, 108941
read onlineEn route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes
Nature Communications 2021, 12, 4972
read onlineEndothelins
Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021
read onlineEnhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer
Journal of Medicinal Chemistry 2021, 64, 14266-14282
read onlineEvaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1
Biochemical Pharmacology 2021, 190, 114656
read onlinePd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics
Chemistry 2020, 26, 3049-3053
read onlinepH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes
ChemBioChem 2020, 21, 1597-1604
read onlinePhage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Nature Nanotechnology 2020, 15, 373-379
read onlinePhosphodiesterase 3A and Arterial Hypertension
Circulation 2020, 142, 133-149
read onlinePhosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway
Journal of Biological Chemistry 2020, 295, 1091-1104
read onlineProtein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide
Magnetic Resonance in Chemistry 2020, 58, 445-465
read onlinePigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage
Angewandte Chemie-International Edition 2020, 59, 11937-11942
read onlinePlasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans
Molecular Ecology 2020, 29, 1745-1755
read onlinePractical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules
Magnetic Resonance in Chemistry 2020, 58, 404-410
read onlinePreclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
Journal of Medicinal Chemistry 2020, 63, 6834-6846
read onlineNMR quality control of fragment libraries for screening
Journal of Biomolecular NMR 2020, 74, 555-563
read onlineNovel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
Progress in Neurobiology 2020, Online ahead of print, 101907
read onlineMeasurements of the Timescale and Conformational Space of AMPA Receptor Desensitization
Biophysical Journal 2020, 119, 206-218
read onlineNeuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
Neuron 2020, 109, 1-15
read onlineN-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
ChemBioChem 2020, 21, 113-119
read onlineMussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins
Macromolecular Rapid Communications 2020, 41, e1900431
read onlineMurine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations
Journal of Virology 2020, Online ahead of print,
read onlineMonensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells
Cancer Letters 2020, 479, 61-70
read onlineMolecular architecture and assembly of the tight junction backbone
Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183279
read onlineModulating TSH Receptor Signaling for Therapeutic Benefit
European Thyroid Journal 2020, 9, 66-77
read onlineModern Peptide and Protein Chemistry: Reaching New Heights
Journal of Organic Chemistry 2020, 85, 1328-1330
read onlineMITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex
EMBO Reports 2020, 21, e48833
read onlineMegadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics
Journal of Molecular Biology 2020, 432, 166689
read onlineMeasurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid-Crystalline-Based Medium
Angewandte Chemie-International Edition 2020, Online ahead of print,
read onlineMAS NMR detection of hydrogen bonds for protein secondary structure characterization
Journal of Biomolecular NMR 2020, 74, 247-256
read onlineRamping up the autophagy-lysosome system to cope with osmotic stress
Autophagy 2020, 16, 1921-1922
read onlineRab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
Nature Communications 2020, 11, 2835
read onlineTriplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
Cell Chemical Biology 2020, 27, 1097-1108
read onlineRapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances
Elife 2020, 9, e51032
read onlineThe Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists
ACS Pharmacology & Translational Science 2020, 3, 345-360
read onlineLive-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7729-7738
read onlineVps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772
read onlineVesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports 2020, 30, 2594-2602
read onlineUncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration
EMBO Journal 2020, 39, e103358
read onlineTriple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules
Angewandte Chemie-International Edition 2020, 59, 5747-5755
read onlineTransfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
Immunity 2020, 52, 767-781
read onlineTight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins
Journal of Cerebral Blood Flow and Metabolism 2020, 271678X20904687
read onlineThe virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30
British Journal of Pharmacology 2020, 177, 1424-1433
read onlineThe Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses
Journal of Neurogenetics 2020, 34, 106-114
read onlineThe noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase
Journal of Biological Chemistry 2020, 295, 3064-3079
read onlineThe INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.
Cancer Discovery 2020, 10, 1226-1239
read onlineThe inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha
Science Advances 2020, 6, eabb8542
read onlineThe impact of non-ideality of lipid mixing on peptide induced lipid clustering
Biochimica et Biophysica Acta - Biomembranes 2020, 1862, 183248
read onlineReducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading
Autophagy 2020, 16, 878-899
read onlineThe glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation
Journal of Biological Chemistry 2020, 295, 17158-17168
read onlineThe axonal endolysosomal and autophagic systems
Journal of Neurochemistry 2020, 158, 589-602
read onlineThe antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes
Scientific Reports 2020, 10, 3681
read onlineTargeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin
Molecular Oncology 2020, 14, 261-276
read onlineSynthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics
Chemistry 2020, Online ahead of print, 2326-2331
read onlineStitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Science Advances 2020, 6, eaax5783
read onlineStereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase
Journal of the American Chemical Society 2020, 142, 2301-2309
read onlineSplicing-accessible coding 3 ' UTRs control protein stability and interaction networks
Genome Biology 2020, 21, 186
read onlineSignalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide
British Journal of Pharmacology 2020, 177, 3905-3923
read onlineSelectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
Journal of Biological Chemistry 2020, 295, 610-618
read onlineSclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content
Journal of Molecular Biology 2020, 432, 2080-2098
read onlineRIM-binding protein couples synaptic vesicle recruitment to release sites
Journal of Cell Biology 2020, 219, e201902059
read onlineRevealing cytotoxic substructures in molecules using deep learning
Journal of Computer-Aided Molecular Design 2020, 34, 731-746
read onlineLocal externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
EMBO Journal 2020, 39, e105380
read onlineCrystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi
Journal of Structural Biology 2020, 211, 107536
read onlineLigand-specific factors influencing GLP-1R post-endocytic trafficking and degradation
International Journal of Molecular Sciences 2020, 21, 33182425
read onlineAptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins
Heliyon 2020, 6, e05421
read onlineCobalt-Exchanged Poly(Heptazine Imides) as Transition Metal-N-x Electrocatalysts for the Oxygen Evolution Reaction
Advanced Materials 2020, 32, e1903942
read onlineChemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations
Journal of the American Chemical Society 2020, 142, 9544-9552
read onlineCellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives
Nature Chemistry 2020, in press,
Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies
Journal of Biological Chemistry 2020, 296, 100074
read onlineCannabinoid receptor type 2 ligands: an analysis of granted patents since 2010
Pharmaceutical Patent Analyst 2020, 10, 111-163
read onlineBiophysics of Membrane Protein Signaling
Biophysical Journal 2020, 118, E01-E01
read onlineBinding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe
Chemical Science 2020, in print,
read onlineAuthor Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Scientific Reports 2020, 10, 8640
read onlineAsymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells
Nature Microbiology 2020, 5, 181-191
read onlineAssembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner
Journal of Molecular Biology 2020, 432, 2405-2427
read onlineAryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
Cell Host & Microbe 2020, 27, 238-248
read onlineArchitecture of the flexible tail tube of bacteriophage SPP1
Nature Communications 2020, 11, 5759
read onlineAP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
Journal of Cell Science 2020, 133, jcs236737
read onlineCombining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
Chemical Science 2020, 11, doi:10.1039/D0SC03930F
read onlineAnalysis of Random Migration of Cancer Cells in 3D
Bio-Protocol 2020, 10,
read onlineAnalysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
Nature Communications 2020, 11, 6035
An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria
Angewandte Chemie-International Edition 2020, 59, 8512-8516
read onlineAmbigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp
ACS Chemical Biology 2020, 15, 2929-2936
read onlineAffinity-enrichment and identification of inositol poly- and pyrophosphate interactomes
STAR Methods 2020, in press,
Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7 )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages
Molecular Microbiology 2020, Online ahead of print,
read onlineA recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration
American Journal of Human Genetics 2020, 107, 1062-1077
read onlineA Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles
Organic Letters 2020, 22, 7393-7396
read onlineA new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance
International Journal of Pharmaceutics 2020, 589, 119822
read onlineA Golgi-associated lipid kinase controls peripheral nerve myelination
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875
read onlineA face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies
Fluids and Barriers of the CNS 2020, 17, 53
read onlineLegionella effector AnkX displaces the switch II region for Rab1b phosphocholination
Science Advances 2020, 6, eaaz8041
read onlineCollective exchange processes reveal an active site proton cage in bacteriorhodopsin
Communications Biology 2020, 3, 4
read onlineAlterations of redox and iron metabolism accompany the development of HIV latency
EMBO Journal 2020, 39, e102209
read onlineControl of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 3568-3574
read onlineEndocytosis in the adaptation to cellular stress
Cell Stress 2020, 4, 230-247
read onlineIP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
mBio 2020, 11,
read onlineCross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Nature Communications 2020, 11, 4845
read onlineIntersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission
Cell Reports 2020, 30, 409-420
read onlineInterrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Chemical Science 2020, 11, 7871-7883
read onlineInteractome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
Cell Reports 2020, 32, 108050
read onlineInhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association
Nature Microbiology 2020, 5, 1361-1373
read onlineGraphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance
Advanced Functional Materials 2020, 2000933
read onlineFunctionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI
Advanced Biosystems 2020, 4, e1900251
read onlineFrom Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement
Journal of Medicinal Chemistry 2020, 63, 14780-14804
read onlineExpanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry
Analytical Chemistry 2020, 92, 10495-10503
read onlineEquine Herpesvirus Type 1 Modulates Cytokine and Chemokine Profiles of Mononuclear Cells for Efficient Dissemination to Target Organs
Viruses 2020, 12, 999
read onlineEndophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Nature Communications 2020, 11, 1266
read onlineInsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 19245-19253
read onlineEndocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Nature Cell Biology 2020, 22, 815-827
read onlineDevelopment of a pathogenesis-based therapy for peeling skin syndrome type 1
British Journal of Dermatology 2020, 184, 1123-1131
read onlineEHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481
read onlineCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Communications Biology 2020, 3, 240
read onlineDelivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide
Angewandte Chemie-International Edition 2020, 59, 15586-15589
read onlineDesigned nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690
read onlineDeuterated rhodamines for protein labelling in nanoscopy
bioRxiv 2020, upload on Monday, 17th Aug
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Journal of the American Chemical Society 2020, 142, 16953-16964
read onlineDual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues
ACS Sensors 2020, 5, 1650-1656
read onlineDynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter
Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183114
read onlineDynamic palmitoylation events following T-cell receptor signaling
Communications Biology 2020, 3, 368
read onlineDynamic profile of EVs in porcine oviductal fluid during the periovulatory period
Reproduction 2020, 159, 371-382
read onlineCyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP
Cells 2020, 9, E673
read onlineRapid active zone remodeling consolidates presynaptic potentiation
Nature Communications 2019, 10, 1085
read onlinePoly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Cell Reports 2019, 27, 3124-3138
read onlineRapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen
Organic Letters 2019, 21, 2121-2125
read onlineQuantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression
Nucleic Acids Research 2019, 47, 953-969
read onlineProtein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
Organic Letters 2019, 21, 10043-10047
read onlineProtein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1
Nature Cell Biology 2019, 21, 1093-1101
read onlineProbing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase
Marine Drugs 2019, 17, E650
read onlineProbing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors
ChemMedChem 2019, 14, 1514-1527
read onlineMolecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Cell Reports 2019, 27, 3049-3061
read onlinePhosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks
Journal of Cell Science 2019, 132, jcs225151
read onlinePharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2
Journal of Biological Chemistry 2019, 294, 18150-18161
read onlinePathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism
Nature Communications 2019, 10, 4678
read onlineNanoscale coupling of endocytic pit growth and stability
Science Advances 2019, 5, eaax5775
read onlineMutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction
PLoS Genetics 2019, 15, e1008088
read onlineMetal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B27 subtype
Journal of Biological Chemistry 2019, 294, 13269-13279
read onlineMechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5
Journal of Cell Biology 2019, 218, 3117-3133
read onlineLysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking
Journal of Biological Chemistry 2019, 294, 9592-9604
read onlineRIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses
Elife 2019, 8, e43243
read onlineLocally renewing resident synovial macrophages provide a protective barrier for the joint
Nature 2019, 572, 670-675
read onlineRegulation of influenza A virus mRNA splicing by CLK1
Antiviral Research 2019, 168, 187-196
read onlineThe Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Scientific Reports 2019, 9, 10878
read onlineSarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis
Journal of Organic Chemistry 2019, 84, 2568-2576
read onlineThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
Nature Communications 2019, 10, 5518
read onlineIdentification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Elife 2019, 8, e49187
read onlineUse of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
International Journal of Molecular Sciences 2019, 20, 4774
read onlineUncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava
Journal of Organic Chemistry 2019, 84, 3083-3092
read onlineTwo bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
Elife 2019, 8, e43582
read onlineTuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles
Organic & Biomolecular Chemistry 2019, 17, 4964-4969
read onlineTight junction proteins at the blood-brain barrier: far more than claudin-5
Cellular and Molecular Life Sciences 2019, 76, 1987-2002
read onlineThyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain
Molecular Pharmacology 2019, 96, 452-462
read onlineThe transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
Nature Communications 2019, 10, 66
read onlineThe conduction pathway of potassium channels is water free under physiological conditions
Science Advances 2019, 5, eaaw6756
read onlineScalable Chemoenzymatic Synthesis of Inositol Pyrophosphates
Biochemistry 2019, 58, 3927-3932
read onlineThe companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants
Nature Communications 2019, 10, 857
read onlineThe cell adhesion protein CAR is a negative regulator of synaptic transmission
Scientific Reports 2019, 9, 6768
read onlineTargeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides
Bioconjugate Chemistry 2019, 30, 400-404
read onlineStructure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR
Journal of the American Chemical Society 2019, 141, 17314-17321
read onlineStructural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes
Biochimica Et Biophysica Acta-Biomembranes 2019, 1861, 1123-1134
read onlineSpermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific Reports 2019, 9, 19616
read onlineSNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9
Journal of Cell Biology 2019, 218, 3039-3059
read onlineSmall-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells
Frontiers in Cellular Neuroscience 2019, 13, 531
read onlineIn-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation
International Journal of Molecular Sciences 2019, 20, 2299
read onlineCrosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease
Frontiers in Aging Neuroscience 2019, 11, 9
read onlineIdentification of functional lipid metabolism biomarkers of brown adipose tissue aging
Molecular Metabolism 2019, 24, 1-17
read onlineAutophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
Nature Communications 2019, 10, 1318
read onlineDiscovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo
Journal of Medicinal Chemistry 2019, 62, 10321-10341
read onlineDetection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR
RSC Advances 2019, 9, 26686-26690
read onlineDelayed allogeneic skin graft rejection in CD26-deficient mice
Cellular and Molecular Immunology 2019, 16, 557-567
read onlineCysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations
Angewandte Chemie-International Edition 2019, 58, 11625-11630
read onlineComparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit
Orphanet Journal of Rare Diseases 2019, 14, 268
read onlineComparison of the 3D structures of mouse and human alpha-synuclein fibrils by it solid-state NMR and STEM
Journal of Structural Biology 2019, 206, 43-48
read onlineClaudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke
Journal of Neuroscience 2019, 39, 743-757
read onlineCharacterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations
Journal of Biomolecular NMR 2019, 73, 281-291
read onlineAtp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells
Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 19983-19988
read onlineDNP NMR of biomolecular assemblies
Journal of Structural Biology 2019, 206, 90-98
read onlineATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
Nature Communications 2019, 10, 486
read onlineA simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells
Methodsx 2019, 6, 2807-2821
read onlineA SEPT1-based scaffold is required for Golgi integrity and function
Journal of Cell Science 2019, 132, jcs225557
read onlineA Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy
American Journal of Human Genetics 2019, 104, 1060-1072
read onlineA pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
Science 2019, 363, 875-880
read onlineA New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid 2019, 29, 111-123
read onlineA Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
Iscience 2019, 12, 194-203
read onlineA FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength
Elife 2019, 8, e45421
read onlineDisruption of endocytosis through chemical inhibition of clathrin heavy chain function
Nature Chemical Biology 2019, 15, 641-649
read onlineDoxorubicin-induced cardiotoxicity involves IFN gamma-mediated metabolic reprogramming in cardiomyocytes
Journal of Pathology 2019, 247, 320-332
read onlineHumanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens
Frontiers in Immunology 2019, 10, 89
read onlineFish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications
ACS Macro Letters 2019, 8, 724-729
read onlineHost monitoring of quorum sensing during Pseudomonas aeruginosa infection
Science 2019, 366, eaaw1629
read onlineHomeostatic scaling of active zone scaffolds maintains global synaptic strength
Journal of Cell Biology 2019, 218, 1706-1724
read onlineHigh-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs
Stem Cell Reports 2019, 12, 1389-1403
read onlineHigh Exchange Rate Complexes of Xe-129 with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI
ChemPhysChem 2019, 20, 246-251
read onlineHarnessing C-13-labeled myo-inositol to interrogate inositol phosphate messengers by NMR
Chemical Science 2019, 10, 5267-5274
read onlineGlobal Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains
Molecular & Cellular Proteomics 2019, 18, 1705-1720
read onlineGating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis
Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 13358-13367
read onlineFluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking
Journal of the American Society of Nephrology 2019, 30, 795-810
read onlineFirst Community-Wide, Comparative Cross-Linking Mass Spectrometry Study
Analytical Chemistry 2019, 91, 6953-6961
read onlineDual Bioorthogonal Labeling of the Amyloid-beta Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products
Journal of Alzheimers Disease 2019, 72, 537-548
read onlineExon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain
Structure 2019, 27, 977-987
read onlineEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
Slas Discovery 2019, 24, 398-413
read onlineEthynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates
Angewandte Chemie-International Edition 2019, 58, 11631-11636
read onlineeNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
PLoS One 2019, 14, e0223620
read onlineEnabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
Mabs 2019, 11, 94-105
read onlineElectroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology
Elife 2019, 8, e48287
read onlineElectron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations
Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585
read onlineDysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells
Journal of the American Chemical Society 2019, 141, 6812-6816
read onlineDynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies
Journal of Physical Chemistry B 2019, 123, 5048-5058
read onlineVinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization
Chemical Science 2019, 10, 6322-6329
read onlineThe keeping of laboratory animals and the performance of experiments on animals are subject to strict regulations based on the EU-Directive 2010/63/EU, which has been implemented at the national level by the Prevention of Cruelty to Animals Act (Tierschutzgesetz - TierSchG) as of July 23, 2013 and the Directive for the Protection of Laboratory Animals (Tierschutz-Versuchstierverordnung - TierSchVersV) as of August 01, 2013.
Laboratory animal report of FMP for the year 2022
Read more about the Animal Facility
"Tierversuche verstehen"-Initiative
"Transparente Tierversuche" Initiative
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany