Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Protocol for semisynthesis of histone H4 with site-specific modifications using irreversible sortase-mediated ligation

  • Yihang Xiao; Kun Zou; Mingxuan Wu

STAR Protocols 2025

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Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes

  • Patrick Watermann; Gurleen K. Kalsi; Ralf Dringen; Christian Arend

Neurochemical Research 2025

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Selective photo crosslinking to methylarginine readers by sulfonium peptides

  • Ting Luo; Feng Feng; Kun Zou; Yumo Zhao; Yingxiao Gao; Mingxuan Wu

Bioorganic & Medicinal Chemistry 2025

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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I

  • Xiaoqi Liu; Zixuan Zhang; Tim Aguirre; Megan L. Shipton; Lin Fu; Jimin Du; David Furkert; Ji Qi; Alfred C. Chin; Andrew M. Riley; Tong Liu; Xu Zhang; Barry V.L. Potter; Dorothea Fiedler; Yi Zhu; Chenglai Fu; Tim Aguirre

Metabolism 2025

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Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR

  • Lisa Gerland; Anne Diehl; Natalja Erdmann; Matthias Hiller; Christina Lang; Christian Teutloff; Jon Hughes; Hartmut Oschkinat

Chemistry – A European Journal 2025

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Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

  • Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss

Journal of the American Chemical Society 2025

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Aminopeptidase-Responsive NIR Photosensitizer for Precision Targeting and Eradication of Pseudomonas aeruginosa Biofilms

  • Yang Liu; Kaixuan Liu; Ling lei; Qinghua Wang; Xiang Wang; Xiangchuan Meng; Qian Liu; Jiacheng Du; Leilei Zhang; Marc Nazaré; Hai-Yu Hu

ACS Applied Materials & Interfaces 2025

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Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation

  • Anton Florian Ketzel; Xiaolu Li; Martin Kaupp; Han Sun; Caspar Jonas Schattenberg

Journal of Chemical Theory and Computation 2025

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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun

Journal of Chemical Information and Modeling 2025

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Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins

  • Joel I. Badillo‐Gómez; Irene Suarez‐Antuña; Ievgen Mazurenko; Frédéric Biaso; Jacques Pécaut; Elisabeth Lojou; Pascale Delangle; Sarah Hostachy

Chemistry – A European Journal 2025

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Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2PChannels

  • Yessenbek K. Aldakul; Marcus Schewe; Carlos C. Diez; Songhwan Hwang; Thomas Baukrowitz; Han Sun
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Integrative Molekulardynamiksimulationen entwirren cross‐linking Daten und zeigen Verteilungen von mitochondrialen Proteinen

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie 2025

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Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Svea Hohensee; Martin Lehmann; Fan Liu; Weria Pezeshkian

Angewandte Chemie International Edition 2025

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IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence

  • Changchang Xing; Linhui Shi; Limei Zhu; Tim Aguirre; Ji Qi; Yuanyuan Chen; Yue Liu; Alfred C. Chin; Hong Zhu; Dorothea Fiedler; Alex F. Chen; Chenglai Fu; Tim Aguirre

Diabetes 2025

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Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG

  • Carl Öster; Veniamin Chevelkov; Adam Lange

Journal of Biomolecular NMR 2025

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Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

  • Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen

RSC Chemical Biology 2025

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Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers

  • Kun Zou; Jinyu Yang; Yingxiao Gao; Feng Feng; Mingxuan Wu

Chemical Science 2025

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Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

  • Milan Avila Clasen; Max Ruwolt; Cong Wang; Julia Ruta; Boris Bogdanow; Louise U. Kurt; Zehong Zhang; Shuai Wang; Fabio C. Gozzo; Tao Chen; Paulo C. Carvalho; Diogo Borges Lima; Fan Liu

Nature Methods 2024

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Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies

  • Boris Bogdanow; Max Ruwolt; Julia Ruta; Lars Mühlberg; Cong Wang; Wen-feng Zeng; Arne Elofsson; Fan Liu

Molecular Systems Biology 2024

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Dual BACH1 regulation by complementary SCF-type E3 ligases

  • Benedikt Goretzki; Maryam Khoshouei; Martin Schröder; Patrick Penner; Luca Egger; Christine Stephan; Dayana Argoti; Nele Dierlamm; Jimena Maria Rada; Sandra Kapps; Catrin Swantje Müller; Zacharias Thiel; Merve Mutlu; Claude Tschopp; David Furkert; Felix Freuler; Simon Haenni; Laurent Tenaillon; Britta Knapp; Alexandra Hinniger; Philipp Hoppe; Enrico Schmidt; Sascha Gutmann; Mario Iurlaro; Grigory Ryzhakov; César Fernández

Cell 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2024

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Chemical probes for imaging cellular compartmentalization

  • Margret H. Bülow; Johannes Broichhagen

Trends in Biochemical Sciences 2024

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ARF1 compartments direct cargo flow via maturation into recycling endosomes

  • Alexander Stockhammer; Petia Adarska; Vini Natalia; Anja Heuhsen; Antonia Klemt; Gresy Bregu; Shelly Harel; Carmen Rodilla-Ramirez; Carissa Spalt; Ece Özsoy; Paula Leupold; Alica Grindel; Eleanor Fox; Joy Orezimena Mejedo; Amin Zehtabian; Helge Ewers; Dmytro Puchkov; Volker Haucke; Francesca Bottanelli

Nature Cell Biology 2024

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Scalable synthesis of sulfonium and selenonium peptides for selective methyllysine reader crosslinking

  • Yingxiao Gao; Feng Feng; Mingxuan Wu

Tetrahedron Letters 2024

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The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

  • Aqfan Jamaluddin; Rachael A. Wyatt; Joon Lee; Georgina K.C. Dowsett; John A. Tadross; Johannes Broichhagen; Giles S.H. Yeo; Joshua Levitz; Caroline M. Gorvin
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Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development

  • Florian Laurent; Caroline Gutjahr; Simon M. Bartsch; Anuj Shukla; Felix Rico-Resendiz; Daniel Couto; Christelle Fuchs; Joël Nicolet; Sylvain Loubéry; Henning J. Jessen; Dorothea Fiedler; Michael Hothorn

PLOS Genetics 2024

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Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

  • Lixiao Zhou; Xingsen Zhao; Jie Sun; Kun Zou; Xiaoli Huang; Liyang Yu; Mingxuan Wu; Yong Wang; Xuekun Li; Wen Yi

Nature Communications 2024

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Energy transfer photoproximity labelling in live cells using an organic cofactor

  • Leander Crocker; Jan Vincent V. Arafiles; Judith M. Müchler; Max Ruwolt; Kristin Kemnitz-Hassanin; Kilian Roßmann; Christian E. Stieger; Fan Liu; Christian P. R. Hackenberger
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Molecular architecture of synaptic vesicles

  • Uljana Kravcenko; Max Ruwolt; Jana Kroll; Artsemi Yushkevich; Martina Zenkner; Julia Ruta; Rowaa Lotfy; Erich Wanker; Christian Rosenmund; Fan Liu; Misha Kudryashev

Proceedings of the National Academy of Sciences 2024

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ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

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Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

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Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network

  • Andromachi Papagiannoula; Ida Marie Vedel; Kathrin Motzny; Maud Tengo; Sigrid Milles
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Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

  • Alice Rossi; Max Ruwolt; Paraskevi Kakouri; Tetiana Kosten; Severine Kunz; Dmytro Puchkov; Jane Reznick; Bettina Purfürst; Damir Omerbašić; Daniel Méndez Aranda; Giorgia Carai; Guido Mastrobuoni; Daniel W. Hart; Michela Carraro; Ludovica Tommasin; Nigel C. Bennett; Valérie Bégay; Katja Faelber; Oliver Daumke; Paolo Bernardi; Thomas J. Park; Stefan Kempa; Fan Liu; Gary R. Lewin
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Biogenesis and reformation of synaptic vesicles

  • Svenja Bolz; Volker Haucke

The Journal of Physiology 2024

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Direct optical measurement of intramolecular distances with angstrom precision

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Michael Weber; Taukeer A. Khan; Christian Brüser; Stefan Jakobs; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell

Science 2024

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Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

  • Maria Kowald; Sylvestre P. J. T. Bachollet; Fritz Benseler; Maria Steinecker; Sofia Kaushik; Tolga Soykan; Sun Siqi; Ramona Birke; Dragana Ilic; Nils Brose; Hanna Hörnberg; Martin Lehmann; Silvio O. Rizzoli; Johannes Broichhagen; Noa Lipstein
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NUDIX Hydrolases Target Specific Inositol Pyrophosphates and Regulate Phosphate and Iron Homeostasis, and the Expression of Defense Genes in Arabidopsis

  • Robin Schneider; Klea Lami; Isabel Prucker; Sara Christina Stolze; Annett Strauß; Kevin Langenbach; Marília Kamleitner; Yemisrach Zewdu Belay; Kevin Ritter; David Furkert; Philipp Gaugler; Esther Lange; Natalie Faiß; Julie Marie Schmidt; Michael Harings; Lukas Krusenbaum; Stefanie Wege; Simon Kriescher; Heiko Schoof; Dorothea Fiedler; Hirofumi Nakagami; Ricardo F. H. Giehl; Thomas Lahaye; Henning J. Jessen; Verena Gaugler; Gabriel Schaaf
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Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras

  • Kate Prichard; Ngoc Chau; Jing Xue; Michael Krauss; Jennette A. Sakoff; Jayne Gilbert; Claudia Bahnik; Maria Muehlbauer; Silke Radetzki; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2024

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Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates

  • Zi Yang; Saori R Yoshii; Yuji Sakai; Jing Zhang; Haruka Chino; Roland L Knorr; Noboru Mizushima

The EMBO Journal 2024

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Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

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Robust and Irreversible Sortase‐Mediated Ligation by Empolyment of Sarkosyl

  • Yihang Xiao; Mingxuan Wu

Chemistry – A European Journal 2024

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List of Publications