Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Scalable synthesis of sulfonium and selenonium peptides for selective methyllysine reader crosslinking

  • Yingxiao Gao; Feng Feng; Mingxuan Wu

Tetrahedron Letters 2024

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Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

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Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

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A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

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Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network

  • Andromachi Papagiannoula; Ida Marie Vedel; Kathrin Motzny; Maud Tengo; Sigrid Milles
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Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

  • Alice Rossi; Max Ruwolt; Paraskevi Kakouri; Tetiana Kosten; Severine Kunz; Dmytro Puchkov; Jane Reznick; Bettina Purfürst; Damir Omerbašić; Daniel Méndez Aranda; Giorgia Carai; Guido Mastrobuoni; Daniel W. Hart; Michela Carraro; Ludovica Tommasin; Nigel C. Bennett; Valérie Bégay; Katja Faelber; Oliver Daumke; Paolo Bernardi; Thomas J. Park; Stefan Kempa; Fan Liu; Gary R. Lewin
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ARF1 compartments direct cargo flow via maturation into recycling endosomes

  • Alexander Stockhammer; Petia Adarska; Vini Natalia; Anja Heuhsen; Antonia Klemt; Gresy Bregu; Shelly Harel; Carmen Rodilla-Ramirez; Carissa Spalt; Ece Özsoy; Paula Leupold; Alica Grindel; Eleanor Fox; Joy Orezimena Mejedo; Amin Zehtabian; Helge Ewers; Dmytro Puchkov; Volker Haucke; Francesca Bottanelli

Nature Cell Biology 2024

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Biogenesis and reformation of synaptic vesicles

  • Svenja Bolz; Volker Haucke

The Journal of Physiology 2024

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Direct optical measurement of intramolecular distances with angstrom precision

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Michael Weber; Taukeer A. Khan; Christian Brüser; Stefan Jakobs; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell

Science 2024

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Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

  • Maria Kowald; Sylvestre P. J. T. Bachollet; Fritz Benseler; Maria Steinecker; Sofia Kaushik; Tolga Soykan; Sun Siqi; Ramona Birke; Dragana Ilic; Nils Brose; Hanna Hörnberg; Martin Lehmann; Silvio O. Rizzoli; Johannes Broichhagen; Noa Lipstein
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NUDIX Hydrolases Target Specific Inositol Pyrophosphates and Regulate Phosphate and Iron Homeostasis, and the Expression of Defense Genes in Arabidopsis

  • Robin Schneider; Klea Lami; Isabel Prucker; Sara Christina Stolze; Annett Strauß; Kevin Langenbach; Marília Kamleitner; Yemisrach Zewdu Belay; Kevin Ritter; David Furkert; Philipp Gaugler; Esther Lange; Natalie Faiß; Julie Marie Schmidt; Michael Harings; Lukas Krusenbaum; Stefanie Wege; Simon Kriescher; Heiko Schoof; Dorothea Fiedler; Hirofumi Nakagami; Ricardo F. H. Giehl; Thomas Lahaye; Henning J. Jessen; Verena Gaugler; Gabriel Schaaf
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Semi-supervised Contrastive Learning for Bioactivity Prediction using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun
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Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

  • Milan Avila Clasen; Max Ruwolt; Cong Wang; Julia Ruta; Boris Bogdanow; Louise U. Kurt; Zehong Zhang; Shuai Wang; Fabio C. Gozzo; Tao Chen; Paulo C. Carvalho; Diogo Borges Lima; Fan Liu

Nature Methods 2024

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Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

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Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler
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Robust and Irreversible Sortase‐Mediated Ligation by Empolyment of Sarkosyl

  • Yihang Xiao; Mingxuan Wu

Chemistry – A European Journal 2024

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Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Martin Lehmann; Fan Liu; Weria Pezeshkian
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A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
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Structural basis for immune cell binding ofFusobacterium nucleatumvia the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Andreas Oder; Jens Peter von Kries; Daniel Roderer
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A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2knock-down new mouse model

  • Xiao Min Zhang; Urielle François; Maria Florencia Angelo; Stéphane Claverol; Magali Mondin; Christelle Martin; Melissa Deshors; Yann Humeau; Noa Lipstein; Etienne Herzog
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A Novel Mouse Model Demonstrates In Vivo Replenishment of Central Nervous System Pericytes After Successful Acute Ablation

  • Dila Atak; Erdost Yıldız; Esra Özkan; Mohammadreza Yousefi; Ayşe Özkan; Aysu Bilge Yılmaz; Ali Burak Kızılırmak; Iman Asaad Alnajjar; Çiçek Kanar; Zeynep Lal Caan; Şakir Ümit Zeybek; Cem İsmail Küçükali; Erdem Tüzün; Yasemin Gürsoy-Özdemir; Atay Vural
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OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó; Rozemarijn Van Der Veen; Volker Haucke; Martin Lehmann

BMC Biology 2024

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Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras

  • Kate Prichard; Ngoc Chau; Jing Xue; Michael Krauss; Jennette A. Sakoff; Jayne Gilbert; Claudia Bahnik; Maria Muehlbauer; Silke Radetzki; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2024

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Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment

  • Maria Mendes; Sandra Nunes; Tânia Cova; Francisco Branco; Michael Dyrks; Beate Koksch; Nuno Vale; João Sousa; Alberto Pais; Carla Vitorino

Colloids and Surfaces B: Biointerfaces 2024

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A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

  • York Posor; Volker Haucke

Journal of Cell Biology 2024

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An anionic two dimensional covalent organic framework from tetratopic borate centres pillared by lithium ions

  • Darosch Asgari; Julia Grüneberg; Yunkai Luo; Hüseyin Küçükkeçeci; Samrat Ghosh; Veniamin Chevelkov; Sabrina Fischer-Lang; Jérôme Roeser; Adam Lange; Bruce Dunn; Michael Gradzielski; Arne Thomas

Nature Communications 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie International Edition 2024

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HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity

  • Sabrina Montresor; Maria Lucia Pigazzini; Sudarson Baskaran; Mira Sleiman; Govinda Adhikari; Lukas Basilicata; Luca Secker; Natascha Jacob; Yara Ehlert; Anushree Kelkar; Gurleen Kaur Kalsi; Niraj Kulkarni; Paul Spellerberg; Janine Kirstein

Journal of Neurochemistry 2024

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When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping

  • Alexander Stockhammer; Carissa Spalt; Antonia Klemt; Laila S. Benz; Shelly Harel; Vini Natalia; Lukas Wiench; Christian Freund; Benno Kuropka; Francesca Bottanelli

Journal of Cell Science 2024

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Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

  • Henry Sawczyc; Takashi Tatsuta; Carl Öster; Spyridon Kosteletos; Sascha Lange; Claudia Bohg; Thomas Langer; Adam Lange

Nature Communications 2024

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Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied
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C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek
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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

  • Aebi J; Atz K; Ametamey SM; Benz J; Blaising J; Butini S; Campiani G; Carreira EM; Collin L; De Lago E; Gazzi T; Gertsch J; Gobbi L; Guba W; Grether U

Chimia 2024

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ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons

  • Alessandro Esposito; Sara Pepe; Maria Sabina Cerullo; Katia Cortese; Hanako Tsushima Semini; Silvia Giovedì; Renzo Guerrini; Fabio Benfenati; Antonio Falace; Anna Fassio

Acta Physiologica 2024

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RawVegetable 2.0: Refining XL-MS Data Acquisition through Enhanced Quality Control

  • Louise Ulrich Kurt; Milan Avila Clasen; Ísis Venturi Biembengut; Max Ruwolt; Fan Liu; Fabio Gozzo; Diogo Borges Lima; Paulo Carvalho

Journal of Proteome Research 2024

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Toward the Next Generation of Density Functionals: Escaping the Zero-Sum Game by Using the Exact-Exchange Energy Density

  • Martin Prof. Dr. Kaupp; Artur Wodyński; Alexei V. Arbuznikov; Susanne Fürst; Caspar J. Schattenberg

Accounts of Chemical Research 2024

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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

  • Borrega-Roman L; Hoare BL; Kosar M; Sarott RC; Patej KJ; Bouma J; Scott-Dennis M; Koers EJ; Gazzi T; Mach L; Barrondo S; Sallés J; Guba W; Kusznir E; Veprintsev DB
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Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB<sub>1</sub>R).

  • Mach L; Omran A; Bouma J; Radetzki S; Sykes DA; Guba W; Li X; Höffelmeyer C; Hentsch A; Gazzi T; Mostinski Y; Wasinska-Kalwa M; de Molnier F; Nazare M

Journal of medicinal chemistry 2024

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Single electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins

  • Mingxuan Wu; Feng Feng; Yingxiao Gao; Qun Zhao; Ting Luo; Qingyun Yang; Nan Zhao; Yihang Xiao; Yusong Han; Jinheng Pan; Shan Feng; Lihua Zhang
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An extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis

  • Samuel Naudi-Fabra; Carlos A. Elena-Real; Ida Marie Vedel; Maud Tengo; Kathrin Motzny; Pin-Lian Jiang; Peter Schmieder; Fan Liu; Sigrid Milles

Nature Communications 2024

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LRRC8/VRAC volume-regulated anion channels are crucial for hearing

  • Deborah A. Knecht; Mariia Zeziulia; Mit B. Bhavsar; Dmytro Puchkov; Hannes Maier; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler
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Melanocortin system activates carotid body arterial chemoreceptors in hypertension

  • Audrys G. Pauza; Pratik Thakkar; Xin Shen; Igor Felippe; Kilian Roßmann; Manami Oya; Kazuhiro Nakamura; Johannes Broichhagen; David J. Hodson; Dainius H. Pauza; David Murphy; Julian F.R. Paton
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Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

  • Saif Mohd; Andreas Oder; Edgar Specker; Martin Neuenschwander; Jens Peter Von Kries; Oliver Daumke

PLOS ONE 2024

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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler
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Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease

  • Maya M. Polovitskaya; Tanushka Rana; Kurt Ullrich; Simona Murko; Tatjana Bierhals; Guido Vogt; Tobias Stauber; Christian Kubisch; René Santer; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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List of Publications