Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment

  • Maria Mendes; Sandra Nunes; Tânia Cova; Francisco Branco; Michael Dyrks; Beate Koksch; Nuno Vale; João Sousa; Alberto Pais; Carla Vitorino

Colloids and Surfaces B: Biointerfaces 2024

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ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons

  • Alessandro Esposito; Sara Pepe; Maria Sabina Cerullo; Katia Cortese; Hanako Tsushima Semini; Silvia Giovedì; Renzo Guerrini; Fabio Benfenati; Antonio Falace; Anna Fassio

Acta Physiologica 2024

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Single electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins

  • Mingxuan Wu; Feng Feng; Yingxiao Gao; Qun Zhao; Ting Luo; Qingyun Yang; Nan Zhao; Yihang Xiao; Yusong Han; Jinheng Pan; Shan Feng; Lihua Zhang
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An extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis

  • Samuel Naudi-Fabra; Carlos A. Elena-Real; Ida Marie Vedel; Maud Tengo; Kathrin Motzny; Pin-Lian Jiang; Peter Schmieder; Fan Liu; Sigrid Milles

Nature Communications 2024

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A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

  • York Posor; Volker Haucke
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LRRC8/VRAC volume-regulated anion channels are crucial for hearing

  • Deborah A. Knecht; Mariia Zeziulia; Mit B. Bhavsar; Dmytro Puchkov; Hannes Maier; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease

  • Maya M. Polovitskaya; Tanushka Rana; Kurt Ullrich; Simona Murko; Tatjana Bierhals; Guido Vogt; Tobias Stauber; Christian Kubisch; René Santer; Thomas J. Jentsch

Journal of Biological Chemistry 2024

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Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

  • Florian Stockinger; Pascal Poc; Alexander Möhwald; Sandra Karch; Stephanie Häfner; Christian Alzheimer; Guillaume Sandoz; Tobias Huth; Johannes Broichhagen

Journal of Medicinal Chemistry 2024

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Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy

  • Evgeny Nimerovsky; Spyridon Kosteletos; Sascha Lange; Stefan Becker; Adam Lange; Loren B. Andreas

The Journal of Physical Chemistry Letters 2024

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Phosphoinositide detection at synapses of fixed murine hippocampal neurons

  • Svenja Bolz; Natalie Kaempf; Maria Muehlbauer; Delia Löwe; Volker Haucke

STAR Protocols 2024

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Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

  • Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez-Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie International Edition 2024

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Patent review of cannabinoid receptor type 2 (CB <sub>2</sub> R) modulators (2016-present)

  • Miroslav Kosar; Leonard Mach; Erick M. Carreira; Marc Nazaré; Pal Pacher; Uwe Grether

Expert Opinion on Therapeutic Patents 2024

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Benzo‐Crown‐Ether functionalized O‐BODIPY Probes for Cations– A Selective Fluorescent Probe for Ba2+

  • Thomas Schwarze; Tobias Sprenger; Marc Nazare; Hans-Jürgen Holdt; Axel Hentsch

Chemistry – A European Journal 2024

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Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

  • Ekaterina Legchenko; Philippe Chouvarine; Fatimunnisa Qadri; Edgar Specker; Marc Nazaré; Radoslaw Wesolowski; Susann Matthes; Michael Bader; Georg Hansmannn

JACC: Basic to Translational Science 2024

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DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue

  • Thais Gazzi; Marina Lesina; Qinghua Wang; Alexandra Berninger; Silke Radetzki; Ihsan Ekin Demir; Larissa Kohlmann; Waldemar Meiser; Sebastian Wilke; Jens Peter von Kries; Hana Algül; Hai-Yu Hu; Marc Nazare

Angewandte Chemie 2024

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Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials.

  • Torsten Bullmann; Kaas T; Ritzau-Jost A; Wöhner A; Toni Kirmann; Filiz Sila Rizalar; Holzer M; Nerlich J; Puchkov D; Christian Geis; Eilers J; Kittel RJ; Arendt T; Haucke V; Stefan Hallermann

The Journal of neuroscience : the official journal of the Society for Neuroscience 2024

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TPT‐004, a Next‐Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats

  • Radoslaw Wesolowski; Dirk Pleimes; Edgar Specker; Michael Bader

Journal of the American Heart Association 2024

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An exploratory research report on brain mineralization in postoperative delirium and cognitive decline

  • Florian Lammers‐Lietz; Friedrich Borchers; Insa Feinkohl; Stefan Hetzer; Cicek Kanar; Frank Konietschke; Gunnar Lachmann; Claudia Chien; Claudia Spies; Georg Winterer; Laszlo Zaborszky; Norman Zacharias; Friedemann Paul

European Journal of Neuroscience 2024

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An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N-Acetylglucosamine Kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler

Journal of the American Chemical Society 2024

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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

  • Berke Türkaydin; Marcus Schewe; Elena Barbara Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun

Nature Communications 2024

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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

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Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies

  • Ying Zhu; Kerem Can Akkaya; Julia Ruta; Nanako Yokoyama; Cong Wang; Max Ruwolt; Diogo Borges Lima; Martin Lehmann; Fan Liu

Nature Communications 2024

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Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase

  • Samira Klössel; Ying Zhu; Lucia Amado; Daniel D Bisinski; Julia Ruta; Fan Liu; Ayelén González Montoro

The EMBO Journal 2024

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Molecular architecture of synaptic vesicles

  • Uljana Kravcenko; Max Ruwolt; Jana Kroll; Artsemi Yushkevich; Martina Zenkner; Julia Ruta; Rowaa Lotfy; Erich E. Wanker; Christian Rosenmund; Fan Liu; Mikhail Kudryashev
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Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

  • Francisco José López-Murcia; Kun-Han Lin; Manon M. M. Berns; Mrinalini Ranjan; Noa Lipstein; Erwin Neher; Nils Brose; Kerstin Reim; Holger Taschenberger

Proceedings of the National Academy of Sciences 2024

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A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

  • Luise Franz; Tihomir Rubil; Anita Balázs; Marie Overtus; Kristin Kemnitz-Hassanin; Cedric Govaerts; Marcus A. Mall; Christian P.R. Hackenberger
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

eLife 2024

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

eLife 2024

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KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation

  • Dmitry Tsvetkov; Johanna Schleifenbaum; Yibin Wang; Mario Kassmann; Maya M. Polovitskaya; Mohamed Ali; Sebastian Schütze; Michael Rothe; Friedrich C. Luft; Thomas J. Jentsch; Maik Gollasch

Hypertension 2024

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Adhesion energy controls lipid binding-mediated endocytosis

  • Raluca Groza; Kita Valerie Schmidt; Paul Markus Müller; Paolo Ronchi; Claire Schlack-Leigers; Ursula Neu; Dmytro Puchkov; Rumiana Dimova; Claudia Matthaeus; Justin Taraska; Thomas Weikl; Helge Ewers

Nature Communications 2024

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Structural basis ofFusobacterium nucleatumadhesin Fap2 interaction with receptors on cancer and immune cells

  • Felix Schöpf; Gian L. Marongiu; Klaudia Milaj; Thiemo Sprink; Judith Kikhney; Annette Moter; Daniel Roderer
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Canonical and non-canonical integrin-based adhesions dynamically interconvert

  • Fabian Lukas; Claudia Matthaeus; Tania López-Hernández; Ines Lahmann; Nicole Schultz; Martin Lehmann; Dmytro Puchkov; Jan Pielage; Volker Haucke; Tanja Maritzen

Nature Communications 2024

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Absolute Configuration of 12S-Deoxynortryptoquivaline from Ascidian-Derived Fungus Aspergillus clavatus Determined by Anisotropic NMR and Chiroptical Spectroscopy

  • Elisa Doro-Goldsmith; Qi Song; Xiao-Lu Li; Xiao-Ming Li; Xue-Yi Hu; Hong-Lei Li; Hao-Ran Liu; Bin-Gui Wang; Han Sun

Journal of Natural Products 2024

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An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells

  • Carolina Vinagreiro; Qian Liu; Qinghua Wang; Xiang Wang; Hai-Yu Hu; Marc Nazare
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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper

Molecular Cancer Therapeutics 2024

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ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

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Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Volker Haucke; Helge Ewers; Michael Krauss
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An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler
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Sedimentation of large, soluble proteins up to 140 kDa for 1H-detected MAS NMR and 13C DNP NMR – practical aspects

  • Bell D; Lindemann F; Gerland L; Aucharova H; Klein A; Friedrich D; Hiller M; Grohe K; Rossum Bv; Diehl A; Hughes J; Mueller LJ; Linser R; Miller A; Oschkinat H
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism

  • Barbara Helm; Pauline Hansen; Li Lai; Luisa Schwarzmüller; Simone M. Clas; Annika Richter; Max Ruwolt; Fan Liu; Dario Frey; Lorenza A. D’Alessandro; Wolf-Dieter Lehmann; Marcel Schilling; Dominic Helm; Dorothea Fiedler; Ursula Klingmüller
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Synthesis of Peptides Containing a Combination of Free and 2‐trans‐Cyclooctene Carbamate Protected Lysine Residues

  • W. Doelman; N. A. M. Ligthart; M. A. T. van de Plassche; M. A. R. de Geus; L. Reinalda; M. M. E. Isendoorn; D. V. Filippov; S. I. van Kasteren

ChemBioChem 2024

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Moments of Gaussian Distributions for Small and Large Sample Sizes Revisited

  • Florian Heiser; E W Knapp

Mathematics and Statistics 2024

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Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Peter Njenga Ng’ang’a; Julian Folz; Svetlana Kucher; Daniel Roderer; Ying Xu; Oleg Sitsel; Alexander Belyy; Daniel Prumbaum; Ralf Kühnemuth; Tufa E. Assafa; Min Dong; Claus A. M. Seidel; Enrica Bordignon; Stefan Raunser
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Myo10 tail is crucial for promoting long filopodia

  • Xingxiang Chen; Jeffrey M. Arciola; Young il Lee; Pak Hung Philip Wong; Haoran Yin; Quanqing Tao; Yuqi Jin; Xianan Qin; H Lee Sweeney; Hyokeun Park

Journal of Biological Chemistry 2024

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Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses

  • Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
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Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin

  • fulin; Jimin Du; David Furkert; Megan L Shipton; Xiaoqi Liu; Tim Aguirre; Alfred C Chin; Andrew M Riley; Barry V L Potter; Dorothea Fiedler; Xu Zhang; Yi Zhu; Chenglai Fu

Cardiovascular Research 2024

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List of Publications