Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

  • Ann‐Kathrin Rückert; Julia Ast; Annie Hasib; Daniela Nasteska; Katrina Viloria; Johannes Broichhagen; David J. Hodson

Diabetic Medicine 2023

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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

  • Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

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Structure–function relationships in protein homorepeats

  • Carlos A. Elena-Real; Pablo Mier; Nathalie Sibille; Miguel A. Andrade-Navarro; Pau Bernadó

Current Opinion in Structural Biology 2023

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Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

  • Stephan J Sigrist; Volker Haucke

EMBO reports 2023

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Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

  • Nathaniel Smith; Han Sun

Journal of General Physiology 2023

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In Situ Spectroscopic Detection of Large‐Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening**

  • Ronja Rabea Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch

Angewandte Chemie International Edition 2023

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In situ‐spektroskopische Detektion der weitreichenden Reorientierung von Transmembranhelices während der Öffnung des Influenza A M2‐Kanals**

  • Ronja Rabea Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch

Angewandte Chemie 2023

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Deciphering histone H4 lysine acetylation and methylation via sortase-mediated semisynthesis

  • Yihang Xiao; Kun Zou; Jinyu Yang; Mingxuan Wu

Cell Reports Physical Science 2023

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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors

  • Edgar Specker; Radoslaw Wesolowski; Anja Schütz; Susann Matthes; Keven Mallow; Malgorzata Wasinska-Kalwa; Lars Winkler; Andreas Oder; Natalia Alenina; Dirk Pleimes; Jens Peter von Kries; Udo Heinemann; Michael Bader; Marc Nazaré

Journal of Medicinal Chemistry 2023

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Deuteration provides a general strategy to enhance azobenzene-based photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez-Hernandez; Rahul Bhuyan; Karl Börjesson; Joshua Levitz; Johannes Broichhagen
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses

  • Christoph Ratswohl; Clara Vázquez García; Ata ul Wakeel Ahmad; Hannes Gonschior; Mikhail Lebedin; Casper Ewijn Silvis; Lisa Spatt; Cathrin Gerhard; Martin Lehmann; Leif E. Sander; Florian Kurth; Simon Olsson; Kathrin de la Rosa

European Journal of Immunology 2023

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From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2Pchannels

  • Berke Türkaydin; Marcus Schewe; Elena Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun
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Design and evaluation of phosphonamidate-linked exatecan constructs for highly loaded, stable, and efficacious Antibody-Drug-Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P. R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-Andre Kasper

Molecular Cancer Therapeutics 2023

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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Diversity of rhodopsin cyclases in zoospore-forming fungi

  • Matthias Broser; Wayne Busse; Anika Spreen; Maila Reh; Yinth Andrea Bernal Sierra; Songhwan Hwang; Tillmann Utesch; Han Sun; Peter Hegemann

Proceedings of the National Academy of Sciences 2023

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CB₂R ligands to treat inflammatory diabetes

  • Uwe Grether; Marc Nazaré

Open Access Government 2023

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Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins

  • Jan Vincent V. Arafiles; Jonathan Franke; Luise Franz; Jacobo Gómez-González; Kristin Kemnitz-Hassanin; Christian P. R. Hackenberger

Journal of the American Chemical Society 2023

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Bioinformatics-Guided Discovery of Biaryl-Linked Lasso Peptides

  • Hamada Saad; Thomas Majer; Keshab Bhattarai; Sarah Lampe; Dinh T. Nguyen; Markus Kramer; Jan Straetener; Heike Broetz-Oesterhelt; Douglas A. Mitchell; Harald Gross

Chemical Science 2023

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Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

  • Murat Kücükdisli; Hassen Bel-Abed; Davide Cirillo; Wen-Ting Lo; Nina-Louisa Efrém; André Horatscheck; Liudmila Perepelittchenko; Polina Prokofeva; Theresa A. L. Ehret; Silke Radetzki; Martin Neuenschwander; Edgar Specker; Guillaume Médard; Susanne Müller; Stephanie Wilhelm; Bernhard Kuster; Jens Peter von Kries; Volker Haucke; Marc Nazare

Journal of Medicinal Chemistry 2023

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Nuclear magnetic resonance/single molecule fluorescence combinations to study dynamic protein systems

  • Ida Marie Vedel; Andromachi Papagiannoula; Samuel Naudi-Fabra; Sigrid Milles

Current Opinion in Structural Biology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Community-developed checklists for publishing images and image analyses

  • Christopher Schmied; Michael S Nelson; Sergiy; Gert-Jan Bakker; Cristina Bertocchi; Johanna Bischof; Ulrike Boehm; Jan Brocher; Carvalho, M. T.; Catalin Chiritescu; Jana Christopher; Beth Cimini; Eduardo Conde-Sousa; Michael Ebner; Rupert C. Ecker; Kevin Eliceiri; Julia Fernandez-Rodriguez; Nathalie Gaudreault; Laurent Gelman; David Grunwald; Tingting Gu; Nadia Halidi; Mathias Hammer; Matthew Hartley; Marie Held; Florian Jug; Varun Kapoor; Ayse Aslihan Aydemir-Koksoy; Judith Lacoste; Sylvia Emmanuelle Le Dévédec; Sylvie Le Guyader; Penghuan Liu; Gabriel G Martins; Aastha Mathur; Kota Miura; Paula Montero Llopis; Roland Nitschke; Alison North; Adam C Parslow; Alexander L. Payne-Dwyer; Laure Plantard; Rizwan Ali; Britta Schroth-Diez; Lucas Schütz; Ryan Scott; Arne Seitz; Olaf Selchow; Ved P Sharma; Martin Spitaler; Sathya Srinivasan; Caterina Strambio-De-Castillia

Nature Methods 2023

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Isoform-selective targeting of PI3K: time to consider new opportunities?

  • Davide Cirillo; Marta Diceglie; Marc Nazaré

Trends in Pharmacological Sciences 2023

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Spatially resolved protein map of intact human cytomegalovirus virions

  • Boris Bogdanow; Iris Gruska; Lars Mühlberg; Jonas Protze; Svea Hohensee; Barbara Vetter; Jens B. Bosse; Martin Lehmann; Mohsen Sadeghi; Lüder Wiebusch; Fan Liu

Nature Microbiology 2023

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Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive–compulsive behaviors in mice

  • Dennis Vollweiter; Jasmeet Kaur Shergill; Alexandra Hilse; Gaga Kochlamazashvili; Stefan Paul Koch; Susanne Mueller; Philipp Boehm-Sturm; Volker Haucke; Tanja Maritzen

Proceedings of the National Academy of Sciences 2023

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OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann
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Cryo-EM structures of actin binding proteins as tool for drug discovery

  • Christian Dahlstroem; Themistoklis Paraschiakos; Han Sun; Sabine Windhorst

Biochemical Pharmacology 2023

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Addressing persistent challenges in digital image analysis of cancerous tissues

  • Sandhya Prabhakaran; Clarence Yapp; Gregory J. Baker; Johanna Beyer; Young Hwan Chang; Allison Creason; Robert Krueger; Jeremy Muhlich; Nathan Patterson; Kevin Sidak; Damir Sudar; Adam J Taylor; Luke Ternes; Jakob Troidl; Yubin Xie; Artem Sokolov; Darren Tyson; the Cell Imaging Hackathon 2022 Participants (Alphabetical authorship, apart from primary contributors)
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CB2R agonists in the clinics: A treasure chest for treating inflammatory diseases

  • Uwe Grether; Marc Nazaré

Open Access Government 2023

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The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

  • Claudia Bohg; Carl Öster; Berke Türkaydin; Michael Lisurek; Pascal Sanchez-Carranza; Sascha Lange; Tillmann Utesch; Han Sun; Adam Lange

Science Advances 2023

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Direct optical measurement of intra-molecular distances down to the Ångström scale

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Taukeer A. Khan; Michael Weber; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Neuronal endoplasmic reticulum architecture and roles in axonal physiology

  • Klaas Yperman; Marijn Kuijpers

Molecular and Cellular Neuroscience 2023

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Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand

  • Ida M. Vedel; Andreas Prestel; Zhenwei Zhang; Natalia T. Skawinska; Holger Stark; Pernille Harris; Birthe B. Kragelund; Günther H.J. Peters

Structure 2023

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A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

  • Nina A.M. Ligthart; Mark A.R. de Geus; Merel A.T. van de Plassche; Diana Torres García; Marjolein M.E. Isendoorn; Luuk Reinalda; Daniëlle Ofman; Tyrza van Leeuwen; Sander I. van Kasteren

Journal of the American Chemical Society 2023

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(3+2)‐Cyclization Reactions of Unsaturated Phosphonites with Aldehydes and Thioketones

  • Don S. Munasinghe; Marc‐André Kasper; Radomir Jasiński; Karolina Kula; Marcin Palusiak; Małgorzata Celeda; Grzegorz Mlostoń; Christian P. R. Hackenberger

Chemistry – A European Journal 2023

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Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

  • Tim Aguirre; Ellen Teichmann; Florian Q. Römpp; Ruthey Vivier; Cole Bryant; Matthew A. Hulverson; Wesley C. Van Voorhis; Kayode K. Ojo; J. Stone Doggett; Dorothea Fiedler; Stefan Hecht

ACS Chemical Biology 2023

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In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening

  • Ronja Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch
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ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution

  • Jing Ze Wu; Mariia Zeziulia; Whijin Kwon; Thomas J. Jentsch; Sergio Grinstein; Spencer A. Freeman

Journal of Cell Biology 2023

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Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

  • Joka Pipercevic; Bastian Kohl; Ruta Gerasimaite; Véronique Comte-Miserez; Sarah Hostachy; Thomas Müntener; Elia Agustoni; Henning Jacob Jessen; Dorothea Fiedler; Andreas Mayer; Sebastian Hiller

Nature Communications 2023

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Cesium activates the neurotransmitter receptor for glycine

  • Steffen Fricke; Magnus Harnau; Florian Hetsch; Haoran Liu; Julia Leonhard; Anna Eylmann; Pina Knauff; Han Sun; Marcus Semtner; Jochen C. Meier

Frontiers in Molecular Neuroscience 2023

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The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

  • Laure Papin; Martin Lehmann; Justine Lagisquet; Ghizlane Maarifi; Véronique Robert-Hebmann; Christophe Mariller; Yann Guerardel; Lucile Espert; Volker Haucke; Fabien P. Blanchet

International Journal of Molecular Sciences 2023

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Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

  • Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann

JCI Insight 2023

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Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling

  • Ji Qi; Weiwei Cheng; Zhe Gao; Yuanyuan Chen; Megan L. Shipton; David Furkert; Alfred C. Chin; Andrew M. Riley; Dorothea Fiedler; Barry V.L. Potter; Chenglai Fu

Biomedicine & Pharmacotherapy 2023

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NMR for Stereochemical Elucidation

  • Xiaolu Li; Xiaoliang Yang; Han Sun

Chiral Separations and Stereochemical Elucidation 2023

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Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1.

  • Elena-Real CA; Urbanek A; Lund XL; Morató A; Sagar A; Fournet A; Estaña A; Bellande T; Allemand F; Cortés J; Sibille N; Melki R; Bernadó P

Structure (London, England : 1993) 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
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List of Publications