Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


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Latest Publications

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HaloTag Ligand and HaloTag Protein engineering for a binary fluorescent turn-on probe

  • Blaise Gatin-Fraudet; Ulrich Pabst; Christina H. Olesen; Bianca C. Baciu; Ramona Birke; Sigrid Milles; Johannes Broichhagen
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Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza

  • Dorothea Fiedler; Maren Schädel; Martina Katharina Ried-Lasi; Verena Gaugler; Gabriel Schaaf; Henning Jacob Jessen; Philipp Gaugler; Michael Harings; Kiran Raj; Guizhen Liu; Mengsi Lu; Charlotte Magdalena Mathilda Grothaus; Ulrike Anna Jochimsen; Athanasios Makris; Simon Maria Bartsch; Anna Maria Frentzen

Science Advances 2026

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Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

  • Sarat Vatsavayai; Peter Penzes; Kuchuan Chen; Euan Parnell; William W. Seeley; Rasheen Powell; Dragana Ilic; Yi Zeng; Noa Lipstein; Aaron D Gitler; Leonard Petrucelli; Caiwei Guo; Tetsuya Akiyama; Chang Liu; Odilia Sianto; Edith Yang; Shannon S Zhen; Mortiz Boll; Georgiana Miller; Juliane Bombosch; Eric Green; Ryan David Morrie; Shila Mekhoubad

Science Translational Medicine 2026

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Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

  • Taoran Xiao; Alexandra Kovinko; Chaowei Shi; Henry Sawczyc; Denis Qoraj; Carl Öster; Thiemo Sprink; Sascha Lange; Spyridon Kosteletos; Han Sun; Daniel Roderer; Shanshuang Chen; Adam Lange
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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Jaime A. Isern; Max Ruwolt; Sarah Lampe; Abhirup Majumdar; Fan Liu; David Furkert; Dorothea Fiedler

Nature Communications 2026

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Dynamics of (Hetero)aryl Motifs: An Integrative Approach To Study the Conformational Landscape in Macrocycles

  • Anton F. Ketzel; Matthew Diamandas; Xiao-Lu Li; Yang Daniel Ou; Xinxiang Lei; Andrei K. Yudin; Han Sun

Journal of the American Chemical Society 2026

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Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

  • Xue Bessie Su; Xinjie Zhang; Valeria Fedeli; An-Li Andrea Ko; Jiarui Nicole Fu; Dorothea Fiedler; Adolfo Saiardi

The EMBO Journal 2026

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Discerning protein pools by selective staining with self‐labeling tags

  • Kati Fischermanns; Johannes Broichhagen

FEBS Letters 2026

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Protein Modifications for Cellular Protein Delivery

  • Jan Vincent V. Arafiles; Jonathan Franke; Palina Dubatouka; Luise Franz; Christian P.R. Hackenberger

Chemical Reviews 2026

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The role of adhesins of Fusobacterium nucleatum in colorectal cancer – a structural perspective

  • Felix Schöpf; Gian Luca Marongiu; Daniel Roderer

Gut Microbes 2026

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Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations

  • Denis Qoraj; Swantje Mohr; Yessenbek K. Aldakul; Thiemo Sprink; Carl Öster; Taoran Xiao; Peter Schmieder; Sascha Lange; Tillmann Utesch; Daniel Roderer; Shanshuang Chen; Han Sun; Adam Lange

Nature Communications 2026

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Characterization of the Direct and Indirect Inhibition of Apoptosis by Full‐Length Recombinant Bcl‐xL Monomers

  • Christina Elsner; Ludovica M. Epasto; Adeline Cieren; Dominik Gendreizig; Svetlana Kucher; Daniel Roderer; Enrica Bordignon

ChemBioChem 2026

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Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations

  • Denis Qoraj; Swantje Mohr; Yessenbek K. Aldakul; Thiemo Sprink; Carl Öster; Taoran Xiao; Peter Schmieder; Sascha Lange; Tillmann Utesch; Daniel Roderer; Shanshuang Chen; Han Sun; Adam Lange

Nature Communications 2026

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Species Context Reverses PPIP5K Control of Fungal Morphogenesis and Actin Organization

  • Elisa Koc; Lisa Juhran; Visnja Emmerich; Abel Alcázar-Román; Simon M. Bartsch; Adolfo Saiardi; Lasse van Wijlick; Johannes Postma; Thomas Lenz; Dorothea Fiedler; Michael Feldbrügge; Kai Stühler; Ingrid Span; Ursula Fleig
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Emergence of new function through evolutionary divergence of an intrinsically disordered region

  • Carlos A. Elena-Real; Antonia M. Körber; Blaise Gatin-Fraudet; Alexandra Kovinko; Kathrin Motzny; Arbesa Saiti; Adam Lange; Johannes Broichhagen; Sigrid Milles
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De-Nterm-ining GLP1R signaling bias

  • Johannes Broichhagen; David J. Hodson

Trends in Pharmacological Sciences 2026

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Structural basis for covalent inhibition of sulfatases by sulfamate warheads

  • Charles W.E. Tomlinson; Stefano Elli; Morgan Batiste-Simms; Zongjia Chen; Chris Taylor; Adam Dowle; Edwin A. Yates; Marc Nazaré; Martin A. Fascione; Lianne I. Willems; Spencer J. Williams; Conor J. Crawford; Alan Cartmell
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Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells

  • Meike M. Amma; Laxmikanth Kollipara; Tobias Dürr-Mayer; Josefin Streeck; Peter Schmieder; Adolfo Saiardi; Henning J. Jessen; Sven Heiles; Dorothea Fiedler

ACS Chemical Biology 2026

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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

  • Sarah Lampe; Tanmay Kumar Mohanty; Rashna Bhandari; Dorothea Fiedler

FEBS Letters 2026

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Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

  • László Albert; Samrat Basak; Henrike Körner; Nazar Oleksiievets; Nikolaos Mougios; Elena R. Cotroneo; Michelle S. Frei; Jörg Enderlein; Johannes Broichhagen; Nadja A. Simeth; Roman Tsukanov; Felipe Opazo

ACS Nano 2026

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Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

  • Dagan C. Marx; Alberto J. Gonzalez-Hernandez; Joon Lee; Dirk Siepe; Willem F. Weber; Kevin Huynh; Pamela N. Gallo; Sheida Sharghi Moshtaghin; Anisul Arefin; Johannes Broichhagen; Marian Kalocsay; David Eliezer; Joshua Levitz

Nature Communications 2026

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Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins

  • Dagan C. Marx; Kevin Huynh; Alberto J. Gonzalez-Hernandez; Alexa Strauss; Carlos Rico; Pamela N. Gallo; Sheida Sharghi Moshtaghin; Anisul Arefin; Johannes Broichhagen; David Eliezer; George Khelashvili; Joshua Levitz

Nature Communications 2026

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Site-resolved spatial and structural interactome of a human cell

  • Zehong Zhang; Nanako Yokoyama; Ying Zhu; Julia Ruta; Jiale Cheng; Vini Natalia; Tolga Soykan; Volker Haucke; Fan Liu
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Phosphoinositides and inositol phosphates—functions and cellular dynamics

  • Feng Rao; Volker Haucke

FEBS Letters 2026

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Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
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Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

  • Christian E. Stieger; Yassmine El Harraoui; Luke Brennan; Michael Lisurek; Jan Vincent V. Arafiles; Charlotte Völkel; Kristin Kemnitz-Hassanin; Han Sun; Stephan Sieber; Christian P.R. Hackenberger
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A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

  • Fabian M.B. Thöne; Maya M. Polovitskaya; Uta E. Höpken; Armin Rehm; Thomas J. Jentsch

Journal of Biological Chemistry 2026

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Conservation and Specificity in Bacillus Biofilm Dynamics: On Structure and Function of B. cereus Camelysins

  • Anne Diehl; Florian Lindemann; Nils Cremer; Yvette Roske; Matthias Hiller; Barth van Rossum; Martina Leidert; Kürşad Turgay; Hartmut Oschkinat

Journal of Molecular Biology 2026

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Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

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Supplementary Figure S1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Methods from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S7 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Data from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S3 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S2 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 5 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Table 1 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Supplementary Figure S6 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie 2026

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Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

  • Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz‐Hassanin; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2026

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Supplementary Table 4 from TUB-010, a Novel Anti-CD30 Antibody–Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy

  • Marcus Gerlach; Saskia Schmitt; Philipp Cyprys; Marc-André Kasper; Isabelle Mai; Magdalena Klanova; Andreas Maiser; Heinrich Leonhardt; Christian P.R. Hackenberger; Günter R. Fingerle-Rowson; Annette M. Vogl; Dominik Schumacher; Jonas Helma
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LRRC8-Mediated Glutamate Release from Astrocytes Is Not Increased During the Initiation of Experimental Temporal Lobe Epilepsy

  • Kamyab Sarmadi; Linda Gaspar; Peter Bedner; Lukas Henning; Christian Henneberger; Ronald Jabs; Thomas J. Jentsch; Christian Steinhäuser; Gerald Seifert

International Journal of Molecular Sciences 2026

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Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

  • Haoran Liu; Klaus Benndorf; Yessenbek K. Aldakul; Han Sun

Advanced Science 2026

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Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides

  • Niklas Piet Doering; Kristina Puls; Marta Diceglie; Anja Meraner; Axel Hentsch; Siriwat Hongnak; Armin Wurzer; Helmut Schmidhammer; Mariana Spetea; Marc Nazare; Gerhard Wolber

Journal of Medicinal Chemistry 2026

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Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

  • Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise‐Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Angewandte Chemie International Edition 2026

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Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Helge Ewers; Volker Haucke; Michael Krauss

Nature Communications 2026

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List of Publications