Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
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Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

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Latest Publications

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KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation

  • Dmitry Tsvetkov; Johanna Schleifenbaum; Yibin Wang; Mario Kassmann; Maya M. Polovitskaya; Mohamed Ali; Sebastian Schütze; Michael Rothe; Friedrich C. Luft; Thomas J. Jentsch; Maik Gollasch

Hypertension 2024

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Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

  • Felix Schöpf; Gian Luca Marongiu; Klaudia Milaj; Thiemo Sprink; Judith Kikhney; Annette Moter; Daniel Roderer
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Absolute Configuration of 12S-Deoxynortryptoquivaline from Ascidian-Derived Fungus Aspergillus clavatus Determined by Anisotropic NMR and Chiroptical Spectroscopy

  • Elisa Doro-Goldsmith; Qi Song; Xiao-Lu Li; Xiao-Ming Li; Xue-Yi Hu; Hong-Lei Li; Hao-Ran Liu; Bin-Gui Wang; Han Sun

Journal of Natural Products 2024

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An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells

  • Carolina Vinagreiro; Qian Liu; Qinghua Wang; Xiang Wang; Hai-Yu Hu; Marc Nazare
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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates

  • Saskia Schmitt; Paul Machui; Isabelle Mai; Sarah Herterich; Swetlana Wunder; Philipp Cyprys; Marcus Gerlach; Philipp Ochtrop; Christian P.R. Hackenberger; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper

Molecular Cancer Therapeutics 2024

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ER remodeling via lipid metabolism

  • Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2

  • Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Volker Haucke; Helge Ewers; Michael Krauss
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An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism

  • Barbara Helm; Pauline Hansen; Li Lai; Luisa Schwarzmüller; Simone M. Clas; Annika Richter; Max Ruwolt; Fan Liu; Dario Frey; Lorenza A. D’Alessandro; Wolf-Dieter Lehmann; Marcel Schilling; Dominic Helm; Dorothea Fiedler; Ursula Klingmüller
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Synthesis of Peptides Containing a Combination of Free and 2‐trans‐Cyclooctene Carbamate Protected Lysine Residues

  • W. Doelman; N. A. M. Ligthart; M. A. T. van de Plassche; M. A. R. de Geus; L. Reinalda; M. M. E. Isendoorn; D. V. Filippov; S. I. van Kasteren

ChemBioChem 2024

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Moments of Gaussian Distributions for Small and Large Sample Sizes Revisited

  • Florian Heiser; E W Knapp

Mathematics and Statistics 2024

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Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

  • Peter Njenga Ng’ang’a; Julian Folz; Svetlana Kucher; Daniel Roderer; Ying Xu; Oleg Sitsel; Alexander Belyy; Daniel Prumbaum; Ralf Kühnemuth; Tufa E. Assafa; Min Dong; Claus A. M. Seidel; Enrica Bordignon; Stefan Raunser
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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

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Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses

  • Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
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Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin

  • fulin; Jimin Du; David Furkert; Megan L Shipton; Xiaoqi Liu; Tim Aguirre; Alfred C Chin; Andrew M Riley; Barry V L Potter; Dorothea Fiedler; Xu Zhang; Yi Zhu; Chenglai Fu

Cardiovascular Research 2024

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Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides

  • Arseniy Galashov; Ekaterina Kazakova; Christian E. Stieger; Christian P. R. Hackenberger; Oliver Seitz

Chemical Science 2024

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Design, Quality and Validation of the EU-OPENSCREEN Fragment Library Poised to a High-Throughput Screening Collection

  • Xavier Jalencas; Hannes Berg; Ludvik Olai Espeland; Sridhar Sreeramulu; Franziska Kinnen; Christian Richter; Charis Georgiou; Vladyslav Yadrykhinsky; Edgar Specker; Kristaps Jaudzems; Tanja Miletić; Robert Harmel; Phil Gribbon; Harald Schwalbe; Ruth Brenk; Aigars Jirgensons; Andrea Zaliani; Jordi Mestres

RSC Medicinal Chemistry 2024

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Revisiting Gauge-Independent Kinetic Energy Densities in Meta-GGAs and Local Hybrid Calculations of Magnetizabilities

  • Caspar J. Schattenberg; Artur Wodyński; Hugo Åström; Dage Matts Börje Sundholm; Martin Prof. Dr. Kaupp; Susi Lehtola

The Journal of Physical Chemistry A 2023

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Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

  • Ann‐Kathrin Rückert; Julia Ast; Annie Hasib; Daniela Nasteska; Katrina Viloria; Johannes Broichhagen; David J. Hodson

Diabetic Medicine 2023

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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

  • Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

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Structure–function relationships in protein homorepeats

  • Carlos A. Elena-Real; Pablo Mier; Nathalie Sibille; Miguel A. Andrade-Navarro; Pau Bernadó

Current Opinion in Structural Biology 2023

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers

  • Joon Lee; Alberto J. Gonzalez-Hernandez; Melanie Kristt; Nohely Abreu; Kilian Roßmann; Anisul Arefin; Dagan C. Marx; Johannes Broichhagen; Joshua Levitz

Science Advances 2023

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Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches

  • Swantje Mohr; Yessenbek K. Aldakul; Han Sun; Henry Sawczyc; Adam Lange

Integrated Structural Biology 2023

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Polyarylisocyanides Derived from an Alkyne-Pd(II) Catalyst as Robust Alignment Media with Excellent Enantiodiscimination

  • Gao-Wei Li; Xiao-Juan Wang; Shuai-Hua Shi; Lan-Tao Liu; Jia-Qian Li; Han Sun; Zong-Quan Wu; Xinxiang Lei

Analytical Chemistry 2023

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Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl−/H+ Exchanger ClC-7

  • Shroddha Bose; Cecilia de Heus; Mary E. Kennedy; Fan Wang; Thomas J. Jentsch; Judith Klumperman; Tobias Stauber

Biomolecules 2023

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Claudin-4 polymerizes after the incorporation of just two extracellular claudin-3 residues

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann
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Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase

  • Jacob L. Gorenflos López; Gillian L. Dornan; Nico Boback; Martin Neuenschwander; Andreas Oder; Kristin Kemnitz‐Hassanin; Peter Schmieder; Edgar Specker; Hatice Ceyda Asikoglu; Christian Oberdanner; Carola Seyffarth; Jens Peter von Kries; Daniel Lauster; Stephan Hinderlich; Christian P.R. Hackenberger

ChemBioChem 2023

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Structural Host-Virus Interactome Profiling of Intact Infected Cells

  • Boris Bogdanow; Lars Mühlberg; Iris Gruska; Barbara Vetter; Julia Ruta; Arne Elofsson; Lüder Wiebusch; Fan Liu
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Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses.

  • Altas B; Tuffy LP; Patrizi A; Dimova K; Soykan T; Brandenburg C; Romanowski AJ; Whitten JR; Robertson CD; Khim SN; Crutcher GW; Mateusz Cyryl Ambrozkiewicz; Yagensky O; Krueger-Burg D; Hammer M; Hsiao HH; Laskowski PR; Dyck L; Puche AC; Sassoè-Pognetto M; John Jia En Chua; Urlaub H; Jahn O; Brose N; Poulopoulos A

Biological psychiatry 2023

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Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

  • Stephan J Sigrist; Volker Haucke

EMBO reports 2023

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Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

  • Nathaniel Smith; Han Sun

Journal of General Physiology 2023

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Nutrient-regulated control of lysosome function by signaling lipid conversion

  • Michael Ebner; Dmytro Puchkov; Orestes López-Ortega; Pathma Muthukottiappan; Yanwei Su; Christopher Schmied; Silke Zillmann; Iryna Nikonenko; Jochen Koddebusch; Gillian L. Dornan; Max T. Lucht; Vonda Koka; Wonyul Jang; Philipp Alexander Koch; Alexander Wallroth; Martin Lehmann; Britta Brügger; Mario Pende; Dominic Winter; Volker Haucke

Cell 2023

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In Situ Spectroscopic Detection of Large‐Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening**

  • Ronja Rabea Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch

Angewandte Chemie International Edition 2023

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In situ‐spektroskopische Detektion der weitreichenden Reorientierung von Transmembranhelices während der Öffnung des Influenza A M2‐Kanals**

  • Ronja Rabea Paschke; Swantje Mohr; Sascha Lange; Adam Lange; Jacek Kozuch

Angewandte Chemie 2023

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Deciphering histone H4 lysine acetylation and methylation via sortase-mediated semisynthesis

  • Yihang Xiao; Kun Zou; Jinyu Yang; Mingxuan Wu

Cell Reports Physical Science 2023

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Deuteration provides a general strategy to enhance azobenzene-based photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez-Hernandez; Rahul Bhuyan; Karl Börjesson; Joshua Levitz; Johannes Broichhagen
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Editorial: Combining computational and experimental approaches to characterize ion channels and transporters

  • Christoph Fahlke; Jan-Philipp Machtens; Walter Sandtner; Klaus Schicker; Han Sun

Frontiers in Physiology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses

  • Christoph Ratswohl; Clara Vázquez García; Ata ul Wakeel Ahmad; Hannes Gonschior; Mikhail Lebedin; Casper Ewijn Silvis; Lisa Spatt; Cathrin Gerhard; Martin Lehmann; Leif E. Sander; Florian Kurth; Simon Olsson; Kathrin de la Rosa

European Journal of Immunology 2023

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From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2Pchannels

  • Berke Türkaydin; Marcus Schewe; Elena Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
read online

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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Nuclear magnetic resonance/single molecule fluorescence combinations to study dynamic protein systems

  • Ida Marie Vedel; Andromachi Papagiannoula; Samuel Naudi-Fabra; Sigrid Milles

Current Opinion in Structural Biology 2023

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Diversity of rhodopsin cyclases in zoospore-forming fungi

  • Matthias Broser; Wayne Busse; Anika Spreen; Maila Reh; Yinth Andrea Bernal Sierra; Songhwan Hwang; Tillmann Utesch; Han Sun; Peter Hegemann

Proceedings of the National Academy of Sciences 2023

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CB₂R ligands to treat inflammatory diabetes

  • Uwe Grether; Marc Nazaré

Open Access Government 2023

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Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins

  • Jan Vincent V. Arafiles; Jonathan Franke; Luise Franz; Jacobo Gómez-González; Kristin Kemnitz-Hassanin; Christian P. R. Hackenberger

Journal of the American Chemical Society 2023

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List of Publications