Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)

OUR RESEARCH: Creating knowledge as the basis of tomorrow's medicine

What keeps us healthy and what makes us sick? How does a drug reach the right target in the body? Conversely, how can viruses and bacteria be prevented from entering cells and tissues? We work on these questions by investigating biochemical processes in cells and organs and by studying the molecular causes of diseases. We also conduct targeted drug research or develop novel diagnostics and therapeutics that form the basis of tomorrow's medicine.
More

Working at FMP

FMP provides an excellent working environment, training and support to equip you with the skills needed for a scientific career and a healthy work-life balance. We foster tolerant and creative collaboration and adhere to the rules of good scientific practice.


Research Groups & Core Facilities

von 21

All Groups A-Z

Latest Publications

of 50

Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie 2024

read online

A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie 2024

read online

Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network

  • Andromachi Papagiannoula; Ida Marie Vedel; Kathrin Motzny; Maud Tengo; Sigrid Milles
read online

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

  • Alice Rossi; Max Ruwolt; Paraskevi Kakouri; Tetiana Kosten; Severine Kunz; Dmytro Puchkov; Jane Reznick; Damir Omerbasic; Daniel Mendez Aranda; Georgia Carai; Guido Mastrobuoni; Daniel W Hart; Michela Carraro; Ludovica Tommasin; Nigel C Bennett; Valerie Begay; Katja Faelber; Oliver Daumke; Paolo Bernardi; Thomas Park; Stefan Kempa; Fan Liu; Gary R Lewin
read online

Extensive protein pyrophosphorylation revealed in human cell lines

  • Jeremy A. M. Morgan; Arpita Singh; Leonie Kurz; Michal Nadler-Holly; Max Ruwolt; Shubhra Ganguli; Sheenam Sharma; Martin Penkert; Eberhard Krause; Fan Liu; Rashna Bhandari; Dorothea Fiedler

Nature Chemical Biology 2024

read online

Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H3K79 modifications

  • Kun Zou; Yihang Xiao; Jinyu Yang; Mingxuan Wu

Chinese Chemical Letters 2024

read online

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

read online

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler
read online

Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes

  • Pawel Guinard; Sarah Hostachy; Léa Diebold; Jacques Pécaut; Alan Le Goff; Carole Duboc; Pascale Delangle

Angewandte Chemie International Edition 2024

read online

A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

  • Lufeng Yan; Manqian Zheng; Mingzhu Fan; Rui Yao; Kun Zou; Shan Feng; Mingxuan Wu

Angewandte Chemie International Edition 2024

read online

Robust and Irreversible Sortase‐Mediated Ligation by Empolyment of Sarkosyl

  • Yihang Xiao; Mingxuan Wu

Chemistry – A European Journal 2024

read online

Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions

  • Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Martin Lehmann; Fan Liu; Weria Pezeshkian
read online

A GAF domain mediates inositol pyrophosphate substrate channeling in PPIP5K phosphatases

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Dorothea Fiedler; Michael Hothorn
read online

Structural basis for immune cell binding ofFusobacterium nucleatumvia the trimeric autotransporter adhesin CbpF

  • Gian Luca Marongiu; Uwe Fink; Andreas Oder; Jens Peter von Kries; Daniel Roderer
read online

A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2knock-down new mouse model

  • Xiao Min Zhang; Urielle François; Maria Florencia Angelo; Stéphane Claverol; Magali Mondin; Christelle Martin; Melissa Deshors; Yann Humeau; Noa Lipstein; Etienne Herzog
read online

A Novel Mouse Model Demonstrates In Vivo Replenishment of Central Nervous System Pericytes After Successful Acute Ablation

  • Dila Atak; Erdost Yildiz; Esra Ozkan; Mohammadreza Yousefi; Ayse Ozkan; Aysu Bilge Gokyuzu; Ali Burak Kizilirmak; Iman Asaad Alnajjar; Cicek Kanar; Zeynep Lal Caan; Sakir Umit Zeybek; Cem Ismail Kucukali; Erdem Tuzun; Yasemin Gursoy-Ozdemir; Atay Vural
read online

OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó; Rozemarijn Van Der Veen; Volker Haucke; Martin Lehmann

BMC Biology 2024

read online

Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras

  • Kate Prichard; Ngoc Chau; Jing Xue; Michael Krauss; Jennette A. Sakoff; Jayne Gilbert; Claudia Bahnik; Maria Muehlbauer; Silke Radetzki; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2024

read online

Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment

  • Maria Mendes; Sandra Nunes; Tânia Cova; Francisco Branco; Michael Dyrks; Beate Koksch; Nuno Vale; João Sousa; Alberto Pais; Carla Vitorino

Colloids and Surfaces B: Biointerfaces 2024

read online

A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

  • York Posor; Volker Haucke

Journal of Cell Biology 2024

read online

An anionic two dimensional covalent organic framework from tetratopic borate centres pillared by lithium ions

  • Darosch Asgari; Julia Grüneberg; Yunkai Luo; Hüseyin Küçükkeçeci; Samrat Ghosh; Veniamin Chevelkov; Sabrina Fischer-Lang; Jérôme Roeser; Adam Lange; Bruce Dunn; Michael Gradzielski; Arne Thomas

Nature Communications 2024

read online

Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

  • Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

read online

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie International Edition 2024

read online

HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity

  • Sabrina Montresor; Maria Lucia Pigazzini; Sudarson Baskaran; Mira Sleiman; Govinda Adhikari; Lukas Basilicata; Luca Secker; Natascha Jacob; Yara Ehlert; Anushree Kelkar; Gurleen Kaur Kalsi; Niraj Kulkarni; Paul Spellerberg; Janine Kirstein

Journal of Neurochemistry 2024

read online

When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping

  • Alexander Stockhammer; Carissa Spalt; Antonia Klemt; Laila S. Benz; Shelly Harel; Vini Natalia; Lukas Wiench; Christian Freund; Benno Kuropka; Francesca Bottanelli

Journal of Cell Science 2024

read online

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

  • Henry Sawczyc; Takashi Tatsuta; Carl Öster; Spyridon Kosteletos; Sascha Lange; Claudia Bohg; Thomas Langer; Adam Lange

Nature Communications 2024

read online

Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied
read online

C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

  • Santhosh Kumar Nagarajan; Joy Weber; Daniel Roderer; Jörg Piontek
read online

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

  • Aebi J; Atz K; Ametamey SM; Benz J; Blaising J; Butini S; Campiani G; Carreira EM; Collin L; De Lago E; Gazzi T; Gertsch J; Gobbi L; Guba W; Grether U

Chimia 2024

read online

ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons

  • Alessandro Esposito; Sara Pepe; Maria Sabina Cerullo; Katia Cortese; Hanako Tsushima Semini; Silvia Giovedì; Renzo Guerrini; Fabio Benfenati; Antonio Falace; Anna Fassio

Acta Physiologica 2024

read online

RawVegetable 2.0: Refining XL-MS Data Acquisition through Enhanced Quality Control

  • Louise Ulrich Kurt; Milan Avila Clasen; Ísis Venturi Biembengut; Max Ruwolt; Fan Liu; Fabio Gozzo; Diogo Borges Lima; Paulo Carvalho

Journal of Proteome Research 2024

read online

Toward the Next Generation of Density Functionals: Escaping the Zero-Sum Game by Using the Exact-Exchange Energy Density

  • Martin Prof. Dr. Kaupp; Artur Wodyński; Alexei V. Arbuznikov; Susanne Fürst; Caspar J. Schattenberg

Accounts of Chemical Research 2024

read online

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

  • Borrega-Roman L; Hoare BL; Kosar M; Sarott RC; Patej KJ; Bouma J; Scott-Dennis M; Koers EJ; Gazzi T; Mach L; Barrondo S; Sallés J; Guba W; Kusznir E; Veprintsev DB
read online

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB<sub>1</sub>R).

  • Mach L; Omran A; Bouma J; Radetzki S; Sykes DA; Guba W; Li X; Höffelmeyer C; Hentsch A; Gazzi T; Mostinski Y; Wasinska-Kalwa M; de Molnier F; Nazare M

Journal of medicinal chemistry 2024

read online

Single electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins

  • Mingxuan Wu; Feng Feng; Yingxiao Gao; Qun Zhao; Ting Luo; Qingyun Yang; Nan Zhao; Yihang Xiao; Yusong Han; Jinheng Pan; Shan Feng; Lihua Zhang
read online

An extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis

  • Samuel Naudi-Fabra; Carlos A. Elena-Real; Ida Marie Vedel; Maud Tengo; Kathrin Motzny; Pin-Lian Jiang; Peter Schmieder; Fan Liu; Sigrid Milles

Nature Communications 2024

read online

LRRC8/VRAC volume-regulated anion channels are crucial for hearing

  • Deborah A. Knecht; Mariia Zeziulia; Mit B. Bhavsar; Dmytro Puchkov; Hannes Maier; Thomas J. Jentsch

Journal of Biological Chemistry 2024

read online

Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler
read online

Melanocortin system activates carotid body arterial chemoreceptors in hypertension

  • Audrys G. Pauza; Pratik Thakkar; Xin Shen; Igor Felippe; Kilian Roßmann; Manami Oya; Kazuhiro Nakamura; Johannes Broichhagen; David J. Hodson; Dainius H. Pauza; David Murphy; Julian F.R. Paton
read online

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

  • Saif Mohd; Andreas Oder; Edgar Specker; Martin Neuenschwander; Jens Peter Von Kries; Oliver Daumke

PLOS ONE 2024

read online

Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler
read online

Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease

  • Maya M. Polovitskaya; Tanushka Rana; Kurt Ullrich; Simona Murko; Tatjana Bierhals; Guido Vogt; Tobias Stauber; Christian Kubisch; René Santer; Thomas J. Jentsch

Journal of Biological Chemistry 2024

read online

Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

  • Florian Stockinger; Pascal Poc; Alexander Möhwald; Sandra Karch; Stephanie Häfner; Christian Alzheimer; Guillaume Sandoz; Tobias Huth; Johannes Broichhagen

Journal of Medicinal Chemistry 2024

read online

Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy

  • Evgeny Nimerovsky; Spyridon Kosteletos; Sascha Lange; Stefan Becker; Adam Lange; Loren B. Andreas

The Journal of Physical Chemistry Letters 2024

read online

Phosphoinositide detection at synapses of fixed murine hippocampal neurons

  • Svenja Bolz; Natalie Kaempf; Maria Muehlbauer; Delia Löwe; Volker Haucke

STAR Protocols 2024

read online

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

  • Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

read online

Patent review of cannabinoid receptor type 2 (CB <sub>2</sub> R) modulators (2016-present)

  • Miroslav Kosar; Leonard Mach; Erick M. Carreira; Marc Nazaré; Pal Pacher; Uwe Grether

Expert Opinion on Therapeutic Patents 2024

read online

Benzo‐Crown‐Ether functionalized O‐BODIPY Probes for Cations– A Selective Fluorescent Probe for Ba2+

  • Thomas Schwarze; Tobias Sprenger; Marc Nazare; Hans-Jürgen Holdt; Axel Hentsch

Chemistry – A European Journal 2024

read online

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

  • Ekaterina Legchenko; Philippe Chouvarine; Fatimunnisa Qadri; Edgar Specker; Marc Nazaré; Radoslaw Wesolowski; Susann Matthes; Michael Bader; Georg Hansmannn

JACC: Basic to Translational Science 2024

read online

DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue

  • Thais Gazzi; Marina Lesina; Qinghua Wang; Alexandra Berninger; Silke Radetzki; Ihsan Ekin Demir; Larissa Kohlmann; Waldemar Meiser; Sebastian Wilke; Jens Peter von Kries; Hana Algül; Hai-Yu Hu; Marc Nazare

Angewandte Chemie 2024

read online

List of Publications