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How the kidney maintains sulfate homeostasis in the body

Sulfates are essential to maintain a healthy life and the kidney plays a central role in transporting sulfate from tubular fluid, thereby retaining it in the…
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Starvation causes cell remodelling

Body cells burn off fat reserves when nutrient supply from food ceases. A team led by Professor Volker Haucke and Dr. Wonyul Jang from the Leibniz-Forschungsinstitut für…
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How do drugs reach their destination in the body in a safe way?

Christian Hackenberger reported on new approaches from chemistry for medicine during ARDalpha's Campus Talks. (in German)
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Bundesagentur für Sprunginnovationen fördert Vorhaben zur Entwicklung antiviraler Mittel

Internationales Antivirus-Projekt MUCBOOST um Dr. Daniel Lauster vom Institut für Chemie und Biochemie erhält rund 1,5 Millionen Euro / eines von sechs ausgezeichneten…
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Inhibitor of lipid kinase PI3KC2α identified as potential new treatment of thrombosis

The lipid kinase PI3KC2α is a potential pharmacological target for the treatment of thrombosis and, possibly, cancer. Researchers from the Leibniz-Forschungsinstitut für…
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How do we design small molecules to target diseases?

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Dense and permeable: molecular organization of tight junctions decoded

They seal epithelial cells and, under certain conditions, allow the passage of ions and water: Tight junctions form a paracellular barrier in tissues and their dysfunction…
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Institute & Campus

Büsten von Marguerite und Marthe Vogt enthüllt

Würdigung von zwei bedeutenden Wissenschaftlerinnen des 20. Jahrhunderts
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Mechanism of bacterial toxins in deadly attacks

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism. Bacterial…
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Remembering your first kiss: How do synapses work?

New technology of Antibody Drug Conjugates (ADCs)

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Fewer side-effects: How we deliver drugs to tumor cells

Treating cancer more selectively and more effectively – this could be achieved with an…
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Chloride ion channel ASOR is required for vesicle shrinkage

Since the discovery of the chloride ion channel ASOR three years ago, researchers have been searching for its biological functions. Now, the team led by Prof. Thomas Jentsch…
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FMP & LMU spin-off Tubulis closes €60 million Series B financing to accelerate its ADC Pipeline

The company Tubulis announced today the closing of a Series B financing round totaling €60 million to advance the development of a novel class of highly stable and efficient…
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How do we study proteins with atomic precision?

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Hyper-CEST NMR technique reveals missing structure of a novel container molecule

Using the Hyper-CEST NMR technique, the team led by Leif Schröder from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Deutsches…
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Exploring the effect of isotopes in Chemical Biology – Johannes Broichhagen receives 1.5 Million Euros of Funding from the European Research Council (ERC)

The prestigious Starting Grant from the European Research Council (ERC) was awarded to Dr. Johannes Broichhagen from the Leibniz-Forschungsinstitut für Molekulare…
Structural model of active PI3KC2α at the plasma membrane

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Class II PI3K lipid kinase: Structure of novel drug target resolved

Phosphatidylinositol 3-kinase, or PI3K for short, is a family of lipid kinases that plays a key role in the human body, performing functions such as cell division,…
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Institute & Campus

Campus Berlin-Buch kürt Regional-Sieger von „Jugend forscht“

Von einer Schul-App für Covid-Schnelltests über Methoden der Makrofotografie bis zum smarten Rollator – beim 57. Regionalwettbewerb wurden in Buch viele spannende Projekte…
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New insights: how potassium and sodium are conducted through ion channels

Tiny ion channels are responsible for transporting potassium and sodium to our cells. In the process, ions must pass through a bottleneck, referred to as the selectivity…
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Solving puzzles of the chloride ion channel ASOR

The chloride ion channel ASOR is found in almost all our cells. But apart from its involvement in cell death, not much is known about its physiological role. Two years ago,…
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Understanding the role of the largest organelle in nerve cells - Marijn Kuijpers receives 1.5 Million Euros of Funding from the European Research Council (ERC)

The prestigious Starting Grant from the European Research Council (ERC) was awarded to Dr. Marijn Kuijpers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie…
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A defective potassium channel disrupts the brain's navigation system.

The potassium channel KCNQ3 is required for our brain to generate accurate spatial maps. In mice, defects in KCNQ3 function have measurable effects on the internal…
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Large Molecules Transported into Living Cells: Researchers Achieve Breakthrough into Cell Interior

It is one of the big pharmacological questions: How do you get large functional biomolecules like proteins or antibodies into a living cell? Linking antibodies or proteins…
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Disorientating dormant tumor cells

Chemotherapy is often unable to ensure adequate destruction of dormant cancer cells that have detached from the primary tumor and are circulating in the bloodstream. Sooner…
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Enhanced speed, contrast, and information: New contrast mechanism improves xenon MRI

Xenon magnetic resonance imaging offers deep insights into the human body and opens up new possibilities in the diagnosis and treatment of diseases. Physicists from the…
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Light shed on the atomic resolution structure of phage DNA tube – a methodological milestone

Given that phages are able to destroy bacteria, they are of particular interest to science. Basic researchers from the Leibniz-Forschungsinstitut für Molekulare…
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Christian Hackenberger receives breakthrough award in life sciences at the Berlin Science Week

Christian Hackenberger is honored at the Falling Walls conference with a “breakthrough of the year”-award in the life sciences. Ten scientific "breakthroughs of the year"…
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Fan Liu receives 1.5 Million Euros of Funding from the European Research Council (ERC)

Prof. Dr. Fan Liu from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) receives a prestigious ERC Starting Grant of the European Research Council (ERC).…
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FMP spin-off Tubulis acquires €10.7 million for the development of novel antibody drug conjugates (ADCs)

The young company Tubulis announced today the closure of a Series A funding round totaling €10.7 million to advance the development of a novel class of highly stable and…
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Understanding the Formation of Nerve Cell Contacts - Volker Haucke receives 2.5 Million Euros of Funding from the European Research Council (ERC)

Professor Volker Haucke from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Freie Universität Berlin receives a prestigious ERC Advanced Grant of…
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Dynamic images show rhomboid protease in action

Rhomboid proteases are clinically relevant membrane proteins that play a key role in various diseases. Using solid-state NMR spectroscopy, researchers from Berlin’s…
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Bringing cancer medication safely to its destination

Treating cancer more selectively and more effectively – this could be achieved with an innovative technology developed by teams of researchers at the…
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Presynapses come in a packet – Berlin Scientists Identify the Components and Architecture of Neuronal Contact Sites

Synapses are the interfaces for information exchange between neurons. Teams of scientists working with Professor Dr. Volker Haucke, Director at the…