Core Facility

Christian Hackenberger

Peptide Chemistry


The core facility aims at providing simple synthetic peptides to FMP research groups.


The core facility was formed in February 2013 as a service unit for peptide synthesis and is part of the department of „Biomolecule Modification and Delivery“. Christian Hackenberger contributes his expertise for the synthesis of advanced post-translationally modified polypeptides as well as unnatural peptide –conjugates and Ines Kretzschmar takes care for the execution of the peptide synthesis procedure.

Our aim is to provide synthetic peptides to all research groups at the FMP. The facility is equipped with two parallel peptide synthesizers and a microwave-assisted synthesizer for challenging peptide sequences, one analytical and one preparative RP-HPLC instruments as well as a MALDI-ToF mass spectrometer.

The full repertoire of standard SPPS methods is employed in this facility to generate linear peptides with or without side chain and / or termini-modifications. More challenging peptides are also made including dye-labeled peptides, head-to-tail or side chain-to-side chain cyclic peptides with and without dye-labeling. Furthermore, peptides containing unnatural amino acids, building blocks or proline-mimetics, D-amino acids, polyethylene glycol chains and phosphorylated amino acids are synthesized. Up to now this facility synthesized 2433 peptides (until 2023), an average of approx. 250 peptides/year.

In addition to its services, this core facility is embedded in several FMP research projects and we process orders from Fiedler lab, Broichhagen lab, Lehmann/Haucke lab and Lange lab. Additionally, we optimize the synthesis of cyclic cell-penetrating peptides (cCPPs), which have been applied to the delivery of functional nanobodies into specific intracellular compartments by the Hackenberger lab.

Sequence Submission for Peptide Synthesis

Please fill in the peptide synthesis order form to submit your sequence and send the form by email to Ines Kretzschmar.

Research Section

Chemical Biology

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