Research groupResearch Unit

Volker Haucke

Molecular Pharmacology and Cell Biology

Portrait Volker Haucke

Research in the laboratory is centered on the visualization and manipulation of the endocytic machinery and of endosomal membrane organization using a combination of biochemical, genetic, chemical, and optical imaging approaches with a particular focus on the nervous system.

How do cells communicate with each other?

Cells communicate with each other by secreting signaling molecules and recognizing those from other cells. For example, nerve cells release neurotransmitters contained in small membrane-bounded vesicles at synaptic cell contacts to elicit responses in neighburing cells. We are studying how nerve cells form and assemble synapses and how synaptic vesicles containing messenger substances are recycled to keep synapses up to speed in fractions of a second. If these processes are disrupted, neurological and neurodegenerative diseases such as Alzheimer’s disease may occur. Not only neurons, but almost all cells in our body release or respond to signaling molecules. Growth factors such as insulin and nutrients promote cell growth and division, while suppressing the degradation of metabolites. In cancer cells, this nutrient signaling pathway is often disturbed. We have deciphered cellular mechanisms that regulate nutrient signaling and thus the balance between cell growth and metabolite degradation. Understanding these mechanisms is essential for a better understanding of diseases such as cancer and diabetes. In addition, we use this knowledge to develop new pharmacological approaches for the treatment of such diseases.

Our Research

In the Haucke laboratory we aim to understand cellular communication in health and disease at the level of membrane-enclosed compartments that dynamically exchange materials between them. Our main focus is on the analysis of the endocytic and endolysosomal systems in genome-engineered cells and in nerve tissue. The laboratory uses a broad range of techniques including biochemical and molecular biology approaches, super-resolution light and electron microscopy, chemical biology and screening technology, electrophysiology as well as genetic and genome engineering in cell-based models and in vivo.
The overarching goal of our research is to understand the basic principles that enable proteins and lipids to control membrane flux within cells and, thereby, regulate cell and tissue function with a focus on the nervous system. We use this know-how to develop novel strategies for pharmacological or genetic interference that can pave the way to cure diseases including epilepsy, neurodegeneration, lysosomal disorders, myopathies, and cancer.

Job Offers

  • We are constantly looking for enthusiastic and motivated students, PhD students and postdocs to join our team. For all enquiries please contact haucke(at)fmp-berlin.de.
  • We are currently seeking a Postdoctoral Fellow in Biochemistry or Structural Biology (f/m/d). For more details, please check here

Green Initiative

The Haucke lab is the first group in Germany to become certified by My Green Lab with the highest sustainable green level.
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Explaining the Recycling Process

Link to Webpage Latest Thinking How Does The Recycling Process Within Eukaryotic Cells Work on a Molecular Level?
(Copyright Latest Thinking)

Research Highlights

Publications

Please browse publications at Pubmed here

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Research Section

Molecular Physiology & Cell Biology

Publications (via ORCID)

of 4

OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

  • Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies.

  • Stephan Steinke; Toni Kirmann; Loi EA; Nerlich J; Weichard I; Kuhn P; Bullmann T; Ritzau-Jost A; Rizalar FS; Prüss H; Haucke V; Christian Geis; Michael Hust; Stefan Hallermann

Brain : a journal of neurology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

  • Laure Papin; Martin Lehmann; Justine Lagisquet; Ghizlane Maarifi; Véronique Robert-Hebmann; Christophe Mariller; Yann Guerardel; Lucile Espert; Volker Haucke; Fabien P. Blanchet

International Journal of Molecular Sciences 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
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Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
read online

Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
read online

Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
read online

Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker
read online

Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive–compulsive behaviors in mice

  • Dennis Vollweiter; Jasmeet Kaur Shergill; Alexandra Hilse; Gaga Kochlamazashvili; Stefan Paul Koch; Susanne Mueller; Philipp Boehm-Sturm; Volker Haucke; Tanja Maritzen

Proceedings of the National Academy of Sciences 2023

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Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

  • Stephan J Sigrist; Volker Haucke

EMBO reports 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
read online

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  • Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke
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of 17

Endosomal phosphatidylinositol 3‐phosphate controls synaptic vesicle cycling and neurotransmission

  • Guan‐Ting Liu; Gaga Kochlamazashvili; Dmytro Puchkov; Rainer Müller; Carsten Schultz; Albert I Mackintosh; Dennis Vollweiter; Volker Haucke; Tolga Soykan

The EMBO Journal 2022

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Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3.

  • mouhannad malek; Wawrzyniak AM; Michael Ebner; Puchkov D; Haucke V

The Journal of biological chemistry 2022

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Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.

  • Birke R; Julia Ast; Roosen DA; Lee J; Kilian Roßmann; Christiane Huhn; Mathes B; Lisurek M; David Bushiri Pwesombo; Han Sun; Benjamin Jones; Martin Lehmann; Levitz J; Volker Haucke; David Hodson; Johannes Broichhagen

Organic & biomolecular chemistry 2022

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Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.

  • Huayi Li; Lorenzo Prever; Hsu MY; Lo WT; Margaria JP; De Santis MC; Cristina Zanini; Forni M; Novelli F; Pece S; Di Fiore PP; Porporato PE; Martini M; Belabed H; Marc Nazare; Haucke V; Gulluni F; Hirsch E

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022

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Selective endocytosis of Ca<sup>2+</sup>-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.

  • Domenico Azarnia Tehran; Kochlamazashvili G; Niccolò Paolo Pampaloni; Silvia Sposini; Jasmeet Kaur Shergill; Martin Lehmann; Natalya Pashkova; Schmidt C; Löwe D; Napieczynska H; Arnd Heuser; Andrew Plested; David Perrais; Robert Piper; Volker Haucke; Tanja Maritzen

Science advances 2022

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Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.

  • Wonyul Jang; Dmytro Puchkov; Paula Samsó; YongTian Liang; Nadler-Holly M; Stephan Sigrist; Ulrich Kintscher; Fan Liu; kamel Mamchaoui; Vincent Mouly; Volker Haucke

Science (New York, N.Y.) 2022

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Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover.

  • Posor Y; Kampyli C; Bilanges B; Ganguli S; Philipp Alexander Koch; Wallroth A; Morelli D; Jenkins M; Alliouachene S; Deltcheva E; Baum B; Haucke V; Vanhaesebroeck B

Developmental cell 2022

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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

  • Lo WT; Belabed H; Kücükdisli M; Metag J; Roske Y; Polina Prokofeva; Yohei Ohashi; Andre Horatscheck; Davide Cirillo; Krauss M; Christopher Schmied; Martin Neuenschwander; von Kries JP; Guillaume Médard; Bernhard Kuster; Perisic O; Roger Williams; Oliver Daumke; Bernard; Sonia SEVERIN; Marc Nazare; Volker Haucke

Nature chemical biology 2022

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Structural basis of phosphatidylinositol 3-kinase C2α function.

  • Wen-Ting Lo; Zhang Y; Oscar Vadas; Roske Y; Gulluni F; Maria Chiara De Santis; Zagar AV; Stephanowitz H; Hirsch E; Fan Liu; Oliver Daumke; Misha Kudryashev; Volker Haucke

Nature structural & molecular biology 2022

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Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

  • Viard J; Yann Loe-Mie; Daudin R; Khelfaoui M; Christine Plançon; Anne Boland; Francisco J Tejedor; Huganir RL; Kim E; MAKOTO KINOSHITA; Guofa Liu; Haucke V; Moncion T; Yu E; Hindie V; Bléhaut H; Clotilde MIRCHER; Yann HERAULT; Deleuze JF; Jean-Christophe RAIN; SIMONNEAU Michel; Aude-Marie LEPAGNOL-BESTEL

Life science alliance 2022

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Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.

  • Luca Gozzelino; Kochlamazashvili G; Sara Baldassari; Mackintosh AI; Licchetta L; Iovino E; Liu YC; Bennett CA; Mark Bennett; Damiano JA; Zsurka G; Marconi C; Giangregorio T; Pamela Magini; Kuijpers M; Maritzen T; Giuseppe Danilo Norata; Baulac S; Canafoglia L; Seri M; Tinuper P; Ingrid Scheffer; Bahlo M; Samuel Berkovic; Hildebrand MS; Wolfram Kunz; Giordano L; Francesca Bisulli; Miriam Martini; Volker Haucke; Emilio Hirsch; Pippucci T

Brain : a journal of neurology 2022

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.

  • Kuijpers M; Kochlamazashvili G; Stumpf A; Puchkov D; Swaminathan A; Lucht MT; Krause E; Maritzen T; Schmitz D; Haucke V

Neuron 2022

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Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.

  • Tania López-Hernández; Koh-ichiro Takenaka; Yasunori Mori; Kongpracha P; Shushi Nagamori; Volker Haucke; Shigeo Takamori

eLife 2022

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The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane

  • Claudia Matthaeus; Kem A. Sochacki; Andrea M. Dickey; Dmytro Puchkov; Volker Haucke; Martin Lehmann; Justin W. Taraska

Nature Communications 2022

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Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

  • Hannes Gonschior; Christopher Schmied; Rozemarijn Eva Van der Veen; Jenny Eichhorst; Nina Himmerkus; Jörg Piontek; Dorothee Günzel; Markus Bleich; Mikio Furuse; Volker Haucke; Martin Lehmann

Nature Communications 2022

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Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

  • Paula Samsó; Philipp A. Koch; York Posor; Wen-Ting Lo; Hassane Belabed; Marc Nazare; Jocelyn Laporte; Volker Haucke

Proceedings of the National Academy of Sciences 2022

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Phosphoinositides as membrane organizers

  • York Posor; Wonyul Jang; Volker Haucke

Nature Reviews Molecular Cell Biology 2022

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Inositol Triphosphate Signaling Triggers Lysosome Biogenesis Via Calcium Release from Endoplasmic Reticulum Stores

  • Mouhannad Malek; Volker Haucke

Contact 2022

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of 18

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

  • Mouhannad Malek; Anna M. Wawrzyniak; Peter Koch; Christian Lüchtenborg; Manuel Hessenberger; Timo Sachsenheimer; Wonyul Jang; Britta Brügger; Volker Haucke

Nature Communications 2021

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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

  • Federico GULLUNI; Lorenzo Prever; Huayi Li; Petra Krafcikova; Ilaria Corrado; Wen-Ting Lo; Jean Piero Margaria; Anlu Chen; Maria Chiara De Santis; Sophie Cnudde; Fogerty J; Alex Yuan; Alberto Massarotti; Sarijalo NT; Oscar Vadas; Roger Williams; Marcus Thelen; david powell; Schueler M; Wiesener MS; Balla T; Hagit Baris Feldman; Tiosano D; McDermott BM Jr; Brian Perkins; Alessandra Ghigo; Miriam Martini; Volker Haucke; Evzen Boura; Merlo GR; David Buchner; Emilio Hirsch

Science (New York, N.Y.) 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

  • Klionsky DJ; Amal Kamal Abdel-Aziz; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Yakubu Princely Abudu; Abraham Acevedo-Arozena; Iannis Adamopoulos; Khosrow Adeli; Timon Adolph; Annagrazia Adornetto; Aflaki E; Agam G; Agarwal A; Aggarwal BB; Agnello M; Patrizia Agostinis; Agrewala JN; Alexander Agrotis; Aguilar PV; Ahmad ST; Ahmed ZM; Ahumada-Castro U; Sonja Aits; Aizawa S; Yunus Akkoc; Akoumianaki T; HAFIZE AYSIN AKPINAR; Ahmed Al-Abd; Al-Akra L; Al-Gharaibeh A; Alaoui-Jamali MA; Simon Alberti; Alcocer-Gómez E; Alessandri C; Ali M; Alim Al-Bari MA; Aliwaini S; Alizadeh J; Almacellas E; Almasan A; Alonso A; Alonso GD; Altan-Bonnet N; Altieri DC; Álvarez ÉMC; Sara Alves; Cristine Alves da Costa

Autophagy 2021

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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs.

  • Sarah Hostachy; Utesch T; Franke K; Gillian Leigh Dornan; David Furkert; Berke Turkaydin; Haucke V; Han Sun; Dorothea Fiedler

Chemical science 2021

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A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval.

  • Haucke V

Developmental cell 2021

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Mechanism of synaptic protein turnover and its regulation by neuronal activity.

  • Soykan T; Haucke V; Marijn Kuijpers

Current opinion in neurobiology 2021

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Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy.

  • MARTA GUERRERO-VALERO; Federica Grandi; SILVIA CIPRIANI; alberizzi valeria; Roberta Di Guardo; Gaetan Chicanne; Sawade L; Francesca Bianchi; Ubaldo Del Carro; Ivanmatteo DE CURTIS; Davide Pareyson; Parman Y; angelo schenone; Volker Haucke; Bernard; Alessandra Bolino

Proceedings of the National Academy of Sciences of the United States of America 2021

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Liquid-like protein assemblies initiate endocytosis

  • Agata Witkowska; Volker Haucke

Nature Cell Biology 2021

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The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology

  • Philipp Alexander Koch; Gillian Leigh Dornan; Manuel Hessenberger; Volker Haucke

The FEBS Journal 2021

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The axonal endolysosomal and autophagic systems

  • Marijn Kuijpers; Domenico Azarnia Tehran; Volker Haucke; Tolga Soykan

Journal of Neurochemistry 2021

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Neuronal autophagy controls the axonal endoplasmic reticulum to regulate neurotransmission in healthy neurons

  • Marijn Kuijpers; Volker Haucke

Autophagy 2021

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Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

  • Tania López-Hernández; Koh-ichiro Takenaka; Yasunori Mori; Pornparn Kongpracha; Shushi Nagamori; Volker Haucke; Shigeo Takamori
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of 12

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

  • Charles Malek; Anna Maria Wawrzyniak; Peter Koch; Manuel Hessenberger; Timo Sachsenheimer; Wonyul Jang; Britta Bruegger; Volker Haucke
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A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation.

  • Filiz Sila Rizalar; Roosen DA; Haucke V

Neuron 2020

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.

  • Marijn Kuijpers; Kochlamazashvili G; Stumpf A; Dmytro Puchkov; Aarti Swaminathan; Lucht MT; Krause E; Maritzen T; Dietmar Schmitz; Haucke V

Neuron 2020

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Endocytosis in the adaptation to cellular stress.

  • López-Hernández T; Haucke V; Maritzen T

Cell stress 2020

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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

  • Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Cancer Discovery 2020

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Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

  • Linda Sawade; Federica Grandi; Marianna Mignanelli; Genaro Patiño-López; Kerstin Klinkert; Francina Langa-Vives; Roberta Di Guardo; Arnaud Echard; Alessandra Bolino; Volker Haucke

Nature Communications 2020

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Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

  • Tania López-Hernández; Dmytro Puchkov; Eberhard Krause; Tanja Maritzen; Volker Haucke

Nature Cell Biology 2020

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Ramping up the autophagy-lysosome system to cope with osmotic stress

  • Tania López-Hernández; Tanja Maritzen; Volker Haucke

Autophagy 2020

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A Golgi-associated lipid kinase controls peripheral nerve myelination

  • York Posor; Volker Haucke

Proceedings of the National Academy of Sciences 2020

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EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.

  • Claudia Matthaeus; Ines Lahmann; Severine Kunz; Jonas W; Melo AA; Martin Lehmann; Larsson E; Lundmark R; Kern M; Blüher M; Olschowski H; Kompa J; Brügger B; Müller DN; Haucke V; Annette Schurmann; Carmen Birchmeier; Daumke O

Proceedings of the National Academy of Sciences of the United States of America 2020

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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.

  • Gowrisankaran S; Sébastien Houy; Del Castillo JGP; Vicky Steubler; Monika Gelker; Jana Kroll; Paulo Pinheiro; Schwitters D; Halbsgut N; Pechstein A; Jan R.T. van Weering; Tanja Maritzen; Volker Haucke; Nuno Raimundo; Jakob Sørensen; Ira Milosevic

Nature communications 2020

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Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation.

  • Pechstein A; Tomilin N; Fredrich K; Vorontsova O; Elena Sopova; Emma Evergren; Haucke V; Brodin L; Oleg Shupliakov

Cell reports 2020

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Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.

  • Ivana Bertović; Kurelić R; Ira Milosevic; Markus Bender; Krauss M; Haucke V; Antonija Jurak Begonja

Journal of thrombosis and haemostasis : JTH 2020

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Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.

  • Jäpel M; Fabian Gerth; Takeshi Sakaba; Bacetic J; Yao L; Koo SJ; Maritzen T; Freund C; Haucke V

Cell reports 2020

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Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

  • Haibin Wang; Dinah Loerke; Caroline Bruns; Rainer Müller; Philipp-Alexander Koch; Dmytro Puchkov; Carsten Schultz; Volker Haucke

Journal of Biological Chemistry 2020

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Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

  • Haibin Wang; Dinah Loerke; Caroline Bruns; Rainer Müller; Philipp-Alexander Koch; Dmytro Puchkov; Carsten Schultz; Volker Haucke

Journal of Biological Chemistry 2020

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Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.

  • Maglione M; Kochlamazashvili G; Tobias Eisenberg; Bence Racz; Michael E; Toppe D; Stumpf A; Alexander Wirth; Andre Zeug; Franziska E. Müller; Laura Moreno Velasquez; Sammons RP; Sebastian J. Hofer; Frank Madeo; Maritzen T; Nikolaus Maier; evgeni Ponimaskin; Dietmar Schmitz; Volker Haucke; Sigrist SJ

Scientific reports 2019

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Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.

  • Megan Stanifer; Markus Mukenhirn; Muenchau S; Pervolaraki K; Kanaya T; Albrecht D; Odendall C; Hielscher T; Volker Haucke; Kagan JC; Sina Bartfeld; Hiroshi Ohno; Steeve Boulant

Nature microbiology 2019

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Phosphoinositides in the control of lysosome function and homeostasis.

  • Michael Ebner; Philipp Alexander Koch; Volker Haucke

Biochemical Society transactions 2019

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

  • Pascolutti R; Algisi V; Conte A; Andrea Raimondi; Pasham M; Upadhyayula S; raphael gaudin; Maritzen T; ELISA BARBIERI; Caldieri G; chiara tordonato; Stefano Confalonieri; Freddi S; Maria Grazia Malabarba; elena maspero; Simona Polo; CARLO TACCHETTI; Haucke V; Kirchhausen T; Di Fiore PP; Sigismund S

Cell reports 2019

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A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.

  • Helbig I; Lopez-Hernandez T; Oded Lipa Shor; Peter D. Galer; Shiva Ganesan; Pendziwiat M; Rademacher A; Ellis CA; Nadja M. Hümpfer; Schwarz N; Seiffert S; Peeden J; Joseph J Shen; Štěrbová K; Hammer TB; Rikke S. Møller; Shinde DN; Tang S; Smith L; Poduri A; Roland Krause; Benninger F; Helbig KL; Haucke V; Weber YG; EuroEPINOMICS-RES Consortium; GRIN Consortium

American journal of human genetics 2019

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The cell adhesion protein CAR is a negative regulator of synaptic transmission.

  • Wrackmeyer U; Kaldrack J; Jüttner R; Pannasch U; Niclas Gimber; Freiberg F; Purfürst B; Dagmar Kainmueller; Dietmar Schmitz; Volker Haucke; Rathjen FG; Michael Gotthardt

Scientific reports 2019

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Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.

  • Fabian Gerth; Jäpel M; Sticht J; Benno Kuropka; Schmitt XJ; Jan H. Driller; Bernhard Loll; Markus Wahl; Kevin Pagel; Haucke V; Freund C

Structure (London, England : 1993) 2019

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Phosphoinositide switches in endocytosis and in the endolysosomal system.

  • Wang H; Wen-Ting Lo; Volker Haucke

Current opinion in cell biology 2019

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Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression.

  • Buntz A; Killian T; Schmid D; Seul H; Brinkmann U; Ravn J; Lindholm M; Knoetgen H; Haucke V; Mundigl O

Nucleic acids research 2019

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Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

  • Alexander Wallroth; Philipp A. Koch; Andrea L. Marat; Eberhard Krause; Volker Haucke

Nature Cell Biology 2019

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Nanoscale coupling of endocytic pit growth and stability

  • Martin Lehmann; Ilya Lukonin; Frank Noé; Jan Schmoranzer; Cecilia Clementi; Dinah Loerke; Volker Haucke

Science Advances 2019

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Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

  • Vukoja A; Ulises Rey; Petzoldt AG; Ott C; Vollweiter D; Quentin C; Dmytro Puchkov; Reynolds E; Martin Lehmann; Hohensee S; Stefanie Rosa; Reinhard Lipowsky; Sigrist SJ; Haucke V

Neuron 2018

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Tamoxifen therapy in a murine model of myotubular myopathy.

  • Nika Maani; Sabha N; Kamran Rezai; Ramani A; Groom L; Eltayeb N; Mavandadnejad F; Pang A; Giulia Russo; Brudno M; Haucke V; Dirksen RT; Dowling JJ

Nature communications 2018

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Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.

  • Katrina Meyer; Marieluise Kirchner; Bora Uyar; Jingyuan Cheng; Russo G; Luis R. Hernandez-Miranda; Szymborska A; Zauber H; Rudolph IM; Thomas Willnow; ALTUNA AKALIN; Haucke V; Holger Gerhardt; Carmen Birchmeier; Ralf Kühn; Michael Krauss; Diecke S; Juan Pascual; Selbach M

Cell 2018

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Mechanical signals regulate TORC2 activity.

  • Ebner M; Haucke V

Nature cell biology 2018

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Identifying Small-Molecule Inhibitors of the Clathrin Terminal Domain.

  • Haucke V; Krauß M

Methods in molecular biology (Clifton, N.J.) 2018

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Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

  • Wang H; Wen-Ting Lo; Vujičić Žagar A; Federico GULLUNI; Martin Lehmann; Leonardo Scapozza; Haucke V; Vadas O

Molecular cell 2018

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PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

  • Kath C; Goni-Oliver P; Müller R; Schultz C; Haucke V; Britta J. Eickholt; Jan Schmoranzer

PloS one 2018

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Presynaptic endocytic factors in autophagy and neurodegeneration.

  • Domenico Azarnia Tehran; Marijn Kuijpers; Haucke V

Current opinion in neurobiology 2018

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Membrane remodeling in clathrin-mediated endocytosis

  • Volker Haucke; Michael M. Kozlov

Journal of Cell Science 2018

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Phosphoinositide conversion in endocytosis and the endolysosomal system.

  • Wallroth A; Haucke V

The Journal of biological chemistry 2017

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Coupling of exocytosis and endocytosis at the presynaptic active zone.

  • Maritzen T; Haucke V

Neuroscience research 2017

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A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

  • Wen-Ting Lo; Vujičić Žagar A; Fabian Gerth; Martin Lehmann; Dmytro Puchkov; Krylova O; Freund C; Leonardo Scapozza; Vadas O; Haucke V

Developmental cell 2017

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Intersectin associates with synapsin and regulates its nanoscale localization and function.

  • Fabian Gerth; Jäpel M; Pechstein A; Kochlamazashvili G; Martin Lehmann; Dmytro Puchkov; Onofri F; Benfenati F; Nikonenko AG; Fredrich K; Oleg Shupliakov; Maritzen T; Freund C; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2017

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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

  • Alexander Matthias Walter; Rainer Mueller; Bassam Tawfik; Keimpe Wierda; Paulo Pinheiro; André Nadler; Anthony William McCarthy; Ziomkiewicz I; Kruse M; Reither G; Jens Rettig; Martin Lehmann; Haucke V; Hille B; Schultz C; Jakob Sørensen

eLife 2017

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Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.

  • Rathjen T; Xin Yan; Natalia Kononenko; Min-Chi Ku; Kun Song; Ferrarese L; Tarallo V; Dmytro Puchkov; Kochlamazashvili G; Sebastian Brachs; Luis Varela; Szigeti-Buck K; Chun-Xia Yi; Sonja C. Schriever; Sudhir Gopal Tattikota; Carlo AS; Moroni M; Jan Siemens; Heuser A; van der Weyden L; Andreas Birkenfeld ; Niendorf T; James Poulet; Horvath TL; Tschöp MH; Matthias Heinig; Mirko Trajkovski; Haucke V; Matthew Poy

Nature neuroscience 2017

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Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission.

  • Johannes Schöneberg; Martin Lehmann; Alexander Ullrich; Posor Y; Wen-Ting Lo; Gregor Lichtner; Jan Schmoranzer; Haucke V; Noé F

Nature communications 2017

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Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

  • Jakob B; Kochlamazashvili G; Jäpel M; Gauhar A; Bock HH; Maritzen T; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2017

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Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.

  • Natalia Kononenko; Claßen GA; Marijn Kuijpers; Dmytro Puchkov; Tanja Maritzen; Aleksandra Tempes; Anna Malik; Skalecka A; Bera S; Jacek Jaworski; Haucke V

Nature communications 2017

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Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.

  • Soykan T; Natalie Kaempf; Takeshi Sakaba; Vollweiter D; Felix Goerdeler; Dmytro Puchkov; Natalia Kononenko; Haucke V

Neuron 2017

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mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

  • Andrea L. Marat; Alexander Wallroth; Wen-Ting Lo; Rainer Müller; Giuseppe Danilo Norata; Marco Falasca; Carsten Schultz; Volker Haucke

Science 2017

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RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

  • M. Katharina Grauel; Marta Maglione; Reddy-Alla S; Claudia Willmes; Marisa M Brockmann; Thorsten Trimbuch; Rosenmund T; Pangalos M; Vardar G; Alexander Stumpf; Alexander Matthias Walter; Benjamin Rost; Britta J. Eickholt; Haucke V; Dietmar Schmitz; Sigrist SJ; Rosenmund C

Proceedings of the National Academy of Sciences of the United States of America 2016

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Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

  • Christiane Wetzel; Pifferi S; Cristina Picci; Gök C; Diana Hoffmann; Bali KK; André Lampe; Lapatsina L; Raluca Fleischer; Ewan Smith; Bégay V; Moroni M; Estebanez L; Kühnemund J; Walcher J; Specker E; Neuenschwander M; von Kries JP; Haucke V; Kuner R; James Poulet; Jan Schmoranzer; Kate Poole; Lewin GR

Nature neuroscience 2016

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Autophagosome Formation by Endophilin Keeps Synapses in Shape.

  • Marijn Kuijpers; Haucke V

Neuron 2016

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Directing lipid transport at membrane contact sites.

  • Krauβ M; Haucke V

Nature cell biology 2016

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Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

  • Andrea Marat; Haucke V

The EMBO journal 2016

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A phosphoinositide conversion mechanism for exit from endosomes.

  • Ketel K; Krauss M; Nicot AS; Puchkov D; Wieffer M; Müller R; Subramanian D; Schultz C; Laporte J; Haucke V
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Modes and mechanisms of synaptic vesicle recycling

  • Tolga Soykan; Tanja Maritzen; Volker Haucke

Current Opinion in Neurobiology 2016

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Gottfried Schatz (1936-2015)-mitochondrial pioneer and ambassador for science.

  • Haucke V; Glick BS
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Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

  • Jung S; Maritzen T; Wichmann C; Jing Z; Neef A; Revelo NH; Al-Moyed H; Meese S; Wojcik SM; Panou I; Bulut H; Schu P; Ficner R; Reisinger E; Rizzoli SO; Neef J; Strenzke N; Haucke V; Moser T
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Hopping Pits Catch Fusing Granules.

  • Haucke V
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Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain.

  • Lehmann M; Gottschalk B; Puchkov D; Schmieder P; Schwagerus S; Hackenberger CP; Haucke V; Schmoranzer J
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Molecular mechanisms of presynaptic membrane retrieval and synaptic vesicle reformation.

  • Natalia Kononenko; Volker Haucke

Neuron 2015

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Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.

  • Gimber N; Tadeus G; Maritzen T; Schmoranzer J; Haucke V
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Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.

  • Koo SJ; Kochlamazashvili G; Rost B; Puchkov D; Gimber N; Lehmann M; Tadeus G; Schmoranzer J; Rosenmund C; Haucke V; Maritzen T
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Crystal structure of the dynamin tetramer.

  • Reubold TF; Faelber K; Plattner N; Posor Y; Ketel K; Curth U; Schlegel J; Anand R; Manstein DJ; Noé F; Haucke V; Daumke O; Eschenburg S
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Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening.

  • Diezmann F; von Kleist L; Haucke V; Seitz O
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Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles.

  • Kaempf N; Kochlamazashvili G; Puchkov D; Maritzen T; Bajjalieh SM; Kononenko NL; Haucke V
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Berlin Editorial.

  • Goody R; Haucke V; Just W
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A grab to move on: ER-endosome contacts in membrane protrusion formation and neurite outgrowth.

  • Krauß M; Haucke V
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Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis.

  • Daniel JA; Chau N; Abdel-Hamid MK; Hu L; von Kleist L; Whiting A; Krishnan S; Maamary P; Joseph SR; Simpson F; Haucke V; McCluskey A; Robinson PJ
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Lipids, GTPases, and their regulators in membrane dynamics: an intracellular menage a trois.

  • Echard A; Haucke V
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Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses.

  • Pechstein A; Gerth F; Milosevic I; Jäpel M; Eichhorn-Grünig M; Vorontsova O; Bacetic J; Maritzen T; Shupliakov O; Freund C; Haucke V
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Cell biology: On the endocytosis rollercoaster.

  • Haucke V
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Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.

  • Seifert W; Kühnisch J; Maritzen T; Lommatzsch S; Hennies HC; Bachmann S; Horn D; Haucke V
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Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway.

  • Caì Y; Postnikova EN; Bernbaum JG; Yú SQ; Mazur S; Deiuliis NM; Radoshitzky SR; Lackemeyer MG; McCluskey A; Robinson PJ; Haucke V; Wahl-Jensen V; Bailey AL; Lauck M; Friedrich TC; O'Connor DH; Goldberg TL; Jahrling PB; Kuhn JH
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Phosphoinositides in endocytosis.

  • Posor Y; Eichhorn-Grünig M; Haucke V
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PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

  • Irene Franco; Federico GULLUNI; Carlo Cosimo Campa; Carlotta Costa; Margaria JP; Elisa Ciraolo; Miriam Martini; Monteyne D; Elisa De Luca; Germena G; Posor Y; Maffucci T; Marengo S; Volker Haucke; Marco Falasca; David Perez-Morga; Boletta A; Merlo GR; Emilio Hirsch

Developmental cell 2014

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BAR domain scaffolds in dynamin-mediated membrane fission.

  • Daumke O; Roux A; Volker Haucke

Cell 2014

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A novel twist in membrane dePHormation.

  • Krauss M; Haucke V
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Imaging of doxorubicin release from theranostic macromolecular prodrugs via fluorescence resonance energy transfer.

  • Krüger HR; Schütz I; Justies A; Licha K; Welker P; Haucke V; Calderón M
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Synthesis of the Pitstop family of clathrin inhibitors.

  • Robertson MJ; Deane FM; Stahlschmidt W; von Kleist L; Haucke V; Robinson PJ; McCluskey A
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Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.

  • Kononenko NL; Puchkov D; Classen GA; Walter AM; Pechstein A; Sawade L; Kaempf N; Trimbuch T; Lorenz D; Rosenmund C; Maritzen T; Haucke V
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A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

  • Podufall J; Tian R; Knoche E; Puchkov D; Walter AM; Rosa S; Quentin C; Vukoja A; Jung N; Lampe A; Wichmann C; Böhme M; Depner H; Zhang YQ; Schmoranzer J; Sigrist SJ; Haucke V
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Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.

  • Wilhelm BG; Mandad S; Truckenbrodt S; Kröhnert K; Schäfer C; Rammner B; Koo SJ; Claßen GA; Krauss M; Haucke V; Urlaub H; Rizzoli SO
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Neurotransmission: spontaneous and evoked release filing for divorce.

  • Walter AM; Haucke V; Sigrist SJ
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Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.

  • Stahlschmidt W; Robertson MJ; Robinson PJ; McCluskey A; Haucke V
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Development of 1,8-naphthalimides as clathrin inhibitors.

  • MacGregor KA; Robertson MJ; Young KA; von Kleist L; Stahlschmidt W; Whiting A; Chau N; Robinson PJ; Haucke V; McCluskey A
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Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles.

  • Yunfeng Hua; Andrew Woehler; Kahms M; Volker Haucke; Neher E; Klingauf J

Neuron 2013

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Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.

  • Natalia Kononenko; Diril MK; Dmytro Puchkov; Michael Kintscher; Koo SJ; Gerit Pfuhl; York Winter; Wienisch M; Klingauf J; Breustedt J; Dietmar Schmitz; Tanja Maritzen; Volker Haucke

Proceedings of the National Academy of Sciences of the United States of America 2013

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Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

  • Posor Y; Eichhorn-Gruenig M; Dmytro Puchkov; Johannes Schöneberg; Alexander Ullrich; André Lampe; Müller R; Zarbakhsh S; Federico GULLUNI; Emilio Hirsch; Michael Krauss; Carsten Schultz; Jan Schmoranzer; Noé F; Volker Haucke

Nature 2013

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PI4K2β/AP-1-based TGN-endosomal sorting regulates Wnt signaling.

  • Wieffer M; Elena Cibrián Uhalte; Posor Y; Cecile Otten; Branz K; Schütz I; Mössinger J; Schu P; Abdelilah-Seyfried S; Krauß M; Volker Haucke

Current biology : CB 2013

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Fast neurotransmitter release regulated by the endocytic scaffold intersectin.

  • Takeshi Sakaba; Natalia Kononenko; Bacetic J; Pechstein A; Jan Schmoranzer; Yao L; Barth H; Oleg Shupliakov; Oliver Kobler; Klaus Aktories; Volker Haucke

Proceedings of the National Academy of Sciences of the United States of America 2013

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Greasing the synaptic vesicle cycle by membrane lipids.

  • Dmytro Puchkov; Volker Haucke

Trends in cell biology 2013

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The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms.

  • Shetty A; Sytnyk V; Leshchyns'ka I; Puchkov D; Haucke V; Schachner M
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The tortoise and the hare revisited.

  • Kononenko NL; Pechstein A; Haucke V
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Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway.

  • Garrison AR; Radoshitzky SR; Kota KP; Pegoraro G; Ruthel G; Kuhn JH; Altamura LA; Kwilas SA; Bavari S; Haucke V; Schmaljohn CS
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A dual role of SNAP-25 as carrier and guardian of synaptic transmission.

  • Kochlamazashvili G; Haucke V
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Synaptic requiem: a duet for Piccolo and Bassoon.

  • Kononenko N; Pechstein A; Haucke V
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Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors.

  • Chowdhury D; Marco S; Brooks IM; Zandueta A; Rao Y; Haucke V; Wesseling JF; Tavalin SJ; Pérez-Otaño I
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Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.

  • Smith CM; Haucke V; McCluskey A; Robinson PJ; Chircop M
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Oligomerization of dynamin superfamily proteins in health and disease.

  • Faelber K; Gao S; Held M; Posor Y; Haucke V; Noé F; Daumke O
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Structural insights into dynamin-mediated membrane fission.

  • Faelber K; Held M; Gao S; Posor Y; Haucke V; Noé F; Daumke O
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Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.

  • Tanja Maritzen; Tobias Zech; Schmidt MR; Krause E; Machesky LM; Volker Haucke

Proceedings of the National Academy of Sciences of the United States of America 2012

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Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

  • Mössinger J; Wieffer M; Krause E; Freund C; Fabian Gerth; Michael Krauss; Volker Haucke

EMBO reports 2012

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Membrane biology: fission behind BARs.

  • Haucke V
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Turning CALM into excitement: AP180 and CALM in endocytosis and disease.

  • Maritzen T; Koo SJ; Haucke V
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Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells.

  • Graf C; Gao Q; Schütz I; Noufele CN; Ruan W; Posselt U; Korotianskiy E; Nordmeyer D; Rancan F; Hadam S; Vogt A; Lademann J; Haucke V; Rühl E
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The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity.

  • Robertson MJ; Hadzic G; Ambrus J; Pomè DY; Hyde E; Whiting A; Mariana A; von Kleist L; Chau N; Haucke V; Robinson PJ; McCluskey A
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Multi-colour direct STORM with red emitting carbocyanines.

  • Lampe A; Haucke V; Sigrist SJ; Heilemann M; Schmoranzer J
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Structure and function of membrane-integral receptors.

  • Saenger W; Haucke V
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At the crossroads of chemistry and cell biology: inhibiting membrane traffic by small molecules.

  • von Kleist L; Haucke V
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Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.

  • Smith KR; Muir J; Rao Y; Browarski M; Gruenig MC; Sheehan DF; Haucke V; Kittler JT
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Regulation of phosphoinositide-metabolizing enzymes by clathrin coat proteins.

  • Wieffer M; Haucke V; Krauss M
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Spontaneous neurotransmission: a SNARE for the rest.

  • Kononenko NL; Haucke V
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The oncogenic TBC domain protein USP6/TRE17 regulates cell migration and cytokinesis.

  • Rueckert C; Haucke V
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The early steps of endocytosis: from cargo selection to membrane deformation.

  • Rao Y; Rückert C; Saenger W; Haucke V
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SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

  • Koo SJ; Markovic S; Dmytro Puchkov; Mahrenholz CC; Beceren-Braun F; Tanja Maritzen; Jens Dernedde; Rudolf Volkmer; Hartmut Oschkinat; Volker Haucke

Proceedings of the National Academy of Sciences of the United States of America 2011

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Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity.

  • Wenke Seifert; Jirko Kühnisch; Tanja Maritzen; Horn D; Volker Haucke; Hennies HC

The Journal of biological chemistry 2011

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Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

  • Lisa von Kleist; Stahlschmidt W; Bulut H; Gromova K; Puchkov D; Mark Robertson; MacGregor KA; Tomilin N; Pechstein A; Chau N; Chircop M; Jennette Sakoff; von Kries JP; Saenger W; Kräusslich HG; Oleg Shupliakov; Phillip J. Robinson; Adam McCluskey; Volker Haucke

Cell 2011

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Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.

  • Volker Haucke; Neher E; Sigrist SJ

Nature reviews. Neuroscience 2011

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Crystal structure of nucleotide-free dynamin.

  • Faelber K; Posor Y; Song Gao; Held M; Roske Y; Schulze D; Volker Haucke; Noé F; Daumke O

Nature 2011

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Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif.

  • Krabben L; Anna Fassio; Bhatia VK; Pechstein A; Onofri F; Fadda M; Messa M; Rao Y; Oleg Shupliakov; Dimitrios Stamou; Benfenati F; Volker Haucke

The Journal of neuroscience : the official journal of the Society for Neuroscience 2011

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Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily.

  • Rao Y; Haucke V
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AP180 and CALM: Dedicated endocytic adaptors for the retrieval of synaptobrevin 2 at synapses.

  • Koo SJ; Puchkov D; Haucke V
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How synapsin I may cluster synaptic vesicles.

  • Shupliakov O; Haucke V; Pechstein A
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Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.

  • Laulagnier K; Schieber NL; Maritzen T; Haucke V; Parton RG; Gruenberg J
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An exciting calcium sensor for smell.

  • Kononenko NL; Haucke V
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Shaping membranes for endocytosis.

  • Krauss M; Haucke V
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CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.

  • Granata A; Koo SJ; Haucke V; Schiavo G; Warner TT
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