Research group

Fan Liu

Structural Interactomics

Portrait

Our group is interested in developing and applying tools to characterize the complexity of protein interactions within the cell. Using state-of-the-art mass spectrometric technologies, in particular cross-linking mass spectrometry (XL-MS), we aim to chart the protein interactomes of complex biological systems.


Better understanding of protein interactions

Nearly every process in the living cell is based on proteins. To precisely execute this plethora of tasks, proteins are highly organized in a variety of assemblies, ranging from stable protein complexes, well-regulated pathways, to extended protein interaction networks. Perturbation of these well-balanced systems is linked to many different physiological and pathological conditions. Our group is interested in developing and applying tools to characterize the complexity of protein interactions within the cell. Using state-of-the-art mass spectrometric technologies, in particular cross-linking mass spectrometry, we aim to gain a better understanding of protein interactomes in complex biological systems. These studies will offer enormous opportunities to elucidate the fundamental organization principles of proteins and discover previously unrecognized protein interactions in health and disease.

 

Research Overview

Proteins are the primary effectors of cells. They are highly organized in a variety of assemblies, forming the basis of well-regulated pathways and networks to precisely execute a plethora of cellular processes. Alternations of proteins expression, and their interaction networks are linked to many physiological and pathological conditions. Our main interest is to develop and apply mass spectrometry-based approaches to understand the spatial organization and dynamic regulation of protein complexes in space and time during cellular processes such as signaling and differentiation.

Publications

Contact

Prof. Dr. Fan Liu

Head, Fan Liu (SI) Group,
Head Mass Spectrometry


Research Section

Structural Biology

Group Members