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Our group is interested in developing and applying tools to characterize the complexity of protein interactions within the cell. Using state-of-the-art mass spectrometric technologies, in particular cross-linking mass spectrometry (XL-MS), we aim to chart the protein interactomes of complex biological systems. https://www.theliulab.com/
Nearly every process in the living cell is based on proteins. To precisely execute this plethora of tasks, proteins are highly organized in a variety of assemblies, ranging from stable protein complexes, well-regulated pathways, to extended protein interaction networks. Perturbation of these well-balanced systems is linked to many different physiological and pathological conditions. Our group is interested in developing and applying tools to characterize the complexity of protein interactions within the cell. Using state-of-the-art mass spectrometric technologies, in particular cross-linking mass spectrometry, we aim to gain a better understanding of protein interactomes in complex biological systems. These studies will offer enormous opportunities to elucidate the fundamental organization principles of proteins and discover previously unrecognized protein interactions in health and disease.
Proteins are the primary effectors of cells. They are highly organized in a variety of assemblies, forming the basis of well-regulated pathways and networks to precisely execute a plethora of cellular processes. Alternations of proteins expression, and their interaction networks are linked to many physiological and pathological conditions. Our main interest is to develop and apply mass spectrometry-based approaches to understand the spatial organization and dynamic regulation of protein complexes in space and time during cellular processes such as signaling and differentiation.
group picture 2019
© Silke Oßwald
group picture 2021
© Silke Oßwald
Retreat 2021
© Heike Stephanowitz
Retreat 2021
© Heike Stephanowitz
group picture 2022
© Diogo Borges
Volleyball match
Retreat 2022
© Diogo Borges
People
Thermo Orbitrap Fusion ETD, coupled to UltiMate 3000 RSLC nano LC system, coupled with Trajan LEAP HDX Platform
Thermo Orbitrap Fusion ETD, coupled to UltiMate 3000 RSLC nano LC system
picture of instrumentation
picture of instrumentation
Agilent 1260 Infinity II UPLC
Thermo Orbitrap Astral Mass Spectrometer, coupled to Vanquish Neo UHPLC System
Vanquish Flex UHPLC System
Bravo Automated Liquid Handling Platform
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
