Molecular Physiology & Cell Biology

A thorough knowledge of the molecular mechanisms that govern cellular life is important to understand the mode of action of drugs and to identify appropriate new targets for pharmaceutical intervention. Genetic modification of mice is an effective tool to elucidate the physiological and pathological roles of individual protein targets.

We conduct basic research on the physiology and cell biology of ion channels and transporters, pre- and postsynaptic membrane proteins, including synaptic vesicles, G-protein-coupled receptors, exoendocytic trafficking, and the permeation properties of epithelia. To study these processes, we employ a broad arsenal of techniques, including biochemistry, molecular and cell biology, biophysics, and imaging (light and electron microscopy), as well as the generation and analysis of transgenic mouse models.

Research Groups & Core Facilities

 Group(s)

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Volker Haucke

Molecular Pharmacology and Cell Biology

Research in the laboratory is centered on the visualization and manipulation of the endocytic machinery and of endosomal membrane…

Department
DepartmentMolecular Physiology & Cell Biology

Thomas J. Jentsch

Physiology and Pathology of Ion Transport

We study ion transport across cellular membranes using techniques of biophysics, cell and molecular biology, and genetically modified mouse…

Department
DepartmentMolecular Physiology & Cell Biology

Noa Lipstein

Synapse Biology

The Synapse Biology group studies the process of information transfer between neurons in the brain. We aim to identify cell biological…

Junior Group
Junior GroupMolecular Physiology & Cell Biology

Andrew Plested

Molecular Neuroscience and Biophysics

Our interest is the glutamate-gated ion channel receptors of excitatory synapses. These receptors underlie essential functions in the brain,…

Junior Group
Junior GroupMolecular Physiology & Cell Biology

Martin Lehmann

Cellular Imaging Facility

We address questions of biological and pharmacological importance using light microscopy techniques (confocal laser scanning microscopy,…

Core Facility
Core FacilityMolecular Physiology & Cell Biology

Ralf Schülein

Cell Engineering

The Cell Engineering Facility uses state of the art CRISPR/Cas techniques to generate gene knock-outs and knock-ins in target cells. Other…

Core Facility
Core FacilityMolecular Physiology & Cell Biology

Natali Wisbrun

Animal Facility

The Animal Facility takes care of all laboratory animals. Our team works with standards based on directives, conventions and guidelines…

Core Facility
Core FacilityMolecular Physiology & Cell Biology

Latest Publications

of 38

14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells

  • Mugabo, Y. et al.

JCI Insight 2022, 7, e156378

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Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis

  • Halland, N. et al.

Journal of Medicinal Chemistry 2022, 65, 1567-1584

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Pharmacological tools to investigate inositol polyphosphate kinases - Enzymes of increasing therapeutic relevance

  • Kröber, T. et al.

Advances in Biological Regulation 2022, 83, 100836

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Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

  • Li, H. Y. et al.

Advanced Science 2022, 9, e2103249

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Phosphoinositides as membrane organizers

  • Posor, Y. et al.

Nature Reviews Molecular Cell Biology 2022, early access,

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Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents

  • Lin, Y. X. et al.

Chemical Science 2022, 13, 5838-5845

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Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components

  • Dahhan, D. A. et al.

Plant Cell 2022

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Proton-gated anion transport governs macropinosome shrinkage

  • Zeziulia, M. et al.

Nature Cell Biology 2022

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Rapid analytical CEST spectroscopy of competitive host-guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

  • Morik, H. et al.

Physical Chemistry Chemical Physics 2022, 24, 12126-12135

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Seeing glutamate at central synapses

  • Hao, Y., & et al.

Journal of Neuroscience Methods 2022, 375, 109531

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Molecular and functional architecture of striatal dopamine release sites

  • Banerjee, A. et al.

Neuron 2022, 110, 248-265

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Serca Modulation Counteracts Glucocorticoid Resistance in T-All

  • Pagliaro, L. et al.

Haematologica 2022, 107, 19-19

Simple, efficient and thorough shotgun proteomic analysis with PatternLab V

  • Santos, M. D. M. et al.

Nature Protocols 2022, Online ahead of print,

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Site-specific N-glycan profiles of alpha(5)beta(1) integrin from rat liver

  • Mirgorodskaya, E. et al.

Biology of the Cell 2022, 114, 160-176

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Slow excitatory synaptic currents generated by AMPA receptors

  • Pampaloni, N. P., & et al.

Journal of Physiology-London 2022, 600, 217-232

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Structural basis of phosphatidylinositol 3-kinase C2 alpha function

  • Lo, W. et al.

Nature Structural & Molecular Biology 2022, 29, 218-228

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Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

  • Birke, R. et al.

Organic & Biomolecular Chemistry 2022, Advance Article,

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A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

  • Jiang, P. L. et al.

Angewandte Chemie International Edition 2022, 61, e202113937

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Optimized TMT-Based Quantitative Cross-Linking Mass Spectrometry Strategy for Large-Scale Interactomic Studies

  • Ruwolt, M. et al.

Analytical Chemistry 2022, 94, 5265-5272

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Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

  • Azarnia Tehran, D. et al.

Science Advances 2022, 8, eabl5032

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Microscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish

  • Jordan, J. E. L. et al.

Magnetic Resonance in Medicine 2022, 87, 1435-1445

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Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

  • Lopez-Hernandez, T. et al.

Elife 2022, 11, e71198

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Major tail proteins of bacteriophages of the order Caudovirales

  • Zinke, M. et al.

Journal of Biological Chemistry 2022, 298, 101472

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Advances in tethered photopharmacology for precise optical control of signaling proteins

  • Broichhagen('), J., & et al.

Current Opinion in Pharmacology 2022, 63, 102196

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An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils

  • Ellson, C. D. et al.

Journal of Molecular Biology 2022, 434, 167533

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An Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber sigma1 Mediates Stability at Low pH and Preserves Trimeric Organization

  • Glorani, G. et al.

Journal of Virology 2022, 96, e0033122

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Atomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein

  • Sarto, C. et al.

Biological Chemistry 2022, 403, 615-624

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Bis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates

  • Kasper, M. et al.

European Journal of Organic Chemistry 2022, 2022, e202101389

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Ca2+-dependent photocrosslinking in the BK channel intracellular inter-subunit interfaces

  • Hernandez, A. J. G. et al.

Biophysical Journal 2022, 121, 502a-502a

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

  • Baltzer, S. et al.

International Journal of Molecular Sciences 2022, 23, 763

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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

  • Gazzi, T. et al.

Chemical Science 2022, 13, 5419-5776

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Disruptors of AKAP-Dependent Protein-Protein Interactions

  • Walker-Gray, R. et al.

Methods in Molecular Biology , Humana, New York, NY, USA , 2022 117-139

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

  • Liu, G. T. et al.

EMBO Journal 2022, 41, e109352

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Gating choreography and mechanism of the human proton-activated chloride channel ASOR

  • Wang, C. Y. et al.

Science Advances 2022, 8, eabm3942

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Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics

  • Jayapaul, J. et al.

Nature Communications 2022, 13, 1708

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Improving HyperCEST performance by favorable xenon exchange conditions in liposomal nanocarriers

  • Jost, J. O., & et al.

NMR in Biomedicine 2022, e4714

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Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

  • Malek, M. et al.

Journal of Biological Chemistry 2022, 298, 101740

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Investigating the Role of Sulfate Groups for the Binding of Gd3+ Ions to Glycosaminoglycans with NMR Relaxometry

  • Werner, P. et al.

ChemMedChem 2022, early access, e202100764

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Latest Publications

of 103

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

  • Cantrelle, F. et al.

Frontiers in Molecular Neuroscience 2021, 14, 661368

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Nonselective cation permeation in an AMPA-type glutamate receptor

  • Biedermann, J. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2012843118

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Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis

  • Stinn, A. et al.

Biosensors-Basel 2021, 11, 60

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Pentafluorosulfanyl (SF5) as a Superior (19)F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

  • Prinz, C. et al.

ACS Sensors 2021, 6, 3948-3956

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Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

  • Götz, T. W. B. et al.

Journal of Cell Biology 2021, 220, e202006040

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Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

  • Lämmle, C. A. et al.

ChemBioChem 2021, 22, 548-556

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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

  • Gulluni, F. et al.

Science 2021, 374, eabk0410

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Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner

  • Yusenko, M. V. et al.

Cancer Letters 2021, 520, 132-142

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Reagents and models for detecting endogenous GLP1R and GIPR

  • Ast, J. et al.

EBioMedicine 2021, 74, 103739

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NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi

  • D'Andrea, E. D. et al.

Journal of Structural Biology 2021, 213, 107715

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Non-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a beta2-arrestin link to the mTOR pathway

  • Catar, R. A. et al.

Kidney International 2021, online ahead of print,

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Leveraging the partition selection bias to achieve a high-quality clustering of mass spectra

  • Silva, A. R. F. et al.

Journal of Proteomics 2021, 245, 104282

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New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

  • Zong, G. et al.

FASEB Journal 2021, 35, e21275

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Natural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor

  • Guba, W. et al.

New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs , Royal Society of Chemistry 2021

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MS Annika: A New Cross-Linking Search Engine

  • Pirklbauer, G. J. et al.

Journal of Proteome Research 2021, 20, 2560-2569

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Molecular Modelling

  • Krause, G. et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

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Mechanism of synaptic protein turnover and its regulation by neuronal activity

  • Soykan, T. et al.

Current Opinion in Neurobiology 2021, 69, 76-83

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Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents

  • Kunth, M. et al.

Pharmaceuticals 2021, 14, 79

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M01 as a novel drug enhancer for specifically targeting the blood-brain barrier

  • Breitkreuz-Korff, O. et al.

Journal of Controlled Release 2021, 338, 137-148

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Liquid-like protein assemblies initiate endocytosis

  • Witkowska, A., & et al.

Nature Cell Biology 2021, 23, 301-302

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Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET

  • Sykes, D. A. et al.

Biophysical and Computational Tools in Drug Discovery , Springer , 2021 1-32

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ITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

  • Riemer, E. et al.

Molecular Plant 2021, 14, 1864-1880

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Septin Remodeling During Mammalian Cytokinesis

  • Russo, G., & et al.

Frontiers in cell and developmental biology 2021, 9, 768309

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Report Structural and compositional diversity in the kainate receptor family

  • Selvakumar, P. et al.

Cell Reports 2021, 37, 109891

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The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

  • Koch, P. A. et al.

FEBS Journal 2021, 288, 7025-7042

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Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

  • Kemter, E. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118

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The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

  • Pras, A. et al.

EMBO Journal 2021, 40, e107568

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XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications

  • Lima, D. B. et al.

Journal of Proteome Research 2021, 20, 1943-1950

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Using Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate-Protein Interactions with Surface-Based Biosensors

  • Couto, D. et al.

Biochemistry 2021, 60, 2739-2748

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Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

  • Khelashvili, G. et al.

Scientific Reports 2021, 11, 10536

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Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders

  • Duncan, A. R. et al.

American Journal of Human Genetics 2021, 108, 1450-1465

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Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

  • Bonnekoh, H. et al.

Clinical and Translational Allergy 2021, 11, e12045

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Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

  • Ried, M. K. et al.

Nature Communications 2021, 12, 384

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The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

  • Park, Y. et al.

Chemical Science 2021, 12, 8141-8148

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The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

  • Willmes, D. M. et al.

JCI Insight 2021, 6, e136083

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The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis

  • Desfougeres, Y. et al.

Advances in Biological Regulation 2021, in press, 100835

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The chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata

  • Li, X. et al.

Magnetic Resonance in Chemistry 2021, 59, 554-560

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Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates

  • Franz, L. et al.

Methods in Molecular Biology 2021, 2355, 287-299

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Similarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation

  • Busi, B. et al.

Journal of Physical Chemistry B 2021, 125, 2212-2221

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SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

  • Schmied, C. et al.

Frontiers in Computer Science 2021, 3, 777837

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Structure, gating and interactions of the voltage-dependent anion channel

  • Najbauer, E. E. et al.

European Biophysics Journal with Biophysics Letters 2021, 50, 159-172

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Structural Plasticity of the Selectivity Filter in Cation Channels

  • Hendriks, K. et al.

Frontiers in Physiology 2021, 12, 792958

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Structural plasticity of the selectivity filter in a nonselective ion channel

  • Roy, R. N. et al.

IUCrJ 2021, 8, 421-430

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Structural evidence for visual arrestin priming via complexation of phosphoinositols

  • Sander, C. L. et al.

Structure 2021, 30, 1-15

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Structural basis of PI3KC2alpha function

  • Lo, W. et al.

Nature Structural & Molecular Biology 2021, in press,

Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel

  • Hendriks, K. et al.

Journal of Molecular Biology 2021, 433, 167091

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SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells

  • Olaniru, O. E. et al.

Molecular Metabolism 2021, 53, 101285

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Slow AMPA receptors in hippocampal principal cells

  • Pampaloni, N. P. et al.

Cell Reports 2021, 36, 109496

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Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

  • Schwach, J. et al.

ChemBioChem 2021, 22, 1205-1209

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Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

  • Malek, M. et al.

Nature Communications 2021, 12, 2673

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Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

  • Brandt, R. et al.

Frontiers in Bioengineering and Biotechnology 2021, 8, 614357

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Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway

  • Pauwels, E. et al.

International Journal of Molecular Sciences 2021, 22, 12007

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An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator

  • Werner, P. et al.

Scientific Reports 2021, 11, 21731

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Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

  • Bui, T. P. N. et al.

Nature Communications 2021, 12, 4798

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Cl(-) channels and Cl(-)/H(+) exchangers

  • Ullrich, F., & et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer , 2021 470-477

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Chemical Biology Tools To Investigate Malaria Parasites

  • Broichhagen, J., & et al.

ChemBioChem 2021, 22, 2219-2236

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Characterizing protein conformers by cross-linking mass spectrometry and pattern recognition

  • Kurt, L. U. et al.

Bioinformatics 2021, 37, 3035-3037

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Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

  • Schneider, A. F. L. et al.

Nature Chemistry 2021, 13, 530-539

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Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells

  • Schneider, A. F. L. et al.

Angewandte Chemie International Edition 2021, 60, 22075-22080

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Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarized Xe-129

  • Kunth, M., & et al.

Chemical Science 2021, 12, 158-169

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Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research

  • Hauser, A. et al.

Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552

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Aptamer BC 007's Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies

  • Haberland, A. et al.

Viruses 2021, 13, 932

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Analyses of Covalent Modifications in Alpha-Glucans

  • Nitschke, F., & et al.

Enzymology of Complex Alpha-Glucans , CRC Press , 2021 34-60

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

  • Pigazzini, M. L. et al.

Frontiers in Molecular Neuroscience 2021, 14, 721749

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Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4

  • Kircher, T. et al.

European Journal of Medicinal Chemistry 2021, 209, 112901

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Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

  • Mantilla, B. S. et al.

Molecular Microbiology 2021, 115, 986-1004

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Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes

  • Furkert, D. et al.

STAR Protocols 2021, 2, 100277

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Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

  • Lucey, M. et al.

Molecular Pharmacology 2021, 100, 319-334

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A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

  • Yan, B. et al.

Organic & Biomolecular Chemistry 2021, 19, 8014-8017

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A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

  • Pauwels, E. et al.

Molecular and Cellular Proteomics 2021, 20, 100144

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A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

  • Rizalar, F. S. et al.

Neuron 2021, 109, 27-41

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A Membrane-Permeable and Immobilized Metal Affinity Chromatography (IMAC)-Enrichable Cross-Linking Reagent to Advance In Vivo Cross-Linking Mass Spectrometry

  • Jiang, P. et al.

Angewandte Chemie International Edition 2021, Online ahead of print,

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A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

  • Haucke, V. et al.

Developmental Cell 2021, 56, 1557-1559

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A fine-tuned azobenzene for enhanced photopharmacology in vivo

  • Gutzeit, V. A. et al.

Cell Chemical Biology 2021, 28, 1648-1663

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In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy

  • Prinz, C. et al.

Theranostics 2021, 11, 2490-2504

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A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

  • Bohg, C. et al.

Chemical Science 2021, 12, 12754-12762

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Crosslinking glutamate receptor ion channels

  • Plested, A. J. R., & et al.

Ion Channels: Channel Biochemistry, Reconstitution, and Function , Elsevier , 2021 161-192

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Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly

  • Ramesh, N. et al.

Current Biology 2021, 31, 1711-1725

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Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

  • Leenders, R. G. G. et al.

Journal of Medicinal Chemistry 2021, 64, 17936-17949

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Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

  • Lan, H. et al.

Nature Communications 2021, 12, 4236

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Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

  • Lazzaretti, C. et al.

International Journal of Molecular Sciences 2021, 22, 151

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Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging

  • Stieger, C. E. et al.

Angewandte Chemie International Edition 2021, 60, 15359-15364

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Identification of extracellular nanoparticle subsets by nuclear magnetic resonance

  • Ullah, M. S. et al.

Chemical Science 2021, 12, 8311-8319

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Identification of disease-relevant modulators of the SHH pathway in the developing brain

  • Mecklenburg, N. et al.

Development 2021, 148, dev199307

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Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

  • Mancini, C. et al.

Scientific Reports 2021, 11, 19928

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Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

  • Breinlinger, S. et al.

Science 2021, 371, eaax9050

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How solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks

  • Urbaniak, T. et al.

Polymer 2021, 229, 123986

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

  • Klionsky, D. J. et al.

Autophagy 2021, 17, 1-382

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Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

  • Böhme, M. A. et al.

Glia 2021, 69, 1897-1915

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GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

  • Mederos, S. et al.

Nature Neuroscience 2021, 24, 82-92

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Functional Imaging Using Fluorine ((19)F) MR - Methods: Basic Concepts

  • Waiczies, S. et al.

Methods in Molecular Biology , Springer Nature , 2021 279-299

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Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses

  • Stadtmueller, M. N. et al.

Journal of Medicinal Chemistry 2021, 64, 12774-12789

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Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening

  • Liao, G. et al.

Acs Pharmacology & Translational Science 2021, 4, 780-789

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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

  • Thibado, J. K. et al.

Elife 2021, 10, e67027

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Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

  • Schneider, A. F. L. et al.

RSC Chemical Biology 2021, 2, 1661-1668

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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

  • Hostachy, S. et al.

Chemical Science 2021, 12, 10696-10702

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DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

  • Brennecke, B. et al.

Bioconjugate Chemistry 2021, 32, 702-712

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Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

  • Guerrero-Valero, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

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eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

  • Liang, Y. T. et al.

Cell Reports 2021, 35, 108941

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En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes

  • Otrin, L. et al.

Nature Communications 2021, 12, 4972

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Endothelins

  • Oksche, A., & et al.

Encyclopedia of Molecular Pharmacology : Third Edition , Springer 2021

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Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

  • Carter, D. M. et al.

Journal of Medicinal Chemistry 2021, 64, 14266-14282

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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

  • Marzook, A. et al.

Biochemical Pharmacology 2021, 190, 114656

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Latest Publications

of 117

Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics

  • Dohmen, S. et al.

Chemistry 2020, 26, 3049-3053

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pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes

  • Gerland, L. et al.

ChemBioChem 2020, 21, 1597-1604

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Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

  • Lauster, D. et al.

Nature Nanotechnology 2020, 15, 373-379

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Phosphodiesterase 3A and Arterial Hypertension

  • Ercu, M. et al.

Circulation 2020, 142, 133-149

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Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

  • Wang, H. B. et al.

Journal of Biological Chemistry 2020, 295, 1091-1104

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Protein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide

  • Hoffmann, J. et al.

Magnetic Resonance in Chemistry 2020, 58, 445-465

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Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

  • Chow, W. Y. et al.

Angewandte Chemie-International Edition 2020, 59, 11937-11942

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Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans

  • Hecht-Höger, A. M. et al.

Molecular Ecology 2020, 29, 1745-1755

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Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules

  • Liu, H. et al.

Magnetic Resonance in Chemistry 2020, 58, 404-410

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Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

  • Waaler, J. et al.

Journal of Medicinal Chemistry 2020, 63, 6834-6846

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NMR quality control of fragment libraries for screening

  • Sreeramulu, S. et al.

Journal of Biomolecular NMR 2020, 74, 555-563

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Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity

  • Gallrein, C. et al.

Progress in Neurobiology 2020, Online ahead of print, 101907

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Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization

  • Salazar, H. et al.

Biophysical Journal 2020, 119, 206-218

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

  • Kuijpers, M. et al.

Neuron 2020, 109, 1-15

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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

  • Kasper, M. A. et al.

ChemBioChem 2020, 21, 113-119

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Mussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins

  • Kohn, J. M. et al.

Macromolecular Rapid Communications 2020, 41, e1900431

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Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations

  • Kutle, I. et al.

Journal of Virology 2020, Online ahead of print,

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Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

  • Yusenko, M. V. et al.

Cancer Letters 2020, 479, 61-70

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Molecular architecture and assembly of the tight junction backbone

  • Piontek, J. et al.

Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183279

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Modulating TSH Receptor Signaling for Therapeutic Benefit

  • Krause, G. et al.

European Thyroid Journal 2020, 9, 66-77

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Modern Peptide and Protein Chemistry: Reaching New Heights

  • Hackenberger, C. P. R. et al.

Journal of Organic Chemistry 2020, 85, 1328-1330

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MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex

  • Wang, C. et al.

EMBO Reports 2020, 21, e48833

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Megadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

  • Verzini, S. et al.

Journal of Molecular Biology 2020, 432, 166689

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Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid-Crystalline-Based Medium

  • Qin, S. Y. et al.

Angewandte Chemie-International Edition 2020, Online ahead of print,

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MAS NMR detection of hydrogen bonds for protein secondary structure characterization

  • Friedrich, D. et al.

Journal of Biomolecular NMR 2020, 74, 247-256

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Ramping up the autophagy-lysosome system to cope with osmotic stress

  • Lopez-Hernandez, T. et al.

Autophagy 2020, 16, 1921-1922

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Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

  • Sawade, L. et al.

Nature Communications 2020, 11, 2835

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Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome

  • Furkert, D. et al.

Cell Chemical Biology 2020, 27, 1097-1108

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Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances

  • Kobbersmed, J. R. L. et al.

Elife 2020, 9, e51032

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The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

  • Fang, Z. et al.

ACS Pharmacology & Translational Science 2020, 3, 345-360

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Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

  • Schuhmacher, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7729-7738

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Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes

  • Bertovic, I. et al.

Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772

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Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

  • Pechstein, A. et al.

Cell Reports 2020, 30, 2594-2602

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Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

  • Weinert, S. et al.

EMBO Journal 2020, 39, e103358

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Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules

  • Maaßen, A. et al.

Angewandte Chemie-International Edition 2020, 59, 5747-5755

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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

  • Zhou, C. et al.

Immunity 2020, 52, 767-781

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Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins

  • Winkler, L. et al.

Journal of Cerebral Blood Flow and Metabolism 2020, 271678X20904687

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The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30

  • Schwiebs, A. et al.

British Journal of Pharmacology 2020, 177, 1424-1433

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The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses

  • Woitkuhn, J. et al.

Journal of Neurogenetics 2020, 34, 106-114

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The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase

  • Iburg, M. et al.

Journal of Biological Chemistry 2020, 295, 3064-3079

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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

  • Liu, H. et al.

Cancer Discovery 2020, 10, 1226-1239

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The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha

  • Chin, A. C. et al.

Science Advances 2020, 6, eabb8542

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The impact of non-ideality of lipid mixing on peptide induced lipid clustering

  • Finger, S. et al.

Biochimica et Biophysica Acta - Biomembranes 2020, 1862, 183248

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Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading

  • Sandhof, C. A. et al.

Autophagy 2020, 16, 878-899

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The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation

  • Heidenreich, S. et al.

Journal of Biological Chemistry 2020, 295, 17158-17168

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The axonal endolysosomal and autophagic systems

  • Kuijpers, M. et al.

Journal of Neurochemistry 2020, 158, 589-602

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The antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes

  • Braun, B. C. et al.

Scientific Reports 2020, 10, 3681

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Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin

  • Piontek, A. et al.

Molecular Oncology 2020, 14, 261-276

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Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics

  • Hauser, A. et al.

Chemistry 2020, Online ahead of print, 2326-2331

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Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions

  • Gonzalez-Lozano, M. A. et al.

Science Advances 2020, 6, eaax5783

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Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase

  • Li, X. L. et al.

Journal of the American Chemical Society 2020, 142, 2301-2309

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Splicing-accessible coding 3 ' UTRs control protein stability and interaction networks

  • Preussner, M. et al.

Genome Biology 2020, 21, 186

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Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

  • Pickford, P. et al.

British Journal of Pharmacology 2020, 177, 3905-3923

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Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

  • Nematian-Ardestani, E. et al.

Journal of Biological Chemistry 2020, 295, 610-618

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Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content

  • Wiglenda, T. et al.

Journal of Molecular Biology 2020, 432, 2080-2098

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RIM-binding protein couples synaptic vesicle recruitment to release sites

  • Petzoldt, A. G. et al.

Journal of Cell Biology 2020, 219, e201902059

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Revealing cytotoxic substructures in molecules using deep learning

  • Webel, H. E. et al.

Journal of Computer-Aided Molecular Design 2020, 34, 731-746

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Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

  • Scott-Hewitt, N. et al.

EMBO Journal 2020, 39, e105380

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Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

  • D'Andrea, E. D. et al.

Journal of Structural Biology 2020, 211, 107536

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Ligand-specific factors influencing GLP-1R post-endocytic trafficking and degradation

  • Fang, Z. et al.

International Journal of Molecular Sciences 2020, 21, 33182425

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Aptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins

  • Weisshoff, H. et al.

Heliyon 2020, 6, e05421

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Cobalt-Exchanged Poly(Heptazine Imides) as Transition Metal-N-x Electrocatalysts for the Oxygen Evolution Reaction

  • Ye, M. Y. et al.

Advanced Materials 2020, 32, e1903942

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Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations

  • Baumann, A. L. et al.

Journal of the American Chemical Society 2020, 142, 9544-9552

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Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives

  • Schneider, A. F. L. et al.

Nature Chemistry 2020, in press,

Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies

  • Göppner, C. et al.

Journal of Biological Chemistry 2020, 296, 100074

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Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010

  • Brennecke, B. et al.

Pharmaceutical Patent Analyst 2020, 10, 111-163

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Biophysics of Membrane Protein Signaling

  • Plested, A., & et al.

Biophysical Journal 2020, 118, E01-E01

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Binding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe

  • Kunth, M., & et al.

Chemical Science 2020, in print,

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Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

  • Lozza, L. et al.

Scientific Reports 2020, 10, 8640

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Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

  • Stanifer, M. L. et al.

Nature Microbiology 2020, 5, 181-191

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Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner

  • Hempel, C. et al.

Journal of Molecular Biology 2020, 432, 2405-2427

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Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes

  • Puyskens, A. et al.

Cell Host & Microbe 2020, 27, 238-248

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Architecture of the flexible tail tube of bacteriophage SPP1

  • Zinke, M. et al.

Nature Communications 2020, 11, 5759

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AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells

  • Kroll, J. et al.

Journal of Cell Science 2020, 133, jcs236737

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Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

  • Hauser, A. et al.

Chemical Science 2020, 11, doi:10.1039/D0SC03930F

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Analysis of Random Migration of Cancer Cells in 3D

  • Visweshwaran, S. P., & et al.

Bio-Protocol 2020, 10,

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Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

  • Qiu, D. et al.

Nature Communications 2020, 11, 6035

An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

  • Brennecke, B. et al.

Angewandte Chemie-International Edition 2020, 59, 8512-8516

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Ambigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp

  • Chilczuk, T. et al.

ACS Chemical Biology 2020, 15, 2929-2936

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Affinity-enrichment and identification of inositol poly- and pyrophosphate interactomes

  • Furkert, D. et al.

STAR Methods 2020, in press,

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7 )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

  • Mantilla, B. S. et al.

Molecular Microbiology 2020, Online ahead of print,

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A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration

  • Polovitskaya, M. M. et al.

American Journal of Human Genetics 2020, 107, 1062-1077

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A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

  • Alsalim, R. et al.

Organic Letters 2020, 22, 7393-7396

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A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance

  • Clochard, J. et al.

International Journal of Pharmaceutics 2020, 589, 119822

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A Golgi-associated lipid kinase controls peripheral nerve myelination

  • Posor, Y., & et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875

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A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies

  • Gericke, B. et al.

Fluids and Barriers of the CNS 2020, 17, 53

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Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

  • Ernst, S. et al.

Science Advances 2020, 6, eaaz8041

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Collective exchange processes reveal an active site proton cage in bacteriorhodopsin

  • Friedrich, D. et al.

Communications Biology 2020, 3, 4

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Alterations of redox and iron metabolism accompany the development of HIV latency

  • Shytaj, I. L. (. (. et al.

EMBO Journal 2020, 39, e102209

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Control of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling

  • Li, X. Y. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 3568-3574

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Endocytosis in the adaptation to cellular stress

  • Lopez-Hernandez, T. et al.

Cell Stress 2020, 4, 230-247

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IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

  • Desmarini, D. et al.

mBio 2020, 11,

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Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

  • Bogdanow, B. et al.

Nature Communications 2020, 11, 4845

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Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

  • Jäpel, M. et al.

Cell Reports 2020, 30, 409-420

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Interrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

  • Poc, P. et al.

Chemical Science 2020, 11, 7871-7883

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Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

  • Haenig, C. et al.

Cell Reports 2020, 32, 108050

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Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association

  • Rabouw, H. H. et al.

Nature Microbiology 2020, 5, 1361-1373

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Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

  • Tu, Z. X. et al.

Advanced Functional Materials 2020, 2000933

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Functionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI

  • Schnurr, M. et al.

Advanced Biosystems 2020, 4, e1900251

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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

  • Mostinski, Y. et al.

Journal of Medicinal Chemistry 2020, 63, 14780-14804

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Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

  • Schnirch, L. et al.

Analytical Chemistry 2020, 92, 10495-10503

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Equine Herpesvirus Type 1 Modulates Cytokine and Chemokine Profiles of Mononuclear Cells for Efficient Dissemination to Target Organs

  • Pavulraj, S. et al.

Viruses 2020, 12, 999

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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

  • Gowrisankaran, S. et al.

Nature Communications 2020, 11, 1266

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InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

  • Sahu, S. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 19245-19253

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Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

  • Lopez-Hernandez, T. et al.

Nature Cell Biology 2020, 22, 815-827

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Development of a pathogenesis-based therapy for peeling skin syndrome type 1

  • Valentin, F. et al.

British Journal of Dermatology 2020, 184, 1123-1131

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EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

  • Matthaeus, C. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481

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Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

  • Nakamura, R. et al.

Communications Biology 2020, 3, 240

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Delivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide

  • Li, M. et al.

Angewandte Chemie-International Edition 2020, 59, 15586-15589

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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

  • Barone, M. et al.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690

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Deuterated rhodamines for protein labelling in nanoscopy

  • Rossmann, K. et al.

bioRxiv 2020, upload on Monday, 17th Aug

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

  • Sarott, R. C. et al.

Journal of the American Chemical Society 2020, 142, 16953-16964

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Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues

  • Xu, S. N. et al.

ACS Sensors 2020, 5, 1650-1656

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Dynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter

  • Finkenwirth, F. et al.

Biochimica Et Biophysica Acta-Biomembranes 2020, 1862, 183114

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Dynamic palmitoylation events following T-cell receptor signaling

  • Morrison, E. et al.

Communications Biology 2020, 3, 368

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Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period

  • Laezer, I. et al.

Reproduction 2020, 159, 371-382

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Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

  • Dema, A. et al.

Cells 2020, 9, E673

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Latest Publications

of 87

Rapid active zone remodeling consolidates presynaptic potentiation

  • Böhme, M. A. et al.

Nature Communications 2019, 10, 1085

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Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization

  • Müller, K. H. et al.

Cell Reports 2019, 27, 3124-3138

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Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

  • Zhang, Q. Y. et al.

Organic Letters 2019, 21, 2121-2125

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Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

  • Buntz, A. et al.

Nucleic Acids Research 2019, 47, 953-969

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Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

  • Apel, C. et al.

Organic Letters 2019, 21, 10043-10047

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Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

  • Wallroth, A. et al.

Nature Cell Biology 2019, 21, 1093-1101

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Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase

  • Milito, A. et al.

Marine Drugs 2019, 17, E650

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Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

  • Schoene, J. et al.

ChemMedChem 2019, 14, 1514-1527

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

  • Pascolutti, R. et al.

Cell Reports 2019, 27, 3049-3061

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Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks

  • Driller, J. H. et al.

Journal of Cell Science 2019, 132, jcs225151

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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

  • Fred, S. M. et al.

Journal of Biological Chemistry 2019, 294, 18150-18161

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Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

  • Göppner, C. et al.

Nature Communications 2019, 10, 4678

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Nanoscale coupling of endocytic pit growth and stability

  • Lehmann, M. et al.

Science Advances 2019, 5, eaax5775

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Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

  • Tiosano, D. et al.

PLoS Genetics 2019, 15, e1008088

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Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B27 subtype

  • Driller, R. et al.

Journal of Biological Chemistry 2019, 294, 13269-13279

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Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5

  • Drogen, F. et al.

Journal of Cell Biology 2019, 218, 3117-3133

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Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

  • Schmidtke, C. et al.

Journal of Biological Chemistry 2019, 294, 9592-9604

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RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

  • Brockmann, M. M. et al.

Elife 2019, 8, e43243

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Locally renewing resident synovial macrophages provide a protective barrier for the joint

  • Culemann, S. et al.

Nature 2019, 572, 670-675

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Regulation of influenza A virus mRNA splicing by CLK1

  • Artarini, A. et al.

Antiviral Research 2019, 168, 187-196

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The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

  • Lozza, L. et al.

Scientific Reports 2019, 9, 10878

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Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis

  • Yang, M. et al.

Journal of Organic Chemistry 2019, 84, 2568-2576

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The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant

  • Bogdanow, B. et al.

Nature Communications 2019, 10, 5518

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Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

  • Ullrich, F. et al.

Elife 2019, 8, e49187

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Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells

  • Beier, L. S. et al.

International Journal of Molecular Sciences 2019, 20, 4774

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Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava

  • Wu, Q. H. et al.

Journal of Organic Chemistry 2019, 84, 3083-3092

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Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

  • Zhu, J. et al.

Elife 2019, 8, e43582

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TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles

  • Stengl, A. et al.

Organic & Biomolecular Chemistry 2019, 17, 4964-4969

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Tight junction proteins at the blood-brain barrier: far more than claudin-5

  • Berndt, P. et al.

Cellular and Molecular Life Sciences 2019, 76, 1987-2002

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Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

  • Marcinkowski, P. et al.

Molecular Pharmacology 2019, 96, 452-462

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The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

  • Wong, E. L. et al.

Nature Communications 2019, 10, 66

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The conduction pathway of potassium channels is water free under physiological conditions

  • Öster, C. et al.

Science Advances 2019, 5, eaaw6756

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Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates

  • Puschmann, R. et al.

Biochemistry 2019, 58, 3927-3932

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The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

  • Kesten, C. et al.

Nature Communications 2019, 10, 857

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The cell adhesion protein CAR is a negative regulator of synaptic transmission

  • Wrackmeyer, U. et al.

Scientific Reports 2019, 9, 6768

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Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

  • Schneider, A. F. L. et al.

Bioconjugate Chemistry 2019, 30, 400-404

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Structure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR

  • Shi, C. W. et al.

Journal of the American Chemical Society 2019, 141, 17314-17321

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Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes

  • Höfer, C. T. et al.

Biochimica Et Biophysica Acta-Biomembranes 2019, 1861, 1123-1134

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Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

  • Maglione, M. et al.

Scientific Reports 2019, 9, 19616

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SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9

  • Klose, M. et al.

Journal of Cell Biology 2019, 218, 3039-3059

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Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

  • Plastira, I. et al.

Frontiers in Cellular Neuroscience 2019, 13, 531

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In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation

  • Nojoumi, S. et al.

International Journal of Molecular Sciences 2019, 20, 2299

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Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

  • Feleciano, D. R. et al.

Frontiers in Aging Neuroscience 2019, 11, 9

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Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

  • Gohlke, S. et al.

Molecular Metabolism 2019, 24, 1-17

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Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

  • Bhukel, A. (. et al.

Nature Communications 2019, 10, 1318

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo

  • Wortmann, L. et al.

Journal of Medicinal Chemistry 2019, 62, 10321-10341

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Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR

  • Goldberga, I. et al.

RSC Advances 2019, 9, 26686-26690

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Delayed allogeneic skin graft rejection in CD26-deficient mice

  • Zhao, X. L. et al.

Cellular and Molecular Immunology 2019, 16, 557-567

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Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations

  • Kasper, M. A. et al.

Angewandte Chemie-International Edition 2019, 58, 11625-11630

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Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit

  • Perez-Rius, C. et al.

Orphanet Journal of Rare Diseases 2019, 14, 268

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Comparison of the 3D structures of mouse and human alpha-synuclein fibrils by it solid-state NMR and STEM

  • Hwang, S. et al.

Journal of Structural Biology 2019, 206, 43-48

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Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke

  • Sladojevic, N. et al.

Journal of Neuroscience 2019, 39, 743-757

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Characterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations

  • Hwang, S. et al.

Journal of Biomolecular NMR 2019, 73, 281-291

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Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells

  • Binger, K. J. et al.

Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 19983-19988

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DNP NMR of biomolecular assemblies

  • Jaudzems, K. et al.

Journal of Structural Biology 2019, 206, 90-98

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ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

  • Kreis, P. et al.

Nature Communications 2019, 10, 486

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A simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells

  • Visweshwaran, S. P., & et al.

Methodsx 2019, 6, 2807-2821

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A SEPT1-based scaffold is required for Golgi integrity and function

  • Song, K. et al.

Journal of Cell Science 2019, 132, jcs225557

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A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

  • Helbig, I. et al.

American Journal of Human Genetics 2019, 104, 1060-1072

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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

  • Schewe, M. et al.

Science 2019, 363, 875-880

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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

  • Marcinkowski, P. et al.

Thyroid 2019, 29, 111-123

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A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring

  • Le Roux, A. L. et al.

Iscience 2019, 12, 194-203

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A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

  • König, B. et al.

Elife 2019, 8, e45421

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Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

  • Dejonghe, W. et al.

Nature Chemical Biology 2019, 15, 641-649

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Doxorubicin-induced cardiotoxicity involves IFN gamma-mediated metabolic reprogramming in cardiomyocytes

  • Ni, C. et al.

Journal of Pathology 2019, 247, 320-332

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Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

  • Arrey, F. et al.

Frontiers in Immunology 2019, 10, 89

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Fish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications

  • Horsch, J. et al.

ACS Macro Letters 2019, 8, 724-729

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Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

  • Moura-Alves, P. et al.

Science 2019, 366, eaaw1629

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Homeostatic scaling of active zone scaffolds maintains global synaptic strength

  • Goel, P. et al.

Journal of Cell Biology 2019, 218, 1706-1724

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High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

  • Merkert, S. et al.

Stem Cell Reports 2019, 12, 1389-1403

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High Exchange Rate Complexes of Xe-129 with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI

  • Schnurr, M. et al.

ChemPhysChem 2019, 20, 246-251

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Harnessing C-13-labeled myo-inositol to interrogate inositol phosphate messengers by NMR

  • Harmel, R. K. et al.

Chemical Science 2019, 10, 5267-5274

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Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains

  • Sap, K. A. et al.

Molecular & Cellular Proteomics 2019, 18, 1705-1720

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Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis

  • Poulsen, M. H. et al.

Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 13358-13367

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Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking

  • Vukicevic, T. et al.

Journal of the American Society of Nephrology 2019, 30, 795-810

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First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

  • Iacobucci, C. et al.

Analytical Chemistry 2019, 91, 6953-6961

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Dual Bioorthogonal Labeling of the Amyloid-beta Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products

  • Husen, L. S. et al.

Journal of Alzheimers Disease 2019, 72, 537-548

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Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

  • Gerth, F. et al.

Structure 2019, 27, 977-987

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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

  • Brennecke, P. et al.

Slas Discovery 2019, 24, 398-413

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Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

  • Kasper, M. A. et al.

Angewandte Chemie-International Edition 2019, 58, 11631-11636

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eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization

  • Matthaeus, C. et al.

PLoS One 2019, 14, e0223620

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Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

  • Brinson, R. G. et al.

Mabs 2019, 11, 94-105

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Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

  • Alex, A. et al.

Elife 2019, 8, e48287

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Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

  • Penkert, M. et al.

Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585

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Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells

  • Liu, C. P. et al.

Journal of the American Chemical Society 2019, 141, 6812-6816

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Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies

  • Gupta, R. et al.

Journal of Physical Chemistry B 2019, 123, 5048-5058

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Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization

  • Kasper, M. A. et al.

Chemical Science 2019, 10, 6322-6329

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List of Publications