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Our group studies the structure of drug-like molecules and characterizes their interactions with proteins. We apply a variety of experimental and computational methods including NMR spectroscopy and molecular dynamics simulations.
Our research interests are the development and application of molecular modelling and molecular dynamics simulations together with other cheminformatic and bioinformatic tools with the aim of designing novel bioactive molecules and characterizing their interactions with biological targets. Furthermore, we seek to develop a better understanding of the biophysical principles of membrane proteins, with a special focus on ion channels.
Our research interests focus on the development and application of molecular modelling, molecular dynamics simulations together with other chem- and bioinformatic tools for designing novel bioactive molecules, and the characterization of their interactions with biological targets. On the experimental side, we are actively involved in the development of novel NMR-based methods for studying structure and stereochemistry of challenging natural products and drug-like molecules, which is still one of the major bottlenecks in drug discovery.
Group 2022
Group Retreat 2022
Group Retreat 2022
Group Retreat 2021
People
MD simulations of ion channels
MD simulations of ion channels
Free energy calculations
NMR investigation of natural products
Free energy calculations
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
