Fewer side-effects: How we deliver drugs to tumor cells

The new technology enables a simple way of connecting the cytsteine residues (SH) of a tumor-sensing antibody (yellow) to toxic drug molecules. The emerging linker is highly stable during blood circulation and enables therefore a safe transport to the tumor side. © Barth van Rossum, FMP

Treating cancer more selectively and more effectively – this could be achieved with an innovative technology developed by teams of researchers at FMP and the Ludwig-Maximilians-Universität München (LMU). The process transforms proteins and antibodies into stable, highly functional drug transporters, with which tumor cells can be detected and killed.

Publications

Marc-André Kasper, Maria Glanz, Andreas Stengl, Martin Penkert, Simon Klenk, Tom Sauer, Dominik Schumacher, Jonas Helma, Eberhard Krause, M. Cristina Cardoso, Heinrich Leonhardt, Christian P. R. Hackenberger, Cysteine‐Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations, Angew. Chem. Int. Ed. 2019 doi:10.1002/anie.201814715

Marc-André Kasper, Andreas Stengl, Philipp Ochtrop, Marcus Gerlach, Tina Stoschek, Dominik Schumacher, Jonas Helma, Martin Penkert, Eberhard Krause, Heinrich Leonhardt, Christian P. R. Hackenberger, Ethynylphosphonamidates for the rapid and cysteine selective generation of efficacious Antibody-Drug-Conjugates, Angew. Chem. Int. Ed. 2019 doi:10.1002/anie.201904193