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Dr.
Nach seinem Chemiestudium in Erlangen und einem einjährigen Aufenthalt in der Weck-Gruppe an der NYU machte JB 2010 seinen Abschluss im Labor von Ivana Ivanovic-Burmazovic. Sein Interesse an Biologie führte ihn in das Labor von Dirk Trauner an der LMU München, wo er 2014 promovierte und seine Arbeit mit Kai Johnsson zunächst an der EPFL und dann am Max-Planck-Institut für medizinische Forschung in Heidelberg fortsetzte. Seit 2020 ist er am FMP als Juniorgruppenleiter im Bereich Chemische Biologie tätig.
Picoquant Young Investigator Award
2022
ORCHEM Award for Young Scientists
2022
EPFL Fellow co-funded by H2020 Marie Skłodowska-Curie
2016
Römer-Prize for excellent academic PhD achievement
2014
European Foundation for the Study of Diabetes Albert Renold fellowship
2013
European Molecular Biology Organization (EMBO) short-term fellowship
2012
PhD fellowship of the German National Academic Foundation (Studienstiftung des deutschen Volkes)
2011
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2014
Zerweck-Prize for outstanding achievements during the Diploma Exams
2011
Foreign Exchange Scholarship, German National Academic Foundation
2008
–
2009
Leonardo-Kolleg of the Friedrich Alexander University
2007
–
2010
Student fellowship of the German National Academic Foundation
2006
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2010
Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization
RSC Chemical Biology 2025
online lesenChemical probes for imaging cellular compartmentalization
Trends in Biochemical Sciences 2025
online lesenDeuterated oxazines are bright near-infrared fluorophores for mitochondrial imaging and single molecule spectroscopy
Chemical Communications 2025
online lesenDeuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology
Angewandte Chemie International Edition 2024
online lesenDeuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology
Angewandte Chemie 2024
online lesenMulticolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules
Journal of Medicinal Chemistry 2024
online lesenDirect optical measurement of intramolecular distances with angstrom precision
Science 2024
online lesenThe MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling
Melanocortin system activates carotid body arterial chemoreceptors in hypertension
Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses
Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes
Diabetic Medicine 2023
online lesenDeuteration provides a general strategy to enhance azobenzene-based photopharmacology
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers
Science Advances 2023
online lesenReal-Time Library Search Increases Cross-Link Identification Depth across All Levels of Sample Complexity
Analytical Chemistry 2023
online lesenHypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding
JCI Insight 2023
online lesenDirect optical measurement of intra-molecular distances down to the Ångström scale
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Communications Biology 2023
online lesenReal-time library search increases cross-link identification depth across all levels of sample complexity
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition
Circulation Research 2022
online lesenA versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Restoration of high-sensitivity patterned vision in motion with an engineered light-gated G protein-coupled receptor
DFT‐basierte Entdeckung von Ethynyl‐Triazolyl‐Phosphinaten als modulare Elektrophile für die chemoselektive Cystein‐Biokonjugation und Profilierung
Angewandte Chemie 2022
online lesenDFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
Angewandte Chemie International Edition 2022
online lesenBack Cover: DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling (Angew. Chem. Int. Ed. 41/2022)
Angewandte Chemie International Edition 2022
online lesenRücktitelbild: DFT‐basierte Entdeckung von Ethynyl‐Triazolyl‐Phosphinaten als modulare Elektrophile für die chemoselektive Cystein‐Biokonjugation und Profilierung (Angew. Chem. 41/2022)
Angewandte Chemie 2022
online lesenControl of Gα q signaling dynamics and GPCR cross-talk by GRKs
Science Advances 2022
online lesenAn examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells
Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy
Chemical Communications 2022
online lesenAdvances in tethered photopharmacology for precise optical control of signaling proteins
Current Opinion in Pharmacology 2022
online lesenVisualisierung endogener Proteine in ihrer natürlichen Umgebung
BIOspektrum 2022
online lesenStructural and compositional diversity in the kainate receptor family
Cell Reports 2021
online lesenReagents and models for detecting endogenous GLP1R and GIPR
eBioMedicine 2021
online lesenChemical Biology Tools To Investigate Malaria Parasites
ChemBioChem 2021
online lesenDifferences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
Evaluation of efficacy-versusaffinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
eLife 2021
online lesenSequentialin vivolabeling of insulin secretory granule pools in INS-SNAP transgenic pigs
SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells
Molecular Metabolism 2021
online lesenSequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs
Proceedings of the National Academy of Sciences 2021
online lesenPurification of age-distinct insulin secretory granules through antigen restriction
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors
Angewandte Chemie International Edition 2020
online lesenTransformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors
Angewandte Chemie 2020
online lesenDeuterated rhodamines for protein labelling in nanoscopy
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)
Journal of Medicinal Chemistry 2020
online lesenLigand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
International Journal of Molecular Sciences 2020
online lesenUnusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin
Optical Control of a Biological Reaction–Diffusion System
Angewandte Chemie 2018
online lesenAuthor Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
Nature Communications 2018
online lesenConditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology
ACS Central Science 2018
online lesenOptical Control of a Biological Reaction–Diffusion System
Angewandte Chemie International Edition 2018
online lesenA Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity
ACS Chemical Biology 2018
online lesenA (+)‐Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6
ChemMedChem 2018
online lesenA New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1
Journal of Medicinal Chemistry 2018
online lesenSNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand
ACS Chemical Biology 2018
online lesenOptical tools for understanding the complexity of β-cell signalling and insulin release
Nature Reviews Endocrinology 2018
online lesenRestoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
Nature Communications 2017
online lesenRemote control of glucose homeostasis in vivo using photopharmacology
Scientific Reports 2017
online lesenDual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors
Proceedings of the National Academy of Sciences 2017
online lesenOptical control of GPR40 signalling in pancreatic β-cells
Chem. Sci. 2017
online lesenPotent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor
ChemistryOpen 2017
online lesenOptical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone
Chemical Science 2017
online lesenAllosteric Optical Control of a Class B G‐Protein‐Coupled Receptor
Angewandte Chemie International Edition 2016
online lesenAllosterische optische Steuerung eines Klasse‐B‐G‐Protein‐gekoppelten Rezeptors
Angewandte Chemie 2016
online lesenAzobenzene-based inhibitors of human carbonic anhydrase II.
A roadmap to success in photopharmacology.
Crystal structure of (E)-1,2-bis-(4-bromo-2,6-di-fluoro-phen-yl)diazene.
AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks.
A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.
Optical Control of Insulin Secretion Using an Incretin Switch.
Optical control of insulin release using a photoswitchable sulfonylurea.
The in vivo chemistry of photoswitched tethered ligands.
Optical control of acetylcholinesterase with a tacrine switch.
Das Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) gehört zum Forschungsverbund Berlin e.V. (FVB), einem Zusammenschluss von sieben natur-, lebens- und umweltwissenschaftlichen Instituten in Berlin. Die Einrichtungen sind Mitglieder der Leibniz-Gemeinschaft.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Deutschland