Portrait Johannes Broichhagen

Dr.

Johannes Broichhagen

After studying Chemistry in Erlangen with a one-year stint in the Weck group at NYU, JB graduated from the lab of Ivana Ivanovic-Burmazovic in 2010. Interested in biology, he joined the lab of Dirk Trauner at LMU Munich, obtaining his PhD in 2014 and pursuing his endeavours with Kai Johnsson, first at EPFL, then at the Max Planck for Medical Research in Heidelberg. He joined the FMP in 2020 as a Junior Group Leader in Chemical Biology.

Chemical Biology


Broichhagen Group


FMP

Awards

Picoquant Young Investigator Award
2022

ORCHEM Award for Young Scientists
2022

EPFL Fellow co-funded by H2020 Marie Skłodowska-Curie
2016

Römer-Prize for excellent academic PhD achievement
2014

European Foundation for the Study of Diabetes Albert Renold fellowship
2013

European Molecular Biology Organization (EMBO) short-term fellowship
2012

PhD fellowship of the German National Academic Foundation (Studienstiftung des deutschen Volkes)
2011 – 2014

Zerweck-Prize for outstanding achievements during the Diploma Exams
2011

Foreign Exchange Scholarship, German National Academic Foundation
2008 – 2009

Leonardo-Kolleg of the Friedrich Alexander University
2007 – 2010

Student fellowship of the German National Academic Foundation
2006 – 2010

Publications

of 4

14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells

  • Mugabo, Y.
  • Zhao, C.
  • Tan, J. J.
  • Ghosh, A.
  • Campbell, S. A.
  • Fadzeyeva, E.
  • Pare, F.
  • Pan, S. S.
  • Galipeau, M.
  • Ast, J.
  • Broichhagen, J.
  • Hodson, D. J.
  • Mulvihill, E. E.
  • Petropoulos, S., &
  • Lim, G. E.

JCI Insight 2022, 7, e156378

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Advances in tethered photopharmacology for precise optical control of signaling proteins

  • Broichhagen('), J., &
  • Levitz, J.

Current Opinion in Pharmacology 2022, 63, 102196

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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

  • Gazzi, T.
  • Brennecke, B.
  • Atz, K.
  • Korn, C.
  • Sykes, D.
  • Forn-Cuni, G.
  • Pfaff, P.
  • Sarott, R. C.
  • Westphal, M. V.
  • Mostinski, Y.
  • Mach, L.
  • Wasinska-Kalwa, M.
  • Weise, M.
  • Hoare, B. L.
  • Miljus, T.
  • Mexi, M.
  • Roth, N.
  • Koers, E. J.
  • Guba, W.
  • Alker, A.
  • Rufer, A. C.
  • Kusznir, E. A.
  • Huber, S.
  • Raposo, C.
  • Zirwes, E. A.
  • Osterwald, A.
  • Pavlovic, A.
  • Moes, S.
  • Beck, J.
  • Nettekoven, M.
  • Benito-Cuesta, I.
  • Grande, T.
  • Drawnel, F.
  • Widmer, G.
  • Holzer, D.
  • Wel, T.
  • Mandhair, H.
  • Honer, M.
  • Fingerle, J.
  • Scheffel, J.
  • Broichhagen, J.
  • Gawrisch, K.
  • Romero, J.
  • Hillard, C. J.
  • Varga, Z. V.
  • Stelt, M.
  • Pacher, P.
  • Gertsch, J.
  • Ullmer, C.
  • McCormick, P. J.
  • Oddi, S.
  • Spaink, H. P.
  • Maccarrone, M.
  • Veprintsev, D. B.
  • Carreira, E. M.
  • Grether, U., &
  • Nazaré, M.

Chemical Science 2022, 13, 5419-5776

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Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

  • Birke, R.
  • Ast, J.
  • Roosen, D. A.
  • Lee, J.
  • Roßmann, K.
  • Huhn, C.
  • Mathes, B.
  • Lisurek, M.
  • Bushiri, D.
  • Sun, H.
  • Jones, B.
  • Lehmann, M.
  • Levitz, J.
  • Haucke, V.
  • Hodson, D. J., &
  • Broichhagen, J.

Organic & Biomolecular Chemistry 2022, Advance Article,

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Publications

of 11

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

  • Khelashvili, G.
  • Pillai, A. N.
  • Lee, J.
  • Pandey, K.
  • Payne, A. M.
  • Siegel, Z.
  • Cuendet, M. A.
  • Lewis, T. R.
  • Arshavsky, V. Y.
  • Broichhagen, J.
  • Levitz, J., &
  • Menon, A. K.

Scientific Reports 2021, 11, 10536

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SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells

  • Olaniru, O. E.
  • Cheng, J. R.
  • Ast, J.
  • Arvaniti, A.
  • Atanes, P.
  • Huang, G. ..
  • King, A.
  • Jones, P. M.
  • Broichhagen, J.
  • Hodson, D. J., &
  • Persaud, S. J.

Molecular Metabolism 2021, 53, 101285

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Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

  • Kemter, E.
  • Müller, A.
  • Neukam, M.
  • Ivanova, A.
  • Klymiuk, N.
  • Renner, S.
  • Yang, K.
  • Broichhagen, J.
  • Kurome, M.
  • Zakhartchenko, V.
  • Kessler, B.
  • Knoch, K.
  • Bickle, M.
  • Ludwig, B.
  • Johnsson, K.
  • Lickert, H.
  • Kurth, T.
  • Wolf, E., &
  • Solimena, M.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118

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Report Structural and compositional diversity in the kainate receptor family

  • Selvakumar, P.
  • Lee, J.
  • Khanra, N.
  • He, C.
  • Munguba, H.
  • Kiese, L.
  • Broichhagen, J.
  • Reiner, A.
  • Levitz, J., &
  • Meyerson, J. R.

Cell Reports 2021, 37, 109891

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Reagents and models for detecting endogenous GLP1R and GIPR

  • Ast, J.
  • Broichhagen, J., &
  • Hodson, D. J.

EBioMedicine 2021, 74, 103739

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Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

  • Lämmle, C. A.
  • Varady, A.
  • Müller, T. G.
  • Sturtzel, C.
  • Riepl, M.
  • Mathes, B.
  • Eichhorst, J.
  • Sporbert, A.
  • Lehmann, M.
  • Kräusslich, H.
  • Distel, M., &
  • Broichhagen, J.

ChemBioChem 2021, 22, 548-556

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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

  • Marzook, A.
  • Chen, S.
  • Pickford, P.
  • Lucey, M.
  • Wang, Y.
  • Correa, J.
  • Broichhagen, J.
  • Hodson, D. J.
  • Salem, V.
  • Rutter, G. A.
  • Tan, T. M.
  • Bloom, S. R.
  • Tomas, A., &
  • Jones, B.

Biochemical Pharmacology 2021, 190, 114656

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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

  • Thibado, J. K.
  • Tano, J.
  • Lee, J.
  • Salas-Estrada, L.
  • Provasi, D.
  • Strauss, A.
  • Ribeiro, J. M. L.
  • Xiang, G.
  • Broichhagen, J.
  • Filizola, M.
  • Lohse, M. J., &
  • Levitz, J.

Elife 2021, 10, e67027

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Chemical Biology Tools To Investigate Malaria Parasites

  • Broichhagen, J., &
  • Kilian, N.

ChemBioChem 2021, 22, 2219-2236

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Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

  • Lucey, M.
  • Ashik, T.
  • Marzook, A.
  • Wang, Y.
  • Goulding, J.
  • Oishi, A.
  • Broichhagen, J.
  • Hodson, D. J.
  • Minnion, J.
  • Elani, Y.
  • Jockers, R.
  • Briddon, S. J.
  • Bloom, S. R.
  • Tomas, A., &
  • Jones, B.

Molecular Pharmacology 2021, 100, 319-334

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A fine-tuned azobenzene for enhanced photopharmacology in vivo

  • Gutzeit, V. A.
  • Acosta-Ruiz, A.
  • Munguba, H.
  • Hafner, S.
  • Landra-Willm, A.
  • Mathes, B.
  • Mony, J.
  • Yarotski, D.
  • Börjesson, K.
  • Liston, C.
  • Sandoz, G.
  • Levitz, J., &
  • Broichhagen, J.

Cell Chemical Biology 2021, 28, 1648-1663

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Publications

of 5

Deuterated rhodamines for protein labelling in nanoscopy

  • Rossmann, K.
  • Akkaya, K. C.
  • Charbonnier, C.
  • Eichhorst, J.
  • Jones, B. J.
  • Lehmann, M., &
  • Broichhagen, J.

bioRxiv 2020, upload on Monday, 17th Aug

Interrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

  • Poc, P.
  • Gutzeit, V. A.
  • Ast, J.
  • Lee, J.
  • Jones, B.
  • D'Este, E.
  • Mathes, B.
  • Lehmann, M.
  • Hodson, D. J.
  • Levitz, J., &
  • Broichhagen, J.

Chemical Science 2020, 11, 7871-7883

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Ligand-specific factors influencing GLP-1R post-endocytic trafficking and degradation

  • Fang, Z.
  • Chen, S.
  • Manchanda, Y.
  • Bitsi, P.
  • Pickford, P.
  • David, A.
  • Shchepinova, M. M.
  • Corrêa Jr, I.
  • Hodson, D. J.
  • Broichhagen, J.
  • Tate, E. W.
  • Reimann, F.
  • Salem, V.
  • Rutter, G. A.
  • Tan, T.
  • Bloom, S. R.
  • Tomas, A., &
  • Jones, B. J.

International Journal of Molecular Sciences 2020, 21, 33182425

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Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

  • Pickford, P.
  • Lucey, M.
  • Fang, Z. J.
  • Bitsi, S.
  • Serna, J. B.
  • Broichhagen, J.
  • Hodson, D. J.
  • Minnion, J.
  • Rutter, G. A.
  • Bloom, S. R.
  • Tomas, A., &
  • Jones, B.

British Journal of Pharmacology 2020, 177, 3905-3923

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The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

  • Fang, Z.
  • Chen, S.
  • Pickford, P.
  • Broichhagen, J.
  • Hodson, D. J.
  • Correa, J.
  • Kumar, S.
  • Görlitz, F.
  • Dunsby, C.
  • French, P. M. W.
  • Rutter, G. A.
  • Tan, T.
  • Bloom, S. R.
  • Tomas, A., &
  • Jones, B.

ACS Pharmacology & Translational Science 2020, 3, 345-360

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