Portrait Johannes Broichhagen

Dr.

Johannes Broichhagen

After studying Chemistry in Erlangen with a one-year stint in the Weck group at NYU, JB graduated from the lab of Ivana Ivanovic-Burmazovic in 2010. Interested in biology, he joined the lab of Dirk Trauner at LMU Munich, obtaining his PhD in 2014 and pursuing his endeavours with Kai Johnsson, first at EPFL, then at the Max Planck for Medical Research in Heidelberg. He joined the FMP in 2020 as a Junior Group Leader in Chemical Biology.

Chemical Biology


Broichhagen Group


FMP

Awards

Picoquant Young Investigator Award
2022

ORCHEM Award for Young Scientists
2022

EPFL Fellow co-funded by H2020 Marie Skłodowska-Curie
2016

Römer-Prize for excellent academic PhD achievement
2014

European Foundation for the Study of Diabetes Albert Renold fellowship
2013

European Molecular Biology Organization (EMBO) short-term fellowship
2012

PhD fellowship of the German National Academic Foundation (Studienstiftung des deutschen Volkes)
2011 – 2014

Zerweck-Prize for outstanding achievements during the Diploma Exams
2011

Foreign Exchange Scholarship, German National Academic Foundation
2008 – 2009

Leonardo-Kolleg of the Friedrich Alexander University
2007 – 2010

Student fellowship of the German National Academic Foundation
2006 – 2010

Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

  • Ann‐Kathrin Rückert; Julia Ast; Annie Hasib; Daniela Nasteska; Katrina Viloria; Johannes Broichhagen; David J. Hodson

Diabetic Medicine 2023

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Deuteration provides a general strategy to enhance azobenzene-based photopharmacology

  • Kilian Roßmann; Alberto J. Gonzalez-Hernandez; Rahul Bhuyan; Karl Börjesson; Joshua Levitz; Johannes Broichhagen
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Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers

  • Joon Lee; Alberto J. Gonzalez-Hernandez; Melanie Kristt; Nohely Abreu; Kilian Roßmann; Anisul Arefin; Dagan C. Marx; Johannes Broichhagen; Joshua Levitz

Science Advances 2023

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Real-Time Library Search Increases Cross-Link Identification Depth across All Levels of Sample Complexity

  • Max Ruwolt; Yi He; Diogo Borges Lima; William Barshop; Johannes Broichhagen; Romain Huguet; Rosa Viner; Fan Liu

Analytical Chemistry 2023

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Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

  • Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann

JCI Insight 2023

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Direct optical measurement of intra-molecular distances down to the Ångström scale

  • Steffen J. Sahl; Jessica Matthias; Kaushik Inamdar; Taukeer A. Khan; Michael Weber; Stefan Becker; Christian Griesinger; Johannes Broichhagen; Stefan W. Hell
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A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding

  • Jerome Jatzlau; Wiktor Burdzinski; Michael Trumpp; Leon Obendorf; Kilian Roßmann; Katharina Ravn; Marko Hyvönen; Francesca Bottanelli; Johannes Broichhagen; Petra Knaus

Communications Biology 2023

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Real-time library search increases cross-link identification depth across all levels of sample complexity

  • Max Ruwolt; Yi He; Diogo Borges Lima; William Barshop; Johannes Broichhagen; Romain Huguet; Rosa Viner; Fan Liu
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GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

  • Audrys G. Pauza; Pratik Thakkar; Tatjana Tasic; Igor Felippe; Paul Bishop; Michael P. Greenwood; Kristina Rysevaite-Kyguoliene; Julia Ast; Johannes Broichhagen; David J. Hodson; Helio C. Salgado; Dainius H. Pauza; Nina Japundzic-Zigon; Julian F.R. Paton; David Murphy

Circulation Research 2022

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A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding

  • Jerome Jatzlau; Wiktor Burdzinski; Michael Trumpp; Leon Obendorf; Kilian Roßmann; Katharina Ravn; Marko Hyvönen; Francesca Bottanelli; Johannes Broichhagen; Petra Knaus
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Restoration of high-sensitivity patterned vision in motion with an engineered light-gated G protein-coupled receptor

  • Amy Holt; Michael H. Berry; Jamie Lo; Prashant Donthamsetti; Meike Visel; Johannes Broichhagen; John G. Flannery; Ehud Y. Isacoff
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DFT‐basierte Entdeckung von Ethynyl‐Triazolyl‐Phosphinaten als modulare Elektrophile für die chemoselektive Cystein‐Biokonjugation und Profilierung

  • Christian E. Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich D. Süssmuth; Johannes Broichhagen; Mu‐Hyun Baik; Christian P. R. Hackenberger

Angewandte Chemie 2022

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DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling

  • Christian E. Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich D. Süssmuth; Johannes Broichhagen; Mu‐Hyun Baik; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2022

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Back Cover: DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling (Angew. Chem. Int. Ed. 41/2022)

  • Christian E. Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich D. Süssmuth; Johannes Broichhagen; Mu‐Hyun Baik; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2022

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Rücktitelbild: DFT‐basierte Entdeckung von Ethynyl‐Triazolyl‐Phosphinaten als modulare Elektrophile für die chemoselektive Cystein‐Biokonjugation und Profilierung (Angew. Chem. 41/2022)

  • Christian E. Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich D. Süssmuth; Johannes Broichhagen; Mu‐Hyun Baik; Christian P. R. Hackenberger

Angewandte Chemie 2022

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Control of Gα q signaling dynamics and GPCR cross-talk by GRKs

  • Guoqing Xiang; Amanda Acosta-Ruiz; Arthur Radoux-Mergault; Melanie Kristt; Jihye Kim; Jared D. Moon; Johannes Broichhagen; Asuka Inoue; Francis S. Lee; Miriam Stoeber; Jeremy S. Dittman; Joshua Levitz

Science Advances 2022

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An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells

  • Yusman Manchanda; Stavroula Bitsi; Shiqian Chen; Johannes Broichhagen; Jorge Bernardino de la Serna; Ben Jones; Alejandra Tomas
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Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy

  • Michael Trumpp; Anna Oliveras; Hannes Gonschior; Julia Ast; David J. Hodson; Petra Knaus; Martin Lehmann; Melissa Birol; Johannes Broichhagen

Chemical Communications 2022

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Advances in tethered photopharmacology for precise optical control of signaling proteins

  • Johannes Broichhagen; Joshua Levitz

Current Opinion in Pharmacology 2022

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Visualisierung endogener Proteine in ihrer natürlichen Umgebung

  • Christiane Huhn; Johannes Broichhagen

BIOspektrum 2022

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Structural and compositional diversity in the kainate receptor family

  • Purushotham Selvakumar; Joon Lee; Nandish Khanra; Changhao He; Hermany Munguba; Lisa Kiese; Johannes Broichhagen; Andreas Reiner; Joshua Levitz; Joel R. Meyerson

Cell Reports 2021

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Reagents and models for detecting endogenous GLP1R and GIPR

  • Julia Ast; Johannes Broichhagen; David J. Hodson

eBioMedicine 2021

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Chemical Biology Tools To Investigate Malaria Parasites

  • Johannes Broichhagen; Nicole Kilian

ChemBioChem 2021

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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

  • Jordana K. Thibado; Jean-Yves Tano; Joon Lee; Leslie Salas-Estrada; Davide Provasi; Alexa Strauss; Joao Marcelo Lamim Ribeiro; Guoqing Xiang; Johannes Broichhagen; Marta Filizola; Martin Lohse; Joshua Levitz
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Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

  • Maria Lucey; Tanyel Ashik; Amaara Marzook; Yifan Wang; Joëlle Goulding; Atsuro Oishi; Johannes Broichhagen; David J Hodson; James Minnion; Yuval Elani; Ralf Jockers; Stephen J Briddon; Stephen R Bloom; Alejandra Tomas; Ben Jones
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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

  • Amaara Marzook; Shiqian Chen; Phil Pickford; Maria Lucey; Yifan Wang; Ivan R Corrêa, Jr; Johannes Broichhagen; David J Hodson; Victoria Salem; Guy A Rutter; Tricia M Tan; Stephen R Bloom; Alejandra Tomas; Ben Jones
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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

  • Jordana K Thibado; Jean-Yves Tano; Joon Lee; Leslie Salas-Estrada; Davide Provasi; Alexa Strauss; Joao Marcelo Lamim Ribeiro; Guoqing Xiang; Johannes Broichhagen; Marta Filizola; Martin J Lohse; Joshua Levitz

eLife 2021

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Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

  • Elisabeth Kemter; Andreas Müller; Martin Neukam; Anna Ivanova; Nikolai Klymiuk; Simone Renner; Kaiyuan Yang; Johannes Broichhagen; Mayuko Kurome; Valerie Zakhartchenko; Barbara Kessler; Klaus-Peter Knoch; Marc Bickle; Barbara Ludwig; Kai Johnsson; Heiko Lickert; Thomas Kurth; Eckhard Wolf; Michele Solimena
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SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

  • Oladapo E. Olaniru; Jordan Cheng; Julia Ast; Anastasia Arvaniti; Patricio Atanes; Guo C. Huang; Aileen J.F. King; Peter M. Jones; Johannes Broichhagen; David J. Hodson; Shanta J. Persaud

Molecular Metabolism 2021

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Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs

  • Elisabeth Kemter; Andreas Müller; Martin Neukam; Anna Ivanova; Nikolai Klymiuk; Simone Renner; Kaiyuan Yang; Johannes Broichhagen; Mayuko Kurome; Valeri Zakhartchenko; Barbara Kessler; Klaus-Peter Knoch; Marc Bickle; Barbara Ludwig; Kai Johnsson; Heiko Lickert; Thomas Kurth; Eckhard Wolf; Michele Solimena

Proceedings of the National Academy of Sciences 2021

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Purification of age-distinct insulin secretory granules through antigen restriction

  • Martin Neukam; Pia Sala; Andreas-David Brunner; Katharina Ganß; Alessandra Palladini; Michal Grzybek; Jovana Vasiljević; Johannes Broichhagen; Kai Johnsson; Thomas Kurth; Matthias Mann; Ünal Coskun; Michele Solimena
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Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

  • Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben J. Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen
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Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors

  • Philipp Leippe; Johannes Broichhagen; Katia Cailliau; Alexandra Mougel; Marion Morel; Colette Dissous; Dirk Trauner; Jérôme Vicogne

Angewandte Chemie International Edition 2020

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Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors

  • Philipp Leippe; Johannes Broichhagen; Katia Cailliau; Alexandra Mougel; Marion Morel; Colette Dissous; Dirk Trauner; Jérôme Vicogne

Angewandte Chemie 2020

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Deuterated rhodamines for protein labelling in nanoscopy

  • Kilian Roßmann; Kerem C. Akkaya; Corentin Charbonnier; Jenny Eichhorst; Ben Jones; Martin Lehmann; Johannes Broichhagen
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Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)

  • Konstantin Hinnah; Sabine Willems; Johannes Morstein; Jan Heering; Felix W. W. Hartrampf; Johannes Broichhagen; Philipp Leippe; Daniel Merk; Dirk Trauner

Journal of Medicinal Chemistry 2020

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Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

  • Zijian Fang; Shiqian Chen; Yusman Manchanda; Stavroula Bitsi; Philip Pickford; Alessia David; Maria M. Shchepinova; Ivan R. Corrêa Jr; David J. Hodson; Johannes Broichhagen; Edward W. Tate; Frank Reimann; Victoria Salem; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones

International Journal of Molecular Sciences 2020

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Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

  • George Khelashvili; Anoop Narayana Pillai; Joon Lee; Kalpana Pandey; Alexander M. Payne; Zarek Siegel; Michel A. Cuendet; Tylor R. Lewis; Vadim Y. Arshavsky; Johannes Broichhagen; Joshua Levitz; Anant K. Menon
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Optical Control of a Biological Reaction–Diffusion System

  • Philipp Glock; Johannes Broichhagen; Simon Kretschmer; Philipp Blumhardt; Jonas Mücksch; Dirk Trauner; Petra Schwille

Angewandte Chemie 2018

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Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

  • Michael H. Berry; Amy Holt; Joshua Levitz; Johannes Broichhagen; Benjamin M. Gaub; Meike Visel; Cherise Stanley; Krishan Aghi; Yang Joon Kim; Kevin Cao; Richard H Kramer; Dirk Trauner; John Flannery; Ehud Y. Isacoff

Nature Communications 2018

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Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

  • Tom Podewin; Julia Ast; Johannes Broichhagen; Nicholas H. F. Fine; Daniela Nasteska; Philipp Leippe; Manuel Gailer; Teresa Buenaventura; Nisha Kanda; Ben J. Jones; Celine M’Kadmi; Jean-Louis Baneres; Jacky Marie; Alejandra Tomas; Dirk Trauner; Anja Hoffmann-Röder; David J. Hodson

ACS Central Science 2018

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Optical Control of a Biological Reaction–Diffusion System

  • Philipp Glock; Johannes Broichhagen; Simon Kretschmer; Philipp Blumhardt; Jonas Mücksch; Dirk Trauner; Petra Schwille

Angewandte Chemie International Edition 2018

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A Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity

  • Kateri H. DuBay; Katharina Iwan; Laura Osorio-Planes; Phillip L. Geissler; Michael Groll; Dirk Trauner; Johannes Broichhagen

ACS Chemical Biology 2018

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A (+)‐Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6

  • Stephanie Häfner; Finn Burg; Martina Kannler; Nicole Urban; Peter Mayer; Alexander Dietrich; Dirk Trauner; Johannes Broichhagen; Michael Schaefer

ChemMedChem 2018

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A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1

  • Sandra Karch; Johannes Broichhagen; Julia Schneider; Daniel Böning; Stephanie Hartmann; Benjamin Schmid; Philipp Tripal; Ralf Palmisano; Christian Alzheimer; Kai Johnsson; Tobias Huth

Journal of Medicinal Chemistry 2018

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SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

  • Helen Farrants; Vanessa A. Gutzeit; Amanda Acosta-Ruiz; Dirk Trauner; Kai Johnsson; Joshua Levitz; Johannes Broichhagen

ACS Chemical Biology 2018

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Optical tools for understanding the complexity of β-cell signalling and insulin release

  • James A. Frank; Johannes Broichhagen; Dmytro A. Yushchenko; Dirk Trauner; Carsten Schultz; David J. Hodson

Nature Reviews Endocrinology 2018

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Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

  • Michael H. Berry; Amy Holt; Joshua Levitz; Johannes Broichhagen; Benjamin M. Gaub; Meike Visel; Cherise Stanley; Krishan Aghi; Yang Joon Kim; Kevin Cao; Richard H. Kramer; Dirk Trauner; John Flannery; Ehud Y. Isacoff

Nature Communications 2017

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Remote control of glucose homeostasis in vivo using photopharmacology

  • Zenobia B. Mehta; Natalie R. Johnston; Marie-Sophie Nguyen-Tu; Johannes Broichhagen; Peter Schultz; Dean P. Larner; Isabelle Leclerc; Dirk Trauner; Guy A. Rutter; David J. Hodson

Scientific Reports 2017

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Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

  • Joshua Levitz; Johannes Broichhagen; Philipp Leippe; David Konrad; Dirk Trauner; Ehud Y. Isacoff

Proceedings of the National Academy of Sciences 2017

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Optical control of GPR40 signalling in pancreatic β-cells

  • James Allen Frank; Dmytro A. Yushchenko; Nicholas H. F. Fine; Margherita Duca; Mevlut Citir; Johannes Broichhagen; David J. Hodson; Carsten Schultz; Dirk Trauner

Chem. Sci. 2017

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Potent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor

  • Ben J. Jones; Rosario Scopelliti; Alejandra Tomas; Stephen R. Bloom; David J. Hodson; Johannes Broichhagen

ChemistryOpen 2017

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Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

  • Tom Podewin; Johannes Broichhagen; Christina Frost; Dieter Groneberg; Julia Ast; Helena Meyer-Berg; Nicholas H. F. Fine; Andreas Friebe; Martin Zacharias; David J. Hodson; Dirk Trauner; Anja Hoffmann-Röder

Chemical Science 2017

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Portraitfoto: © Matthias Rethmann