Johannes Broichhagen

14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells

• Mugabo, Y.
• Zhao, C.
• Tan, J. J.
• Ghosh, A.
• Campbell, S. A.
• Fadzeyeva, E.
• Pare, F.
• Pan, S. S.
• Galipeau, M.
• Ast, J.
• Broichhagen, J.
• Hodson, D. J.
• Mulvihill, E. E.
• Petropoulos, S., &
• Lim, G. E.

JCI Insight 2022, 7, e156378

Advances in tethered photopharmacology for precise optical control of signaling proteins

• Broichhagen('), J., &
• Levitz, J.

Current Opinion in Pharmacology 2022, 63, 102196

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

• Gazzi, T.
• Brennecke, B.
• Atz, K.
• Korn, C.
• Sykes, D.
• Forn-Cuni, G.
• Pfaff, P.
• Sarott, R. C.
• Westphal, M. V.
• Mostinski, Y.
• Mach, L.
• Wasinska-Kalwa, M.
• Weise, M.
• Hoare, B. L.
• Miljus, T.
• Mexi, M.
• Roth, N.
• Koers, E. J.
• Guba, W.
• Alker, A.
• Rufer, A. C.
• Kusznir, E. A.
• Huber, S.
• Raposo, C.
• Zirwes, E. A.
• Osterwald, A.
• Pavlovic, A.
• Moes, S.
• Beck, J.
• Nettekoven, M.
• Benito-Cuesta, I.
• Grande, T.
• Drawnel, F.
• Widmer, G.
• Holzer, D.
• Wel, T.
• Mandhair, H.
• Honer, M.
• Fingerle, J.
• Scheffel, J.
• Broichhagen, J.
• Gawrisch, K.
• Romero, J.
• Hillard, C. J.
• Varga, Z. V.
• Stelt, M.
• Pacher, P.
• Gertsch, J.
• Ullmer, C.
• McCormick, P. J.
• Oddi, S.
• Spaink, H. P.
• Maccarrone, M.
• Veprintsev, D. B.
• Carreira, E. M.
• Grether, U., &
• Nazaré, M.

Chemical Science 2022, 13, 5419-5776

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

• Birke, R.
• Ast, J.
• Roosen, D. A.
• Lee, J.
• Roßmann, K.
• Huhn, C.
• Mathes, B.
• Lisurek, M.
• Bushiri, D.
• Sun, H.
• Jones, B.
• Lehmann, M.
• Levitz, J.
• Haucke, V.
• Hodson, D. J., &
• Broichhagen, J.

Organic & Biomolecular Chemistry 2022, Advance Article,

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

• Khelashvili, G.
• Pillai, A. N.
• Lee, J.
• Pandey, K.
• Payne, A. M.
• Siegel, Z.
• Cuendet, M. A.
• Lewis, T. R.
• Arshavsky, V. Y.
• Broichhagen, J.
• Levitz, J., &
• Menon, A. K.

Scientific Reports 2021, 11, 10536

SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic -cells

• Olaniru, O. E.
• Cheng, J. R.
• Ast, J.
• Arvaniti, A.
• Atanes, P.
• Huang, G. ..
• King, A.
• Jones, P. M.
• Broichhagen, J.
• Hodson, D. J., &
• Persaud, S. J.

Molecular Metabolism 2021, 53, 101285

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

• Kemter, E.
• Müller, A.
• Neukam, M.
• Ivanova, A.
• Klymiuk, N.
• Renner, S.
• Yang, K.
• Broichhagen, J.
• Kurome, M.
• Zakhartchenko, V.
• Kessler, B.
• Knoch, K.
• Bickle, M.
• Ludwig, B.
• Johnsson, K.
• Lickert, H.
• Kurth, T.
• Wolf, E., &
• Solimena, M.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2107665118

Report Structural and compositional diversity in the kainate receptor family

• Selvakumar, P.
• Lee, J.
• Khanra, N.
• He, C.
• Munguba, H.
• Kiese, L.
• Broichhagen, J.
• Reiner, A.
• Levitz, J., &
• Meyerson, J. R.

Cell Reports 2021, 37, 109891

Reagents and models for detecting endogenous GLP1R and GIPR

• Ast, J.
• Broichhagen, J., &
• Hodson, D. J.

EBioMedicine 2021, 74, 103739

Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

• Lämmle, C. A.
• Varady, A.
• Müller, T. G.
• Sturtzel, C.
• Riepl, M.
• Mathes, B.
• Eichhorst, J.
• Sporbert, A.
• Lehmann, M.
• Kräusslich, H.
• Distel, M., &
• Broichhagen, J.

ChemBioChem 2021, 22, 548-556

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

• Marzook, A.
• Chen, S.
• Pickford, P.
• Lucey, M.
• Wang, Y.
• Correa, J.
• Broichhagen, J.
• Hodson, D. J.
• Salem, V.
• Rutter, G. A.
• Tan, T. M.
• Bloom, S. R.
• Tomas, A., &
• Jones, B.

Biochemical Pharmacology 2021, 190, 114656

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

• Thibado, J. K.
• Tano, J.
• Lee, J.
• Salas-Estrada, L.
• Provasi, D.
• Strauss, A.
• Ribeiro, J. M. L.
• Xiang, G.
• Broichhagen, J.
• Filizola, M.
• Lohse, M. J., &
• Levitz, J.

Elife 2021, 10, e67027

Chemical Biology Tools To Investigate Malaria Parasites

• Broichhagen, J., &
• Kilian, N.

ChemBioChem 2021, 22, 2219-2236

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

• Lucey, M.
• Ashik, T.
• Marzook, A.
• Wang, Y.
• Goulding, J.
• Oishi, A.
• Broichhagen, J.
• Hodson, D. J.
• Minnion, J.
• Elani, Y.
• Jockers, R.
• Briddon, S. J.
• Bloom, S. R.
• Tomas, A., &
• Jones, B.

Molecular Pharmacology 2021, 100, 319-334

A fine-tuned azobenzene for enhanced photopharmacology in vivo

• Gutzeit, V. A.
• Acosta-Ruiz, A.
• Munguba, H.
• Hafner, S.
• Landra-Willm, A.
• Mathes, B.
• Mony, J.
• Yarotski, D.
• Börjesson, K.
• Liston, C.
• Sandoz, G.
• Levitz, J., &
• Broichhagen, J.

Cell Chemical Biology 2021, 28, 1648-1663

Deuterated rhodamines for protein labelling in nanoscopy

• Rossmann, K.
• Akkaya, K. C.
• Charbonnier, C.
• Eichhorst, J.
• Jones, B. J.
• Lehmann, M., &
• Broichhagen, J.

bioRxiv 2020, upload on Monday, 17th Aug

Interrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

• Poc, P.
• Gutzeit, V. A.
• Ast, J.
• Lee, J.
• Jones, B.
• D'Este, E.
• Mathes, B.
• Lehmann, M.
• Hodson, D. J.
• Levitz, J., &
• Broichhagen, J.

Chemical Science 2020, 11, 7871-7883

Ligand-specific factors influencing GLP-1R post-endocytic trafficking and degradation

• Fang, Z.
• Chen, S.
• Manchanda, Y.
• Bitsi, P.
• Pickford, P.
• David, A.
• Shchepinova, M. M.
• Corrêa Jr, I.
• Hodson, D. J.
• Broichhagen, J.
• Tate, E. W.
• Reimann, F.
• Salem, V.
• Rutter, G. A.
• Tan, T.
• Bloom, S. R.
• Tomas, A., &
• Jones, B. J.

International Journal of Molecular Sciences 2020, 21, 33182425

Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

• Pickford, P.
• Lucey, M.
• Fang, Z. J.
• Bitsi, S.
• Serna, J. B.
• Broichhagen, J.
• Hodson, D. J.
• Minnion, J.
• Rutter, G. A.
• Bloom, S. R.
• Tomas, A., &
• Jones, B.

British Journal of Pharmacology 2020, 177, 3905-3923

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

• Fang, Z.
• Chen, S.
• Pickford, P.
• Broichhagen, J.
• Hodson, D. J.
• Correa, J.
• Kumar, S.
• Görlitz, F.
• Dunsby, C.
• French, P. M. W.
• Rutter, G. A.
• Tan, T.
• Bloom, S. R.
• Tomas, A., &
• Jones, B.

ACS Pharmacology & Translational Science 2020, 3, 345-360