Han Sun

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

• Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler

Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines

• Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied

Absolute Configuration of 12S-Deoxynortryptoquivaline from Ascidian-Derived Fungus Aspergillus clavatus Determined by Anisotropic NMR and Chiroptical Spectroscopy

• Elisa Doro-Goldsmith; Qi Song; Xiao-Lu Li; Xiao-Ming Li; Xue-Yi Hu; Hong-Lei Li; Hao-Ran Liu; Bin-Gui Wang; Han Sun

Journal of Natural Products 2024

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

• Kilian Roßmann; Alberto J. Gonzalez‐Hernandez; Rahul Bhuyan; Caspar Schattenberg; Han Sun; Karl Börjesson; Joshua Levitz; Johannes Broichhagen

Angewandte Chemie 2024

Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

• Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Jonas Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss

Journal of the American Chemical Society 2024

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

• Berke Türkaydin; Marcus Schewe; Elena Barbara Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun

Nature Communications 2024

Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors

• Sonja Minniberger; Saeid Abdolvand; Sebastian Braunbeck; Han Sun; Andrew J.R. Plested

Journal of Molecular Biology 2023

Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel

• Florian Karl Schackert; Johann Biedermann; Saeid Abdolvand; Sonja Minniberger; Chen Song; Andrew J. R. Plested; Paolo Carloni; Han Sun

Journal of Chemical Information and Modeling 2023

NMR for Stereochemical Elucidation

• Xiaolu Li; Xiaoliang Yang; Han Sun

Chiral Separations and Stereochemical Elucidation 2023

Cryo-EM structures of actin binding proteins as tool for drug discovery

• Christian Dahlstroem; Themistoklis Paraschiakos; Han Sun; Sabine Windhorst

Biochemical Pharmacology 2023

Cesium activates the neurotransmitter receptor for glycine

• Steffen Fricke; Magnus Harnau; Florian Hetsch; Haoran Liu; Julia Leonhard; Anna Eylmann; Pina Knauff; Han Sun; Marcus Semtner; Jochen C. Meier

Frontiers in Molecular Neuroscience 2023

The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

• Claudia Bohg; Carl Öster; Berke Türkaydin; Michael Lisurek; Pascal Sanchez-Carranza; Sascha Lange; Tillmann Utesch; Han Sun; Adam Lange

Science Advances 2023

Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

• Nathaniel Smith; Han Sun

Journal of General Physiology 2023

Diversity of rhodopsin cyclases in zoospore-forming fungi

• Matthias Broser; Wayne Busse; Anika Spreen; Maila Reh; Yinth Andrea Bernal Sierra; Songhwan Hwang; Tillmann Utesch; Han Sun; Peter Hegemann

Proceedings of the National Academy of Sciences 2023

Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches

• Swantje Mohr; Yessenbek K. Aldakul; Han Sun; Henry Sawczyc; Adam Lange

Integrated Structural Biology 2023

Polyarylisocyanides Derived from an Alkyne-Pd(II) Catalyst as Robust Alignment Media with Excellent Enantiodiscimination

• Gao-Wei Li; Xiao-Juan Wang; Shuai-Hua Shi; Lan-Tao Liu; Jia-Qian Li; Han Sun; Zong-Quan Wu; Xinxiang Lei

Analytical Chemistry 2023

Editorial: Combining computational and experimental approaches to characterize ion channels and transporters

• Christoph Fahlke; Jan-Philipp Machtens; Walter Sandtner; Klaus Schicker; Han Sun

Frontiers in Physiology 2023

Probing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands

• Han Sun

Journal of Medicinal Chemistry 2022

Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents

• Yuexiao Lin; Jiaqian Li; Si-Yong Qin; Han Sun; Yan-Ling Yang; Armando Navarro-Vázquez; Xinxiang Lei

Chemical Science 2022

QuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins.

• Han Sun

Nature communications 2022

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

• Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen

Organic & Biomolecular Chemistry 2022

Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+ Probability and CASE-3D

• Xiao-Lu Li; Tong Ru; Armando Navarro-Vázquez; Peter Lindemann; Marc Nazaré; Xu-Wen Li; Yue-Wei Guo; Han Sun

Journal of Natural Products 2022

Structural plasticity of the selectivity filter in a nonselective ion channel

• Raktim N. Roy; Kitty Hendriks; Wojciech Kopec; Saeid Abdolvand; Kevin L. Weiss; Bert L. de Groot; Adam Lange; Han Sun; Leighton Coates

IUCrJ 2021

The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

• Han Sun

Chemical Science 2021

Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel

• Han Sun

Journal of Molecular Biology 2021

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

• Han Sun

Chemical Science 2021

A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

• Han Sun

Chemical Science 2021

NMR of natural products

• Han Sun; Josep Saurí

Magnetic Resonance in Chemistry 2021

Nonselective cation permeation in an AMPA-type glutamate receptor

• Johann Biedermann; Sebastian Braunbeck; Andrew J. R. Plested; Han Sun

Proceedings of the National Academy of Sciences 2021

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

• Han Sun

Journal of Biological Chemistry 2020

Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase

• Han Sun

Journal of the American Chemical Society 2020

Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid‐Crystalline‐Based Medium

• Si‐Yong Qin; Yan Jiang; Han Sun; Han Liu; Ai‐Qing Zhang; Xinxiang Lei

Angewandte Chemie International Edition 2020

Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid‐Crystalline‐Based Medium

• Si‐Yong Qin; Yan Jiang; Han Sun; Han Liu; Ai‐Qing Zhang; Xinxiang Lei

Angewandte Chemie 2020

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

• Anett Hauser; Songhwan Hwang; Han Sun; Christian P. R. Hackenberger

Chemical Science 2020

Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava

• Han Sun

The Journal of Organic Chemistry 2019

Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells

• Han Sun

Journal of the American Chemical Society 2019

Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.02,16]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis

• Han Sun

The Journal of Organic Chemistry 2019

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

• Han Sun

Thyroid 2019

Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules

• Han Sun

Magnetic Resonance in Chemistry 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

• Marcus Schewe; Han Sun; Ümit Mert; Alexandra Mackenzie; Ashley C. W. Pike; Friederike Schulz; Cristina Constantin; Kirsty S. Vowinkel; Linus J. Conrad; Aytug K. Kiper; Wendy Gonzalez; Marianne Musinszki; Marie Tegtmeier; David C. Pryde; Hassane Belabed; Marc Nazare; Bert L. de Groot; Niels Decher; Bernd Fakler; Elisabeth P. Carpenter; Stephen J. Tucker; Thomas Baukrowitz

Science 2019

The conduction pathway of potassium channels is water free under physiological conditions

• Carl Öster; Kitty Hendriks; Wojciech Kopec; Veniamin Chevelkov; Chaowei Shi; Dagmar Michl; Sascha Lange; Han Sun; Bert L. de Groot; Adam Lange

Science Advances 2019

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings.

• Li GW; Cao JM; Zong W; Hu L; Hu ML; Lei X; Sun H; Tan RX

Chemistry (Weinheim an der Bergstrasse, Germany) 2017

Complete NMR assignment and conformational analysis of 17-α-ethinylestradiol by using RDCs obtained in grafted graphene oxide

• Han Sun

Magnetic resonance in chemistry : MRC 2017

Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances.

• Sun H; Horatscheck A; Martos V; Bartetzko M; Uhrig U; Lentz D; Schmieder P; Nazaré M

Angewandte Chemie (International ed. in English) 2017

A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol.

• Lei X; Qiu F; Sun H; Bai L; Wang WX; Xiang W; Xiao H

Angewandte Chemie (International ed. in English) 2017

The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp

• Han Sun

Natural products and bioprospecting 2016

An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes

• Han Sun

Angewandte Chemie (International ed. in English) 2016

Deciphering the Multisite Interactions of a Protein and Its Ligand at Atomic Resolution by Using Sensitive Paramagnetic Effects.

• Ma FH; Wang X; Chen JL; Wen X; Sun H; Su XC

Chemistry (Weinheim an der Bergstrasse, Germany) 2016

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

• Schewe M; Nematian-Ardestani E; Sun H; Musinszki M; Cordeiro S; Bucci G; de Groot BL; Tucker SJ; Rapedius M; Baukrowitz T

Cell 2016

Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels

• Han Sun

Magnetic resonance in chemistry : MRC 2012

Relative and absolute configuration of vatiparol (1 mg): a novel anti-inflammatory polyphenol

• Han Sun

Chemistry (Weinheim an Der Bergstrasse, Germany) 2012

Determining the absolute configuration of (+)-mefloquine HCl, the side-effect-reducing enantiomer of the antimalaria drug Lariam

• Han Sun

Journal of the American Chemical Society 2012

Predicting the structure of cyclic lipopeptides by bioinformatics: structure revision of arthrofactin.

• Lange A; Sun H; Pilger J; Reinscheid UM; Gross H

Chembiochem : a European journal of chemical biology 2012

Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima

• Han Sun

Journal of natural products 2012

Residual dipolar coupling enhanced NMR spectroscopy and chiroptics: a powerful combination for the complete elucidation of symmetrical small molecules

• Han Sun

Chemistry (Weinheim an Der Bergstrasse, Germany) 2011

Residual chemical shift anisotropy (RCSA): a tool for the analysis of the configuration of small molecules

• Han Sun

Angewandte Chemie (International ed. in English) 2011

Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A

• Han Sun

Journal of the American Chemical Society 2011

Bijvoet in solution reveals unexpected stereoselectivity in a Michael addition

• Han Sun

Chemistry (Weinheim an der Bergstrasse, Germany) 2011