Portrait Han Sun

Prof. Dr.

Han Sun

Han Sun studied chemistry in Nankai University in China and the University of Göttingen in Germany. She received her PhD from the Max Planck Institute for Biophysical Chemistry in 2013, where she subsequently worked as a postdoctoral fellow in two different research groups. Since 2017, she has been at the Leibniz Research Institute for Molecular Pharmacology, initially as a project leader, and since 2020 as the head of the Structural Chemistry and Computational Biophysics research unit. Additionally, since 2022, she has held the position of W2 professor at the Technical University of Berlin.

  • Ombudsperson
  • Professorin Technische Universität Berlin

Chemical Biology


Sun Group


FMP
TU Berlin

Curriculum Vitae

Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

  • Anton F. Ketzel; Yang Hu; Xiao‐Lu Li; Jiaqian Li; Xinxiang Lei; Han Sun

Magnetic Resonance in Chemistry 2025

read online

Morphological profiling data resource enables prediction of chemical compound properties

  • Christopher Wolff; Martin Neuenschwander; Carsten Jörn Beese; Divya Sitani; Maria C. Ramos; Alzbeta Srovnalova; María José Varela; Pavel Polishchuk; Katholiki E. Skopelitou; Ctibor Škuta; Bahne Stechmann; José Brea; Mads Hartvig Clausen; Petr Dzubak; Rosario Fernández-Godino; Olga Genilloud; Marian Hajduch; María Isabel Loza; Martin Lehmann; Jens Peter von Kries; Han Sun; Christopher Schmied

iScience 2025

read online

Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation

  • Anton Florian Ketzel; Xiaolu Li; Martin Kaupp; Han Sun; Caspar Jonas Schattenberg

Journal of Chemical Theory and Computation 2025

read online

Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

  • David Bushiri Pwesombo; Carsten Beese; Christopher Schmied; Han Sun

Journal of Chemical Information and Modeling 2025

read online

Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2PChannels

  • Yessenbek K. Aldakul; Marcus Schewe; Carlos C. Diez; Songhwan Hwang; Thomas Baukrowitz; Han Sun
read online

Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution

  • Klaus Benndorf; Uta Enke; Debanjan Tewari; Jana Kusch; Haoran Liu; Han Sun; Ralf Schmauder; Christian Sattler

Proceedings of the National Academy of Sciences 2025

read online

Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

  • Matthias Mulder; Songhwan Hwang; Matthias Broser; Steffen Brünle; Petr Skopintsev; Caspar Jonas Schattenberg; Christina Schnick; Sina Hartmann; Jonathan Church; Igor Schapiro; Florian Dworkowski; Tobias Weinert; Peter Hegemann; Han Sun; Jörg Standfuss

Journal of the American Chemical Society 2025

read online

Structural insights into light-gating of potassium-selective channelrhodopsin

  • Takefumi Morizumi; Kyumhyuk Kim; Hai Li; Probal Nag; Tal Dogon; Oleg A. Sineshchekov; Yumei Wang; Leonid S. Brown; Songhwan Hwang; Han Sun; Ana-Nicoleta Bondar; Igor Schapiro; Elena G. Govorunova; John L. Spudich; Oliver P. Ernst

Nature Communications 2025

read online
of 8
of 4

Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors

  • Sonja Minniberger; Saeid Abdolvand; Sebastian Braunbeck; Han Sun; Andrew J.R. Plested

Journal of Molecular Biology 2023

read online

Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel

  • Florian Karl Schackert; Johann Biedermann; Saeid Abdolvand; Sonja Minniberger; Chen Song; Andrew J. R. Plested; Paolo Carloni; Han Sun

Journal of Chemical Information and Modeling 2023

read online

NMR for Stereochemical Elucidation

  • Xiaolu Li; Xiaoliang Yang; Han Sun

Chiral Separations and Stereochemical Elucidation 2023

read online

Cryo-EM structures of actin binding proteins as tool for drug discovery

  • Christian Dahlstroem; Themistoklis Paraschiakos; Han Sun; Sabine Windhorst

Biochemical Pharmacology 2023

read online

Cesium activates the neurotransmitter receptor for glycine

  • Steffen Fricke; Magnus Harnau; Florian Hetsch; Haoran Liu; Julia Leonhard; Anna Eylmann; Pina Knauff; Han Sun; Marcus Semtner; Jochen C. Meier

Frontiers in Molecular Neuroscience 2023

read online

The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

  • Claudia Bohg; Carl Öster; Berke Türkaydin; Michael Lisurek; Pascal Sanchez-Carranza; Sascha Lange; Tillmann Utesch; Han Sun; Adam Lange

Science Advances 2023

read online

Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

  • Nathaniel Smith; Han Sun

Journal of General Physiology 2023

read online

Diversity of rhodopsin cyclases in zoospore-forming fungi

  • Matthias Broser; Wayne Busse; Anika Spreen; Maila Reh; Yinth Andrea Bernal Sierra; Songhwan Hwang; Tillmann Utesch; Han Sun; Peter Hegemann

Proceedings of the National Academy of Sciences 2023

read online

Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches

  • Swantje Mohr; Yessenbek K. Aldakul; Han Sun; Henry Sawczyc; Adam Lange

Integrated Structural Biology 2023

read online

Polyarylisocyanides Derived from an Alkyne-Pd(II) Catalyst as Robust Alignment Media with Excellent Enantiodiscimination

  • Gao-Wei Li; Xiao-Juan Wang; Shuai-Hua Shi; Lan-Tao Liu; Jia-Qian Li; Han Sun; Zong-Quan Wu; Xinxiang Lei

Analytical Chemistry 2023

read online

Editorial: Combining computational and experimental approaches to characterize ion channels and transporters

  • Christoph Fahlke; Jan-Philipp Machtens; Walter Sandtner; Klaus Schicker; Han Sun

Frontiers in Physiology 2023

read online
of 11
of 5
of 7
of 5

Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava

  • Han Sun

The Journal of Organic Chemistry 2019

read online

Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells

  • Han Sun

Journal of the American Chemical Society 2019

read online

Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.02,16]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis

  • Han Sun

The Journal of Organic Chemistry 2019

read online

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

  • Han Sun

Thyroid 2019

read online

Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules

  • Han Sun

Magnetic Resonance in Chemistry 2019

read online

A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

  • Marcus Schewe; Han Sun; Ümit Mert; Alexandra Mackenzie; Ashley C. W. Pike; Friederike Schulz; Cristina Constantin; Kirsty S. Vowinkel; Linus J. Conrad; Aytug K. Kiper; Wendy Gonzalez; Marianne Musinszki; Marie Tegtmeier; David C. Pryde; Hassane Belabed; Marc Nazare; Bert L. de Groot; Niels Decher; Bernd Fakler; Elisabeth P. Carpenter; Stephen J. Tucker; Thomas Baukrowitz

Science 2019

read online

The conduction pathway of potassium channels is water free under physiological conditions

  • Carl Öster; Kitty Hendriks; Wojciech Kopec; Veniamin Chevelkov; Chaowei Shi; Dagmar Michl; Sascha Lange; Han Sun; Bert L. de Groot; Adam Lange

Science Advances 2019

read online
of 7
of 4
of 4
of 5
of 4