Peter Schmieder

How solvent-free crosslinking conditions alter the chemistry and topology of hemiketal based polymer networks

• Tobias Urbaniak; Katrin Greta Hoffmann; Matthias Herrera Glomm; Hartmut Oschkinat; Peter Schmieder; Katharina Koschek

Polymer 2021

Synthesis and Evaluation of Non‐Hydrolyzable Phospho‐Lysine Peptide Mimics

• Anett Hauser; Eleftheria Poulou; Fabian Müller; Peter Schmieder; Christian P. R. Hackenberger

Chemistry – A European Journal 2021

Synthesis and Evaluation of Non‐Hydrolyzable Phospho‐Lysine Peptide Mimics

• Anett Hauser; Eleftheria Poulou; Fabian Müller; Peter Schmieder; Christian P. R. Hackenberger

Chemistry – A European Journal 2021

Front Cover: Synthesis and Evaluation of Non‐Hydrolyzable Phospho‐Lysine Peptide Mimics (Chem. Eur. J. 7/2021)

• Anett Hauser; Eleftheria Poulou; Fabian Müller; Peter Schmieder; Christian P. R. Hackenberger

Chemistry – A European Journal 2021

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

• Steffen Breinlinger; Tabitha J. Phillips; Brigette N. Haram; Jan Mareš; José A. Martínez Yerena; Pavel Hrouzek; Roman Sobotka; W. Matthew Henderson; Peter Schmieder; Susan M. Williams; James D. Lauderdale; H. Dayton Wilde; Wesley Gerrin; Andreja Kust; John W. Washington; Christoph Wagner; Benedikt Geier; Manuel Liebeke; Heike Enke; Timo H. J. Niedermeyer; Susan B. Wilde

Science 2021

Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content

• Peter Schmieder

Journal of Molecular Biology 2020

NMR quality control of fragment libraries for screening

• Peter Schmieder

Journal of Biomolecular NMR 2020

Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase

• Peter Schmieder

Journal of the American Chemical Society 2020

pH‐Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes

• Peter Schmieder

ChemBioChem 2020

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

• Peter Schmieder

Journal of Structural Biology 2020

Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol–Thiol Bioconjugations

• Peter Schmieder

Journal of the American Chemical Society 2020

The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

• Peter Schmieder

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

• Peter Schmieder

MAbs 2019

Harnessing 13C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR

• Peter Schmieder

Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype

• Ronja Driller; Martin Ballaschk; Peter Schmieder; Barbara Uchanska-Ziegler; Andreas Ziegler; Bernhard Loll

Journal of Biological Chemistry 2019

Structural changes of TasA in biofilm formation of Bacillus subtilis

• Peter Schmieder

Proc Natl Acad Sci U S A 2018

Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes

• Peter Schmieder

J Biotechnol 2018

A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System

• Peter Schmieder

Chemistry 2018

A Computational Modeling Approach Predicts Interaction of the Antifungal Protein AFP from Aspergillus giganteus with Fungal Membranes via Its gamma-Core Motif

• Peter Schmieder

mSphere 2018

Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides

• Peter Schmieder

Nat Commun 2016

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6

• Peter Schmieder

Open Biol 2016

Chemical shift assignments and secondary structure prediction for Q4DY78, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

• Peter Schmieder

Biomol NMR Assign 2016

Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin

• Peter Schmieder

J Am Chem Soc 2016

Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2

• Peter Schmieder

Marine Drugs 2016

Direct access to site-specifically phosphorylated-lysine peptides from a solid-support

• Peter Schmieder

Org Biomol Chem 2015

SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR

• Peter Schmieder

Journal of Cell Science 2015

Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain

• Peter Schmieder

Angew Chem Int Ed Engl 2015

A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions

• Peter Schmieder

Proc Natl Acad Sci U S A 2015

Site-specifically phosphorylated lysine peptides

• Peter Schmieder

J Am Chem Soc 2014

Controlled thioamide vs. amide formation in the thioacid-azide reaction under acidic aqueous conditions

• Peter Schmieder

Chem Commun (Camb) 2014

Isolation of Microcystins from the Cyanobacterium Planktothrix rubescens Strain No80

• Peter Schmieder

Nat Prod Bioprospect 2014

Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions

• Peter Schmieder

ChemMedChem 2014

Active and silent chromophore isoforms for phytochrome Pr photoisomerization: An alternative evolutionary strategy to optimize photoreaction quantum yields

• Peter Schmieder

Structural Dynamics 2014

The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed

• Peter Schmieder

Molecules 2013

NMR spectroscopy reveals unexpected structural variation at the protein–protein interface in MHC class I molecules

• Peter Schmieder

J Biomol NMR 2013

Unraveling the existence of dynamic water channels in light-harvesting proteins: alpha-C-phycocyanobilin in vitro

• Peter Schmieder

Chemical Science 2013

Efficient α-Helix Induction in a Linear Peptide Chain by N-Capping with a Bridged-tricyclic Diproline Analogue

• Peter Schmieder

Angewandte Chemie International Edition 2013

Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules

• Peter Schmieder

Immunogenetics 2013

The blue-light receptor YtvA from Bacillus subtilis is permanently incorporated into the stressosome independent of the illumination state

• Peter Schmieder

Biochem Biophys Res Commun 2013

The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein

• Peter Schmieder

Nucleic Acids Res 2013

Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease

• Peter Schmieder

Cell metabolism 2013

Determination of glucan phosphorylation using heteronuclear 1H,13C double and 1H,13C,31P triple-resonance NMR spectra

• Peter Schmieder

Magnetic Resonance in Chemistry 2013

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

• Peter Schmieder

Angew Chem Int Ed Engl 2013

Structural and dynamic features of HLA-B27 subtypes

• Peter Schmieder

Current Opinion in Rheumatology 2013

LOV takes a pick: thermodynamic and structural aspects of the flavin-LOV-interaction of the blue-light sensitive photoreceptor YtvA from Bacillus subtilis

• Peter Schmieder

PLoS One 2013

Assignment of phycocyanobilin in HMPT using triple resonance experiments

• Peter Schmieder

Magn Reson Chem 2011

Chemical synthesis of the third WW domain of TCERG 1 by native chemical ligation

• Peter Schmieder

J Pept Sci 2011

Photocontrol of contracting muscle fibers

• Peter Schmieder

Angew Chem Int Ed Engl 2011

Blue flickers of hope: secondary structure, dynamics, and putative dimerization interface of the blue-light receptor YtvA from Bacillus subtilis

• Peter Schmieder

Biochemistry 2011

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes

• Peter Schmieder

J Biol Chem 2011

Photoswitchable click amino acids: light control of conformation and bioactivity

• Peter Schmieder

Chembiochem 2011

The structure of MESD45-184 brings light into the mechanism of LDLR family folding

• Peter Schmieder

Structure 2011

Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins

• Peter Schmieder

Angew Chem Int Ed Engl 2011

The E. coli siderophores enterobactin and salmochelin form six-coordinate silicon complexes at physiological pH

• Peter Schmieder

Angew Chem Int Ed Engl 2011

Design, synthesis, structure and binding properties of PDZ binding, cyclic beta-finger peptides

• Peter Schmieder

Biochem Biophys Res Commun 2010

High Resolution 1H-Detected Solid-State NMR Spectroscopy of Protein Aliphatic Resonances: Access to Tertiary Structure Information

• Peter Schmieder

J Am Chem Soc 2010

The switch that does not flip: the blue-light receptor YtvA from Bacillus subtilis adopts an elongated dimer conformation independent of the activation state as revealed by a combined AUC and SAXS study

• Peter Schmieder

J Mol Biol 2010

NMR spectroscopic investigation of mobility and hydrogen bonding of the chromophore in the binding pocket of phytochrome proteins

• Peter Schmieder

Chemphyschem 2010

A convenient method for saponin isolation in tumour therapy

• Peter Schmieder

J Chromatogr B Analyt Technol Biomed Life Sci 2010

High-Resolution Double-Quantum Deuterium Magic Angle Spinning Solid-State NMR Spectroscopy of Perdeuterated Proteins

• Peter Schmieder

J Am Chem Soc 2009

NMR assignments of the periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter

• Peter Schmieder

Biomol NMR Assign 2009

Light-directed protein binding of a biologically relevant beta-sheet

• Peter Schmieder

Angew Chem Int Ed Engl 2009

Chromophore structure of cyanobacterial phytochrome Cph1 in the Pr state: reconciling structural and spectroscopic data by QM/MM calculations

• Peter Schmieder

Biophys J 2009

Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies

• Peter Schmieder

FEBS Lett 2009

NMR structure of the Wnt modulator protein Sclerostin

• Peter Schmieder

Biochem Biophys Res Commun 2009

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics

• Peter Schmieder

Angew Chem Int Ed Engl 2009

Periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE

• Peter Schmieder

Biochemistry 2009

Structures of cyclic, antimicrobial peptides in a membrane-mimicking environment define requirements for activity

• Peter Schmieder

J Pept Sci 2008

The depsipeptide technique applied to peptide segment condensation: scope and limitations

• Peter Schmieder

J Pept Sci 2008

Solid-phase synthesis of a cyclodepsipeptide: cotransin

• Peter Schmieder

Org Lett 2008

Heteronuclear NMR Investigation on the Structure and Dynamics of the Chromophore Binding Pocket of the Cyanobacterial Phytochrome Cph1

• Peter Schmieder

J Am Chem Soc 2008

Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein

• Peter Schmieder

Biomol NMR Assign 2008

Methods for Detection and Quantification of Polyphosphate and Polyphosphate Accumulating Microorganisms in Aquatic Sediments

• Peter Schmieder

International Review of Hydrobiology 2008

Design of antimicrobial compounds based on peptide structures

• Peter Schmieder

Bioorg Med Chem Lett 2007

Resonance assignment of the RGS domain of human RGS10

• Peter Schmieder

J Biomol NMR 2007

Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14

• Peter Schmieder

Biomol NMR Assign 2007

Solution-state (15)N NMR spectroscopic study of alpha-C-phycocyanin: implications for the structure of the chromophore-binding pocket of the cyanobacterial phytochrome Cph1

• Peter Schmieder

Chembiochem 2007

J-Deconvolution Using Maximum Entropy Reconstruction Applied to 13C−13C Solid-State Cross-Polarization Magic-Angle-Spinning NMR of Proteins

• Peter Schmieder

J Am Chem Soc 2007

Discovery of low-molecular-weight ligands for the AF6 PDZ domain

• Peter Schmieder

Angew Chem Int Ed Engl 2006

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family

• Peter Schmieder

J Struct Funct Genomics 2006

15N MAS NMR studies of cph1 phytochrome: Chromophore dynamics and intramolecular signal transduction

• Peter Schmieder

J Phys Chem B 2006

Probing protein-chromophore interactions in Cph1 phytochrome by mutagenesis

• Peter Schmieder

FEBS J 2006

Hassallidin B--second antifungal member of the Hassallidin family

• Peter Schmieder

Bioorg Med Chem Lett 2006

High yield expression and purification of isotopically labelled human endothelin-1 for use in NMR studies

• Peter Schmieder

Protein Expr Purif 2006

Interaction of the antimicrobial peptide cyclo(RRWWRF) with membranes by molecular dynamics simulations

• Peter Schmieder

Biophys J 2005

The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology

• Peter Schmieder

FEBS Lett 2005

Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp

• Peter Schmieder

J Nat Prod 2005

A modified strategy for sequence specific assignment of protein NMR spectra based on amino acid type selective experiments

• Peter Schmieder

J Biomol NMR 2005

Heteronuclear solution-state NMR studies of the chromophore in cyanobacterial phytochrome Cph1

• Peter Schmieder

Biochemistry 2005

Light-dependent dimerisation in the N-terminal sensory module of cyanobacterial phytochrome 1

• Peter Schmieder

FEBS Lett 2005

Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles

• Peter Schmieder

Chembiochem 2005

Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1

• Peter Schmieder

Biochemistry 2004

Origin and diagenesis of polyphosphate in lake sediments: A P-31-NMR study

• Peter Schmieder

Limnology and Oceanography 2004

The oxidized subunit B8 from human complex I adopts a thioredoxin fold

• Peter Schmieder

Structure 2004

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro

• Peter Schmieder

Proc Natl Acad Sci U S A 2004

MUSIC, selective pulses, and tuned delays: amino acid type-selective (1)H-(15)N correlations, II

• Peter Schmieder

J Magn Reson 2001

MUSIC and aromatic residues: amino acid type-selective (1)H-(15)N correlations, III

• Peter Schmieder

J Magn Reson 2001

Amino acid type-selective backbone 1H-15N-correlations for Arg and Lys

• Peter Schmieder

J Biomol NMR 2001

The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site

• Peter Schmieder

Proc Natl Acad Sci U S A 2001

Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: potential for NMR structure determination of large proteins

• Peter Schmieder

J Biomol NMR 1999

The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA

• Peter Schmieder

Proc Natl Acad Sci U S A 1999

MUSIC in triple-resonance experiments: amino acid type-selective (1)H-(15)N correlations

• Peter Schmieder

J Magn Reson 1999

Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites

• Peter Schmieder

Protein Sci 1999

Heteronuclear two-and three-dimensional nmr spectroscopy of 13C in natural abundance by multiplicity selection and editing: Application to peptides

• Peter Schmieder

Biopolymers 1991

Determination of heteronuclear long-range couplings to heteronuclei in natural abundance by two- and three-dimensional NMR spectroscopy

• Peter Schmieder

J Biomol NMR 1991

Measurements of H.alpha.-HN vicinal coupling constants in a protein with large line widths in a new 3D 1H-15N-13C quadruple resonance NMR experiment

• Peter Schmieder

J Am Chem Soc 1991

Editing of multiplicity in two- and three-dimensional heteronuclear NMR spectroscopy by fourier transformation of the pulse-angle dependency

• Peter Schmieder

Journal of Magnetic Resonance (1969) 1991

Thiocyclosporins: Preparation, Solution and Crystal Structure, and Immunosuppressive Activity

• Peter Schmieder

Helvetica Chimica Acta 1991

Selection of Methyl Resonances in Proton-Detected Heteronuclear Shift Correlation, the Hqqc Experiment

• Peter Schmieder

Journal of Magnetic Resonance 1991

Hetloc, an Efficient Method for Determining Heteronuclear Long-Range Couplings with Heteronuclei in Natural Abundance

• Peter Schmieder

Angewandte Chemie-International Edition in English 1991

A New H-1-N-15-C-13 Triple-Resonance Experiment for Sequential Assignments and Measuring Homonuclear H-Alpha-H-N Vicinal Coupling-Constants in Polypeptides

• Peter Schmieder

Journal of Magnetic Resonance 1991

Increased Resolution in Proton Detected Heteronuclear Nmr Experiments by Folding in the Hetero-Dimension

• Peter Schmieder

Magnetic Resonance in Chemistry 1991

Conformational Analysis of the cis- and trans-Isomers of FK506 by NMR and Molecular Dynamics

• Peter Schmieder

Helvetica Chimica Acta 1991

Improved resolution in proton-detected heteronuclear long-range correlation

• Peter Schmieder

Journal of Magnetic Resonance (1969) 1990

3D Heteronuclear NMR techniques for carbon-13 in natural abundance

• Peter Schmieder

J Am Chem Soc 1990

Improvement of carbon-detected H,H-TOCSY experiments by employing a DEPT transfer

• Peter Schmieder

Magnetic Resonance in Chemistry 1990

Fast Heteronuclear 3D NMR Spectroscopy

• Peter Schmieder

Angewandte Chemie International Edition in English 1990

Complete assignment of the noncarbonylic carbon-13 resonances of Tendamistat

• Peter Schmieder

Biopolymers 1990