Noa Lipstein

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

• Francisco José López-Murcia; Kun-Han Lin; Manon M. M. Berns; Mrinalini Ranjan; Noa Lipstein; Erwin Neher; Nils Brose; Kerstin Reim; Holger Taschenberger

Proceedings of the National Academy of Sciences 2024

Mechanism underlying a risk gene in neurodegeneration

• Noa Lipstein

Nature 2022

Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion

• Sébastien Houy; Joana S Martins; Noa Lipstein; Jakob Balslev Sørensen

eLife 2022

Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission

• Noa Lipstein

Neuron 2021

Delineating the Molecular Basis of the Calmodulin–bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry—Evidence for a Novel CaM Binding Motif in bMunc13-2

• Christine Piotrowski; Rocco Moretti; Christian H. Ihling; André Haedicke; Thomas Liepold; Noa Lipstein; Jens Meiler; Olaf Jahn; Andrea Sinz

Cells 2020

Presynaptic disorders: a clinical and pathophysiological approach focused on the synaptic vesicle

• Cortès-Saladelafont, E.; Lipstein, N.; García-Cazorla, À.

Journal of Inherited Metabolic Disease 2018

Apparent calcium dependence of vesicle recruitment

• Ritzau-Jost, A.; Jablonski, L.; Viotti, J.; Lipstein, N.; Eilers, J.; Hallermann, S.

Journal of Physiology 2018

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

• Lipstein, N.; Verhoeven-Duif, N.M.; Michelassi, F.E.; Calloway, N.; Van Hasselt, P.M.; Pienkowska, K.; Van Haaften, G.; Van Haelst, M.M.; Van Empelen, R.; Cuppen, I.; Van Teeseling, H.C.; Evelein, A.M.V.; Vorstman, J.A.; Thoms, S.; Jahn, O.; Duran, K.J.; Monroe, G.R.; Ryan, T.A.; Taschenberger, H.; Dittman, J.S.; Rhee, J.-S.; Visser, G.; Jans, J.J.; Brose, N.

Journal of Clinical Investigation 2017

Presynaptic Calmodulin targets: lessons from structural proteomics

• Lipstein, N.; Göth, M.; Piotrowski, C.; Pagel, K.; Sinz, A.; Jahn, O.

Expert Review of Proteomics 2017

Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of held terminal of rats and mice

• Okamoto, Y.; Lipstein, N.; Hua, Y.; Lin, K.-H.; Brose, N.; Sakaba, T.; Midorikawa, M.

eLife 2016

Photoswitchable diacylglycerols enable optical control of protein kinase C

• Frank, J.A.; Yushchenko, D.A.; Hodson, D.J.; Lipstein, N.; Nagpal, J.; Rutter, G.A.; Rhee, J.-S.; Gottschalk, A.; Brose, N.; Schultz, C.; Trauner, D.

Nature Chemical Biology 2016

Structural insights into calmodulin/Munc13 interaction

• Herbst, S.; Lipstein, N.; Jahn, O.; Sinz, A.

Biological Chemistry 2014

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

• Dolev, I.; Fogel, H.; Milshtein, H.; Berdichevsky, Y.; Lipstein, N.; Brose, N.; Gazit, N.; Slutsky, I.

Nature Neuroscience 2013

Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca²⁺-Calmodulin-Munc13-1 Signaling

• Lipstein, N.; Sakaba, T.; Cooper, B.; Lin, K.-H.; Strenzke, N.; Ashery, U.; Rhee, J.-S.; Taschenberger, H.; Neher, E.; Brose, N.

Neuron 2013

Nonconserved Ca²⁺/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity

• Lipstein, N.; Schaks, S.; Dimova, K.; Kalkhof, S.; Ihling, C.; Kölbel, K.; Ashery, U.; Rhee, J.S.; Brose, N.; Sinz, A.; Jahn, O.

Molecular and Cellular Biology 2012

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses

• Cooper, B.; Hemmerlein, M.; Ammermüller, J.; Imig, C.; Reim, K.; Lipstein, N.; Kalla, S.; Kawabe, H.; Brose, N.; Brandstätter, J.H.; Varoqueaux, F.

Journal of Neuroscience 2012

Erratum: Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin (Journal of Neurochemistry (2012) 120 (248-258))

• Orenbuch, A.; Shulman, Y.; Lipstein, N.

Journal of Neurochemistry 2012

Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2 and possible function in short-term synaptic plasticity

• Rodríguez-Castãeda, F.; Maestre-Martínez, M.; Coudevylle, N.; Dimova, K.; Junge, H.; Lipstein, N.; Lee, D.; Becker, S.; Brose, N.; Jahn, O.; Carlomagno, T.; Griesinger, C.

EMBO Journal 2010

Miniaturization of scorpion β-toxins uncovers a putative ancestral surface of interaction with voltage-gated sodium channels

• Cohen, L.; Lipstein, N.; Karbat, I.; Ilan, N.; Gilles, N.; Kahn, R.; Gordon, D.; Gurevitz, M.

Journal of Biological Chemistry 2008

Multiple functional domains are involved in tomosyn regulation of exocytosis

• Yizhar, O.; Lipstein, N.; Gladycheva, S.E.; Matti, U.; Ernst, S.A.; Rettig, J.; Stuenkel, E.L.; Ashery, U.

Journal of Neurochemistry 2007

Allosteric interactions between scorpion toxin receptor sites on voltage-gated Na channels imply a novel role for weakly active components in arthropod venom.

• Cohen, L.; Lipstein, N.; Gordon, D.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006