List of Publications

2025

Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T, Sun S, Birke R, Ilic D, Brose N, Hörnberg H, Lehmann M, Rizzoli SO, Broichhagen J, Lipstein N
JACS Au DOI: 10.1021/jacsau.4c00946 (2025)
Endogenous SNAP-Tagging of Munc13-1 for Monitoring Synapse Nanoarchitecture
Link to the article

Lohse M, Sun S, Fiosins M, Bonn S, Zamorano P, Jahn O, Lipstein N
Methods Mol Biol. 2910, 105-125, DOI: 10.1007/978-1-0716-4446-1_7 (2025)
Investigating the Molecuar Composition of Neuronal Subcompartments Using Proximity Labeling
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Hentsch A, Guberman M., Radetzki S, Kaushik S, Huizenga M, He Y, Contzen J, Kuhn B, Benz J, Schippers M, Paul J,  Leibrock L, Collin L, Wittwer M, Topp A, O'Hara F, Heer D, Hochstrasser R, Blaising J, von Kries JP, Mu L, van der Stelt M, Mergenthaler P, Lipstein N, Grether U, Nazaré M
J Am Chem Soc. 147(12), 10188-10202, DOI: 10.1021/jacs.4c15233 (2025)
Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research
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Feuermann M, Mi H, Gaudet P, Muruganujan A, Lewis SE, Ebert D, Mushayahama T, Gene Ontology Consortium, Thomas PD
Nature 640(8057), 146-154, DOI: 10.1038/s41586-025-08592-0
A compendium of human gene functions derived from evolutionary modelling
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Hentsch A, Guberman M., Radetzki S, Kaushik S, Huizenga M, Paul J, Schippers M, Benz J, Kuhn B, Heer D, Topp A, Esteves Gloria L, Walter A, Hochstrasser R, Wittwer MB, von Kries JP, Collin L, Blaising J, van der Stelt M, Lipstein N, Grether U, Nazaré M
Angew. Chem. Int. Ed. 64(10):e202413405, DOI: 10.1002/anie.202413405 (2025)
A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase
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Lin K-H, Ranjan M, Lipstein N, Brose N, Neher E, Taschenberger H
J Physiol. DOI: 10.1113/JP286282 (2025)
Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity
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Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, Ma D., Xie Y
Theranostics 15(5), 1842-1863, DOI: 10.7150/thno.104282 (2025)
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula
Link to the article

2024

Lopez-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H
Proc Natl Acad Sci USA 121, e2320505121. DOI: 10.1073/pnas.2320505121 (2024)
Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion<
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Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D'Este E, Fauth M, Fernandez-Busnadiego R, Fiosins M, Fischer A, et al.
J Physiol. DOI: 10.1113/JP286400 (2024)
The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function.
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Zhang XM, François U, Angelo MF, Claverol S, Mondin M, Martin C, Deshors M, Humeau Y, Lipstein N, Herzog E
bioRxiv, Pages 2024.09. 23.614439 (2024)
A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2 knock-down new mouse model
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Rossmann K, Sun S, Holmboe Olesen C, Kowald M, Tapp E, Pabst U, Bieck M, Birke R, Shields BC, Jeong P, Hong J, Tadross MR, Levitz J, Lehmann M, Lipstein N, Broichhagen J
bioRxiv, Pages 2024.09.20.614087 (2024)
A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging
Link to the article

2023

Eshra A, Lipstein N, Hallermann S
bioRxiv, Pages 2023.12. 17.571741 (2023)
Ketamine potentiates a central glutamatergic presynapse
Link to the article

2022

Houy S, Martins JS, Lipstein N, Sorensen JB
Elife 11, DOI: 10.7554/eLife.79433 (2022)
Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion.
Link to the article

Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, et al.
Nature 10.1038/s41586-022-04434-5. (2022)
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Link to the article

Lipstein N
Nature 603, 33-34. 10.1038/d41586-022-00383-1 (2022)
Mechanism underlying a risk gene in neurodegeneration.
Link to the article

2021

Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen RL, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS
Neuron 110: 248-265 e249 DOI 10.1016/j.neuron.2021.10.028 (2022)
Molecular and functional architecture of striatal dopamine release sites.
Link to the article

Lipstein N, Chang S, Lin KH, Lopez-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron 109: 3980-4000 e3987 DOI 10.1016/j.neuron.2021.09.054 (2021)
Munc13-1 is a Ca(2+)-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Link to the article

2020

Piotrowski C, Moretti R, Ihling CH, Haedicke A, Liepold T, Lipstein N, Meiler J, Jahn O, and Sinz A 
Cells 9, doi:10.3390/cells9010136 (2020)
Delineating the Molecular Basis of the Calmodulin-bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2.
Link to the article

2019

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M
Neuron 103, 217-234 e214, doi:10.1016/j.neuron.2019.05.002 (2019)
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
Link to the article

2018

Ritzau-Jost A, Jablonski L, Viotti J, Lipstein N, Eilers J, Hallermann S
J Physiol 596, 4693-4707, doi:10.1113/JP275911 (2018)
Apparent calcium dependence of vesicle recruitment.
Link to the article

2017

Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N
J Clin Invest 127, 1005-1018, doi:10.1172/JCI90259 (2017)
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
Link to the article

2016

Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D
Nat Chem Biol 12, 755-762, doi:10.1038/nchembio.2141 (2016)
Photoswitchable diacylglycerols enable optical control of protein kinase C.
Link to the article

Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M
Elife 5, doi:10.7554/eLife.14643 (2016)
Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.
Link to the article

2013

Dolev I, Fogel H, Milshtein H, Berdichevsky Y, Lipstein N, Brose N, Gazit N, Slutsky I
Nat Neurosci 16, 587-595, doi:10.1038/nn.3376 (2013)
Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change.
Link to the article

Lipstein N, Sakaba T, Cooper BH, Lin KH, Strenzke N, Ashery U, Rhee JS, Taschenberger H, Neher E, Brose N. 
Neuron 79, 82-96, doi:10.1016/j.neuron.2013.05.011 (2013)
Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.
Link to the article

2012

Cooper B, Hemmerlein M, Ammermuller J, Imig C, Reim K, Lipstein N, Kalla S, Kawabe H, Brose N, Brandstatter JH, Varoqueaux F
J Neurosci 32, 8040-8052, doi:10.1523/JNEUROSCI.4240-11.2012 (2012)
Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.
Link to the article

Lipstein N, Schaks S, Dimova K, Kalkhof S, Ihling C, Kolbel K, Ashery U, Rhee J, Brose N, Sinz A, Jahn O
Mol Cell Biol 32, 4628-4641, doi:10.1128/MCB.00933-12 (2012)
Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.
Link to the article

Orenbuch A, Shulman Y, Lipstein N, Bechar A, Lavy Y, Brumer E, Vasileva M, Kahn J, Barki-Harrington L, Kuner T, Gitler D
J Neurochem 120, 248-258, doi:10.1111/j.1471-4159.2011.07579.x (2012)
Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.
Link to the article

2010

Rodriguez-Castaneda F, Maestre-Martinez M, Coudevylle N, Dimova K, Junge H, Lipstein N, Lee D, Becker S, Brose N, Jahn O, Carlomagno T, Griesinger C. et al.
EMBO J 29, 680-691, doi:10.1038/emboj.2009.373 (2010)
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity.
Link to the article

2008

Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M
J Biol Chem 283, 15169-15176, doi:10.1074/jbc.M801229200 (2008)
Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated sodium channels.
Link to the article

2007

Yizhar O, Lipstein N, Gladycheva SE, Matti U, Ernst SA, Rettig J, Stuenkel EL, Ashery U
J Neurochem 103, 604-616, doi:10.1111/j.1471-4159.2007.04791.x (2007)
Multiple functional domains are involved in tomosyn regulation of exocytosis.
Link to the article

2006

Cohen L, Lipstein N, Gordon D
FASEB J 20, 1933-1935, doi:10.1096/fj.05-5545fje (2006)
Allosteric interactions between scorpion toxin receptor sites on voltage-gated Na channels imply a novel role for weakly active components in arthropod venom.
Link to the article

Reviews

2018

Cortes-Saladelafont E, Lipstein N, Garcia-Cazorla A
J Inherit Metab Dis 41, 1131-1145, doi:10.1007/s10545-018-0230-z (2018)
Presynaptic disorders: a clinical and pathophysiological approach focused on the synaptic vesicle.
Link to the article

2017

Lipstein N, Goth M, Piotrowski C, Pagel K, Sinz A, Jahn O
Expert Rev Proteomics 14, 223-242, doi:10.1080/14789450.2017.1275966 (2017)
Presynaptic Calmodulin targets: lessons from structural proteomics.
Link to the article

2014

Herbst S, Lipstein N, Jahn O & Sinz A
Biol Chem 395, 763-768, doi:10.1515/hsz-2014-0134 (2014)
Structural insights into calmodulin/Munc13 interaction.
Link to the article