Portrait

Dr.

Marc Nazaré

Head Nazaré Group

 +49 30 94793 581

+49 30 94063 084

 nazare@fmp-berlin.de

0000-0002-1602-2330

Marc Nazare studied chemistry at the University of Karlsruhe and obtained his PhD in organic chemistry with Herbert Waldmann in the field of natural product total synthesis in 1999. He then joined pharmaceutical industry at Sanofi in Frankfurt as a medicinal chemist. In 2013, Dr. Nazaré started a medicinal chemistry group at the Leibniz Research Institute for Molecular Pharmacology FMP. His current research interests are focused on the design and optimization of chemical probes and imaging tools for chemical biology and translational applications.

Chemical Biology


Nazaré Group


FMP

Publications

Publications

of 9

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

  • Alsalim, R.
  • Lindemann, P.
  • Lopez-Alberca, M. P.
  • Miksche, S.
  • Czechtizky, W.
  • Halland, N., &
  • Nazare, M.

Organic Letters 2020, 22, 7393-7396

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An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

  • Brennecke, B.
  • Wang, Q.
  • Zhang, Q.
  • Hu, H. Y., &
  • Nazare, M.

Angewandte Chemie-International Edition 2020, 59, 8512-8516

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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

  • Barone, M.
  • Müller, M.
  • Chiha, S.
  • Ren, J.
  • Albat, D.
  • Soicke, A.
  • Dohmen, S.
  • Klein, M.
  • Bruns, J.
  • Dinther, M.
  • Opitz, R.
  • Lindemann, P.
  • Beerbaum, M.
  • Motzny, K.
  • Roske, Y.
  • Schmieder, P.
  • Volkmer, R.
  • Nazare, M.
  • Heinemann, U.
  • Oschkinat, H.
  • Ten Dijke, P.
  • Schmalz, H. G., &
  • Kühne, R.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690

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Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

  • Sarott, R. C.
  • Westphal, M. V.
  • Pfaff, P.
  • Korn, C.
  • Sykes, D. A.
  • Gazzi, T.
  • Brennecke, B.
  • Atz, K.
  • Weise, M.
  • Mostinski, Y.
  • Hompluem, P.
  • Koers, E.
  • Miljus, T.
  • Roth, N. J.
  • Asmelash, H.
  • Vong, M. C.
  • Piovesan, J.
  • Guba, W.
  • Rufer, A. C.
  • Kusznir, E. A.
  • Huber, S.
  • Raposo, C.
  • Zirwes, E. A.
  • Osterwald, A.
  • Pavlovic, A.
  • Moes, S.
  • Beck, J.
  • Benito-Cuesta, I.
  • Grande, T.
  • Esteban, S. R. D.
  • Yeliseev, A.
  • Drawnel, F.
  • Widmer, G.
  • Holzer, D.
  • Wel, T.
  • Mandhair, H.
  • Yuan, C. Y.
  • Drobyski, W. R.
  • Saroz, Y.
  • Grimsey, N.
  • Honer, M.
  • Fingerle, J.
  • Gawrisch, K.
  • Romero, J.
  • Hillard, C. J.
  • Varga, Z. V.
  • Stelt, M.
  • Pacher, P.
  • Gertsch, J.
  • McCormick, P. J.
  • Ullmer, C.
  • Oddi, S.
  • Maccarrone, M.
  • Veprintsev, D. B.
  • Nazare, M.
  • Grether, U., &
  • Carreira, E. M.

Journal of the American Chemical Society 2020, 142, 16953-16964

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Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues

  • Xu, S. N.
  • Zhang, Q. Y.
  • Han, X. W.
  • Wang, Y. L.
  • Wang, X.
  • Nazare, M.
  • Jiang, J. D., &
  • Hu, H. Y.

ACS Sensors 2020, 5, 1650-1656

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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

  • Mostinski, Y.
  • Heynen, G.
  • Lopez-Alberca, M. P.
  • Paul, J.
  • Miksche, S.
  • Radetzki, S.
  • Schaller, D.
  • Shanina, E.
  • Seyffarth, C.
  • Kolomeets, Y.
  • Ziebart, N.
  • Schryver, J.
  • Oestreich, S.
  • Neuenschwander, M.
  • Roske, Y.
  • Heinemann, U.
  • Rademacher, C.
  • Volkamer, A.
  • Kries, J. P.
  • Birchmeier, W., &
  • Nazare, M.

Journal of Medicinal Chemistry 2020, 63, 14780-14804

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NMR quality control of fragment libraries for screening

  • Sreeramulu, S.
  • Richter, C.
  • Kuehn, T.
  • Azzaoui, K.
  • Blommers, M. J. J.
  • Del Conte, R.
  • Fragai, M.
  • Trieloff, N.
  • Schmieder, P.
  • Nazare, M.
  • Specker, E.
  • Ivanov, V.
  • Oschkinat, H.
  • Banci, L., &
  • Schwalbe, H.

Journal of Biomolecular NMR 2020, 74, 555-563

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Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

  • Waaler, J.
  • Leenders, R. G. G.
  • Sowa, S. T.
  • Brinch, S. A.
  • Lycke, M.
  • Nieczypor, P.
  • Aertssen, S.
  • Murthy, S.
  • Galera-Prat, A.
  • Damen, E.
  • Wegert, A.
  • Nazare, M.
  • Lehtio, L., &
  • Krauss, S.

Journal of Medicinal Chemistry 2020, 63, 6834-6846

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Revealing cytotoxic substructures in molecules using deep learning

  • Webel, H. E.
  • Kimber, T. B.
  • Radetzki, S.
  • Neuenschwander, M.
  • Nazare, M., &
  • Volkamer, A.

Journal of Computer-Aided Molecular Design 2020, 34, 731-746

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Publications

of 6

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

  • Marcinkowski, P.
  • Hoyer, I.
  • Specker, E.
  • Furkert, J.
  • Rutz, C.
  • Neuenschwander, M.
  • Sobottka, S.
  • Sun, H.
  • Nazare, M.
  • Berchner-Pfannschmidt, U.
  • Von Kries, J. P.
  • Eckstein, A.
  • Schülein, R., &
  • Krause, G.

Thyroid 2019, 29, 111-123

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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

  • Schewe, M.
  • Sun, H.
  • Mert, U.
  • Mackenzie, A.
  • Pike, A. C. W.
  • Schulz, F.
  • Constantin, C.
  • Vowinkel, K. S.
  • Conrad, L. J.
  • Kiper, A. K.
  • Gonzalez, W.
  • Musinszki, M.
  • Tegtmeier, M.
  • Pryde, D. C.
  • Belabed, H.
  • Nazare, M.
  • Groot, B. L.
  • Decher, N.
  • Fakler, B.
  • Carpenter, E. P.
  • Tucker, S. J., &
  • Baukrowitz, T.

Science 2019, 363, 875-880

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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

  • Brennecke, P.
  • Rasina, D.
  • Aubi, O.
  • Herzog, K.
  • Landskron, J.
  • Cautain, B.
  • Vicente, F.
  • Quintana, J.
  • Mestres, J.
  • Stechmann, B.
  • Ellinger, B.
  • Brea, J.
  • Kolanowski, J. L.
  • Pilarski, R.
  • Orzaez, M.
  • Pineda-Lucena, A.
  • Laraia, L.
  • Nami, F.
  • Zielenkiewicz, P.
  • Paruch, K.
  • Hansen, E.
  • Kries, J. P.
  • Neuenschwander, M.
  • Specker, E.
  • Bartunek, P.
  • Simova, S.
  • Lesnikowski, Z.
  • Krauss, S.
  • Lehtio, L.
  • Bilitewski, U.
  • Bronstrup, M.
  • Tasken, K.
  • Jirgensons, A.
  • Lickert, H.
  • Clausen, M. H.
  • Andersen, J. H.
  • Vicent, M. J.
  • Genilloud, O.
  • Martinez, A.
  • Nazare, M.
  • Fecke, W., &
  • Gribbon, P.

Slas Discovery 2019, 24, 398-413

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Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

  • Schoene, J.
  • Gazzi, T.
  • Lindemann, P.
  • Christmann, M.
  • Volkamer, A., &
  • Nazare, M.

ChemMedChem 2019, 14, 1514-1527

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Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

  • Zhang, Q. Y.
  • Xu, S. N.
  • Lai, F. F.
  • Wang, Y. L.
  • Zhang, N.
  • Nazare, M., &
  • Hu, H. Y.

Organic Letters 2019, 21, 2121-2125

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Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

  • Plastira, I.
  • Joshi, L.
  • Bernhart, E.
  • Schoene, J.
  • Specker, E.
  • Nazare, M., &
  • Sattler, W.

Frontiers in Cellular Neuroscience 2019, 13, 531

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