„”
To comprehensively understand the protein interactome, our group is developing XL-MS methods to characterize the structures and interactions of proteins within their native environments in a high-throughput manner.
Our proteome-wide XL-MS approaches allows us to characterize highly complex samples and simultaneously investigate stable and dynamic protein assemblies by capturing their residue-residue connectivities in vivo. We aim to enhance the power and scope of this technique by designing novel cross-linkers, implementing creative approaches for cross-link enrichment, developing a cutting-edge data analysis tools, and applying state-of-the-art MS technology. We integrate expertise from synthetic chemistry, analytical chemistry, mass spectrometry and informatics to advance the analytical depth, information content and precision of interactome profiling.
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
