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Besides known adhesins, more proteins with unknown function and a validated role in colorectal cancer development were identified in commensals. The underlying mechanisms are entirely unknown, i.e. if the proteins mediate cell or extracellular matrix adhesion or activate a signaling pathway, such as Wnt/b-catenin or TLR signaling. Therefore, we apply genomic screenings (e.g. CRISPR-Cas9) and biochemical screening methods to identify the cellular receptors of these proteins with unknown function.
After confirming protein-protein interactions between CRC-driving commensal factors and human epithelial receptors, we will determine the complex structures to understand the underlying molecular mechanisms and facilitate drug development.
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
