Katina Lazarow / Martin Neuenschwander

Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation.

• Renikunta HV; Lazarow K; Gong Y; Shukla PC; Nageswaran V; Giral H; Kratzer A; Opitz L; Engel FB; Haghikia A; Costantino S; Paneni F; von Kries JP; Streckfuss-Bömeke K; Landmesser U; Jakob P

iScience 2023

7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

• Brenner, M.; Zink, C.; Witzinger, L.; Keller, A.; Hadamek, K.; Bothe, S.; Neuenschwander, M.; Villmann, C.; von Kries, J.P.; Schindelin, H.; Jeanclos, E.; Gohla, A.

bioRxiv 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Aguirre, T.; Dornan, G.L.; Hostachy, S.; Neuenschwander, M.; Seyffarth, C.; Haucke, V.; Schütz, A.; von Kries, J.P.; Fiedler, D.

eLife 2023

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

• Kücükdisli, M.; Bel-Abed, H.; Cirillo, D.; Lo, W.-T.; Efrém, N.-L.; Horatscheck, A.; Perepelittchenko, L.; Prokofeva, P.; Ehret, T.A.L.; Radetzki, S.; Neuenschwander, M.; Specker, E.; Médard, G.; Müller, S.; Wilhelm, S.; Kuster, B.; Von Kries, J.P.; Haucke, V.; Nazaré, M.

Journal of Medicinal Chemistry 2023

Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase

• Gorenflos López, J.L.; Dornan, G.L.; Boback, N.; Neuenschwander, M.; Oder, A.; Kemnitz-Hassanin, K.; Schmieder, P.; Specker, E.; Asikoglu, H.C.; Oberdanner, C.; Seyffarth, C.; von Kries, J.P.; Lauster, D.; Hinderlich, S.; Hackenberger, C.P.R.

ChemBioChem 2023

The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions

• Ahmed, S.M.; Ragunathan, P.; Shin, J.; Peter, S.; Kleissle, S.; Neuenschwander, M.; Schäfer, R.; Kries, J.P.V.; Grüber, G.; Dröge, P.

FEBS Letters 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

• Lo, W.-T.; Belabed, H.; Kücükdisli, M.; Metag, J.; Roske, Y.; Prokofeva, P.; Ohashi, Y.; Horatscheck, A.; Cirillo, D.; Krauss, M.; Schmied, C.; Neuenschwander, M.; von Kries, J.P.; Médard, G.; Kuster, B.; Perisic, O.; Williams, R.L.; Daumke, O.; Payrastre, B.; Severin, S.; Nazaré, M.; Haucke, V.

Nature Chemical Biology 2023

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors

• Mucka, P.; Lindemann, P.; Bosco, B.; Willenbrock, M.; Radetzki, S.; Neuenschwander, M.; Brischetto, C.; Peter von Kries, J.; Nazaré, M.; Scheidereit, C.

Cell Chemical Biology 2023

Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

• Jordan, P.; Costa, A.; Specker, E.; Popp, O.; Volkamer, A.; Piske, R.; Obrusnik, T.; Kleissle, S.; Stuke, K.; Rex, A.; Neuenschwander, M.; von Kries, J.P.; Nazare, M.; Mertins, P.; Kettenmann, H.; Wolf, S.A.

PLoS ONE 2023

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.

• Tufan AB; Lazarow K; Kolesnichenko M; Sporbert A; von Kries JP; Scheidereit C

The EMBO journal 2022

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

• Specker, E.; Matthes, S.; Wesolowski, R.; Schütz, A.; Grohmann, M.; Alenina, N.; Pleimes, D.; Mallow, K.; Neuenschwander, M.; Gogolin, A.; Weise, M.; Pfeifer, J.; Ziebart, N.; Heinemann, U.; Von Kries, J.P.; Nazaré, M.; Bader, M.

Journal of Medicinal Chemistry 2022

AML-377 A “Designed” High-Throughput Drug Screening Strategy Identifies Aurora Kinase A Inhibitors as Promising Preclinical Candidates for the Treatment of NPM1-Mutated AML

• Ranieri, R.; Neuenschwander, M.; Kleissle, S.; Mezzasoma, F.; Silvestri, S.; Ferrari, A.; Pierangeli, S.; Donnini, S.; Milano, F.; Sabino, M.; Tini, V.; Spinozzi, G.; Falini, B.; Kries, J.P.V.; Gionfriddo, I.; Martelli, M.P.

Clinical Lymphoma, Myeloma and Leukemia 2022

Disruptors of AKAP-Dependent Protein–Protein Interactions

• Walker-Gray, R.; Pallien, T.; Miller, D.C.; Oder, A.; Neuenschwander, M.; von Kries, J.P.; Diecke, S.; Klussmann, E.

Methods in Molecular Biology 2022

Glycolytic flux control by drugging phosphoglycolate phosphatase

• Jeanclos, E.; Schlötzer, J.; Hadamek, K.; Yuan-Chen, N.; Alwahsh, M.; Hollmann, R.; Fratz, S.; Yesilyurt-Gerhards, D.; Frankenbach, T.; Engelmann, D.; Keller, A.; Kaestner, A.; Schmitz, W.; Neuenschwander, M.; Hergenröder, R.; Sotriffer, C.; von Kries, J.P.; Schindelin, H.; Gohla, A.

Nature Communications 2022

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.

• Dema A; Faust D; Lazarow K; Wippich M; Neuenschwander M; Zühlke K; Geelhaar A; Pallien T; Hallscheidt E; Eichhorst J; Wiesner B; Černecká H; Popp O; Mertins P; Dittmar G; von Kries JP; Klussmann E

Cells 2020

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

• Mostinski, Y.; Heynen, G.J.J.E.; López-Alberca, M.P.; Paul, J.; Miksche, S.; Radetzki, S.; Schaller, D.; Shanina, E.; Seyffarth, C.; Kolomeets, Y.; Ziebart, N.; De Schryver, J.; Oestreich, S.; Neuenschwander, M.; Roske, Y.; Heinemann, U.; Rademacher, C.; Volkamer, A.; Von Kries, J.P.; Birchmeier, W.; Nazaré, M.

Journal of Medicinal Chemistry 2020

Revealing cytotoxic substructures in molecules using deep learning

• Webel, H.E.; Kimber, T.B.; Radetzki, S.; Neuenschwander, M.; Nazaré, M.; Volkamer, A.

Journal of Computer-Aided Molecular Design 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP

• Dema, A.; Faust, D.; Lazarow, K.; Wippich, M.; Neuenschwander, M.; Zühlke, K.; Geelhaar, A.; Pallien, T.; Hallscheidt, E.; Eichhorst, J.; Wiesner, B.; Černecká, H.; Popp, O.; Mertins, P.; Dittmar, G.; von Kries, J.P.; Klussmann, E.

Cells 2020

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.

• Ullrich F; Blin S; Lazarow K; Daubitz T; von Kries JP; Jentsch TJ

eLife 2019

Regulation of influenza a virus mRNA splicing by CLK1

• Artarini, A.; Meyer, M.; Shin, Y.J.; Huber, K.; Hilz, N.; Bracher, F.; Eros, D.; Orfi, L.; Keri, G.; Goedert, S.; Neuenschwander, M.; von Kries, J.; Domovich-Eisenberg, Y.; Dekel, N.; Szabadkai, I.; Lebendiker, M.; Horváth, Z.; Danieli, T.; Livnah, O.; Moncorgé, O.; Frise, R.; Barclay, W.; Meyer, T.F.; Karlas, A.

Antiviral Research 2019

A new highly thyrotropin receptor-selective small-molecule antagonist with potential for the treatment of graves' orbitopathy

• Marcinkowski, P.; Hoyer, I.; Specker, E.; Furkert, J.; Rutz, C.; Neuenschwander, M.; Sobottka, S.; Sun, H.; Nazare, M.; Berchner-Pfannschmidt, U.; Von Kries, J.P.; Eckstein, A.; Schülein, R.; Krause, G.

Thyroid 2019

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

• Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J.; Kolanowski, J.L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; von Kries, J.P.; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Leśnikowski, Z.; Krauss, S.; Lehtiö, L.; Bilitewski, U.; Brönstrup, M.; Taskén, K.; Jirgensons, A.; Lickert, H.; Clausen, M.H.; Andersen, J.H.; Vicent, M.J.; Genilloud, O.; Martinez, A.; Nazaré, M.; Fecke, W.; Gribbon, P.

SLAS Discovery 2019

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

• Liss, M.; Radke, M.H.; Eckhard, J.; Neuenschwander, M.; Dauksaite, V.; Von Kries, J.-P.; Gotthardt, M.

PLoS ONE 2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/ translocation pathway

• Klein, W.; Rutz, C.; Eckhard, J.; Provinciael, B.; Specker, E.; Neuenschwander, M.; Kleinau, G.; Scheerer, P.; Von Kries, J.-P.; Nazaré, M.; Vermeire, K.; Schülein, R.

PLoS ONE 2018

Loss-of-function uORF mutations in human malignancies

• Schulz, J.; Mah, N.; Neuenschwander, M.; Kischka, T.; Ratei, R.; Schlag, P.M.; Castaños-Vélez, E.; Fichtner, I.; Tunn, P.-U.; Denkert, C.; Klaas, O.; Berdel, W.E.; Von Kries, J.P.; Makalowski, W.; Andrade-Navarro, M.A.; Leutz, A.; Wethmar, K.

Scientific Reports 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

• Schrade, K.; Tröger, J.; Eldahshan, A.; Zühlke, K.; Abdul Azeez, K.R.; Elkins, J.M.; Neuenschwander, M.; Oder, A.; Elkewedi, M.; Jaksch, S.; Andrae, K.; Li, J.; Fernandes, J.; Müller, P.M.; Grunwald, S.; Marino, S.F.; Vukićević, T.; Eichhorst, J.; Wiesner, B.; Weber, M.; Kapiloff, M.; Rocks, O.; Daumke, O.; Wieland, T.; Knapp, S.; Von Kries, J.P.; Klussmann, E.

PLoS ONE 2018

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

• Otten, C.; Knox, J.; Boulday, G.; Eymery, M.; Haniszewski, M.; Neuenschwander, M.; Radetzki, S.; Vogt, I.; Hähn, K.; De Luca, C.; Cardoso, C.; Hamad, S.; Igual Gil, C.; Roy, P.; Albiges-Rizo, C.; Faurobert, E.; von Kries, J.P.; Campillos, M.; Tournier-Lasserve, E.; Derry, W.B.; Abdelilah-Seyfried, S.

EMBO Molecular Medicine 2018

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.

• Zhou MB; Hu H; Miskey C; Lazarow K; Ivics Z; Kunze R; Yang G; Izsvák Z; Tang DQ

Molecular phylogenetics and evolution 2017

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

• Anumala UR; Waaler J; Nkizinkiko Y; Ignatev A; Lazarow K; Lindemann P; Olsen PA; Murthy S; Obaji E; Majouga AG; Leonov S; von Kries JP; Lehtiö L; Krauss S; Nazaré M

Journal of medicinal chemistry 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

• Wetzel, C.; Pifferi, S.; Picci, C.; Gök, C.; Hoffmann, D.; Bali, K.K.; Lampe, A.; Lapatsina, L.; Fleischer, R.; Smith, E.S.J.; Bégay, V.; Moroni, M.; Estebanez, L.; Kühnemund, J.; Walcher, J.; Specker, E.; Neuenschwander, M.; Von Kries, J.P.; Haucke, V.; Kuner, R.; Poulet, J.F.A.; Schmoranzer, J.; Poole, K.; Lewin, G.R.

Nature Neuroscience 2017

Small Molecules Targeting Human N-Acetylmannosamine Kinase

• Hinderlich, S.; Neuenschwander, M.; Wratil, P.R.; Oder, A.; Lisurek, M.; Nguyen, L.D.; von Kries, J.P.; Hackenberger, C.P.R.

ChemBioChem 2017

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

• Carter, D.M.; Specker, E.; Przygodda, J.; Neuenschwander, M.; von Kries, J.P.; Heinemann, U.; Nazaré, M.; Gohlke, U.

SLAS Discovery 2017

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus

• Fetzer, C.; Korotkov, V.S.; Thänert, R.; Lee, K.M.; Neuenschwander, M.; von Kries, J.P.; Medina, E.; Sieber, S.A.

Angewandte Chemie - International Edition 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

• Juneja, M.; Kobelt, D.; Walther, W.; Voss, C.; Smith, J.; Specker, E.; Neuenschwander, M.; Gohlke, B.-O.; Dahlmann, M.; Radetzki, S.; Preissner, R.; von Kries, J.P.; Schlag, P.M.; Stein, U.

PLoS Biology 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

• Du, J.; Neuenschwander, M.; Yu, Y.; Däbritz, J.H.M.; Neuendorff, N.-R.; Schleich, K.; Bittner, A.; Milanovic, M.; Beuster, G.; Radetzki, S.; Specker, E.; Reimann, M.; Rosenbauer, F.; Mathas, S.; Lohneis, P.; Hummel, M.; Dörken, B.; Von Kries, J.P.; Lee, S.; Schmitt, C.A.

Blood 2017