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Beyond our research on membrane transport mechanisms focusing on ion channels, we have expanded our investigations to include substrate transport and antibiotic drug delivery mechanisms. Limiting antibiotics influx into bacterial cells is a major resistance strategy employed by various Gram-negative bacteria. Our current studies aim to simulate antibiotic transport through porins located in the outer membrane of gram-negative bacterial cells using large-scale enhanced sampling MD techniques.
Additionally, another focus of our research is to enhance the atomistic understanding of the penetrating mechanisms of cell-permeable peptides. These peptides, in particular, have gained increasing attention due to their ability to traverse the cell membrane, making them valuable delivery systems. However, the atomistic mechanism by which certain cyclic permeable peptides traverse the cell membrane remains largely unknown. We aim to combine anisotropic NMR and computational simulations to study the conformational dynamics of these peptides in both aqueous and membrane-mimicking environments. These projects are supported by a DFG funding within the Graduate School “SynPepBio”.
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
