Publications 2016-2020



A. Hauser, S. Hwang, H. Sun, C.P.R. Hackenberger

Chem.Sci. 2020, 11, 12655-12661
Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
Link to the article

C.P.R. Hackenberger, P.E. Dawson, Y.X. Chen, H. Hojo

J. Org. Chem. 2020, 85, 1328-1330
Modern Peptide and Protein Chemistry: Reaching New Heights
Link to the article

T. Zhaoxu, I.S. Donskyi, H. Qiao, Z. Zhu, W.E.S. Unger,  C.P.R. Hackenberger, W. Chen, M. Adeli, R. Haag

Adv. Funct. Mater. 2020, 30, 2000933
Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance
Link to the article

A.L. Baumann, S. Schwagerus, K. Broi, K. Kemnitz-Hassanin, C.E. Stieger, N. Trieloff, P. Schmieder, C.P.R. Hackenberger

JACS 2020, 142(20), 9544-9552
Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations
Link to the article

highlighted in: Synfacts 2020, 16(07), 0851, DOI: 10.1055/s-0040-1707878
Link to the article

P. Ochtrop, C.P.R. Hackenberger

Curr. Op. in Chem. Biology 2020, 58, 28-36
Recent advances of thiol-selective bioconjugation reactions (review)
Link to the article

D. Lauster, S. Klenk, K. Ludwig, S. Nojoumi, S. Behren, L. Adam, M. Stadtmüller, S. Saenger, S. Franz, K. Hönzke, L. Yao, U. Hoffmann, M. Bardua, A. Hamann, M. Witzenrath, L.E. Sander, T. Wolff, A.C. Hocke, S. Hippenstiel, S. DeCarlo, J. Neudecker, K. Osterrieder, N. Budisa, R.R. Netz, C. Böttcher, S. Liese, A. Herrmann, C.P.R. Hackenberger

Nature Nanotechnology 2020, 15, 373-379
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Link to the article

highlighted in: ChemBioChem 2020, 22(3), 478-480
Link to the article

M.-A. Kasper, M. Gerlach, A.F.L. Schneider, C. Groneberg, P. Ochtrop, S. Boldt, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C.P.R. Hackenberger

ChemBioChem 2020, 21, 113-119
N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
Link to the article


C. Apel, M.-A. Kasper, C.E. Stieger, C.P.R. Hackenberger, M. Christmann

Org. Lett. 2019, 21(24), 10043-10047
Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
Link to the article

highlighted in: Synfacts 2020, 16(04), 0465
Protein Modification by Cope Rearrangement

A.L. Baumann, C.P.R. Hackenberger

Curr. Opin. Chem. Biol. 2019, 52, 39-46
Tag and release: strategies for the intracellular cleavage of protein conjugates (Review)
Link to the article

M.-A. Kasper, M. Glanz, A. Oder, P. Schmieder, J.P. von Kries, C.P.R. Hackenberger

Chem Sci. 2019, 10, 6322-6329
Vinylphosphonites for Staudinger-induced chemoselective peptide cyclizaton and functionalization

Dedicated to Prof. Ron Raines on the occasion of his 60th birthday
Link to the article

M.-A. Kasper, A. Stengl, P. Ochtrop, M. Gerlach, T. Stoschek, D. Schumacher, J. Helma, M. Penkert, E. Krause, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2019, 58(34), 11631-11636
Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates
Link to the article

Angew. Chem. 2019, 131(34), 11757-11762
Link to the article

Dedicated to Prof. Sam Gellman on the occasion of his 60th birthday

highlighted in: ADC review 2019 (July)
New Reagents for the Rapid Generation of Efficacious Antibody-Drug Conjugates

highlighted in: Synfacts 2019, 15(10), 1189
Ethynylphosphonamidates in the Synthesis of Antibody–Drug Conjugates

M.-A. Kasper, M. Glanz, A. Stengl, M. Penkert, S. Klenk, T. Sauer, D. Schumacher, J. Helma, E. Krause, C. Cardoso, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2019, 58(34), 11625-11630
Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations
Link to the article

Angew. Chem. 2019, 131(34), 11751-11756
Cysteinselektive phosphonamidatbasierte Elektrophile für modulare Biokonjugationen
Link to the article

Dedicated to Prof. Hans-Ulrich Reißig on the occasion of his 70th birthday

highlighted in: Synfacts 2019, 15(05), 0561
Ethynylphosphonamidate-Cysteine Bioconjugation

M. Penkert, A. Hauser, R. Harmel, D. Fiedler, C.P.R. Hackenberger, E. Krause

J. Am. Soc. Mass Spectrom. 2019, 30(9), 1578-1585
Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identificaton of Labile Protein Phosphorylations
Link to the article

S. Nojoumi, Y. Ma, A. Oder, S. Schwagerus, C.P.R. Hackenberger, N. Budisa

Int. J. Mol. Sci. 2019, 20(9), 2299
In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocycteine and Its Coupling with Reprogrammed Translation
Link to the article

A. Stengl, M. Gerlach, M.-A. Kasper, C.P.R. Hackenberger, H. Leonhardt, D. Schumacher, J. Helma

OBC 2019, 17, 4964-4969
TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles
Link to the article

A.F.L. Schneider, A.L.D. Wallabregue, L. Franz, C.P.R. Hackenberger

Bioconjugate Chem. 2019, 30(2), 400-404
Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides
Link to the article


A. Baumann, C.P.R. Hackenberger

CHIMIA 2018, 72(11), 802-808
Modern Ligations Methods to Access Natural and Modified Proteins
Link to the article

D. Schumacher, J. Helma, A.F.L. Schneider, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2018, 57, 2314-2333
Chemical Functionalization Strategies and Intracellular Applications
Link to the article

Angew. Chem. 2018, 130, 2336-2357
Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen
Link to the article

K.D. Siebertz, C.P.R. Hackenberger

Chem. Comm. 2018, 54, 763-766
Chemoselective triazole-phosphonamidate conjugates suitable for photo-release
Link to the article


H.D. Herce, D. Schumacher, A.F.L. Schneider, A.K. Ludwig, F.A. Mann, M. Fillies, M.-A. Kasper, S. Reinke, E. Krause, H. Leonhardt, M.C. Cardoso, C.P.R. Hackenberger

Nature Chemistry 2017, 9, 762-771
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells
Link to the article
Link to supplementary movie

highlighted in: Nature Chemistry 2017, 9, 727-728
Cytosolic delivery - Just passing through

highlighted in: c&en 2017, 95(30), 8-9
Drug Delivery -Two new ways to get proteins into cells

highlighted in: ChemBioChem 2017, 18(22), 2196-2198
Dodging Endosomes: Effective Cytosolic Antibody Delivery

A. Hauser, M. Penkert, C.P.R. Hackenberger

Acc. Chem. Res. 2017, 50(8), 1883-1893
Chemical Approaches to Investigate Labile Peptide and Protein Phosphorylation
Link to the article

D. Schumacher, O. Lemke, J. Helma, L. Gerszonowicz, V. Waller, T. Stoschek, P.M. Durkin, N. Budisa, H. Leonhardt, B.G. Keller, C.P.R. Hackenberger

Chemical Science 2017, 8, 3471-3478
Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling
Link to the article

D. Lauster, M. Glanz, M. Bardua, K. Ludwig, M. Hellmund, U. Hoffmann, A. Hamann, C. Böttcher, R. Haag, C.P.R. Hackenberger, A. Herrmann

Angew. Chem. Int. Ed. 2017, 56(21), 5931-5936
Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition
Link to the article

Angew. Chem. 2017, 129(21), 6025-6030
Multivalente Peptid-Nanopartikel-Konjugate zur Hemmung des Influenzavirus
Link to the article

S. Hinderlich, R. Tauber, C.R. Bertozzi , C.P.R. Hackenberger

ChemBioChem 2017, 18(13), 1141-1145
Werner Reutter: A Visionary Pioneer in Molecular Glycobiology
Link to the article

S. Hinderlich, M. Neuenschwander, P.R. Wratil, A. Oder, M. Lisurek, L.D. Nguyen, J.P. von Kries, C.P.R. Hackenberger

ChemBioChem 2017, 18(13), 1279-1285
Small Molecules Targeting Human N-Acetylmannosamine Kinase
Link to the article

A.F.L. Schneider, C.P.R. Hackenberger

Curr. Opin. in Biotechnology 2017, 48, 61-68
Fluorescent labeling in living cells
Link to the article

M.P. Exner, T. Kuenzl, T.M.T. To, Z. Ouyang, S. Schwagerus, M.G. Hoesl, C.P.R. Hackenberger, M.C. Lensen, S. Panke, N. Budisa

ChemBioChem 2017, 18, 85-90
Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant
Link to the article


J. Bertran-Vicente, M. Penkert, O. Nieto-Garcia, J.-M. Jeckelmann, P. Schmieder, E. Krause, C.P.R. Hackenberger

Nature Comm. 2016, 7, Article number: 12703
Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
Link to the article

O. Reimann, C.P.R. Hackenberger

in "Tau Protein - Methods and Protocols", Verlag Humana Press, Caroline Smet-Nocca (ed.) 2017
Tag-Free Semi-Synthesis of the Tau Protein (Book Chapter)
Link to the article

N. Nischan, M.-A. Kasper, T. Mathew, C.P.R. Hackenberger

Org. Biomol. Chem. 2016, 14, 7500-7508
Bis(arylmethyl)-substituted unsymmetrical phosphites for the synthesis of lipidated peptides via Staudinger-phosphite reactions
Link to the article

D. Schumacher, C.P.R. Hackenberger, H. Leonhardt, J. Helma

J. Clin. Immunol. 2016, 36, 100-107
Current Status: Site-Specific Antibody Drug Conjugates
Link to the article

S. Schwagerus, O. Reimann, C. Despres, C. Smet-Nocca, C.P.R. Hackenberger

J. Pept. Sci. 2016, 22(5), 327-333
Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation
Link to the article

O. Nieto-Garcia, P.R. Wratil, L.D. Nguyen, V. Böhrsch, S. Hinderlich, W. Reutter, C.P.R. Hackenberger

Chem. Sci. 2016, 7, 3928-3933
Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs
Link to the article

E. Hoffmann, K. Streichert, N. Nischan, C. Seitz, T. Brunner, S. Schwagerus, C.P.R. Hackenberger, M. Rubini

Molecular BioSystems 2016, 12, 1750-1755
Stabilization of bacterially expressed erythropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylation sites
Link to the article