Publications 2000-2010


M.M. Chen, A.I. Bartlett, P.S. Nerenberg, C.T. Friel, C.P.R. Hackenberger, C.M. Stultz, S.E. Radford, B. Imperiali

Proc. Natl. Acad. Sci. 2010, 107, 22528-22533
Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation
Link to the article

R. Serwa, B. Horstmann, P. Majkut, J.-M. Swiecicki, M. Gerrits, E. Krause, C.P.R. Hackenberger

Chemical Science 2010, 1, 596-602
Site-specific PEGylation of proteins by a Staudinger-phosphite reaction
Link to the article

M. Mühlberg, D. Jaradat, R. Kleineweischede, I. Papp, D. Dechtrirat, S. Muth, M. Broncel, C.P.R. Hackenberger

Bioorg. Med. Chem. 2010, 18, 3679-3686
Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation
Link to the article

R. Serwa, J.-M. Swiecicki, D. Homann, C.P.R. Hackenberger

J. Pep. Sci. 2010, 16, 563-567
Phosphoramidate-peptide synthesis by solution and solid-phase Staudinger-phosphite reactions
Link to the article

D.M.M. Jaradat, H. Hamouda, C.P.R. Hackenberger

Eur. J. Org. Chem. 2010, 26, 5004-5009
Solid-Phase Synthesis of Phosphoramidate-Linked Glycopeptides
Link to the article

M. Broncel, S.C. Wagner, C.P.R. Hackenberger, B. Koksch

Chem. Commun. 2010, 46, 3080-3082
Enzymatically triggered amyloid formation: an approach for studying peptide aggregation
Link to the article

M. Broncel, J.A. Falenski, S.C. Wagner, C.P.R. Hackenberger, B. Koksch

Chem. Eur. J. 2010, 16, 7881-7888
How Post-Translational Modifications Influence Amyloid Formation: A Systematic Study of Phosphorylation and Glycosylation in Model Peptides
Link to the article

M. Broncel, S. C. Wagner, K. Paul, C.P.R. Hackenberger, B. Koksch

Org. Biomol. Chem. 2010, 8, 2575-2579
Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides
Link to the article

V. Böhrsch, R. Serwa, P. Majkut, E. Krause, C.P.R. Hackenberger

Chem. Commun. 2010, 46, 3176-3178
Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
Link to the article

C.P.R. Hackenberger, J.W. Bode, D. Schwarzer

in "Amino Acids, Peptides and Proteins in Organic Chemistry", Wiley-VCh, Andrew B. Huges (ed.) 2010, 445-494
Chemoselective Peptide Ligation - A Privileged Tool for Protein Synthesis (Book Chapter)
Link to the article

A.K. Udit, C.P.R. Hackenberger, M.K. O'Reilly

ChemBioChem 2010, 11, 481-484
Chemically Tailored Multivalent Virus Platforms - From Drug Delivery to Catalysis (Highlight)
Link to the article

V. Böhrsch, C.P.R. Hackenberger

ChemCatChem 2010, 2, 243-245
Suzuki-Miyaura Couplings on pProteins - a Simple and Ready-to-use Catalytic System in Water (Highlight)
Link to the article

C.P.R. Hackenberger, H.-D. Arndt, D. Schwarzer

Chemie in unserer Zeit 2010, 44, 198-206
Semisynthese: Ein zentrales Werkzeug für die Chemische Biologie (Review)
Link to the article

H.-D. Arndt, C.P.R. Hackenberger, D. Schwarzer

Chemie in unserer Zeit 2010, 44, 130-137
Semisynthese: Chemie mit den Molekülen der Natur (Review)
Link to the article


R. Serwa, I. Wilkening, G. del Signore, M. Mühlberg, I. Claußnitzer, C. Weise, M. Gerrits, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2009, 48, 8234-8239
Chemoselective Staudinger-Phoshpite Reaction of Azides for the Phosphorylation of Proteins
Link to the article

Angew. Chem. 2009, 121, 8382-8387
Chemoselektive Staudinger-Phosphit-Reaktion von Aziden für die Phosphorylierung von Proteinen
Link to the article

C.P.R. Hackenberger, D. Schwarzer

Angew. Chem. Int. Ed. 2008, 47, 10030-10074
Chemoselective Ligation and Modification Strategies of Peptides and Proteins
Link to the article

Angew. Chem. 2008, 120, 10182-10228
Chemoselektive Ligations- und Modifikationsstrategien für Peptide und Proteine
Link to the article

I. Wilkening, G. del Signore, C.P.R. Hackenberger

Chem. Commun. 2008, 25, 2932-2934
Synthesis of N,N-disubstituted phosphoramidates via a Lewis acid-catalyzed phosphorimidate rearrangement
Link to the article

R. Kleineweischede, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2008, 47, 5984-5988
Chemoselective Peptide Cyclization by Traceless Staudinger Ligation
Link to the article

Angew. Chem. 2008, 120, 6073-6078
Chemoselektive Peptidcyclisierung über spurlose Staudinger-Ligation
Link to the article


C.P.R. Hackenberger, S. Hinderlich

ChemBioChem 2007, 8, 1763-1765
Chemoselective Labeling of Engineered Fucosylated Glycoproteins
Link to the article

C.P.R. Hackenberger

ChemBioChem 2007, 8, 1221-1223
A Synthetic Kiss of Death: Expressed Protein Ligation of a Ubiquitin-Peptide Conjugate
Link to the article

C.P.R. Hackenberger

Org. Biomol. Chem. 2006, 4, 2291-2295
The reduction of oxidized methionine residues in peptide thioesters with NH4I/Me2S
Link to the article

C.P.R. Hackenberger

Chemie in unserer Zeit (ChiuZ) 2006, 40, 174-183
Proteinstrukturen aus dem Chemie-Baukasten. Definierte Peptidarchitekturen
Link to the article

C.P.R. Hackenberger, M. Chen, B. Imperiali

Bioorg. Med. Chem. 2006, 14, 5043-5048
Expression of N-terminal Cys-protein fragments using an intein refolding strategy
Link to the article


C.P.R. Hackenberger, C.T. Friel, S.E. Radford, B. Imperiali

J. Am. Chem. Soc. 2005, 127, 12882-12889
Semisynthesis of a Glycosylated Im7 Analogue for Protein Folding Studies
Link to the article

C.P.R. Hackenberger, M.K. O'Reilly, B. Imperiali

J. Org. Chem. 2005, 70, 3574-3578
Improving Glycopeptide Synthesis: A Convenient Protocol for the Preparation of ß-Glycosylamines and the Synthesis of Glycopeptides
Link to the article

C. Bolm, M. Verrucci, O. Simic, C.P.R. Hackenberger

Adv. Synth. Catal. 2005, 347, 1696-1700
Ethylene-Bridged Bissulfoximines in Copper-Catalyzed Enantioselective Hetero-Diels-Alder Reactions
Link to the article

C.P.R. Hackenberger, G. Raabe, C. Bolm

Chem. Eur. J. 2004, 10, 2942-2952
Synthetic and Spectroscopic Investigation of N-Acylated Sulfoximines
Link to the article

C.P.R. Hackenberger, I. Schiffers, J. Runsink, C. Bolm

J. Org. Chem. 2004, 69, 739-743
General Synthesis of Unsymmetrical Norbornane Scaffolds as Inducers for Hydrogen Bond Interactions in Peptides
Link to the article


C. Bolm, I. Schiffers, I. Atodiresei, C.P.R. Hackenberger

Tetrahedron: Asymmetry 2003, 14, 3455-3467
An alkaloid-mediated desymmetrization of meso-anhydrides via a nucleophilic ring opening with benzyl alcohol and its application in the synthesis of highly enantiomerically enriched ß-amino acids
Link to the article

C. Bolm, D. Müller, C. Dalhoff, C.P.R. Hackenberger, E. Weinhold

Bioorg. Med. Chem. Lett. 2003, 13, 3207-3211
The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K
Link to the article

C. Bolm, C.P.R. Hackenberger, O. Simic, M. Verrucci, D. Müller, F. Bienewald

Synthesis 2002, 7, 879-887
N-Alkylation of Sulfoximines: A Mild Synthetic Procedure for the Introduction of Carbon Side-Chains via an Acylation and Reduction Route

C. Bolm, D. Müller, C.P.R. Hackenberger

Org. Lett. 2002, 4, 893-897
Turn Formation Initiated by a Bissulfoximine Motif: Synthesis and Structural Investigation
Link to the article

S.M. Yu, D.T. McQuade, M.A. Quinn, C.P.R. Hackenberger, M.P. Krebs, A.S. Polans and S.H. Gellman

Protein Sci. 2000, 9, 2518-2527
An improved tripod amphiphile for membrane protein solubilization
Link to the article