Publications 2026-2030

2026

150.
L. Franz, T. Rubil, A. Balazs, M. Overtus, K. Kemnitz-Hassanin, C. Govaerts, M. A. Mall, C. P. R. Hackenberger

Nat. Chem. Biol. 2026 DOI:10.1038/s41589-026-02199-w
A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity
Link to the article

149.
S. Hansen, H. Zupan, F. Mutlu, J. V. V. Arafiles, R. Cruz, P. Dubatouka, K. Ataka, M. Lehmann, B. G. Keller, J. Heberle, C. P. R. Hackenberger

Angew. Chem. Int. Ed. 2026. e24419
Polyfluoroalkyl-Tagged Cell-Penetrating Peptide Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction
Link to the article

Angew. Chem. 2026. e24419
Polyfluoralkylierte zellpenetrierende Peptid-Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion
Link to the article

148.
J. Franke, P. Dubatouka, A. Yourdkhani, S. Soni, T. Utesch, J. Serrano, T. Soykan, M. Lehmann, H. Sun, J. V. V. Arafiles, C. P. R. Hackenberger

Preprint
Cellular protein delivery through membrane potential driven water pores
Link to the article

147.
C. E. Stieger, C. Völkel, M. B. Bertelsen, M. Lisurek, J. V. V. Arafiles, J. Franke, L. Crocker, K. Schuppe, Y. Lim, C. Groneberg, M. Christmann, H. Sun, C. P. R. Hackenberger

J. Am. Chem. Soc. 2026, 148, 7, 7772–7781
Modular Vinyl-Phosphonamidates for Cysteine Directed Protein Targeting
Link to the article

146.
E. Poulou, M. Ruwolt, C. E. Stieger, K. Kemnitz-Hassanin, C. P. R. Hackenberger

Angew. Chem. Int. Ed. 2026, 65, e21902
Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases
Link to the article

Angew. Chem. 2026, 65, e21902
Ungesättigte Phosphor-Elektrophile zur Untersuchung von Protein-Tyrosin-Phosphatasen
Link to the article

Dedicated to Prof. Oliver Seitz on the occasion of his 60th birthday

145.
C. E. Stieger, Y. El Harraoui, L. Brennan, M. Lisurek, J. V. V. Arafiles, C. Voelkel, K. Kemnitz-Hassanin, H. Sun, S. Sieber, C. P. R. Hackenberger

Preprint
Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases
Link to the article

144.
Z. Valbret, P. L. Lamothe-Molina, S. Papadogkonaki, A. Koehl, J. V. V. Arafiles, Z. Shapiro Tuchman, N. M. Fisher, A. Radoux-Mergault, A. Canziani, G. Huang, M. Von Zastrow, M. Kosloff, C. P. R. Hackenberger, A. Manglik, T. Patriarchi, M. Stoeber

Preprint
An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function
Link to the article

143.
P. Ochtrop, A. P. Jagtap, J. G. Felber, S. Vogt, S. Herterich, I. Mai, P. Cyprys, S. Schmitt, S. Payer, A. Kitowski, S. Wunder, P. Machui, J. Brandmeier, N. Leonardi, E. Poliak, C. P. R. Hackenberger, O. Marcq, D. Schumacher, J. Helma, M.-A. Kasper 

Nature Comm. 2026, 17, 759
Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates
Link to the article

142.
M. Gerlach, S. Schmitt, P. Cyprys, M.-A. Kasper, I. Mai, M. Klanova, A. Maiser, H. Leonhardt, C. P. R. Hackenberger, G. R. Fingerle-Rowson, A. M. Vogl, D. Schumacher, J. Helma

Mol. Canc. Ther. 2026, 25 (2): 216–229.
TUB-010, a novel anti-CD30 antibody-drug conjugate based on Tub-tag technology, widens the therapeutic window by reducing toxicity while maintaining high efficacy
Link to the article