New Review Published

on isoform-selective targeting of PI3Ks in TIPS

We review recent and anticipated progress on isoform-selective drugs and chemical probes that target Phosphoinositide-3-kinases (PI3Ks). The current lack of isoform-selective, covalent or allosteric PI3K inhibitors limits both our understanding of the complex physiological functions of PI3Ks but also the exploitation of their therapeutic potential. See how this challenge may be addressed in the latest issue of Trends in Pharmacological Sciences: