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In a fantastic collaboration with the group of Hana Algül (TUM) and Haiyu Hu (IMM Beijing) we have developed a DOTA-based fluorescent probe for in vivo imaging of plectin-1 that can aid early diagnosis of pancreatic cancer. See the communication here: T. Gazzi, M. Lesina, Q. Wang et al. https://doi.org/10.1002/anie.202318485
Meanwhile, in our most recent J Med Chem paper, Leo Mach et al. report specific drug-derived fluorescent probes for the Cannabinoid Receptor 1 (CB1R). In a highly collaborative effort, the probes were used in target engagement studies and live cell imaging to further our understanding of CB1R pharmacology and cell signaling. Congratulations, Leo! Check out the full story: https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.4c00465