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Prof. Dr.
Volker Haucke studied biochemistry in Berlin and Basel and conducted research at Yale University, the University of Göttingen and the Freie Universität of Berlin. Since 2012, he has been Director at the FMP, Professor of Pharmacology at the Freie Universität of Berlin and a member of the NeuroCure Cluster of Excellence. He is an international leader in molecular cell biology and neuroscience and has been awarded numerous scientific prizes, including the Feldberg Prize 2020.
Feldberg Prize for Research in Physiology and Pharmacology
2020
Professeur invité at the Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes (iPNP)
2020
ERC Advanced Grant, European Research Council
2020
Elected Member of the Academia Europaea/ Academy of Europe (AE)
2019
Elected Member of The German National Academy of Sciences, Leopoldina
2017
Avanti Award of the American Society for Biochemistry & Molecular Biology (ASBMB)
2017
Reinhart-Koselleck-Award of the Deutsche Forschungsgemeinschaft (DFG)
2016
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Elife 2022, 11, e71198
read onlineInositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3
Journal of Biological Chemistry 2022, 298, 101740
read onlinePhosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer
Advanced Science 2022, 9, e2103249
read onlinePhosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology 2022, early access,
read onlineSelective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity
Science Advances 2022, 8, eabl5032
read onlineStructural basis of phosphatidylinositol 3-kinase C2 alpha function
Nature Structural & Molecular Biology 2022, 29, 218-228
read onlineSulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins
Organic & Biomolecular Chemistry 2022, Advance Article,
read onlineEndosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
EMBO Journal 2022, 41, e109352
read onlineMechanism of synaptic protein turnover and its regulation by neuronal activity
Current Opinion in Neurobiology 2021, 69, 76-83
read onlineThe molecular mechanisms mediating class II PI 3-kinase function in cell physiology
FEBS Journal 2021, 288, 7025-7042
read onlineSynActJ: Easy-to-Use Automated Analysis of Synaptic Activity
Frontiers in Computer Science 2021, 3, 777837
read onlineStructural basis of PI3KC2alpha function
Nature Structural & Molecular Biology 2021, in press,
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
Science 2021, 374, eabk0410
read onlineLiquid-like protein assemblies initiate endocytosis
Nature Cell Biology 2021, 23, 301-302
read onlineInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Nature Communications 2021, 12, 2673
read onlineDysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy
Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118
read onlineDissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
Chemical Science 2021, 12, 10696-10702
read onlineA Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation
Neuron 2021, 109, 27-41
read onlineA mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval
Developmental Cell 2021, 56, 1557-1559
read onlinePhosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway
Journal of Biological Chemistry 2020, 295, 1091-1104
read onlineVps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772
read onlineVesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports 2020, 30, 2594-2602
read onlineThe INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.
Cancer Discovery 2020, 10, 1226-1239
read onlineThe axonal endolysosomal and autophagic systems
Journal of Neurochemistry 2020, 158, 589-602
read onlineRamping up the autophagy-lysosome system to cope with osmotic stress
Autophagy 2020, 16, 1921-1922
read onlineRab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
Nature Communications 2020, 11, 2835
read onlineEndocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Nature Cell Biology 2020, 22, 815-827
read onlineNeuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
Neuron 2020, 109, 1-15
read onlineEndophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Nature Communications 2020, 11, 1266
read onlineEndocytosis in the adaptation to cellular stress
Cell Stress 2020, 4, 230-247
read onlineEHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481
read onlineAsymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells
Nature Microbiology 2020, 5, 181-191
read onlineA Golgi-associated lipid kinase controls peripheral nerve myelination
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875
read onlineIntersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission
Cell Reports 2020, 30, 409-420
read onlineNanoscale coupling of endocytic pit growth and stability
Science Advances 2019, 5, eaax5775
read onlineSpermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Scientific Reports 2019, 9, 19616
read onlineQuantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression
Nucleic Acids Research 2019, 47, 953-969
read onlineProtein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1
Nature Cell Biology 2019, 21, 1093-1101
read onlineDisruption of endocytosis through chemical inhibition of clathrin heavy chain function
Nature Chemical Biology 2019, 15, 641-649
read onlineMutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction
PLoS Genetics 2019, 15, e1008088
read onlineMolecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Cell Reports 2019, 27, 3049-3061
read onlineExon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain
Structure 2019, 27, 977-987
read onlineA Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy
American Journal of Human Genetics 2019, 104, 1060-1072
read onlineThe cell adhesion protein CAR is a negative regulator of synaptic transmission
Scientific Reports 2019, 9, 6768
read onlineThe Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany