Portrait Volker Haucke

Prof. Dr.

Volker Haucke

Volker Haucke studied biochemistry in Berlin and Basel and conducted research at Yale University, the University of Göttingen and the Freie Universität of Berlin. Since 2012, he has been Director at the FMP, Professor of Pharmacology at the Freie Universität of Berlin and a member of the NeuroCure Cluster of Excellence. He is an international leader in molecular cell biology and neuroscience and has been awarded numerous scientific prizes, including the Feldberg Prize 2020.

 

 

 

Awards

Feldberg Prize for Research in Physiology and Pharmacology
2020

Professeur invité at the Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes (iPNP)
2020

ERC Advanced Grant, European Research Council
2020

Elected Member of the Academia Europaea/ Academy of Europe (AE)
2019

Elected Member of The German National Academy of Sciences, Leopoldina
2017

Avanti Award of the American Society for Biochemistry & Molecular Biology (ASBMB)
2017

Reinhart-Koselleck-Award of the Deutsche Forschungsgemeinschaft (DFG)
2016

Publications

of 8

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

  • Lopez-Hernandez, T.
  • Takenaka, K. I.
  • Mori, Y.
  • Kongpracha, P.
  • Nagamori, S.
  • Haucke, V., &
  • Takamori, S.

Elife 2022, 11, e71198

read online

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

  • Malek, M.
  • Wawrzyniak, A. M.
  • Ebner, M.
  • Puchkov, D., &
  • Haucke, V.

Journal of Biological Chemistry 2022, 298, 101740

read online

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

  • Li, H. Y.
  • Prever, L.
  • Hsu, M. Y.
  • Lo, W.
  • Margaria, J. P.
  • De Santis, M. C.
  • Zanini, C.
  • Forni, M.
  • Novelli, F.
  • Pece, S.
  • Di Fiore, P. P.
  • Porporato, P. E.
  • Martini, M.
  • Belabed, H.
  • Nazaré, M.
  • Haucke, V.
  • Gulluni, F., &
  • Hirsch, E.

Advanced Science 2022, 9, e2103249

read online

Phosphoinositides as membrane organizers

  • Posor, Y.
  • Jang, W., &
  • Haucke, V.

Nature Reviews Molecular Cell Biology 2022, early access,

read online

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

  • Azarnia Tehran, D.
  • Kochlamazashvili, G.
  • Pampaloni, N. P.
  • Sposini, S.
  • Shergill, J. K.
  • Lehmann, M.
  • Pashkova, N.
  • Schmidt, C.
  • Löwe, D.
  • Napieczynska, H.
  • Heuser, A.
  • Plested, A. J. R.
  • Perrais, D.
  • Piper, R. C.
  • Haucke, V., &
  • Maritzen, T.

Science Advances 2022, 8, eabl5032

read online

Structural basis of phosphatidylinositol 3-kinase C2 alpha function

  • Lo, W.
  • Zhang, Y. Y.
  • Vadas, O.
  • Roske, Y.
  • Gulluni, F.
  • De Santis, M. C.
  • Zagar, A. V.
  • Stephanowitz, H.
  • Hirsch, E.
  • Liu, F.
  • Daumke, O.
  • Kudryashev, M., &
  • Haucke, V.

Nature Structural & Molecular Biology 2022, 29, 218-228

read online

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

  • Birke, R.
  • Ast, J.
  • Roosen, D. A.
  • Lee, J.
  • Roßmann, K.
  • Huhn, C.
  • Mathes, B.
  • Lisurek, M.
  • Bushiri, D.
  • Sun, H.
  • Jones, B.
  • Lehmann, M.
  • Levitz, J.
  • Haucke, V.
  • Hodson, D. J., &
  • Broichhagen, J.

Organic & Biomolecular Chemistry 2022, Advance Article,

read online

Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

  • Liu, G. T.
  • Kochlamazashvili, G.
  • Puchkov, D.
  • Müller, R.
  • Schultz, C.
  • Mackintosh, A. I.
  • Vollweiter, D.
  • Haucke, V., &
  • Soykan, T.

EMBO Journal 2022, 41, e109352

read online

Publications

of 11

Mechanism of synaptic protein turnover and its regulation by neuronal activity

  • Soykan, T.
  • Haucke, V., &
  • Kuijpers, M.

Current Opinion in Neurobiology 2021, 69, 76-83

read online

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

  • Koch, P. A.
  • Dornan, G. L.
  • Hessenberger, M., &
  • Haucke, V.

FEBS Journal 2021, 288, 7025-7042

read online

SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

  • Schmied, C.
  • Soykan, T.
  • Bolz, S.
  • Haucke, V., &
  • Lehmann, M.

Frontiers in Computer Science 2021, 3, 777837

read online

Structural basis of PI3KC2alpha function

  • Lo, W.
  • Zhang, Y.
  • Vadas, O.
  • Belabed, H.
  • Roske, Y.
  • Gulluni, F.
  • De Santis, M.
  • Vujicic Zagar, A.
  • Stephanowitz, H.
  • Hirsch, E.
  • Liu, F.
  • Daumke, O.
  • Kudryashev, M., &
  • Haucke, V.

Nature Structural & Molecular Biology 2021, in press,

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

  • Gulluni, F.
  • Prever, L.
  • Li, H. Y.
  • Krafcikova, P.
  • Corrado, I.
  • Lo, W.
  • Margaria, J. P.
  • Chen, A. L.
  • De Santis, M. C.
  • Cnudde, S. J.
  • Fogerty, J.
  • Yuan, A.
  • Massarotti, A.
  • Sarijalo, N. T.
  • Vadas, O.
  • Williams, R. L.
  • Thelen, M.
  • Powell, D. R.
  • Schueler, M.
  • Wiesener, M. S.
  • Balla, T.
  • Baris, H. N.
  • Tiosano, D.
  • McDermott, B. M.
  • Perkins, B. D.
  • Ghigo, A.
  • Martini, M.
  • Haucke, V.
  • Boura, E.
  • Merlo, G. R.
  • Buchner, D. A., &
  • Hirsch, E.

Science 2021, 374, eabk0410

read online

Liquid-like protein assemblies initiate endocytosis

  • Witkowska, A., &
  • Haucke, V.

Nature Cell Biology 2021, 23, 301-302

read online

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

  • Malek, M.
  • Wawrzyniak, A. M.
  • Koch, P.
  • Lüchtenborg, C.
  • Hessenberger, M.
  • Sachsenheimer, T.
  • Jang, W.
  • Brügger, B., &
  • Haucke, V.

Nature Communications 2021, 12, 2673

read online

Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

  • Guerrero-Valero, M.
  • Grandi, F.
  • Cipriani, S.
  • Alberizzi, V.
  • Di Guardo, R.
  • Chicanne, G.
  • Sawade, L.
  • Bianchi, F.
  • Del Carro, U.
  • Curtis, I. D.
  • Pareyson, D.
  • Parman, Y.
  • Schenone, A.
  • Haucke, V.
  • Payrastre, B., &
  • Bolino, A.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

read online

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

  • Hostachy, S.
  • Utesch, T.
  • Franke, K.
  • Dornan, G. L.
  • Furkert, D.
  • Turkaydin, B.
  • Haucke, V.
  • Sun, H., &
  • Fiedler, D.

Chemical Science 2021, 12, 10696-10702

read online

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

  • Rizalar, F. S.
  • Roosen, D. A., &
  • Haucke, V.

Neuron 2021, 109, 27-41

read online

A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

  • Haucke, V.

Developmental Cell 2021, 56, 1557-1559

read online

Publications

of 15

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

  • Wang, H. B.
  • Loerke, D.
  • Bruns, C.
  • Müller, R.
  • Koch, P. A.
  • Puchkov, D.
  • Schultz, C., &
  • Haucke, V.

Journal of Biological Chemistry 2020, 295, 1091-1104

read online

Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes

  • Bertovic, I.
  • Kurelic, R.
  • Milosevic, I.
  • Bender, M.
  • Krauss, M.
  • Haucke, V., &
  • Jurak Begonja, A.

Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772

read online

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

  • Pechstein, A.
  • Tomilin, N.
  • Fredrich, K.
  • Vorontsova, O.
  • Sopova, E.
  • Evergren, E.
  • Haucke, V.
  • Brodin, L., &
  • Shupliakov, O.

Cell Reports 2020, 30, 2594-2602

read online

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

  • Liu, H.
  • Paddock, M.
  • Wang, H.
  • Murphy, C.
  • Geck, R.
  • Navarro, A.
  • Wulf, G.
  • Elemento, O.
  • Haucke, V.
  • Cantley, L., &
  • Toker, A.

Cancer Discovery 2020, 10, 1226-1239

read online

The axonal endolysosomal and autophagic systems

  • Kuijpers, M.
  • Azarnia Tehran, D.
  • Haucke, V., &
  • Soykan, T.

Journal of Neurochemistry 2020, 158, 589-602

read online

Ramping up the autophagy-lysosome system to cope with osmotic stress

  • Lopez-Hernandez, T.
  • Maritzen, T., &
  • Haucke, V.

Autophagy 2020, 16, 1921-1922

read online

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

  • Sawade, L.
  • Grandi, F.
  • Mignanelli, M.
  • Patino-Lopez, G.
  • Klinkert, K.
  • Langa-Vives, F.
  • Di Guardo, R.
  • Echard, A.
  • Bolino, A., &
  • Haucke, V.

Nature Communications 2020, 11, 2835

read online

Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

  • Lopez-Hernandez, T.
  • Puchkov, D.
  • Krause, E.
  • Maritzen, T., &
  • Haucke, V.

Nature Cell Biology 2020, 22, 815-827

read online

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

  • Kuijpers, M.
  • Kochlamazashvili, G.
  • Stumpf, A.
  • Puchkov, D.
  • Swaminathan, A.
  • Lucht, M. T.
  • Krause, E.
  • Maritzen, T.
  • Schmitz, D., &
  • Haucke, V.

Neuron 2020, 109, 1-15

read online

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

  • Gowrisankaran, S.
  • Houy, S.
  • Castillo, J. G. P.
  • Steubler, V.
  • Gelker, M.
  • Kroll, J.
  • Pinheiro, P. S.
  • Schwitters, D.
  • Halbsgut, N.
  • Pechstein, A.
  • Weering, J. R. T.
  • Maritzen, T.
  • Haucke, V.
  • Raimundo, N.
  • Sorensen, J. B., &
  • Milosevic, I.

Nature Communications 2020, 11, 1266

read online

Endocytosis in the adaptation to cellular stress

  • Lopez-Hernandez, T.
  • Haucke, V., &
  • Maritzen, T.

Cell Stress 2020, 4, 230-247

read online

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

  • Matthaeus, C.
  • Lahmann, I.
  • Kunz, S.
  • Jonas, W.
  • Melo, A. A.
  • Lehmann, M.
  • Larsson, E.
  • Lundmark, R.
  • Kern, M.
  • Bluher, M.
  • Olschowski, H.
  • Kompa, J.
  • Brügger, B.
  • Müller, D. N.
  • Haucke, V.
  • Schürmann, A.
  • Birchmeier, C., &
  • Daumke, O.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481

read online

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

  • Stanifer, M. L.
  • Mukenhirn, M.
  • Muenchau, S.
  • Pervolaraki, K.
  • Kanaya, T.
  • Albrecht, D.
  • Odendall, C.
  • Hielscher, T.
  • Haucke, V.
  • Kagan, J. C.
  • Bartfeld, S.
  • Ohno, H., &
  • Boulant, S.

Nature Microbiology 2020, 5, 181-191

read online

A Golgi-associated lipid kinase controls peripheral nerve myelination

  • Posor, Y., &
  • Haucke, V.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875

read online

Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

  • Jäpel, M.
  • Gerth, F.
  • Sakaba, T.
  • Bacetic, J.
  • Yao, L. J.
  • Koo, S. J.
  • Maritzen, T.
  • Freund, C., &
  • Haucke, V.

Cell Reports 2020, 30, 409-420

read online

Publications

of 10

Nanoscale coupling of endocytic pit growth and stability

  • Lehmann, M.
  • Lukonin, I.
  • Noe, F.
  • Schmoranzer, J.
  • Clementi, C.
  • Loerke, D., &
  • Haucke, V.

Science Advances 2019, 5, eaax5775

read online

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

  • Maglione, M.
  • Kochlamazashvili, G.
  • Eisenberg, T.
  • Racz, B.
  • Michael, E.
  • Toppe, D.
  • Stumpf, A.
  • Wirth, A.
  • Zeug, A.
  • Müller, F. E.
  • Moreno-Velasquez, L.
  • Sammons, R. P.
  • Hofer, S. J.
  • Madeo, F.
  • Maritzen, T.
  • Maier, N.
  • Ponimaskin, E.
  • Schmitz, D.
  • Haucke, V., &
  • Sigrist, S. J.

Scientific Reports 2019, 9, 19616

read online

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

  • Buntz, A.
  • Killian, T.
  • Schmid, D.
  • Seul, H.
  • Brinkmann, U.
  • Ravn, J.
  • Lindholm, M.
  • Knoetgen, H.
  • Haucke, V., &
  • Mundigl, O.

Nucleic Acids Research 2019, 47, 953-969

read online

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

  • Wallroth, A.
  • Koch, P. A.
  • Marat, A. L.
  • Krause, E., &
  • Haucke, V.

Nature Cell Biology 2019, 21, 1093-1101

read online

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

  • Dejonghe, W.
  • Sharma, I.
  • Denoo, B.
  • De Munck, S.
  • Lu, Q.
  • Mishev, K.
  • Bulut, H.
  • Mylle, E.
  • De Rycke, R.
  • Vasileva, M.
  • Savatin, D. V.
  • Nerinckx, W.
  • Staes, A.
  • Drozdzecki, A.
  • Audenaert, D.
  • Yperman, K.
  • Madder, A.
  • Friml, J.
  • Van Damme, D.
  • Gevaert, K.
  • Haucke, V.
  • Savvides, S. N.
  • Winne, J., &
  • Russinova, E.

Nature Chemical Biology 2019, 15, 641-649

read online

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

  • Tiosano, D.
  • Baris, H. N.
  • Chen, A.
  • Hitzert, M. M.
  • Schueler, M.
  • Gulluni, F.
  • Wiesener, A.
  • Bergua, A.
  • Mory, A.
  • Copeland, B.
  • Gleeson, J. G.
  • Rump, P.
  • Meer, H.
  • Sival, D. A.
  • Haucke, V.
  • Kriwinsky, J.
  • Knaup, K. X.
  • Reis, A.
  • Hauer, N. N.
  • Hirsch, E.
  • Roepman, R.
  • Pfundt, R.
  • Thiel, C. T.
  • Wiesener, M. S.
  • Aslanyan, M. G., &
  • Buchner, D. A.

PLoS Genetics 2019, 15, e1008088

read online

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

  • Pascolutti, R.
  • Algisi, V.
  • Conte, A.
  • Raimondi, A.
  • Pasham, M.
  • Upadhyayula, S.
  • Gaudin, R.
  • Maritzen, T.
  • Barbieri, E.
  • Caldieri, G.
  • Tordonato, C.
  • Confalonieri, S.
  • Freddi, S.
  • Malabarba, M. G.
  • Maspero, E.
  • Polo, S.
  • Tacchetti, C.
  • Haucke, V.
  • Kirchhausen, T.
  • Di Fiore, P. P., &
  • Sigismund, S. (.

Cell Reports 2019, 27, 3049-3061

read online

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

  • Gerth, F.
  • Jäpel, M.
  • Sticht, J.
  • Kuropka, B.
  • Schmitt, X. J.
  • Driller, J. H.
  • Loll, B.
  • Wahl, M. C.
  • Pagel, K.
  • Haucke, V., &
  • Freund, C.

Structure 2019, 27, 977-987

read online

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

  • Helbig, I.
  • Lopez-Hernandez, T.
  • Shor, O.
  • Galer, P.
  • Ganesan, S.
  • Pendziwiat, M.
  • Rademacher, A.
  • Ellis, C. A.
  • Humpfer, N.
  • Schwarz, N.
  • Seiffert, S.
  • Peeden, J.
  • Shen, J.
  • Sterbova, K.
  • Hammer, T. B.
  • Moller, R. S.
  • Shinde, D. N.
  • Tang, S.
  • Smith, L.
  • Poduri, A.
  • Krause, R.
  • Benninger, F.
  • Helbig, K. L.
  • Haucke, V.
  • Weber, Y. G.
  • Consortium, E., &
  • Consortium, G.

American Journal of Human Genetics 2019, 104, 1060-1072

read online

The cell adhesion protein CAR is a negative regulator of synaptic transmission

  • Wrackmeyer, U.
  • Kaldrack, J.
  • Jüttner, R.
  • Pannasch, U.
  • Gimber, N.
  • Freiberg, F.
  • Purfürst, B.
  • Kainmueller, D.
  • Schmitz, D.
  • Haucke, V.
  • Rathjen, F. G., &
  • Gotthardt, M.

Scientific Reports 2019, 9, 6768

read online