„”
Prof. Dr.
Structural characterisation of protein-protein interactions responsible for the reception and transduction of signals in biological systems, and their disruption by small molecules. Protein domains which recognize peptides with characteristic motifs, proteins involved in protein homeosthasis, structural investigations on membrane proteins and cytoskeleton-attached proteins by solid state NMR.
More than 180 publications in the fields of protein structure and NMR methods development. More than 50 structures deposited in the PDB. Among those are first structures of the PH- and WW-domains. Development of small molecular inhibitors of interactions of PDZ domains. First assignment of protein resonances on the basis of solid-state NMR data, first structure of a protein by solid-state NMR. Structure of a fibril formed by a WW-domain at atomic resolution. Structure of alphaB-crystallin oligomers by solid-state NMR and SAXS. Applications of dynamic nuclear polarisation to large biological complexes. Structure of the dark-adapted form of bacteriorhodopsin by solution NMR.
2009 – 2011
Acting Director
FMP
since 1998
Head of the department "NMR-supported Structural Biology“ at the FMP, Professor of Structural Chemistry at the Free University in Berlin
FMP, FU Berlin
1992 – 1998
Group leader. Work on structure and function of signalling domains
EMBL, Heidelberg
1987 – 1991
Position as NMR-spectroscopist, first in the Clore/Gronenborn group, later independently in the department of Prof. Huber. Pulse sequence development, 3D-NMR
Max-Planck-Institute for Biochemistry (Martinsried)
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
