„”
Prof. Dr.
Structural characterisation of protein-protein interactions responsible for the reception and transduction of signals in biological systems, and their disruption by small molecules. Protein domains which recognize peptides with characteristic motifs, proteins involved in protein homeosthasis, structural investigations on membrane proteins and cytoskeleton-attached proteins by solid state NMR.
More than 180 publications in the fields of protein structure and NMR methods development. More than 50 structures deposited in the PDB. Among those are first structures of the PH- and WW-domains. Development of small molecular inhibitors of interactions of PDZ domains. First assignment of protein resonances on the basis of solid-state NMR data, first structure of a protein by solid-state NMR. Structure of a fibril formed by a WW-domain at atomic resolution. Structure of alphaB-crystallin oligomers by solid-state NMR and SAXS. Applications of dynamic nuclear polarisation to large biological complexes. Structure of the dark-adapted form of bacteriorhodopsin by solution NMR.
2009 – 2011
Acting Director
FMP
since 1998
Head of the department "NMR-supported Structural Biology“ at the FMP, Professor of Structural Chemistry at the Free University in Berlin
FMP, FU Berlin
1992 – 1998
Group leader. Work on structure and function of signalling domains
EMBL, Heidelberg
1987 – 1991
Position as NMR-spectroscopist, first in the Clore/Gronenborn group, later independently in the department of Prof. Huber. Pulse sequence development, 3D-NMR
Max-Planck-Institute for Biochemistry (Martinsried)
Collective exchange processes reveal an active site proton cage in bacteriorhodopsin
Communications Biology 2020, 3, 4
read onlineCrystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi
Journal of Structural Biology 2020, 211, 107536
read onlineDesigned nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690
read onlineMAS NMR detection of hydrogen bonds for protein secondary structure characterization
Journal of Biomolecular NMR 2020, 74, 247-256
read onlineNMR quality control of fragment libraries for screening
Journal of Biomolecular NMR 2020, 74, 555-563
read onlinepH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes
ChemBioChem 2020, 21, 1597-1604
read onlinePigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage
Angewandte Chemie-International Edition 2020, 59, 11937-11942
read onlineProtein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide
Magnetic Resonance in Chemistry 2020, 58, 445-465
read onlineDetection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR
RSC Advances 2019, 9, 26686-26690
read onlineDNP NMR of biomolecular assemblies
Journal of Structural Biology 2019, 206, 90-98
read onlineDynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies
Journal of Physical Chemistry B 2019, 123, 5048-5058
read onlineHost monitoring of quorum sensing during Pseudomonas aeruginosa infection
Science 2019, 366, eaaw1629
read onlinePoly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Cell Reports 2019, 27, 3124-3138
read onlineThe companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants
Nature Communications 2019, 10, 857
read onlineThe Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany