Portrait

Prof. Dr.

Fan Liu

Head Fan Liu (SI) Group

 +49 30 94793 141

 fliu@fmp-berlin.de

0000-0002-2358-549X

Fan graduated from Fudan University in Shanghai with a B.Sc. in Biology. Afterwards she joined the lab of Prof. Dr. Mike Goshe at North Carolina State University and obtained her PhD in Biochemistry in 2013. Fan did her postdoc in the lab of Prof. Dr. Albert Heck (Utrecht, The Netherlands).
In 2017 Fan joined the Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP) in Berlin as a group leader for Structural Interactomics and head of the proteomics research platform. In addition to her position at the FMP, Fan is jointly appointed as Professor for Structural Interactomics at Charité - Universitätsmedizin Berlin.

  • Head Mass Spectrometry

Structural Biology

Fan Liu (SI) Group
Mass Spectrometry

FMP

Publications

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2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2010
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A Membrane‐Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross‐Linking Reagent to Advance In Vivo Cross‐Linking Mass Spectrometry

  • Fan Liu

Angewandte Chemie International Edition 2022

read online

XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications

  • Fan Liu

Journal of Proteome Research 2021

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Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity

  • Fan Liu

Progress in Neurobiology 2021

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eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

  • Fan Liu

Cell Reports 2021

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Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions

  • Fan Liu

Science Advances 2020

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MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex

  • Fan Liu

EMBO reports 2020

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RIM-binding protein couples synaptic vesicle recruitment to release sites

  • Fan Liu

Journal of Cell Biology 2020

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Expanding the depth and sensitivity of cross-link identification by differential ion mobility using FAIMS

  • Fan Liu

Analytical Chemistry 2020

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First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

  • Fan Liu

Analytical Chemistry 2019

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The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

  • Fan Liu

Molecular & Cellular Proteomics 2018

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Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry

  • Fan Liu

Scientific Reports 2017

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Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification

  • Fan Liu

Nature Communications 2017

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Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System.

  • Lössl P; Brunner AM; Liu F; Leney AC; Yamashita M; Scheltema RA; Heck AJ
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MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis

  • Fan Liu

Journal of Biological Chemistry 2016

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Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

  • Fan Liu

Nature Communications 2016

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Interrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry.

  • Liu F; Heck AJ
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Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.

  • Liu F; Rijkers DT; Post H; Heck AJ
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The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.

  • Glas M; van den Berg van Saparoea HB; McLaughlin SH; Roseboom W; Liu F; Koningstein GM; Fish A; den Blaauwen T; Heck AJ; de Jong L; Bitter W; de Esch IJ; Luirink J
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Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization.

  • Brunner AM; Lössl P; Liu F; Huguet R; Mullen C; Yamashita M; Zabrouskov V; Makarov A; Altelaar AF; Heck AJ
read online

Performing protein crosslinking using gas-phase cleavable chemical crosslinkers and liquid chromatography-tandem mass spectrometry.

  • Argo AS; Shi C; Liu F; Goshe MB
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Facilitating protein disulfide mapping by a combination of pepsin digestion, electron transfer higher energy dissociation (EThcD), and a dedicated search algorithm SlinkS.

  • Liu F; van Breukelen B; Heck AJ
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Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB.

  • Olson AL; Liu F; Tucker AT; Goshe MB; Cavanagh J
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An enhanced protein crosslink identification strategy using CID-cleavable chemical crosslinkers and LC/MS(n) analysis.

  • Liu F; Wu C; Sweedler JV; Goshe MB
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Combinatorial electrostatic collision-induced dissociative chemical cross-linking reagents for probing protein surface topology.

  • Liu F; Goshe MB
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