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Prof. Dr.
Fan graduated from Fudan University in Shanghai with a B.Sc. in Biology. Afterwards she joined the lab of Prof. Dr. Mike Goshe at North Carolina State University and obtained her PhD in Biochemistry in 2013. Fan did her postdoc in the lab of Prof. Dr. Albert Heck (Utrecht, The Netherlands).
In 2017 Fan joined the Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP) in Berlin as a group leader for Structural Interactomics and head of the proteomics research platform. In addition to her position at the FMP, Fan is jointly appointed as Professor for Structural Interactomics at Charité - Universitätsmedizin Berlin.
Extensive protein pyrophosphorylation revealed in human cell lines
Nature Chemical Biology 2024
read onlineRawVegetable 2.0: Refining XL-MS Data Acquisition through Enhanced Quality Control
Journal of Proteome Research 2024
read onlineYeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase
The EMBO Journal 2024
read onlineCross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies
Nature Communications 2024
read onlineAn extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis
Nature Communications 2024
read onlinePROTEOME-SCALE RECOMBINANT STANDARDS AND A ROBUST HIGH-SPEED SEARCH ENGINE TO ADVANCE CROSS-LINKING MS-BASED INTERACTOMICS
Real-Time Library Search Increases Cross-Link Identification Depth across All Levels of Sample Complexity
Analytical Chemistry 2023
read onlineThe potential of cross-linking mass spectrometry in the development of protein–protein interaction modulators
Current Opinion in Structural Biology 2023
read onlineAn antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
eLife 2023
read onlineCaMKII autophosphorylation can occur between holoenzymes without subunit exchange
eLife 2023
read onlineSpatially resolved protein map of intact human cytomegalovirus virions
Nature Microbiology 2023
read onlineStructural Host-Virus Interactome Profiling of Intact Infected Cells
XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications
Journal of Proteome Research 2021
read onlineNovel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
Progress in Neurobiology 2021
read onlineeIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
Cell Reports 2021
read onlineStitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Science Advances 2020
read onlineMITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex
EMBO reports 2020
read onlineRIM-binding protein couples synaptic vesicle recruitment to release sites
Journal of Cell Biology 2020
read onlineExpanding the depth and sensitivity of cross-link identification by differential ion mobility using FAIMS
Analytical Chemistry 2020
read onlineDeciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System.
MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis
Journal of Biological Chemistry 2016
read onlineHybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
Nature Communications 2016
read onlineInterrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry.
Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.
The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.
Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization.
Performing protein crosslinking using gas-phase cleavable chemical crosslinkers and liquid chromatography-tandem mass spectrometry.
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany