Portrait Dorothea Fiedler

Prof. Dr.

Dorothea Fiedler

Dorothea grew up in the most beautiful city in Germany: Hamburg. She went to college at the University of Wuerzburg and did her Diploma work at UC Berkeley. She decided she liked the United States for many reasons that include Thanksgiving (and also German beers are overrated), so she stayed at Berkeley for her Ph.D. She worked in the Raymond and Bergman labs, studying host-guest systems and their application to catalysis. She then moved across the Bay to UCSF, where she joined the Shokat lab to investigate signal transduction pathways. She started her academic career at Princeton University but recently relocated to the FMP, Berlin.

  • Managing Director

Chemical Biology


Fiedler Group


FMP

Publications

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2024

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2024

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An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler
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Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

  • Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

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An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N-Acetylglucosamine Kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler

Journal of the American Chemical Society 2024

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Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler
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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler
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Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

  • Tim Aguirre; Ellen Teichmann; Florian Q. Römpp; Ruthey Vivier; Cole Bryant; Matthew A. Hulverson; Wesley C. Van Voorhis; Kayode K. Ojo; J. Stone Doggett; Dorothea Fiedler; Stefan Hecht

ACS Chemical Biology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Real-time monitoring of the sialic acid biosynthesis pathway by NMR

  • Jacob L. Gorenflos López; Peter Schmieder; Kristin Kemnitz-Hassanin; Hatice Ceyda Asikoglu; Arif Celik; Christian E. Stieger; Dorothea Fiedler; Stephan Hinderlich; Christian P. R. Hackenberger

Chemical Science 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
read online

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

  • Joka Pipercevic; Bastian Kohl; Ruta Gerasimaite; Véronique Comte-Miserez; Sarah Hostachy; Thomas Müntener; Elia Agustoni; Henning Jacob Jessen; Dorothea Fiedler; Andreas Mayer; Sebastian Hiller

Nature Communications 2023

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Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

  • Soumyadip Sahu; Jacob Gordon; Chunfang Gu; Mack Sobhany; Dorothea Fiedler; Robin E. Stanley; Stephen B. Shears

Biomolecules 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
read online

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

  • Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

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Portraitfoto: © Silke Oßwald