Portrait Dorothea Fiedler

Prof. Dr.

Dorothea Fiedler

Dorothea grew up in the most beautiful city in Germany: Hamburg. She went to college at the University of Wuerzburg and did her Diploma work at UC Berkeley. She decided she liked the United States for many reasons that include Thanksgiving (and also German beers are overrated), so she stayed at Berkeley for her Ph.D. She worked in the Raymond and Bergman labs, studying host-guest systems and their application to catalysis. She then moved across the Bay to UCSF, where she joined the Shokat lab to investigate signal transduction pathways. She started her academic career at Princeton University but recently relocated to the FMP, Berlin.

  • Director

Chemical Biology


Fiedler Group


FMP

Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza

  • Dorothea Fiedler; Maren Schädel; Martina Katharina Ried-Lasi; Verena Gaugler; Gabriel Schaaf; Henning Jacob Jessen; Philipp Gaugler; Michael Harings; Kiran Raj; Guizhen Liu; Mengsi Lu; Charlotte Magdalena Mathilda Grothaus; Ulrike Anna Jochimsen; Athanasios Makris; Simon Maria Bartsch; Anna Maria Frentzen

Science Advances 2026

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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Jaime A. Isern; Max Ruwolt; Sarah Lampe; Abhirup Majumdar; Fan Liu; David Furkert; Dorothea Fiedler

Nature Communications 2026

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Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

  • Xue Bessie Su; Xinjie Zhang; Valeria Fedeli; An-Li Andrea Ko; Jiarui Nicole Fu; Dorothea Fiedler; Adolfo Saiardi

The EMBO Journal 2026

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Species Context Reverses PPIP5K Control of Fungal Morphogenesis and Actin Organization

  • Elisa Koc; Lisa Juhran; Visnja Emmerich; Abel Alcázar-Román; Simon M. Bartsch; Adolfo Saiardi; Lasse van Wijlick; Johannes Postma; Thomas Lenz; Dorothea Fiedler; Michael Feldbrügge; Kai Stühler; Ingrid Span; Ursula Fleig
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Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells

  • Meike M. Amma; Laxmikanth Kollipara; Tobias Dürr-Mayer; Josefin Streeck; Peter Schmieder; Adolfo Saiardi; Henning J. Jessen; Sven Heiles; Dorothea Fiedler

ACS Chemical Biology 2026

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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

  • Sarah Lampe; Tanmay Kumar Mohanty; Rashna Bhandari; Dorothea Fiedler

FEBS Letters 2026

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Isotopic tracing of [13C6]scyllo-inositol uncovers its incorporation into phosphatidylinositols in mammalian cells

  • Meike Marie Amma; Laxmikanth Kollipara; Peter Schmieder; Adolfo Saiardi; Sven Heiles; Dorothea Fiedler
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Rücktitelbild: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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An inositol pyrophosphate interaction screen provides insight into the regulation of plant casein kinase II

  • Kristina Sturm; Oded Pri-Tal; Felix Rico-Resendiz; Yash Verma; Annika Richter; Houming Chen; Larissa Broger; Ludwig A. Hothorn; Dorothea Fiedler; Vikram Govind Panse; Michael Hothorn
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Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method

  • Xue Bessie Su; Valeria Fedeli; Guizhen Liu; Meike Marie Amma; Paraskevi Boulasiki; Jingyi Wang; Mariano Bizzarri; Henning Jacob Jessen; Dorothea Fiedler; Antonella Riccio; Adolfo Saiardi

Biochemical Journal 2025

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2025

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Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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Semi-enzymatic synthesis and application of 13C-isotopically labelled inositol-(1,4,5)-trisphosphate

  • Atharva Patharkar; Meike Amma; Jaime Isern; Zoé Chaudron; Angélique Besson-Bard; Valérie Nicolas-Francès; Claire Rosnoblet; David Wendehenne; Peter Schmieder; Dorothea Fiedler

RSC Chemical Biology 2025

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A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn

Nature Communications 2025

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Back Cover: Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents (Angew. Chem. Int. Ed. 11/2025)

  • Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2025

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A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

  • Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

  • Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

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An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler
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Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

  • Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

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An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N-Acetylglucosamine Kinase

  • Arif Celik; Ida Beyer; Dorothea Fiedler

Journal of the American Chemical Society 2024

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Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

  • Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler
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Proteome-wide quantification of inositol pyrophosphate-protein interactions

  • Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler
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Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

  • Tim Aguirre; Ellen Teichmann; Florian Q. Römpp; Ruthey Vivier; Cole Bryant; Matthew A. Hulverson; Wesley C. Van Voorhis; Kayode K. Ojo; J. Stone Doggett; Dorothea Fiedler; Stefan Hecht

ACS Chemical Biology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Real-time monitoring of the sialic acid biosynthesis pathway by NMR

  • Jacob L. Gorenflos López; Peter Schmieder; Kristin Kemnitz-Hassanin; Hatice Ceyda Asikoglu; Arif Celik; Christian E. Stieger; Dorothea Fiedler; Stephan Hinderlich; Christian P. R. Hackenberger

Chemical Science 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
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Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

  • Joka Pipercevic; Bastian Kohl; Ruta Gerasimaite; Véronique Comte-Miserez; Sarah Hostachy; Thomas Müntener; Elia Agustoni; Henning Jacob Jessen; Dorothea Fiedler; Andreas Mayer; Sebastian Hiller

Nature Communications 2023

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Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

  • Soumyadip Sahu; Jacob Gordon; Chunfang Gu; Mack Sobhany; Dorothea Fiedler; Robin E. Stanley; Stephen B. Shears

Biomolecules 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler
read online

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

  • Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

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Portraitfoto: © Silke Oßwald