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Prof. Dr.
Dorothea grew up in the most beautiful city in Germany: Hamburg. She went to college at the University of Wuerzburg and did her Diploma work at UC Berkeley. She decided she liked the United States for many reasons that include Thanksgiving (and also German beers are overrated), so she stayed at Berkeley for her Ph.D. She worked in the Raymond and Bergman labs, studying host-guest systems and their application to catalysis. She then moved across the Bay to UCSF, where she joined the Shokat lab to investigate signal transduction pathways. She started her academic career at Princeton University but recently relocated to the FMP, Berlin.
Photoswitchable Inhibitors to Optically Control Specific Kinase Activity
ACS Chemical Biology 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Real-time monitoring of the sialic acid biosynthesis pathway by NMR
Chemical Science 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction
Nature Communications 2023
read onlineNucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7
Biomolecules 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Pharmacological tools to investigate inositol polyphosphate kinases – Enzymes of increasing therapeutic relevance
Advances in Biological Regulation 2022
read onlineVersatile signaling mechanisms of inositol pyrophosphates
Current Opinion in Chemical Biology 2022
read onlineStable isotopomers of myo-inositol to uncover the complex MINPP1-dependent inositol phosphate network
Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in <i>S. pombe</i>
Journal of Fungi 2022
read onlineStable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network
ACS Central Science 2022
read onlineInvestigation of a potential electrogenic transport-system for myo-inositol in the small intestine of laying hens
British Poultry Science 2022
read onlineUsing Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate–Protein Interactions with Surface-Based Biosensors
Biochemistry 2021
read onlineConversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
Nature Communications 2021
read onlineDissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
Chemical Science 2021
read onlineDelivery of myo‐Inositol Hexakisphosphate to the Cell Nucleus with a Proline‐Based Cell‐Penetrating Peptide
Angewandte Chemie 2020
read onlineDelivery of myo‐Inositol Hexakisphosphate to the Cell Nucleus with a Proline‐Based Cell‐Penetrating Peptide
Angewandte Chemie International Edition 2020
read onlineInsP 7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
Proceedings of the National Academy of Sciences 2020
read onlineHarnessing13C-labeledmyo-inositol to interrogate inositol phosphate messengers by NMR
Chemical Science 2019
read onlineScalable Chemoenzymatic Synthesis of Inositol Pyrophosphates
Biochemistry 2019
read onlineThe Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany