Portrait

Prof. Dr.

Christian Hackenberger

Prof. Dr. Christian Hackenberger studied chemistry at the University of Freiburg, at the RWTH Aachen and at the University of Wisconsin/Madison (USA). Since 2012, he is Leibniz-Humboldt Professor of Chemical Biology at Humboldt University and Head of the Chemical Biology II Department at the FMP. He is the founder of Tubulis GmbH, a company that develops new, better-tolerated therapeutics against cancer.

  • Head Peptide Chemistry
  • Humboldt-Leibniz Professor Chemical Biology Humboldt-Universität zu Berlin

Chemical Biology


Hackenberger Group
Peptide Chemistry


FMP

Curriculum Vitae

Since 2012

Leibniz-Humboldt-Professor (W3) for Chemical Biology

FMP and HU Berlin

2011

Habilitation and venia legendi in Organic Chemistry

Freie Universität Berlin

2011 – 2012

Associate Professor (W2) for Bioorganic Chemistry

Freie Universität Berlin

2006 – 2011

Emmy-Noether-Group leader (DFG)

Freie Universität Berlin

2005 – 2006

Junior group leader as Liebig-Scholar (FCI)

Freie Universität Berlin

2003 – 2005

Postdoctoral work with Prof. Barbara Imperiali

Massachusetts Institute of Technology, USA

Awards

Breakthrough of the Year-Award (Life Sciences) by the Falling Walls Foundation
2020

Novartis Lecturer and Visiting Professor New York University (NYU)
2019

Leonidas Zervas Award of the European Peptide Society
2018

JSPS Invitational Fellowship (Japan)
2018

Leibniz-Gründerpreis and m4 award for the biotech start-up Tubulis
2018

Visiting Professor at the Leopold-Franzens Universität Innsbruck
2018

Fellow of the Royal Society of Chemistry
2016

“The best 40 under 40 in Germany” (Welt am Sonntag)
2014

Harlan L. and Margaret L. Goering Visiting Professor of Chemistry (UW Madison/WI, USA)
2013

ORCHEM-Award of the GDCh
2012

Recognized as “Top 40 young German scientists under 40” (Capital)
2011/2012/2014

Heinz-Maier-Leibnitz-Award of the DFG
2011

ADUC-Award of the GDCh
2011

Dozentenstipendium of the Fonds der chemischen Industrie (FCI) and the Aventis Foundation
2011

Award in the competition “Junior investigator of the year 2010”
2010

Plus 3-Award of the Boehringer-Ingelheim Foundation
2010

Award of the GDCh section “Macromolecular Chemistry” (FG Makromolekulare Chemie)
2009

Award of the Otto-Röhm Memorial Foundation
2008

Emmy-Noether-Group leader
2006

Liebig-Scholarship of the FCI
2005

Thieme-Journal Award
2005

Postdoctoral fellowship of the DAAD and DFG
2003/2005

Borchers Medal and Friedrich-Wilhelm Preis (RWTH Aachen)
2003

Scholarship for scientific journalism of the FCI
2001

Kekulé-Ph.D.-Scholarship of the FCI and of the Studienstiftung des deutschen Volkes
2000/2001

Study-abroad Scholarship of the Universität Freiburg within the “Academic-Year-Programs”
1998

Scholarship of the Studienstiftung des deutschen Volkes
1997

Cooperations

Tubulis GmbH

Publications

of 8

Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives

  • Schneider, A. F. L.
  • Kithil, M.
  • Cardoso, M. C.
  • Lehmann, M., &
  • Hackenberger, C. P. R.

Nature Chemistry 2020, in press,

Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations

  • Baumann, A. L.
  • Schwagerus, S.
  • Broi, K.
  • Kemnitz-Hassanin, K.
  • Stieger, C. E.
  • Trieloff, N.
  • Schmieder, P., &
  • Hackenberger, C. P. R.

Journal of the American Chemical Society 2020, 142, 9544-9552

read online

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

  • Hauser, A.
  • Hwang, S.
  • Sun, H., &
  • Hackenberger, C. P. R.

Chemical Science 2020, 11, doi:10.1039/D0SC03930F

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Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

  • Tu, Z. X.
  • Donskyi, E. G.
  • Qiao, H. S.
  • Zhu, Z. L.
  • Unger, W. E. S.
  • Hackenberger, C. P. R.
  • Chen, W.
  • Adeli, M., &
  • Haag, R.

Advanced Functional Materials 2020, 2000933

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Modern Peptide and Protein Chemistry: Reaching New Heights

  • Hackenberger, C. P. R.
  • Dawson, P. E.
  • Chen, Y. X., &
  • Hojo, H.

Journal of Organic Chemistry 2020, 85, 1328-1330

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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

  • Kasper, M. A.
  • Gerlach, M.
  • Schneider, A. F. L.
  • Groneberg, C.
  • Ochtrop, P.
  • Boldt, S.
  • Schumacher, D.
  • Helma, J.
  • Leonhardt, H.
  • Christmann, M., &
  • Hackenberger, C. P. R.

ChemBioChem 2020, 21, 113-119

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Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

  • Lauster, D.
  • Klenk, S.
  • Ludwig, K.
  • Nojoumi, S.
  • Behren, S.
  • Adam, L.
  • Stadtmüller, M.
  • Saenger, S.
  • Zimmler, S.
  • Honzke, K.
  • Yao, L.
  • Hoffmann, U.
  • Bardua, M.
  • Hamann, A.
  • Witzenrath, M.
  • Sander, L. E.
  • Wolff, T.
  • Hocke, A. C.
  • Hippenstiel, S.
  • De Carlo, S.
  • Neudecker, J.
  • Osterrieder, K.
  • Budisa, N.
  • Netz, R. R.
  • Böttcher, C.
  • Liese, S.
  • Herrmann, A., &
  • Hackenberger, C. P. R.

Nature Nanotechnology 2020, 15, 373-379

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Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics

  • Hauser, A.
  • Poulou, E.
  • Müller, F.
  • Schmieder, P., &
  • Hackenberger, C. P. R.

Chemistry 2020, Online ahead of print, 2326-2331

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Publications

of 8

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations

  • Kasper, M. A.
  • Glanz, M.
  • Stengl, A.
  • Penkert, M.
  • Klenk, S.
  • Sauer, T.
  • Schumacher, D.
  • Helma, J.
  • Krause, E.
  • Cardoso, M. C.
  • Leonhardt, H., &
  • Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11625-11630

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Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

  • Penkert, M.
  • Hauser, A.
  • Harmel, R.
  • Fiedler, D.
  • Hackenberger, C. P. R., &
  • Krause, E.

Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585

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Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

  • Kasper, M. A.
  • Stengl, A.
  • Ochtrop, P.
  • Gerlach, M.
  • Stoschek, T.
  • Schumacher, D.
  • Helma, J.
  • Penkert, M.
  • Krause, E.
  • Leonhardt, H., &
  • Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11631-11636

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In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation

  • Nojoumi, S.
  • Ma, Y.
  • Schwagerus, S.
  • Hackenberger, C. P. R., &
  • Budisa, N.

International Journal of Molecular Sciences 2019, 20, 2299

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Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

  • Apel, C.
  • Kasper, M. A.
  • Stieger, C. E.
  • Hackenberger, C. P. R., &
  • Christmann, M.

Organic Letters 2019, 21, 10043-10047

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Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

  • Schneider, A. F. L.
  • Wallabregue, A. L. D.
  • Franz, L., &
  • Hackenberger, C. P. R.

Bioconjugate Chemistry 2019, 30, 400-404

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TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles

  • Stengl, A.
  • Gerlach, M.
  • Kasper, M. A.
  • Hackenberger, C. P. R.
  • Leonhardt, H.
  • Schumacher, D., &
  • Helma, J.

Organic & Biomolecular Chemistry 2019, 17, 4964-4969

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Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization

  • Kasper, M. A.
  • Glanz, M.
  • Oder, A.
  • Schmieder, P.
  • Kries, J. P., &
  • Hackenberger, C. P. R.

Chemical Science 2019, 10, 6322-6329

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