Wen-Ting Lo

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

• Jiachen Sun; Seohyeon Song; Indira Singaram; Ashutosh Sharma; Wei Wang; Yusi Hu; Wen-Ting Lo; Philipp Alexander Koch; Jean J. Zhao; Volker Haucke; Ruixuan Gao; Wonhwa Cho

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

• Murat Kücükdisli; Hassen Bel-Abed; Davide Cirillo; Wen-Ting Lo; Nina-Louisa Efrém; André Horatscheck; Liudmila Perepelittchenko; Polina Prokofeva; Theresa A. L. Ehret; Silke Radetzki; Martin Neuenschwander; Edgar Specker; Guillaume Médard; Susanne Müller; Stephanie Wilhelm; Bernhard Kuster; Jens Peter von Kries; Volker Haucke; Marc Nazare

Journal of Medicinal Chemistry 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

• Wen-Ting Lo; Hassane Belabed; Murat Kücükdisli; Juliane Metag; Yvette Roske; Polina Prokofeva; Yohei Ohashi; Andre Horatscheck; Davide Cirillo; Michael Krauss; Christopher Schmied; Martin Neuenschwander; Jens Peter von Kries; Guillaume Médard; Bernhard Kuster; Olga Perisic; Roger Williams; Oliver Daumke; Bernard; Sonia Severin; Marc Nazare; Volker Haucke

Nature Chemical Biology 2023

Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

• Paula Samsó; Philipp Alexander Koch; York Posor; Wen-Ting Lo; Hassane Belabed; Marc Nazare; jocelyn laporte; Volker Haucke

Proceedings of the National Academy of Sciences 2022

Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer

• Huayi Li; Lorenzo Prever; Myriam Y. Hsu; Wen‐Ting Lo; Jean Piero Margaria; Maria Chiara De Santis; Cristina Zanini; Marco Forni; Francesco Novelli; Salvatore Pece; Pier Paolo Di Fiore; Paolo Ettore Porporato; Miriam Martini; Hassane Belabed; Marc Nazare; Volker Haucke; Federico Gulluni; Emilio Hirsch

Advanced Science 2022

Structural basis of phosphatidylinositol 3-kinase C2α function

• Wen-Ting Lo; Yingyi Zhang; Oscar Vadas; Yvette Roske; Federico Gulluni; Maria Chiara De Santis; Andreja Vujicic Zagar; Heike Stephanowitz; Emilio Hirsch; Fan Liu; Oliver Daumke; Misha Kudryashev; Volker Haucke

Nature Structural & Molecular Biology 2022

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

• Wen-Ting Lo

Science 2021

Phosphoinositide switches in endocytosis and in the endolysosomal system

• Wen-Ting Lo

Current Opinion in Cell Biology 2019

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module

• Wen-Ting Lo

Molecular Cell 2018

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

• Wen-Ting Lo

Science 2017

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission

• Wen-Ting Lo

Nature Communications 2017

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch

• Wen-Ting Lo

Developmental Cell 2017

A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress

• Wen-Ting Lo

Nucleic Acids Research 2013

Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress

• Wen-Ting Lo

Nucleic Acids Research 2012

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

• Wen-Ting Lo

Molecular Cell 2012

Crystal Structure of the C-Terminal Domain of a Flagellar Hook-Capping Protein from Xanthomonas campestris

• Wen-Ting Lo

Journal of Molecular Biology 2008

Crystallization and preliminary X-ray analysis of XC1015, a histidine triad-like protein fromXanthomonas campestris

• Wen-Ting Lo

Acta Crystallographica Section F Structural Biology and Crystallization Communications 2006