„”
Dr.
Process Automation and HTS Data Analysis
Project management for biochemical screens
Specialised in automated liquid handling (Tecan, Beckman Coulter systems) and automated data analysis (R and Python scripting, image analysis, KNIME workflow creation). Basic experience in Design of Experiments (DoE).
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
bioRxiv 2024
read online7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
eLife 2024
read online7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
bioRxiv 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
eLife 2023
read onlineStructural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition
Journal of Medicinal Chemistry 2023
read onlineSmall Molecules Targeting Human UDP-GlcNAc 2-Epimerase
ChemBioChem 2023
read onlineThe FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions
FEBS Letters 2023
read onlineDevelopment of selective inhibitors of phosphatidylinositol 3-kinase C2α
Nature Chemical Biology 2023
read onlineCLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors
Cell Chemical Biology 2023
read onlineSmall molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation
PLoS ONE 2023
read onlineStructure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors
Journal of Medicinal Chemistry 2022
read onlineAML-377 A “Designed” High-Throughput Drug Screening Strategy Identifies Aurora Kinase A Inhibitors as Promising Preclinical Candidates for the Treatment of NPM1-Mutated AML
Clinical Lymphoma, Myeloma and Leukemia 2022
read onlineDisruptors of AKAP-Dependent Protein–Protein Interactions
Methods in Molecular Biology 2022
read onlineGlycolytic flux control by drugging phosphoglycolate phosphatase
Nature Communications 2022
read onlinePentafluorosulfanyl (SF<sub>5</sub>) as a Superior <sup>19</sup>F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives
ACS Sensors 2021
read onlineTopical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Clinical and Translational Allergy 2021
read onlineAuthor Correction: Loss-of-function uORF mutations in human malignancies (Scientific Reports, (2018), 8, 1, (2395), 10.1038/s41598-018-19201-8)
Scientific Reports 2021
read onlineFrom Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement
Journal of Medicinal Chemistry 2020
read onlineRevealing cytotoxic substructures in molecules using deep learning
Journal of Computer-Aided Molecular Design 2020
read onlineCyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP
Cells 2020
read onlineRegulation of influenza a virus mRNA splicing by CLK1
Antiviral Research 2019
read onlineA new highly thyrotropin receptor-selective small-molecule antagonist with potential for the treatment of graves' orbitopathy
Thyroid 2019
read onlineEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discovery 2019
read onlineDrug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling
PLoS ONE 2018
read onlineUse of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/ translocation pathway
PLoS ONE 2018
read onlineLoss-of-function uORF mutations in human malignancies
Scientific Reports 2018
read onlineAn AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells
PLoS ONE 2018
read onlineSystematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
EMBO Molecular Medicine 2018
read onlineSmall-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Nature Neuroscience 2017
read onlineSmall Molecules Targeting Human N-Acetylmannosamine Kinase
ChemBioChem 2017
read onlineIdentification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells
SLAS Discovery 2017
read onlineA Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus
Angewandte Chemie - International Edition 2017
read onlineStatin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
PLoS Biology 2017
read onlinePharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma
Blood 2017
read onlineTractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform
Molecular Diversity 2014
read onlineFunctional mapping of protein-protein interactions in an enzyme complex by directed evolution
PloS one 2014
read onlineIdentification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A
Biochemical and Biophysical Research Communications 2013
read onlineSmall-molecule screening identifies modulators of aquaporin-2 trafficking
Journal of the American Society of Nephrology 2013
read onlinePharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL
Cancer Cell 2012
read onlineSustainable synthesis and automated deposition: An accessible discovery screening library of fragment-like purines
Molecular Diversity 2012
read onlineEquipping in vivo Selection Systems with Tunable Stringency
Protein Engineering Handbook, Volume 1 & Volume 2 2011
read onlineAn N-terminal protein degradation tag enables robust selection of highly active enzymes
Biochemistry 2011
read onlineA simple selection strategy for evolving highly efficient enzymes
Nature Biotechnology 2007
read onlineMetabolic engineering of a genetic selection system with tunable stringency
Proceedings of the National Academy of Sciences of the United States of America 2007
read onlineThe Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany