Martin Neuenschwander

Dr.

Martin Neuenschwander

Process Automation and HTS Data Analysis

Project management for biochemical screens

Specialised in automated liquid handling (Tecan, Beckman Coulter systems) and automated data analysis (R and Python scripting, image analysis, KNIME workflow creation). Basic experience in Design of Experiments (DoE).

Chemical Biology


Screening-Unit


FMP

7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

  • Brenner, M.; Zink, C.; Witzinger, L.; Keller, A.; Hadamek, K.; Bothe, S.; Neuenschwander, M.; Villmann, C.; von Kries, J.P.; Schindelin, H.; Jeanclos, E.; Gohla, A.

bioRxiv 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Aguirre, T.; Dornan, G.L.; Hostachy, S.; Neuenschwander, M.; Seyffarth, C.; Haucke, V.; Schütz, A.; von Kries, J.P.; Fiedler, D.

eLife 2023

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Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

  • Kücükdisli, M.; Bel-Abed, H.; Cirillo, D.; Lo, W.-T.; Efrém, N.-L.; Horatscheck, A.; Perepelittchenko, L.; Prokofeva, P.; Ehret, T.A.L.; Radetzki, S.; Neuenschwander, M.; Specker, E.; Médard, G.; Müller, S.; Wilhelm, S.; Kuster, B.; Von Kries, J.P.; Haucke, V.; Nazaré, M.

Journal of Medicinal Chemistry 2023

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Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase

  • Gorenflos López, J.L.; Dornan, G.L.; Boback, N.; Neuenschwander, M.; Oder, A.; Kemnitz-Hassanin, K.; Schmieder, P.; Specker, E.; Asikoglu, H.C.; Oberdanner, C.; Seyffarth, C.; von Kries, J.P.; Lauster, D.; Hinderlich, S.; Hackenberger, C.P.R.

ChemBioChem 2023

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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions

  • Ahmed, S.M.; Ragunathan, P.; Shin, J.; Peter, S.; Kleissle, S.; Neuenschwander, M.; Schäfer, R.; Kries, J.P.V.; Grüber, G.; Dröge, P.

FEBS Letters 2023

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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

  • Lo, W.-T.; Belabed, H.; Kücükdisli, M.; Metag, J.; Roske, Y.; Prokofeva, P.; Ohashi, Y.; Horatscheck, A.; Cirillo, D.; Krauss, M.; Schmied, C.; Neuenschwander, M.; von Kries, J.P.; Médard, G.; Kuster, B.; Perisic, O.; Williams, R.L.; Daumke, O.; Payrastre, B.; Severin, S.; Nazaré, M.; Haucke, V.

Nature Chemical Biology 2023

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CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors

  • Mucka, P.; Lindemann, P.; Bosco, B.; Willenbrock, M.; Radetzki, S.; Neuenschwander, M.; Brischetto, C.; Peter von Kries, J.; Nazaré, M.; Scheidereit, C.

Cell Chemical Biology 2023

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Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

  • Jordan, P.; Costa, A.; Specker, E.; Popp, O.; Volkamer, A.; Piske, R.; Obrusnik, T.; Kleissle, S.; Stuke, K.; Rex, A.; Neuenschwander, M.; von Kries, J.P.; Nazare, M.; Mertins, P.; Kettenmann, H.; Wolf, S.A.

PLoS ONE 2023

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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

  • Liss, M.; Radke, M.H.; Eckhard, J.; Neuenschwander, M.; Dauksaite, V.; Von Kries, J.-P.; Gotthardt, M.

PLoS ONE 2018

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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/ translocation pathway

  • Klein, W.; Rutz, C.; Eckhard, J.; Provinciael, B.; Specker, E.; Neuenschwander, M.; Kleinau, G.; Scheerer, P.; Von Kries, J.-P.; Nazaré, M.; Vermeire, K.; Schülein, R.

PLoS ONE 2018

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Loss-of-function uORF mutations in human malignancies

  • Schulz, J.; Mah, N.; Neuenschwander, M.; Kischka, T.; Ratei, R.; Schlag, P.M.; Castaños-Vélez, E.; Fichtner, I.; Tunn, P.-U.; Denkert, C.; Klaas, O.; Berdel, W.E.; Von Kries, J.P.; Makalowski, W.; Andrade-Navarro, M.A.; Leutz, A.; Wethmar, K.

Scientific Reports 2018

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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

  • Schrade, K.; Tröger, J.; Eldahshan, A.; Zühlke, K.; Abdul Azeez, K.R.; Elkins, J.M.; Neuenschwander, M.; Oder, A.; Elkewedi, M.; Jaksch, S.; Andrae, K.; Li, J.; Fernandes, J.; Müller, P.M.; Grunwald, S.; Marino, S.F.; Vukićević, T.; Eichhorst, J.; Wiesner, B.; Weber, M.; Kapiloff, M.; Rocks, O.; Daumke, O.; Wieland, T.; Knapp, S.; Von Kries, J.P.; Klussmann, E.

PLoS ONE 2018

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Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

  • Otten, C.; Knox, J.; Boulday, G.; Eymery, M.; Haniszewski, M.; Neuenschwander, M.; Radetzki, S.; Vogt, I.; Hähn, K.; De Luca, C.; Cardoso, C.; Hamad, S.; Igual Gil, C.; Roy, P.; Albiges-Rizo, C.; Faurobert, E.; von Kries, J.P.; Campillos, M.; Tournier-Lasserve, E.; Derry, W.B.; Abdelilah-Seyfried, S.

EMBO Molecular Medicine 2018

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Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

  • Wetzel, C.; Pifferi, S.; Picci, C.; Gök, C.; Hoffmann, D.; Bali, K.K.; Lampe, A.; Lapatsina, L.; Fleischer, R.; Smith, E.S.J.; Bégay, V.; Moroni, M.; Estebanez, L.; Kühnemund, J.; Walcher, J.; Specker, E.; Neuenschwander, M.; Von Kries, J.P.; Haucke, V.; Kuner, R.; Poulet, J.F.A.; Schmoranzer, J.; Poole, K.; Lewin, G.R.

Nature Neuroscience 2017

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Small Molecules Targeting Human N-Acetylmannosamine Kinase

  • Hinderlich, S.; Neuenschwander, M.; Wratil, P.R.; Oder, A.; Lisurek, M.; Nguyen, L.D.; von Kries, J.P.; Hackenberger, C.P.R.

ChemBioChem 2017

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Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

  • Carter, D.M.; Specker, E.; Przygodda, J.; Neuenschwander, M.; von Kries, J.P.; Heinemann, U.; Nazaré, M.; Gohlke, U.

SLAS Discovery 2017

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A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus

  • Fetzer, C.; Korotkov, V.S.; Thänert, R.; Lee, K.M.; Neuenschwander, M.; von Kries, J.P.; Medina, E.; Sieber, S.A.

Angewandte Chemie - International Edition 2017

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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

  • Juneja, M.; Kobelt, D.; Walther, W.; Voss, C.; Smith, J.; Specker, E.; Neuenschwander, M.; Gohlke, B.-O.; Dahlmann, M.; Radetzki, S.; Preissner, R.; von Kries, J.P.; Schlag, P.M.; Stein, U.

PLoS Biology 2017

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Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

  • Du, J.; Neuenschwander, M.; Yu, Y.; Däbritz, J.H.M.; Neuendorff, N.-R.; Schleich, K.; Bittner, A.; Milanovic, M.; Beuster, G.; Radetzki, S.; Specker, E.; Reimann, M.; Rosenbauer, F.; Mathas, S.; Lohneis, P.; Hummel, M.; Dörken, B.; Von Kries, J.P.; Lee, S.; Schmitt, C.A.

Blood 2017

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