Mark de Geus

Synthesis of Peptides Containing a Combination of Free and 2‐trans‐Cyclooctene Carbamate Protected Lysine Residues

• W. Doelman; N. A. M. Ligthart; M. A. T. van de Plassche; M. A. R. de Geus; L. Reinalda; M. M. E. Isendoorn; D. V. Filippov; S. I. van Kasteren

ChemBioChem 2024

A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

• Nina A.M. Ligthart; Mark A.R. de Geus; Merel A.T. van de Plassche; Diana Torres García; Marjolein M.E. Isendoorn; Luuk Reinalda; Daniëlle Ofman; Tyrza van Leeuwen; Sander I. van Kasteren

Journal of the American Chemical Society 2023

DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling

• Christian Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich Süssmuth; Johannes Broichhagen; Mu-Hyun Baik; Christian P.R. Hackenberger

Angewandte Chemie International Edition 2022

Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands

• Michel J. van de Graaff; Timo Oosenbrug; Mikkel H. S. Marqvorsen; Clarissa R. Nascimento; Mark A.R. de Geus; Bénédicte Manoury; Maaike E. Ressing

Bioconjugate Chemistry 2020

Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

• Mark A.R. de Geus; Elmer Maurits; Alexi J. C. Sarris; Thomas Hansen; Max Kloet; Kiki Kamphorst; Wolter Hoeve; Marc Robillard; Andrea Pannwitz; Sylvestre Bonnet; Jeroen Codee; Dmitri V. Filippov; Herman Overkleeft

Chemistry – A European Journal 2020

Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the<i>lac</i>repressor

• Mark A.R. de Geus; G. J. Mirjam Groenewold; Elmer Maurits; Can Araman

Chemical Science 2020

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

• Anouk M. F. van der Gracht; Mark A. R. de Geus; Marcel G. M. Camps; Tracy J. Ruckwardt; Alexi J. C. Sarris; Jessica Bremmers; Elmer Maurits; Joanna B. Pawlak; Michelle M. Posthoorn; Kimberly Bonger; Dmitri V. Filippov; Herman Overkleeft; Marc Robillard; Ferry Ossendorp

ACS Chemical Biology 2018

Click‐to‐Release from trans‐Cyclooctenes: Mechanistic Insights and Expansion of Scope from Established Carbamate to Remarkable Ether Cleavage

• Ron M. Versteegen; Wolter ten Hoeve; Raffaella Rossin; Mark A. R. de Geus; Henk M. Janssen; Marc Robillard

Angewandte Chemie International Edition 2018

Fast and pH‐Independent Elimination of trans‐Cyclooctene by Using Aminoethyl‐Functionalized Tetrazines

• Alexi J. C. Sarris; Thomas Hansen; Mark A. R. de Geus; Elmer Maurits; Ward Doelman; Herman S. Overkleeft; Jeroen D. C. Codée; Dmitri V. Filippov; Sander I. van Kasteren

Chemistry – A European Journal 2018

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

• Kassiani Kytidou; Thomas J. M. Beenakker; Lotte B. Westerhof; Cornelis H. Hokke; Geri F. Moolenaar; Nora Goosen; Mina Mirzaian; Maria J. Ferraz; Mark de Geus; Wouter W. Kallemeijn; Herman S. Overkleeft; Rolf G. Boot; Arjen Schots; Dirk Bosch; Johannes M. F. G. Aerts

Frontiers in Plant Science 2017

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy

• Patrick Wisse; Mark A. R. de Geus; Gen Cross; Adrianus M. C. H. van den Nieuwendijk; Eva J. van Rooden; Richard J. B. H. N. van den Berg; Johannes M. F. G. Aerts; Gijsbert A. van der Marel; Jeroen D. C. Codée; Herman S. Overkleeft

The Journal of Organic Chemistry 2015