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Dr.
Head of Screening Unit
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Journal of medicinal chemistry 2023
read onlineDiscovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
eLife 2023
read onlineSmall Molecules Targeting Human UDP-GlcNAc 2-Epimerase.
Chembiochem : a European journal of chemical biology 2023
read onlineStructural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Journal of medicinal chemistry 2023
read online7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection.
Frontiers in neurology 2023
read onlineAn unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation.
iScience 2023
read onlineSmall molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
PloS one 2023
read onlineThe FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
FEBS letters 2023
read onlineGlycolytic flux control by drugging phosphoglycolate phosphatase.
Nature communications 2022
read onlineTSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
The EMBO journal 2022
read onlineDevelopment of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Nature chemical biology 2022
read onlineStructure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Journal of medicinal chemistry 2022
read onlineDisruptors of AKAP-Dependent Protein-Protein Interactions.
Methods in molecular biology (Clifton, N.J.) 2022
read onlineAurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
International Journal of Molecular Sciences 2022
read onlineTSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation
Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner.
Cancer letters 2021
read onlineAuthor Correction: Loss-of-function uORF mutations in human malignancies.
Scientific reports 2021
read onlineA Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
Frontiers in cell and developmental biology 2021
read onlineTopical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
Clinical and translational allergy 2021
read onlineFrom Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Journal of medicinal chemistry 2020
read onlineA semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.
Cells 2020
read onlineIdentification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.
eLife 2019
read onlineRegulation of influenza A virus mRNA splicing by CLK1.
Antiviral research 2019
read onlineVinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization.
Chemical science 2019
read onlineHigh-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.
Stem cell reports 2019
read onlineEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.
SLAS discovery : advancing life sciences R & D 2019
read onlineIdentification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.
Thyroid : official journal of the American Thyroid Association 2018
read onlineUse of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
PloS one 2018
read onlineSystematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
EMBO molecular medicine 2018
read onlineDrug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
PloS one 2018
read onlineLoss-of-function uORF mutations in human malignancies.
Scientific reports 2018
read onlineAn AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
PloS one 2018
read onlineSmall Molecules Targeting Human N-Acetylmannosamine Kinase.
Chembiochem : a European journal of chemical biology 2017
read onlineDiscovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Journal of medicinal chemistry 2017
read onlineA Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.
Angewandte Chemie (International ed. in English) 2017
read onlineNeuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of <i>aqp-8</i> in <i>C. elegans</i>.
Frontiers in physiology 2017
read onlineStatin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
PLoS biology 2017
read onlineIdentification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.
SLAS discovery : advancing life sciences R & D 2017
read onlineSmall-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Nature neuroscience 2016
read onlineStructural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
The Journal of biological chemistry 2016
read onlinePharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.
Blood 2016
read onlineA Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.
Cancer research 2015
read onlineSubstrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.
Chembiochem : a European journal of chemical biology 2015
read onlineSelective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.
ChemMedChem 2015
read onlineDesign of a general-purpose European compound screening library for EU-OPENSCREEN.
ChemMedChem 2014
read onlineIdentification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Science (New York, N.Y.) 2014
read onlineHighly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Angewandte Chemie (International ed. in English) 2013
read onlineSmall-molecule screening identifies modulators of aquaporin-2 trafficking.
Journal of the American Society of Nephrology : JASN 2013
read onlineIdentification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Biochemical and biophysical research communications 2013
read onlineFunctional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression.
Molecular and cellular biology 2012
read onlineA novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Cancer research 2012
read onlineIdentification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase.
Chembiochem : a European journal of chemical biology 2011
read onlineNovel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Cancer research 2011
read onlineMicrotubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
The Journal of biological chemistry 2011
read onlineRole of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
Cell 2011
read onlineBisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.
Proceedings of the National Academy of Sciences of the United States of America 2011
read onlineSmall molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
The Journal of biological chemistry 2010
read onlineThe use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction.
Clinical and experimental immunology 2010
read onlineA novel DNA gyrase inhibitor rescues Escherichia coli dnaAcos mutant cells from lethal hyperinitiation.
The Journal of antimicrobial chemotherapy 2010
read onlineIdentification of small-molecule scaffolds for p450 inhibitors.
Current protocols in microbiology 2010
read onlineDesign of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.
Molecular diversity 2009
read onlineInteraction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
The Journal of biological chemistry 2009
read onlineTranslocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.
Sensors (Basel, Switzerland) 2009
read onlineIndomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
Journal of medicinal chemistry 2009
read onlineSpecific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Proceedings of the National Academy of Sciences of the United States of America 2008
read onlineX-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).
The Journal of biological chemistry 2008
read onlineThe structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.
Proceedings of the National Academy of Sciences of the United States of America 2006
read onlineCrystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
The Biochemical journal 2006
read onlineChicken MAR binding protein p120 is identical to human heterogeneous nuclear ribonucleoprotein (hnRNP) U.
Nucleic acids research 1994
read onlineBiochemical properties of attachment region binding protein ARBP.
FEBS letters 1994
read onlineA non-curved chicken lysozyme 5' matrix attachment site is 3' followed by a strongly curved DNA sequence.
Nucleic acids research 1990
read onlineThe chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.
Molecular and cellular biology 1990
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The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany
