Jacobo started his scientific career doing his final degree project under the supervision of Professor Eugenio Uriarte (Department of Pharmaceutical Chemistry, Faculty of Pharmacy). In this first stage, the synthesis of coumarin derivatives with interest in neurodegenerative diseases such as Parkinson's and Alzheimer's has been addressed.
Later, he studied the master's degree in Chemical Research, where he developed the master's thesis under the supervision of professors Miguel Vázquez and Eugenio Vázquez (CIQUS) in the area of biological chemistry. This work is based on the obtention of enantiopure peptide helicates that recognize minor DNA structures, called three-way junction DNA. This work has been the starting point for the projects carried out a posteriori during his doctoral thesis, which has been developed in the same research group and has followed a continuous line focused on the synthesis of metallopeptides with the capacity to recognize this non-canonical DNA structures.
During the doctoral thesis period he has spent 4 months in the group of Prof. Thorfinnur Gunnlaugsson (Trinity College of Dublin). During this time, a project based on obtaining rotaxanes with phosphorescent properties has been developed.