Gillian Leigh Dornan

The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology

• Philipp Alexander Koch; Gillian Leigh Dornan; Manuel Hessenberger; Volker Haucke

The FEBS Journal 2021

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

• Sarah Hostachy; Tillmann Utesch; Katy Franke; Gillian Leigh Dornan; David Furkert; Berke Türkaydin; Volker Haucke; Han Sun; Dorothea Fiedler

Chemical Science 2021

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.

• Gillian Leigh Dornan

Structure (London, England : 1993) 2019

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

• Dornan GL; Burke JE

Frontiers in Immunology 2018

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex

• Gillian L. Dornan; Udit Dalwadi; David J. Hamelin; Reece M. Hoffmann; Calvin K. Yip; John E. Burke

Journal of Molecular Biology 2018

Architecture of eukaryotic mRNA 3'-end processing machinery.

• Casañal A; Kumar A; Hill CH; Easter AD; Emsley P; Degliesposti G; Gordiyenko Y; Santhanam B; Wolf J; Wiederhold K; Dornan GL; Skehel M; Robinson CV; Passmore LA

Science (New York, N.Y.) 2017

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans.

• Takeda AJ; Zhang Y; Dornan GL; Siempelkamp BD; Jenkins ML; Matthews HF; McElwee JJ; Bi W; Seeborg FO; Su HC; Burke JE; Lucas CL

The Journal of allergy and clinical immunology 2017

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

• Dornan GL; Siempelkamp BD; Jenkins ML; Vadas O; Lucas CL; Burke JE

Proceedings of the National Academy of Sciences of the United States of America 2017

The genetic and biochemical basis of FANCD2 monoubiquitination.

• Rajendra E; Oestergaard VH; Langevin F; Wang M; Dornan GL; Patel KJ; Passmore LA

Molecular cell 2014