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Dr.
Edgar Specker studied chemistry at the University of Münster, Germany. After his diplomacy thesis at the Bayer AG he received his PhD in 2004 as a member of Prof. Klebe´s research group at the University of Marburg. During his postdoctoral studies he joined the group of Prof. Bradley at the Universities of Southampton and Edinburgh. His professional career as medicinal chemist started at the biotech company Zedira GmbH in 2005 working on the synthesis of transglutaminase inhibitors to treat Celiac disease. In 2007, he moved to the Jerini AG and collaborated in a joined project with the company Alcon. Since 2010 he is responsible for the compound management at the FMP, at first in the Screening Unit and then as part of the medicinal chemistry group. Since the beginning of 2020 he is the head of the independent core facility compound management at the FMP and helped to build up the compound management for EU-OPENSCREEN ERIC over the last 3 years. He is one of the founders of the start-up company Trypto Therapeutics GmbH.
Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression
JACC: Basic to Translational Science 2024
read onlineTPT‐004, a Next‐Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats
Journal of the American Heart Association 2024
read onlineDesign, Quality and Validation of the EU-OPENSCREEN Fragment Library Poised to a High-Throughput Screening Collection
RSC Medicinal Chemistry 2024
read onlineIdentification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
PLOS ONE 2024
read onlineStructure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors
Journal of Medicinal Chemistry 2023
read onlineSmall Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase
ChemBioChem 2023
read onlineSmall molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation
PLOS ONE 2023
read onlineDiscovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis
Biomedicine & Pharmacotherapy 2023
read onlineStructural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition
Journal of Medicinal Chemistry 2023
read onlineStructure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors
Journal of Medicinal Chemistry 2022
read onlineProbing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands
Journal of Medicinal Chemistry 2022
read onlineTopical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Clinical and Translational Allergy 2021
read onlineEnhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer
Journal of Medicinal Chemistry 2021
read onlineSmall-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells
Frontiers in Cellular Neuroscience 2019
read onlineEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discovery 2019
read onlineA New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid 2019
read onlineUse of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
PLOS ONE 2018
read onlineCellFy: A Cell-Based Fragment Screen against C-Type Lectins
ACS Chemical Biology 2018
read onlineIdentification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells
SLAS Discovery 2017
read onlineStatin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
PLOS Biology 2017
read onlineSmall-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Nature Neuroscience 2017
read onlinePharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma
Blood 2017
read onlineA Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Cancer Research 2016
read onlineTemperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures
Physical Chemistry Chemical Physics 2016
read onlineDesign of a General‐Purpose European Compound Screening Library for EU‐OPENSCREEN
ChemMedChem 2014
read onlineTractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform
Molecular Diversity 2014
read onlineNeurotoxin II Bound to Acetylcholine Receptors in Native Membranes Studied by Dynamic Nuclear Polarization NMR
Journal of the American Chemical Society 2011
read onlineAspartic Acid Proteases as Therapeutic Targets. Edited by Arun K. Ghosh.
ChemMedChem 2011
read onlineZwei neue privilegierte Bausteine und ein unerwarteter Bindungsmodus für HIV‐Protease‐Inhibitoren †
Angewandte Chemie 2005
read onlineAn Old Target Revisited: Two New Privileged Skeletons and an Unexpected Binding Mode For HIV‐Protease Inhibitors †
Angewandte Chemie 2005
read onlineHydroxyethylene sulfones as a new scaffold to address aspartic proteases
Journal of medicinal chemistry 2005
read onlineDde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA–peptide conjugates
Tetrahedron 2005
read onlineThe Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10,
13125 Berlin, Germany