portrait edgar specker

Dr.

Edgar Specker

Edgar Specker studied chemistry at the University of Münster, Germany. After his diplomacy thesis at the Bayer AG he received his PhD in 2004 as a member of Prof. Klebe´s research group at the University of Marburg. During his postdoctoral studies he joined the group of Prof. Bradley at the Universities of Southampton and Edinburgh. His professional career as medicinal chemist started at the biotech company Zedira GmbH in 2005 working on the synthesis of transglutaminase inhibitors to treat Celiac disease. In 2007, he moved to the Jerini AG and collaborated in a joined project with the company Alcon. Since 2010 he is responsible for the compound management at the FMP, at first in the Screening Unit and then as part of the medicinal chemistry group. Since the beginning of 2020 he is the head of the independent core facility compound management at the FMP and helped to build up the compound management for EU-OPENSCREEN ERIC over the last 3 years. He is one of the founders of the start-up company Trypto Therapeutics GmbH.


Chemical Biology


Compound Management


FMP
Trypto Therapeutics GmbH

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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors

  • Edgar Specker; Radoslaw Wesolowski; Anja Schütz; Susann Matthes; Keven Mallow; Malgorzata Wasinska-Kalwa; Lars Winkler; Andreas Oder; Natalia Alenina; Dirk Pleimes; Jens Peter von Kries; Udo Heinemann; Michael Bader; Marc Nazaré

Journal of Medicinal Chemistry 2023

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Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase

  • Jacob L. Gorenflos López; Gillian L. Dornan; Nico Boback; Martin Neuenschwander; Andreas Oder; Kristin Kemnitz‐Hassanin; Peter Schmieder; Edgar Specker; Hatice Ceyda Asikoglu; Christian Oberdanner; Carola Seyffarth; Jens Peter von Kries; Daniel Lauster; Stephan Hinderlich; Christian P.R. Hackenberger

ChemBioChem 2023

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Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

  • Philipp Jordan; Amanda Costa; Edgar Specker; Oliver Popp; Andrea Volkamer; Regina Piske; Tessa Obrusnik; Sabrina Kleissle; Kevin Stuke; André Rex; Martin Neuenschwander; Jens Peter von Kries; Marc Nazare; Phillip Mertins; Helmut Kettenmann; Susanne A. Wolf

PLOS ONE 2023

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Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

  • Shixian Yan; Paul Curtis Schöpe; Joe Lewis; Kerstin Putzker; Ulrike Uhrig; Edgar Specker; Jens Peter von Kries; Peter Lindemann; Anahid Omran; Hector E. Sanchez-Ibarra; Anke Unger; Mia-Lisa Zischinsky; Bert Klebl; Wolfgang Walther; Marc Nazaré; Dennis Kobelt; Ulrike Stein

Biomedicine & Pharmacotherapy 2023

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Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

  • Murat Kücükdisli; Hassen Bel-Abed; Davide Cirillo; Wen-Ting Lo; Nina-Louisa Efrém; André Horatscheck; Liudmila Perepelittchenko; Polina Prokofeva; Theresa A. L. Ehret; Silke Radetzki; Martin Neuenschwander; Edgar Specker; Guillaume Médard; Susanne Müller; Stephanie Wilhelm; Bernhard Kuster; Jens Peter von Kries; Volker Haucke; Marc Nazare

Journal of Medicinal Chemistry 2023

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Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

  • Ioanna Plastira; Lisha Joshi; Eva Bernhart; Jens Schoene; Edgar Specker; Marc Nazare; Wolfgang Sattler

Frontiers in Cellular Neuroscience 2019

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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

  • Philip Brennecke; Dace Rasina; Oscar Aubi; Katja Herzog; Johannes Landskron; Bastien Cautain; Francisca Vicente; Jordi Quintana; Jordi Mestres; Bahne Stechmann; Bernhard Ellinger; Jose Brea; Jacek L. Kolanowski; Radosław Pilarski; Mar Orzaez; Antonio Pineda-Lucena; Luca Laraia; Faranak Nami; Piotr Zielenkiewicz; Kamil Paruch; Espen Holst Hansen; Jens P. von Kries; Martin Neuenschwander; Edgar Specker; Petr Bartunek; Sarka Simova; Zbigniew Leśnikowski; Stefan Krauss; Lari Lehtiö; Ursula Bilitewski; Mark Brönstrup; Kjetil Taskén; Aigars Jirgensons; Heiko Lickert; Mads H. Clausen; Jeanette H. Andersen; Maria J. Vicent; Olga Genilloud; Aurora Martinez; Marc Nazaré; Wolfgang Fecke; Philip Gribbon

SLAS Discovery 2019

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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

  • Patrick Marcinkowski; Inna Hoyer; Edgar Specker; Jens Furkert; Claudia Rutz; Martin Neuenschwander; Sebastian Sobottka; Han Sun; Marc Nazare; Utta Berchner-Pfannschmidt; Jens Peter von Kries; Anja Eckstein; Ralf Schülein; Gerd Krause

Thyroid 2019

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Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

  • David M. Carter; Edgar Specker; Jessica Przygodda; Martin Neuenschwander; Jens Peter von Kries; Udo Heinemann; Marc Nazaré; Ulrich Gohlke

SLAS Discovery 2017

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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

  • Manisha Juneja; Dennis Kobelt; Wolfgang Walther; Cynthia Voss; Janice Smith; Edgar Specker; Martin Neuenschwander; Björn-Oliver Gohlke; Mathias Dahlmann; Silke Radetzki; Robert Preissner; Jens Peter von Kries; Peter Michael Schlag; Ulrike Stein

PLOS Biology 2017

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Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

  • Christiane Wetzel; Simone Pifferi; Cristina Picci; Caglar Gök; Diana Hoffmann; Bali KK; André Lampe; Liudmila Lapatsina; Raluca Fleischer; Ewan Smith; Valérie Bégay; Mirko Moroni; Luc Estebanez; Johannes Kühnemund; Jan Walcher; Edgar Specker; Martin Neuenschwander; Jens Peter von Kries; Volker Haucke; Rohini Kuner; James F A Poulet; Jan Schmoranzer; Kate Poole; Lewin GR

Nature Neuroscience 2017

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Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

  • Jing Du; Martin Neuenschwander; Yong Yu; J. Henry M. Däbritz; Nina-Rosa Neuendorff; Kolja Schleich; Aitomi Bittner; Maja Milanovic; Gregor Beuster; Silke Radetzki; Edgar Specker; Maurice Reimann; Frank Rosenbauer; Stephan Mathas; Philipp Lohneis; Michael Hummel; Bernd Dörken; Jens Peter von Kries; Soyoung Lee; Clemens A. Schmitt

Blood 2017

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Portraitfoto: © Katy Franke