Volker Haucke

Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

• Gaga Kochlamazashvili; Aarti Swaminathan; Alexander Stumpf; Amit Kumar; York Posor; Dietmar Schmitz; Volker Haucke; Marijn Kuijpers

Proceedings of the National Academy of Sciences 2025

Biogenesis and reformation of synaptic vesicles

• Svenja Bolz; Volker Haucke

The Journal of Physiology 2025

Control of renal calcium permeability via a tight junctional claudin switch

• Rozemarijn E. van der Veen; Marie Bieck; Nacéra Mezouar; Volker Haucke; Henrik Dimke; Martin Lehmann

Proceedings of the National Academy of Sciences 2025

mTORC1-Dependent Signaling in Layer 5b Neurons Is Required for Memory Consolidation

• Mik Schutte; Alexander Biermeier; Kinga Konkel; Anna Nasr; Anisha Dayaram; Christian Rosenmund; Robert Sachdev; Matthew E Larkum; Volker Haucke; Marina Mikhaylova

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

• Kate Prichard; Mark J. Robertson; Ngoc Chau; Jing Xue; Martin Neuenschwander; Uwe Fink; Andre Horatscheck; Marc Nazare; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2025

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

• Kate Prichard; Mark J Robertson; Ngoc Chau; Jing Xue; Martin Neuenschwander; Uwe Fink; Andre Horatscheck; Marc Nazare; Phillip J Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2025

Mechanisms and functions of lysosomal lipid homeostasis

• Michael Ebner; Florian Fröhlich; Volker Haucke

Cell Chemical Biology 2025

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

• Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

eLife 2024

ER remodeling via lipid metabolism

• Wonyul Jang; Volker Haucke

Trends in Cell Biology 2024

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

• Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

eLife 2024

Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2

• Giulia Russo; Nadja Hümpfer; Nina Jaensch; Steffen Restel; Christopher Schmied; Florian Heyd; Martin Lehmann; Volker Haucke; Helge Ewers; Michael Krauss

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

• Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

Phosphoinositide detection at synapses of fixed murine hippocampal neurons

• Svenja Bolz; Natalie Kaempf; Maria Muehlbauer; Delia Löwe; Volker Haucke

STAR Protocols 2024

A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

• York Posor; Volker Haucke

Journal of Cell Biology 2024

Canonical and non-canonical integrin-based adhesions dynamically interconvert

• Fabian Lukas; Claudia Matthaeus; Tania López-Hernández; Ines Lahmann; Nicole Schultz; Martin Lehmann; Dmytro Puchkov; Jan Pielage; Volker Haucke; Tanja Maritzen

Nature Communications 2024

OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

• Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies.

• Steinke S; Kirmann T; Loi EA; Nerlich J; Weichard I; Kuhn P; Bullmann T; Ritzau-Jost A; Rizalar FS; Prüss H; Haucke V; Geis C; Hust M; Hallermann S

Brain : a journal of neurology 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

• Laure Papin; Martin Lehmann; Justine Lagisquet; Ghizlane Maarifi; Véronique Robert-Hebmann; Christophe Mariller; Yann Guerardel; Lucile Espert; Volker Haucke; Fabien P. Blanchet

International Journal of Molecular Sciences 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Supplementary Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Supplementary Methods from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive–compulsive behaviors in mice

• Dennis Vollweiter; Jasmeet Kaur Shergill; Alexandra Hilse; Gaga Kochlamazashvili; Stefan Paul Koch; Susanne Mueller; Philipp Boehm-Sturm; Volker Haucke; Tanja Maritzen

Proceedings of the National Academy of Sciences 2023

Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

• Stephan J Sigrist; Volker Haucke

EMBO reports 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

• Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

• Kristine Oevel; Svea Hohensee; Atul Kumar; Irving Rosas-Brugada; Francesca Bartolini; Tolga Soykan; Volker Haucke

Data from The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Endosomal phosphatidylinositol 3‐phosphate controls synaptic vesicle cycling and neurotransmission

• Guan‐Ting Liu; Gaga Kochlamazashvili; Dmytro Puchkov; Rainer Müller; Carsten Schultz; Albert I Mackintosh; Dennis Vollweiter; Volker Haucke; Tolga Soykan

The EMBO Journal 2022

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3.

• Malek M; Wawrzyniak AM; Ebner M; Puchkov D; Haucke V

The Journal of biological chemistry 2022

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.

• Birke R; Ast J; Roosen DA; Lee J; Roßmann K; Huhn C; Mathes B; Lisurek M; Bushiri D; Sun H; Jones B; Lehmann M; Levitz J; Haucke V; Hodson DJ; Broichhagen J

Organic & biomolecular chemistry 2022

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.

• Li H; Prever L; Hsu MY; Lo WT; Margaria JP; De Santis MC; Zanini C; Forni M; Novelli F; Pece S; Di Fiore PP; Porporato PE; Martini M; Belabed H; Nazare M; Haucke V; Gulluni F; Hirsch E

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022

Selective endocytosis of Ca²⁺-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.

• Azarnia Tehran D; Kochlamazashvili G; Pampaloni NP; Sposini S; Shergill JK; Lehmann M; Pashkova N; Schmidt C; Löwe D; Napieczynska H; Heuser A; Plested AJR; Perrais D; Piper RC; Haucke V; Maritzen T

Science advances 2022

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.

• Jang W; Puchkov D; Samsó P; Liang Y; Nadler-Holly M; Sigrist SJ; Kintscher U; Liu F; Mamchaoui K; Mouly V; Haucke V

Science (New York, N.Y.) 2022

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover.

• Posor Y; Kampyli C; Bilanges B; Ganguli S; Koch PA; Wallroth A; Morelli D; Jenkins M; Alliouachene S; Deltcheva E; Baum B; Haucke V; Vanhaesebroeck B

Developmental cell 2022

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

• Lo WT; Belabed H; Kücükdisli M; Metag J; Roske Y; Prokofeva P; Ohashi Y; Horatscheck A; Cirillo D; Krauss M; Schmied C; Neuenschwander M; von Kries JP; Médard G; Kuster B; Perisic O; Williams RL; Daumke O; Payrastre B; Severin S; Nazaré M; Haucke V

Nature chemical biology 2022

Structural basis of phosphatidylinositol 3-kinase C2α function.

• Lo WT; Zhang Y; Vadas O; Roske Y; Gulluni F; De Santis MC; Zagar AV; Stephanowitz H; Hirsch E; Liu F; Daumke O; Kudryashev M; Haucke V

Nature structural & molecular biology 2022

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

• Viard J; Loe-Mie Y; Daudin R; Khelfaoui M; Plancon C; Boland A; Tejedor F; Huganir RL; Kim E; Kinoshita M; Liu G; Haucke V; Moncion T; Yu E; Hindie V; Bléhaut H; Mircher C; Herault Y; Deleuze JF; Rain JC; Simonneau M; Lepagnol-Bestel AM

Life science alliance 2022

Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.

• Gozzelino L; Kochlamazashvili G; Baldassari S; Mackintosh AI; Licchetta L; Iovino E; Liu YC; Bennett CA; Bennett MF; Damiano JA; Zsurka G; Marconi C; Giangregorio T; Magini P; Kuijpers M; Maritzen T; Norata GD; Baulac S; Canafoglia L; Seri M; Tinuper P; Scheffer IE; Bahlo M; Berkovic SF; Hildebrand MS; Kunz WS; Giordano L; Bisulli F; Martini M; Haucke V; Hirsch E; Pippucci T

Brain : a journal of neurology 2022

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.

• Kuijpers M; Kochlamazashvili G; Stumpf A; Puchkov D; Swaminathan A; Lucht MT; Krause E; Maritzen T; Schmitz D; Haucke V

Neuron 2022

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.

• López-Hernández T; Takenaka KI; Mori Y; Kongpracha P; Nagamori S; Haucke V; Takamori S

eLife 2022

The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane

• Claudia Matthaeus; Kem A. Sochacki; Andrea M. Dickey; Dmytro Puchkov; Volker Haucke; Martin Lehmann; Justin W. Taraska

Nature Communications 2022

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

• Hannes Gonschior; Christopher Schmied; Rozemarijn Eva Van der Veen; Jenny Eichhorst; Nina Himmerkus; Jörg Piontek; Dorothee Günzel; Markus Bleich; Mikio Furuse; Volker Haucke; Martin Lehmann

Nature Communications 2022

Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

• Paula Samsó; Philipp A. Koch; York Posor; Wen-Ting Lo; Hassane Belabed; Marc Nazare; Jocelyn Laporte; Volker Haucke

Proceedings of the National Academy of Sciences 2022

Phosphoinositides as membrane organizers

• York Posor; Wonyul Jang; Volker Haucke

Nature Reviews Molecular Cell Biology 2022

Inositol Triphosphate Signaling Triggers Lysosome Biogenesis Via Calcium Release from Endoplasmic Reticulum Stores

• Mouhannad Malek; Volker Haucke

Contact 2022

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

• Mouhannad Malek; Anna M. Wawrzyniak; Peter Koch; Christian Lüchtenborg; Manuel Hessenberger; Timo Sachsenheimer; Wonyul Jang; Britta Brügger; Volker Haucke

Nature Communications 2021

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

• Gulluni F; Prever L; Li H; Krafcikova P; Corrado I; Lo WT; Margaria JP; Chen A; De Santis MC; Cnudde SJ; Fogerty J; Yuan A; Massarotti A; Sarijalo NT; Vadas O; Williams RL; Thelen M; Powell DR; Schueler M; Wiesener MS; Balla T; Baris HN; Tiosano D; McDermott BM Jr; Perkins BD; Ghigo A; Martini M; Haucke V; Boura E; Merlo GR; Buchner DA; Hirsch E

Science (New York, N.Y.) 2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.

• Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Abudu YP; Acevedo-Arozena A; Adamopoulos IE; Adeli K; Adolph TE; Adornetto A; Aflaki E; Agam G; Agarwal A; Aggarwal BB; Agnello M; Agostinis P; Agrewala JN; Agrotis A; Aguilar PV; Ahmad ST; Ahmed ZM; Ahumada-Castro U; Aits S; Aizawa S; Akkoc Y; Akoumianaki T; Akpinar HA; Al-Abd AM; Al-Akra L; Al-Gharaibeh A; Alaoui-Jamali MA; Alberti S; Alcocer-Gómez E; Alessandri C; Ali M; Alim Al-Bari MA; Aliwaini S; Alizadeh J; Almacellas E; Almasan A; Alonso A; Alonso GD; Altan-Bonnet N; Altieri DC; Álvarez ÉMC; Alves S; Alves da Costa C

Autophagy 2021

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs.

• Hostachy S; Utesch T; Franke K; Dornan GL; Furkert D; Türkaydin B; Haucke V; Sun H; Fiedler D

Chemical science 2021

A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval.

• Haucke V

Developmental cell 2021

Mechanism of synaptic protein turnover and its regulation by neuronal activity.

• Soykan T; Haucke V; Kuijpers M

Current opinion in neurobiology 2021

Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy.

• Guerrero-Valero M; Grandi F; Cipriani S; Alberizzi V; Di Guardo R; Chicanne G; Sawade L; Bianchi F; Del Carro U; De Curtis I; Pareyson D; Parman Y; Schenone A; Haucke V; Payrastre B; Bolino A

Proceedings of the National Academy of Sciences of the United States of America 2021

Liquid-like protein assemblies initiate endocytosis

• Agata Witkowska; Volker Haucke

Nature Cell Biology 2021

The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology

• Philipp Alexander Koch; Gillian Leigh Dornan; Manuel Hessenberger; Volker Haucke

The FEBS Journal 2021

The axonal endolysosomal and autophagic systems

• Marijn Kuijpers; Domenico Azarnia Tehran; Volker Haucke; Tolga Soykan

Journal of Neurochemistry 2021

Neuronal autophagy controls the axonal endoplasmic reticulum to regulate neurotransmission in healthy neurons

• Marijn Kuijpers; Volker Haucke

Autophagy 2021

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

• Tania López-Hernández; Koh-ichiro Takenaka; Yasunori Mori; Pornparn Kongpracha; Shushi Nagamori; Volker Haucke; Shigeo Takamori

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

• Charles Malek; Anna Maria Wawrzyniak; Peter Koch; Manuel Hessenberger; Timo Sachsenheimer; Wonyul Jang; Britta Bruegger; Volker Haucke

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation.

• Rizalar FS; Roosen DA; Haucke V

Neuron 2020

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.

• Kuijpers M; Kochlamazashvili G; Stumpf A; Puchkov D; Swaminathan A; Lucht MT; Krause E; Maritzen T; Schmitz D; Haucke V

Neuron 2020

Endocytosis in the adaptation to cellular stress.

• López-Hernández T; Haucke V; Maritzen T

Cell stress 2020

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

• Hui Liu; Marcia N. Paddock; Haibin Wang; Charles J. Murphy; Renee C. Geck; Adrija J. Navarro; Gerburg M. Wulf; Olivier Elemento; Volker Haucke; Lewis C. Cantley; Alex Toker

Cancer Discovery 2020

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

• Linda Sawade; Federica Grandi; Marianna Mignanelli; Genaro Patiño-López; Kerstin Klinkert; Francina Langa-Vives; Roberta Di Guardo; Arnaud Echard; Alessandra Bolino; Volker Haucke

Nature Communications 2020

Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

• Tania López-Hernández; Dmytro Puchkov; Eberhard Krause; Tanja Maritzen; Volker Haucke

Nature Cell Biology 2020

Ramping up the autophagy-lysosome system to cope with osmotic stress

• Tania López-Hernández; Tanja Maritzen; Volker Haucke

Autophagy 2020

A Golgi-associated lipid kinase controls peripheral nerve myelination

• York Posor; Volker Haucke

Proceedings of the National Academy of Sciences 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.

• Matthaeus C; Lahmann I; Kunz S; Jonas W; Melo AA; Lehmann M; Larsson E; Lundmark R; Kern M; Blüher M; Olschowski H; Kompa J; Brügger B; Müller DN; Haucke V; Schürmann A; Birchmeier C; Daumke O

Proceedings of the National Academy of Sciences of the United States of America 2020

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.

• Gowrisankaran S; Houy S; Del Castillo JGP; Steubler V; Gelker M; Kroll J; Pinheiro PS; Schwitters D; Halbsgut N; Pechstein A; van Weering JRT; Maritzen T; Haucke V; Raimundo N; Sørensen JB; Milosevic I

Nature communications 2020

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation.

• Pechstein A; Tomilin N; Fredrich K; Vorontsova O; Sopova E; Evergren E; Haucke V; Brodin L; Shupliakov O

Cell reports 2020

Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.

• Bertović I; Kurelić R; Milošević I; Bender M; Krauss M; Haucke V; Jurak Begonja A

Journal of thrombosis and haemostasis : JTH 2020

Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.

• Jäpel M; Gerth F; Sakaba T; Bacetic J; Yao L; Koo SJ; Maritzen T; Freund C; Haucke V

Cell reports 2020

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

• Haibin Wang; Dinah Loerke; Caroline Bruns; Rainer Müller; Philipp-Alexander Koch; Dmytro Puchkov; Carsten Schultz; Volker Haucke

Journal of Biological Chemistry 2020

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

• Haibin Wang; Dinah Loerke; Caroline Bruns; Rainer Müller; Philipp-Alexander Koch; Dmytro Puchkov; Carsten Schultz; Volker Haucke

Journal of Biological Chemistry 2020

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.

• Maglione M; Kochlamazashvili G; Eisenberg T; Rácz B; Michael E; Toppe D; Stumpf A; Wirth A; Zeug A; Müller FE; Moreno-Velasquez L; Sammons RP; Hofer SJ; Madeo F; Maritzen T; Maier N; Ponimaskin E; Schmitz D; Haucke V; Sigrist SJ

Scientific reports 2019

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.

• Stanifer ML; Mukenhirn M; Muenchau S; Pervolaraki K; Kanaya T; Albrecht D; Odendall C; Hielscher T; Haucke V; Kagan JC; Bartfeld S; Ohno H; Boulant S

Nature microbiology 2019

Phosphoinositides in the control of lysosome function and homeostasis.

• Ebner M; Koch PA; Haucke V

Biochemical Society transactions 2019

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

• Pascolutti R; Algisi V; Conte A; Raimondi A; Pasham M; Upadhyayula S; Gaudin R; Maritzen T; Barbieri E; Caldieri G; Tordonato C; Confalonieri S; Freddi S; Malabarba MG; Maspero E; Polo S; Tacchetti C; Haucke V; Kirchhausen T; Di Fiore PP; Sigismund S

Cell reports 2019

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.

• Helbig I; Lopez-Hernandez T; Shor O; Galer P; Ganesan S; Pendziwiat M; Rademacher A; Ellis CA; Hümpfer N; Schwarz N; Seiffert S; Peeden J; Shen J; Štěrbová K; Hammer TB; Møller RS; Shinde DN; Tang S; Smith L; Poduri A; Krause R; Benninger F; Helbig KL; Haucke V; Weber YG; EuroEPINOMICS-RES Consortium; GRIN Consortium

American journal of human genetics 2019

The cell adhesion protein CAR is a negative regulator of synaptic transmission.

• Wrackmeyer U; Kaldrack J; Jüttner R; Pannasch U; Gimber N; Freiberg F; Purfürst B; Kainmueller D; Schmitz D; Haucke V; Rathjen FG; Gotthardt M

Scientific reports 2019

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.

• Gerth F; Jäpel M; Sticht J; Kuropka B; Schmitt XJ; Driller JH; Loll B; Wahl MC; Pagel K; Haucke V; Freund C

Structure (London, England : 1993) 2019

Phosphoinositide switches in endocytosis and in the endolysosomal system.

• Wang H; Lo WT; Haucke V

Current opinion in cell biology 2019

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression.

• Buntz A; Killian T; Schmid D; Seul H; Brinkmann U; Ravn J; Lindholm M; Knoetgen H; Haucke V; Mundigl O

Nucleic acids research 2019

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

• Alexander Wallroth; Philipp A. Koch; Andrea L. Marat; Eberhard Krause; Volker Haucke

Nature Cell Biology 2019

Nanoscale coupling of endocytic pit growth and stability

• Martin Lehmann; Ilya Lukonin; Frank Noé; Jan Schmoranzer; Cecilia Clementi; Dinah Loerke; Volker Haucke

Science Advances 2019

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

• Vukoja A; Rey U; Petzoldt AG; Ott C; Vollweiter D; Quentin C; Puchkov D; Reynolds E; Lehmann M; Hohensee S; Rosa S; Lipowsky R; Sigrist SJ; Haucke V

Neuron 2018

Tamoxifen therapy in a murine model of myotubular myopathy.

• Maani N; Sabha N; Rezai K; Ramani A; Groom L; Eltayeb N; Mavandadnejad F; Pang A; Russo G; Brudno M; Haucke V; Dirksen RT; Dowling JJ

Nature communications 2018

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.

• Meyer K; Kirchner M; Uyar B; Cheng JY; Russo G; Hernandez-Miranda LR; Szymborska A; Zauber H; Rudolph IM; Willnow TE; Akalin A; Haucke V; Gerhardt H; Birchmeier C; Kühn R; Krauss M; Diecke S; Pascual JM; Selbach M

Cell 2018

Mechanical signals regulate TORC2 activity.

• Ebner M; Haucke V

Nature cell biology 2018

Identifying Small-Molecule Inhibitors of the Clathrin Terminal Domain.

• Haucke V; Krauß M

Methods in molecular biology (Clifton, N.J.) 2018

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

• Wang H; Lo WT; Vujičić Žagar A; Gulluni F; Lehmann M; Scapozza L; Haucke V; Vadas O

Molecular cell 2018

PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

• Kath C; Goni-Oliver P; Müller R; Schultz C; Haucke V; Eickholt B; Schmoranzer J

PloS one 2018

Presynaptic endocytic factors in autophagy and neurodegeneration.

• Azarnia Tehran D; Kuijpers M; Haucke V

Current opinion in neurobiology 2018

Membrane remodeling in clathrin-mediated endocytosis

• Volker Haucke; Michael M. Kozlov

Journal of Cell Science 2018

Phosphoinositide conversion in endocytosis and the endolysosomal system.

• Wallroth A; Haucke V

The Journal of biological chemistry 2017

Coupling of exocytosis and endocytosis at the presynaptic active zone.

• Maritzen T; Haucke V

Neuroscience research 2017

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

• Lo WT; Vujičić Žagar A; Gerth F; Lehmann M; Puchkov D; Krylova O; Freund C; Scapozza L; Vadas O; Haucke V

Developmental cell 2017

Intersectin associates with synapsin and regulates its nanoscale localization and function.

• Gerth F; Jäpel M; Pechstein A; Kochlamazashvili G; Lehmann M; Puchkov D; Onofri F; Benfenati F; Nikonenko AG; Fredrich K; Shupliakov O; Maritzen T; Freund C; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2017

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

• Walter AM; Müller R; Tawfik B; Wierda KD; Pinheiro PS; Nadler A; McCarthy AW; Ziomkiewicz I; Kruse M; Reither G; Rettig J; Lehmann M; Haucke V; Hille B; Schultz C; Sørensen JB

eLife 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.

• Rathjen T; Yan X; Kononenko NL; Ku MC; Song K; Ferrarese L; Tarallo V; Puchkov D; Kochlamazashvili G; Brachs S; Varela L; Szigeti-Buck K; Yi CX; Schriever SC; Tattikota SG; Carlo AS; Moroni M; Siemens J; Heuser A; van der Weyden L; Birkenfeld AL; Niendorf T; Poulet JFA; Horvath TL; Tschöp MH; Heinig M; Trajkovski M; Haucke V; Poy MN

Nature neuroscience 2017

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission.

• Schöneberg J; Lehmann M; Ullrich A; Posor Y; Lo WT; Lichtner G; Schmoranzer J; Haucke V; Noé F

Nature communications 2017

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

• Jakob B; Kochlamazashvili G; Jäpel M; Gauhar A; Bock HH; Maritzen T; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2017

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.

• Kononenko NL; Claßen GA; Kuijpers M; Puchkov D; Maritzen T; Tempes A; Malik AR; Skalecka A; Bera S; Jaworski J; Haucke V

Nature communications 2017

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.

• Soykan T; Kaempf N; Sakaba T; Vollweiter D; Goerdeler F; Puchkov D; Kononenko NL; Haucke V

Neuron 2017

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

• Andrea L. Marat; Alexander Wallroth; Wen-Ting Lo; Rainer Müller; Giuseppe Danilo Norata; Marco Falasca; Carsten Schultz; Volker Haucke

Science 2017

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

• Grauel MK; Maglione M; Reddy-Alla S; Willmes CG; Brockmann MM; Trimbuch T; Rosenmund T; Pangalos M; Vardar G; Stumpf A; Walter AM; Rost BR; Eickholt BJ; Haucke V; Schmitz D; Sigrist SJ; Rosenmund C

Proceedings of the National Academy of Sciences of the United States of America 2016

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

• Wetzel C; Pifferi S; Picci C; Gök C; Hoffmann D; Bali KK; Lampe A; Lapatsina L; Fleischer R; Smith ES; Bégay V; Moroni M; Estebanez L; Kühnemund J; Walcher J; Specker E; Neuenschwander M; von Kries JP; Haucke V; Kuner R; Poulet JF; Schmoranzer J; Poole K; Lewin GR

Nature neuroscience 2016

Autophagosome Formation by Endophilin Keeps Synapses in Shape.

• Kuijpers M; Haucke V

Neuron 2016

Directing lipid transport at membrane contact sites.

• Krauβ M; Haucke V

Nature cell biology 2016

Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

• Marat AL; Haucke V

The EMBO journal 2016

A phosphoinositide conversion mechanism for exit from endosomes.

• Ketel K; Krauss M; Nicot AS; Puchkov D; Wieffer M; Müller R; Subramanian D; Schultz C; Laporte J; Haucke V

Modes and mechanisms of synaptic vesicle recycling

• Tolga Soykan; Tanja Maritzen; Volker Haucke

Current Opinion in Neurobiology 2016

Gottfried Schatz (1936-2015)-mitochondrial pioneer and ambassador for science.

• Haucke V; Glick BS

Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

• Jung S; Maritzen T; Wichmann C; Jing Z; Neef A; Revelo NH; Al-Moyed H; Meese S; Wojcik SM; Panou I; Bulut H; Schu P; Ficner R; Reisinger E; Rizzoli SO; Neef J; Strenzke N; Haucke V; Moser T

Hopping Pits Catch Fusing Granules.

• Haucke V

Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain.

• Lehmann M; Gottschalk B; Puchkov D; Schmieder P; Schwagerus S; Hackenberger CP; Haucke V; Schmoranzer J

Molecular mechanisms of presynaptic membrane retrieval and synaptic vesicle reformation.

• Kononenko NL; Haucke V

Neuron 2015

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.

• Gimber N; Tadeus G; Maritzen T; Schmoranzer J; Haucke V

Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.

• Koo SJ; Kochlamazashvili G; Rost B; Puchkov D; Gimber N; Lehmann M; Tadeus G; Schmoranzer J; Rosenmund C; Haucke V; Maritzen T

Crystal structure of the dynamin tetramer.

• Reubold TF; Faelber K; Plattner N; Posor Y; Ketel K; Curth U; Schlegel J; Anand R; Manstein DJ; Noé F; Haucke V; Daumke O; Eschenburg S

Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening.

• Diezmann F; von Kleist L; Haucke V; Seitz O

Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles.

• Kaempf N; Kochlamazashvili G; Puchkov D; Maritzen T; Bajjalieh SM; Kononenko NL; Haucke V

Berlin Editorial.

• Goody R; Haucke V; Just W

A grab to move on: ER-endosome contacts in membrane protrusion formation and neurite outgrowth.

• Krauß M; Haucke V

Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis.

• Daniel JA; Chau N; Abdel-Hamid MK; Hu L; von Kleist L; Whiting A; Krishnan S; Maamary P; Joseph SR; Simpson F; Haucke V; McCluskey A; Robinson PJ

Lipids, GTPases, and their regulators in membrane dynamics: an intracellular menage a trois.

• Echard A; Haucke V

Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses.

• Pechstein A; Gerth F; Milosevic I; Jäpel M; Eichhorn-Grünig M; Vorontsova O; Bacetic J; Maritzen T; Shupliakov O; Freund C; Haucke V

Cell biology: On the endocytosis rollercoaster.

• Haucke V

Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.

• Seifert W; Kühnisch J; Maritzen T; Lommatzsch S; Hennies HC; Bachmann S; Horn D; Haucke V

Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway.

• Caì Y; Postnikova EN; Bernbaum JG; Yú SQ; Mazur S; Deiuliis NM; Radoshitzky SR; Lackemeyer MG; McCluskey A; Robinson PJ; Haucke V; Wahl-Jensen V; Bailey AL; Lauck M; Friedrich TC; O'Connor DH; Goldberg TL; Jahrling PB; Kuhn JH

Phosphoinositides in endocytosis.

• Posor Y; Eichhorn-Grünig M; Haucke V

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

• Franco I; Gulluni F; Campa CC; Costa C; Margaria JP; Ciraolo E; Martini M; Monteyne D; De Luca E; Germena G; Posor Y; Maffucci T; Marengo S; Haucke V; Falasca M; Perez-Morga D; Boletta A; Merlo GR; Hirsch E

Developmental cell 2014

BAR domain scaffolds in dynamin-mediated membrane fission.

• Daumke O; Roux A; Haucke V

Cell 2014

A novel twist in membrane dePHormation.

• Krauss M; Haucke V

Imaging of doxorubicin release from theranostic macromolecular prodrugs via fluorescence resonance energy transfer.

• Krüger HR; Schütz I; Justies A; Licha K; Welker P; Haucke V; Calderón M

Synthesis of the Pitstop family of clathrin inhibitors.

• Robertson MJ; Deane FM; Stahlschmidt W; von Kleist L; Haucke V; Robinson PJ; McCluskey A

Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.

• Kononenko NL; Puchkov D; Classen GA; Walter AM; Pechstein A; Sawade L; Kaempf N; Trimbuch T; Lorenz D; Rosenmund C; Maritzen T; Haucke V

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

• Podufall J; Tian R; Knoche E; Puchkov D; Walter AM; Rosa S; Quentin C; Vukoja A; Jung N; Lampe A; Wichmann C; Böhme M; Depner H; Zhang YQ; Schmoranzer J; Sigrist SJ; Haucke V

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.

• Wilhelm BG; Mandad S; Truckenbrodt S; Kröhnert K; Schäfer C; Rammner B; Koo SJ; Claßen GA; Krauss M; Haucke V; Urlaub H; Rizzoli SO

Neurotransmission: spontaneous and evoked release filing for divorce.

• Walter AM; Haucke V; Sigrist SJ

Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.

• Stahlschmidt W; Robertson MJ; Robinson PJ; McCluskey A; Haucke V

Development of 1,8-naphthalimides as clathrin inhibitors.

• MacGregor KA; Robertson MJ; Young KA; von Kleist L; Stahlschmidt W; Whiting A; Chau N; Robinson PJ; Haucke V; McCluskey A

Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles.

• Hua Y; Woehler A; Kahms M; Haucke V; Neher E; Klingauf J

Neuron 2013

Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.

• Kononenko NL; Diril MK; Puchkov D; Kintscher M; Koo SJ; Pfuhl G; Winter Y; Wienisch M; Klingauf J; Breustedt J; Schmitz D; Maritzen T; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2013

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

• Posor Y; Eichhorn-Gruenig M; Puchkov D; Schöneberg J; Ullrich A; Lampe A; Müller R; Zarbakhsh S; Gulluni F; Hirsch E; Krauss M; Schultz C; Schmoranzer J; Noé F; Haucke V

Nature 2013

PI4K2β/AP-1-based TGN-endosomal sorting regulates Wnt signaling.

• Wieffer M; Cibrián Uhalte E; Posor Y; Otten C; Branz K; Schütz I; Mössinger J; Schu P; Abdelilah-Seyfried S; Krauß M; Haucke V

Current biology : CB 2013

Fast neurotransmitter release regulated by the endocytic scaffold intersectin.

• Sakaba T; Kononenko NL; Bacetic J; Pechstein A; Schmoranzer J; Yao L; Barth H; Shupliakov O; Kobler O; Aktories K; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2013

Greasing the synaptic vesicle cycle by membrane lipids.

• Puchkov D; Haucke V

Trends in cell biology 2013

The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms.

• Shetty A; Sytnyk V; Leshchyns'ka I; Puchkov D; Haucke V; Schachner M

The tortoise and the hare revisited.

• Kononenko NL; Pechstein A; Haucke V

Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway.

• Garrison AR; Radoshitzky SR; Kota KP; Pegoraro G; Ruthel G; Kuhn JH; Altamura LA; Kwilas SA; Bavari S; Haucke V; Schmaljohn CS

A dual role of SNAP-25 as carrier and guardian of synaptic transmission.

• Kochlamazashvili G; Haucke V

Synaptic requiem: a duet for Piccolo and Bassoon.

• Kononenko N; Pechstein A; Haucke V

Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors.

• Chowdhury D; Marco S; Brooks IM; Zandueta A; Rao Y; Haucke V; Wesseling JF; Tavalin SJ; Pérez-Otaño I

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.

• Smith CM; Haucke V; McCluskey A; Robinson PJ; Chircop M

Oligomerization of dynamin superfamily proteins in health and disease.

• Faelber K; Gao S; Held M; Posor Y; Haucke V; Noé F; Daumke O

Structural insights into dynamin-mediated membrane fission.

• Faelber K; Held M; Gao S; Posor Y; Haucke V; Noé F; Daumke O

Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.

• Maritzen T; Zech T; Schmidt MR; Krause E; Machesky LM; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2012

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

• Mössinger J; Wieffer M; Krause E; Freund C; Gerth F; Krauss M; Haucke V

EMBO reports 2012

Membrane biology: fission behind BARs.

• Haucke V

Turning CALM into excitement: AP180 and CALM in endocytosis and disease.

• Maritzen T; Koo SJ; Haucke V

Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells.

• Graf C; Gao Q; Schütz I; Noufele CN; Ruan W; Posselt U; Korotianskiy E; Nordmeyer D; Rancan F; Hadam S; Vogt A; Lademann J; Haucke V; Rühl E

The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity.

• Robertson MJ; Hadzic G; Ambrus J; Pomè DY; Hyde E; Whiting A; Mariana A; von Kleist L; Chau N; Haucke V; Robinson PJ; McCluskey A

Multi-colour direct STORM with red emitting carbocyanines.

• Lampe A; Haucke V; Sigrist SJ; Heilemann M; Schmoranzer J

Structure and function of membrane-integral receptors.

• Saenger W; Haucke V

At the crossroads of chemistry and cell biology: inhibiting membrane traffic by small molecules.

• von Kleist L; Haucke V

Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.

• Smith KR; Muir J; Rao Y; Browarski M; Gruenig MC; Sheehan DF; Haucke V; Kittler JT

Regulation of phosphoinositide-metabolizing enzymes by clathrin coat proteins.

• Wieffer M; Haucke V; Krauss M

Spontaneous neurotransmission: a SNARE for the rest.

• Kononenko NL; Haucke V

The oncogenic TBC domain protein USP6/TRE17 regulates cell migration and cytokinesis.

• Rueckert C; Haucke V

The early steps of endocytosis: from cargo selection to membrane deformation.

• Rao Y; Rückert C; Saenger W; Haucke V

SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

• Koo SJ; Markovic S; Puchkov D; Mahrenholz CC; Beceren-Braun F; Maritzen T; Dernedde J; Volkmer R; Oschkinat H; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2011

Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity.

• Seifert W; Kühnisch J; Maritzen T; Horn D; Haucke V; Hennies HC

The Journal of biological chemistry 2011

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

• von Kleist L; Stahlschmidt W; Bulut H; Gromova K; Puchkov D; Robertson MJ; MacGregor KA; Tomilin N; Pechstein A; Chau N; Chircop M; Sakoff J; von Kries JP; Saenger W; Kräusslich HG; Shupliakov O; Robinson PJ; McCluskey A; Haucke V

Cell 2011

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.

• Haucke V; Neher E; Sigrist SJ

Nature reviews. Neuroscience 2011

Crystal structure of nucleotide-free dynamin.

• Faelber K; Posor Y; Gao S; Held M; Roske Y; Schulze D; Haucke V; Noé F; Daumke O

Nature 2011

Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif.

• Krabben L; Fassio A; Bhatia VK; Pechstein A; Onofri F; Fadda M; Messa M; Rao Y; Shupliakov O; Stamou D; Benfenati F; Haucke V

The Journal of neuroscience : the official journal of the Society for Neuroscience 2011

Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily.

• Rao Y; Haucke V

AP180 and CALM: Dedicated endocytic adaptors for the retrieval of synaptobrevin 2 at synapses.

• Koo SJ; Puchkov D; Haucke V

How synapsin I may cluster synaptic vesicles.

• Shupliakov O; Haucke V; Pechstein A

Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.

• Laulagnier K; Schieber NL; Maritzen T; Haucke V; Parton RG; Gruenberg J

An exciting calcium sensor for smell.

• Kononenko NL; Haucke V

Shaping membranes for endocytosis.

• Krauss M; Haucke V

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.

• Granata A; Koo SJ; Haucke V; Schiavo G; Warner TT

Gadkin: A novel link between endosomal vesicles and microtubule tracks.

• Maritzen T; Haucke V

Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation.

• Rao Y; Ma Q; Vahedi-Faridi A; Sundborger A; Pechstein A; Puchkov D; Luo L; Shupliakov O; Saenger W; Haucke V

Adaptin' endosomes for synaptic vesicle recycling, learning and memory.

• Krauss M; Haucke V

Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.

• Pechstein A; Bacetic J; Vahedi-Faridi A; Gromova K; Sundborger A; Tomlin N; Krainer G; Vorontsova O; Schäfer JG; Owe SG; Cousin MA; Saenger W; Shupliakov O; Haucke V

Intersectin 1: a versatile actor in the synaptic vesicle cycle.

• Pechstein A; Shupliakov O; Haucke V

Stonins--specialized adaptors for synaptic vesicle recycling and beyond?

• Maritzen T; Podufall J; Haucke V

A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.

• Maritzen T; Schmidt MR; Kukhtina V; Higman VA; Strauss H; Volkmer R; Oschkinat H; Dotti CG; Haucke V

The Journal of biological chemistry 2009

Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.

• Kahlfeldt N; Vahedi-Faridi A; Koo SJ; Schäfer JG; Krainer G; Keller S; Saenger W; Krauss M; Haucke V

The Journal of biological chemistry 2009

Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.

• Schmidt MR; Maritzen T; Kukhtina V; Higman VA; Doglio L; Barak NN; Strauss H; Oschkinat H; Dotti CG; Haucke V

Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction.

• Diril MK; Schmidt S; Krauss M; Gawlik V; Joost HG; Schürmann A; Haucke V; Augustin R

SnapShot: endocytic trafficking.

• Wieffer M; Maritzen T; Haucke V

Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding.

• Krauss M; Jia JY; Roux A; Beck R; Wieland FT; De Camilli P; Haucke V

Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor.

• Smith KR; McAinsh K; Chen G; Arancibia-Carcamo IL; Haucke V; Yan Z; Moss SJ; Kittler JT

Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.

• Kittler JT; Chen G; Kukhtina V; Vahedi-Faridi A; Gu Z; Tretter V; Smith KR; McAinsh K; Arancibia-Carcamo IL; Saenger W; Haucke V; Yan Z; Moss SJ

The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit.

• Demmel L; Gravert M; Ercan E; Habermann B; Müller-Reichert T; Kukhtina V; Haucke V; Baust T; Sohrmann M; Kalaidzidis Y; Klose C; Beck M; Peter M; Walch-Solimena C

Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.

• Rumpf J; Simon B; Jung N; Maritzen T; Haucke V; Sattler M; Groemping Y

Clathrin/AP-2-dependent endocytosis: a novel playground for the pharmacological toolbox?

• Rodemer C; Haucke V

Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2.

• Jung N; Wienisch M; Gu M; Rand JB; Müller SL; Krause G; Jorgensen EM; Klingauf J; Haucke V

Lipids and lipid modifications in the regulation of membrane traffic.

• Haucke V; Di Paolo G

Clathrin-mediated endocytosis at synapses.

• Jung N; Haucke V

Trafficking and signalling at the synapse: where are we heading to?

• Galli T; Haucke V

Recycling endosomes in neuronal membrane traffic.

• Schmidt MR; Haucke V

Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling.

• Krauss M; Haucke V

Phosphoinositides: regulators of membrane traffic and protein function.

• Krauss M; Haucke V

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.

• Kastning K; Kukhtina V; Kittler JT; Chen G; Pechstein A; Enders S; Lee SH; Sheng M; Yan Z; Haucke V

Cargo takes control of endocytosis.

• Haucke V

Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes.

• Krauss M; Kukhtina V; Pechstein A; Haucke V

Quantitative proteomics analysis of detergent-resistant membranes from chemical synapses: evidence for cholesterol as spatial organizer of synaptic vesicle cycling.

• Jia JY; Lamer S; Schümann M; Schmidt MR; Krause E; Haucke V

Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling.

• Diril MK; Wienisch M; Jung N; Klingauf J; Haucke V

Phosphoinositide regulation of clathrin-mediated endocytosis.

• Haucke V

Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission.

• Kittler JT; Chen G; Honing S; Bogdanov Y; McAinsh K; Arancibia-Carcamo IL; Jovanovic JN; Pangalos MN; Haucke V; Yan Z; Moss SJ

Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.

• Höning S; Ricotta D; Krauss M; Späte K; Spolaore B; Motley A; Robinson M; Robinson C; Haucke V; Owen DJ

Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells.

• Milosevic I; Sørensen JB; Lang T; Krauss M; Nagy G; Haucke V; Jahn R; Neher E

Teaching resources. Calcium-triggered exocytosis and clathrin-mediated endocytosis of synaptic vesicles.

• Galli T; Haucke V

Teaching resources. A model for fast-track exocytosis of synaptic vesicles.

• Galli T; Haucke V

Functional assay of effectors of ADP ribosylation factor 6 during clathrin/AP-2 coat recruitment to membranes.

• Krauss M; Haucke V

Recognition of the tryptophan-based endocytosis signal in the neonatal Fc Receptor by the mu subunit of adaptor protein-2.

• Wernick NL; Haucke V; Simister NE

Recognition of a basic AP-2 binding motif within the C2B domain of synaptotagmin is dependent on multimerization.

• Grass I; Thiel S; Höning S; Haucke V

Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.

• Kittler JT; Thomas P; Tretter V; Bogdanov YD; Haucke V; Smart TG; Moss SJ

Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin.

• Walther K; Diril MK; Jung N; Haucke V

Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport.

• Chidambaram S; Müllers N; Wiederhold K; Haucke V; von Mollard GF

Cycling of synaptic vesicles: how far? How fast!

• Galli T; Haucke V

A putative role for intramolecular regulatory mechanisms in the adaptor function of amphiphysin in endocytosis.

• Farsad K; Slepnev V; Ochoa G; Daniell L; Haucke V; De Camilli P

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.

• Krauss M; Kinuta M; Wenk MR; De Camilli P; Takei K; Haucke V

Where proteins and lipids meet: membrane trafficking on the move.

• Haucke V

Vesicle budding: a coat for the COPs.

• Haucke V

Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating.

• Walther K; Krauss M; Diril MK; Lemke S; Ricotta D; Honing S; Kaiser S; Haucke V

EMBO reports 2001

Shuttling receptors for peroxisomes.

• Haucke V

Vacuoles fuse with V0.

• Haucke V

A matrix to build on.

• Haucke V

Clathrin-mediated endocytosis: membrane factors pull the trigger.

• Takei K; Haucke V

Cycling of synaptic vesicles: how far? How fast!

• Galli T; Haucke V

Dissecting the ins and outs of excitement: glutamate receptors on the move.

• Haucke V

ATM-dependent cell-cycle arrest tamed in the test tube

• Haucke V V

Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.

• Haucke V; Wenk MR; Chapman ER; Farsad K; De Camilli P

Liberating sleeping beauties by cutting the hook

• Haucke V V

Reconstitution of the protein insertion machinery of the mitochondrial inner membrane.

• Haucke V; Schatz G

The EMBO journal 1997

Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria.

• Haucke V; Ocana CS; Hönlinger A; Tokatlidis K; Pfanner N; Schatz G

Molecular and cellular biology 1997

Import of proteins into mitochondria and chloroplasts.

• Haucke V; Schatz G

Trends in cell biology 1997

The first steps of protein import into mitochondria.

• Haucke V; Lithgow T