Ralf Schülein

Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway

• Catar, Rusan Ali; Wischnewski, Oskar; Chen, Lei; Heidecke, Harald; Rutz, Claudia; Schülein, Ralf; Dragun, Duska; Philippe, Aurélie; Kusch, Angelika

Kidney international 2022

Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway

• Pauwels, Eva; Schülein, Ralf; Vermeire, Kurt

International journal of molecular sciences 2021

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

• Pauwels, Eva; Rutz, Claudia; Provinciael, Becky; Stroobants, Joren; Schols, Dominique; Hartmann, Enno; Krause, Eberhard; Stephanowitz, Heike; Schülein, Ralf; Vermeire, Kurt

Molecular & cellular proteomics : MCP 2021

Modulating TSH Receptor Signaling for Therapeutic Benefit

• Krause, Gerd; Eckstein, Anja; Schülein, Ralf

European thyroid journal 2020

Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation

• Prosperi, Federica; Suzumoto, Yoko; Marzuillo, Pierluigi; Costanzo, Vincenzo; Jelen, Sabina; Iervolino, Anna; Guarino, Stefano; La Manna, Angela; Miraglia Del Giudice, Emanuele; Perna, Alessandra F; Zacchia, Miriam; Cordat, Emmanuelle; Capasso, Giovambattista; Trepiccione, Francesco

Scientific reports 2020

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

• Marcinkowski, Patrick; Hoyer, Inna; Specker, Edgar; Furkert, Jens; Rutz, Claudia; Neuenschwander, Martin; Sobottka, Sebastian; Sun, Han; Nazare, Marc; Berchner-Pfannschmidt, Utta; von Kries, Jens Peter; Eckstein, Anja; Schülein, Ralf; Krause, Gerd

Thyroid : official journal of the American Thyroid Association 2019

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

• Marcinkowski, Patrick; Kreuchwig, Annika; Mendieta, Sandro; Hoyer, Inna; Witte, Franziska; Furkert, Jens; Rutz, Claudia; Lentz, Dieter; Krause, Gerd; Schülein, Ralf

Molecular pharmacology 2019

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

• Fischer, Jana; Kleinau, Gunnar; Rutz, Claudia; Zwanziger, Denise; Khajavi, Noushafarin; Müller, Anne; Rehders, Maren; Brix, Klaudia; Worth, Catherine L; Führer, Dagmar; Krude, Heiko; Wiesner, Burkhard; Schülein, Ralf; Biebermann, Heike

Cellular and molecular life sciences : CMLS 2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

• Klein, Wolfgang; Rutz, Claudia; Eckhard, Jamina; Provinciael, Becky; Specker, Edgar; Neuenschwander, Martin; Kleinau, Gunnar; Scheerer, Patrick; von Kries, Jens-Peter; Nazaré, Marc; Vermeire, Kurt; Schülein, Ralf

PloS one 2018

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS

• Leonhardt, Julia; Villela, Daniel C; Teichmann, Anke; Münter, Lisa-Marie; Mayer, Magnus C; Mardahl, Maibritt; Kirsch, Sebastian; Namsolleck, Pawel; Lucht, Kristin; Benz, Verena; Alenina, Natalia; Daniell, Nicholas; Horiuchi, Masatsugu; Iwai, Masaru; Multhaup, Gerhard; Schülein, Ralf; Bader, Michael; Santos, Robson A; Unger, Thomas; Steckelings, Ulrike Muscha

Hypertension (Dallas, Tex. : 1979) 2017

Targeting G Protein-Coupled Receptors by Capture Compound Mass Spectrometry: A Case Study with Sertindole

• Blex, Christian; Michaelis, Simon; Schrey, Anna K; Furkert, Jens; Eichhorst, Jenny; Bartho, Kathrin; Gyapon Quast, Frederick; Marais, Anett; Hakelberg, Matthias; Gruber, Uschi; Niquet, Sylvia; Popp, Oliver; Kroll, Friedrich; Sefkow, Michael; Schülein, Ralf; Dreger, Mathias; Köster, Hubert

Chembiochem : a European journal of chemical biology 2017

Functional Significance of the Signal Peptides of Corticotropin-Releasing Factor Receptors

• Schulein, Ralf; Gibert, Arthur; Rutz, Claudia

Current molecular pharmacology 2017

The specific monomer/dimer equilibrium of the corticotropin-releasing factor receptor type 1 is established in the endoplasmic reticulum

• Teichmann, Anke; Gibert, Arthur; Lampe, André; Grzesik, Paul; Rutz, Claudia; Furkert, Jens; Schmoranzer, Jan; Krause, Gerd; Wiesner, Burkhard; Schülein, Ralf

The Journal of biological chemistry 2014

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation

• Grzesik, Paul; Teichmann, Anke; Furkert, Jens; Rutz, Claudia; Wiesner, Burkhard; Kleinau, Gunnar; Schülein, Ralf; Gromoll, Jörg; Krause, Gerd

The FEBS journal 2014

Use of Kaede and Kikume green-red fusions for live cell imaging of G protein-coupled receptors

• Schmidt, Antje; Wiesner, Burkhard; Schülein, Ralf; Teichmann, Anke

Methods in molecular biology (Clifton, N.J.) 2014

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists

• Hoyer, Inna; Haas, Ann-Karin; Kreuchwig, Annika; Schülein, Ralf; Krause, Gerd

Biochemical Society transactions 2013

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity

• Schulz, Katharina; Rutz, Claudia; Westendorf, Carolin; Ridelis, Ingrid; Vogelbein, Susanne; Furkert, Jens; Schmidt, Antje; Wiesner, Burkhard; Schülein, Ralf

The Journal of biological chemistry 2010

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

• Kleinau, Gunnar; Haas, Ann-Karin; Neumann, Susanne; Worth, Catherine L; Hoyer, Inna; Furkert, Jens; Rutz, Claudia; Gershengorn, Marvin C; Schülein, Ralf; Krause, Gerd

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010

Use of Kaede fusions to visualize recycling of G protein-coupled receptors

• Schmidt, Antje; Wiesner, Burkhard; Weisshart, Klaus; Schulz, Katharina; Furkert, Jens; Lamprecht, Björn; Rosenthal, Walter; Schülein, Ralf

Traffic (Copenhagen, Denmark) 2009

The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane

• Alken, Martina; Schmidt, Antje; Rutz, Claudia; Furkert, Jens; Kleinau, Gunnar; Rosenthal, Walter; Schülein, Ralf

Molecular pharmacology 2009

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides

• Oueslati, Morad; Hermosilla, Ricardo; Schönenberger, Eva; Oorschot, Viola; Beyermann, Michael; Wiesner, Burkhard; Schmidt, Antje; Klumperman, Judith; Rosenthal, Walter; Schülein, Ralf

The Journal of biological chemistry 2007

The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide

• Rutz, Claudia; Renner, Armin; Alken, Martina; Schulz, Katharina; Beyermann, Michael; Wiesner, Burkhard; Rosenthal, Walter; Schülein, Ralf

The Journal of biological chemistry 2006

TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression

• Bulwin, Grit-Carsta; Heinemann, Thomas; Bugge, Volker; Winter, Michael; Lohan, Anke; Schlawinsky, Mirko; Schulze, Anke; Wälter, Stephanie; Sabat, Robert; Schülein, Ralf; Wiesner, Burkhard; Veh, Rüdiger W; Löhler, Jürgen; Blumberg, Richard S; Volk, Hans-Dieter; Utku, Nalân

Journal of immunology (Baltimore, Md. : 1950) 2006

The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens

• Engelsberg, Arne; Hermosilla, Ricardo; Karsten, Uwe; Schülein, Ralf; Dörken, Bernd; Rehm, Armin

The Journal of biological chemistry 2003

The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process

• Grantcharova, Evelina; Furkert, Jens; Reusch, H Peter; Krell, Hans-Willi; Papsdorf, Gisela; Beyermann, Michael; Schulein, Ralf; Rosenthal, Walter; Oksche, Alexander

The Journal of biological chemistry 2002

The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane

• Köchl, Robert; Alken, Martina; Rutz, Claudia; Krause, Gerd; Oksche, Alexander; Rosenthal, Walter; Schülein, Ralf

The Journal of biological chemistry 2002

Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation

• Schülein, R; Zühlke, K; Krause, G; Rosenthal, W

The Journal of biological chemistry 2001

Sorting functions of the individual cytoplasmic domains of the G protein-coupled vasopressin V(2) receptor in Madin Darby canine kidney epithelial cells

• Hermosilla, R; Schülein, R

Molecular pharmacology 2001

The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues

• Schülein, R; Zühlke, K; Oksche, A; Hermosilla, R; Furkert, J; Rosenthal, W

FEBS letters 2000

Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor

• Krause, G; Hermosilla, R; Oksche, A; Rutz, C; Rosenthal, W; Schülein, R

Molecular pharmacology 2000

A single negatively charged residue affects the orientation of a membrane protein in the inner membrane of Escherichia coli only when it is located adjacent to a transmembrane domain

• Rutz, C; Rosenthal, W; Schülein, R

The Journal of biological chemistry 1999

Polarized expression of the vasopressin V2 receptor in Madin-Darby canine kidney cells

• Andersen-Beckh, B; Dehe, M; Schülein, R; Wiesner, B; Rutz, C; Liebenhoff, U; Rosenthal, W; Oksche, A

Kidney international 1999

Topology of eukaryotic multispanning transmembrane proteins: use of LacZ fusions for the localization of cytoplasmic domains in COS.M6 cells

• Schülein, R; Rutz, C; Rosenthal, W

Protein engineering 1997

Membrane targeting and determination of transmembrane topology of the human vasopressin V2 receptor

• Schülein, R; Rutz, C; Rosenthal, W

The Journal of biological chemistry 1996

Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function

• Oksche, A; Schülein, R; Rutz, C; Liebenhoff, U; Dickson, J; Müller, H; Birnbaumer, M; Rosenthal, W

Molecular pharmacology 1996

Properties of the human arginine vasopressin V2 receptor after site-directed mutagenesis of its putative palmitoylation site

• Schülein, R; Liebenhoff, U; Müller, H; Birnbaumer, M; Rosenthal, W

The Biochemical journal 1996

Identification and characterization of two functional domains of the hemolysin translocator protein HlyD

• Schülein, R; Gentschev, I; Schlör, S; Gross, R; Goebel, W

Molecular & general genetics : MGG 1994

Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus

• Oksche, A; Dickson, J; Schülein, R; Seyberth, HW; Müller, M; Rascher, W; Birnbaumer, M; Rosenthal, W

Biochemical and biophysical research communications 1994

A topological model for the haemolysin translocator protein HlyD

• Schülein, R; Gentschev, I; Mollenkopf, HJ; Goebel, W

Molecular & general genetics : MGG 1992

Preprosubtilisin Carlsberg processing and secretion is blocked after deletion of amino acids 97-101 in the mature part of the enzyme

• Schülein, R; Kreft, J; Gonski, S; Goebel, W

Molecular & general genetics : MGG 1991