Volker Haucke

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

• Lopez-Hernandez, T.
• Takenaka, K. I.
• Mori, Y.
• Kongpracha, P.
• Nagamori, S.
• Haucke, V., &
• Takamori, S.

Elife 2022, 11, e71198

Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

• Malek, M.
• Wawrzyniak, A. M.
• Ebner, M.
• Puchkov, D., &
• Haucke, V.

Journal of Biological Chemistry 2022, 298, 101740

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

• Li, H. Y.
• Prever, L.
• Hsu, M. Y.
• Lo, W.
• Margaria, J. P.
• De Santis, M. C.
• Zanini, C.
• Forni, M.
• Novelli, F.
• Pece, S.
• Di Fiore, P. P.
• Porporato, P. E.
• Martini, M.
• Belabed, H.
• Nazaré, M.
• Haucke, V.
• Gulluni, F., &
• Hirsch, E.

Advanced Science 2022, 9, e2103249

Phosphoinositides as membrane organizers

• Posor, Y.
• Jang, W., &
• Haucke, V.

Nature Reviews Molecular Cell Biology 2022, early access,

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

• Azarnia Tehran, D.
• Kochlamazashvili, G.
• Pampaloni, N. P.
• Sposini, S.
• Shergill, J. K.
• Lehmann, M.
• Pashkova, N.
• Schmidt, C.
• Löwe, D.
• Napieczynska, H.
• Heuser, A.
• Plested, A. J. R.
• Perrais, D.
• Piper, R. C.
• Haucke, V., &
• Maritzen, T.

Science Advances 2022, 8, eabl5032

Structural basis of phosphatidylinositol 3-kinase C2 alpha function

• Lo, W.
• Zhang, Y. Y.
• Vadas, O.
• Roske, Y.
• Gulluni, F.
• De Santis, M. C.
• Zagar, A. V.
• Stephanowitz, H.
• Hirsch, E.
• Liu, F.
• Daumke, O.
• Kudryashev, M., &
• Haucke, V.

Nature Structural & Molecular Biology 2022, 29, 218-228

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

• Birke, R.
• Ast, J.
• Roosen, D. A.
• Lee, J.
• Roßmann, K.
• Huhn, C.
• Mathes, B.
• Lisurek, M.
• Bushiri, D.
• Sun, H.
• Jones, B.
• Lehmann, M.
• Levitz, J.
• Haucke, V.
• Hodson, D. J., &
• Broichhagen, J.

Organic & Biomolecular Chemistry 2022, Advance Article,

Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

• Liu, G. T.
• Kochlamazashvili, G.
• Puchkov, D.
• Müller, R.
• Schultz, C.
• Mackintosh, A. I.
• Vollweiter, D.
• Haucke, V., &
• Soykan, T.

EMBO Journal 2022, 41, e109352

Mechanism of synaptic protein turnover and its regulation by neuronal activity

• Soykan, T.
• Haucke, V., &
• Kuijpers, M.

Current Opinion in Neurobiology 2021, 69, 76-83

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

• Koch, P. A.
• Dornan, G. L.
• Hessenberger, M., &
• Haucke, V.

FEBS Journal 2021, 288, 7025-7042

SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

• Schmied, C.
• Soykan, T.
• Bolz, S.
• Haucke, V., &
• Lehmann, M.

Frontiers in Computer Science 2021, 3, 777837

Structural basis of PI3KC2alpha function

• Lo, W.
• Zhang, Y.
• Vadas, O.
• Belabed, H.
• Roske, Y.
• Gulluni, F.
• De Santis, M.
• Vujicic Zagar, A.
• Stephanowitz, H.
• Hirsch, E.
• Liu, F.
• Daumke, O.
• Kudryashev, M., &
• Haucke, V.

Nature Structural & Molecular Biology 2021, in press,

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

• Gulluni, F.
• Prever, L.
• Li, H. Y.
• Krafcikova, P.
• Corrado, I.
• Lo, W.
• Margaria, J. P.
• Chen, A. L.
• De Santis, M. C.
• Cnudde, S. J.
• Fogerty, J.
• Yuan, A.
• Massarotti, A.
• Sarijalo, N. T.
• Vadas, O.
• Williams, R. L.
• Thelen, M.
• Powell, D. R.
• Schueler, M.
• Wiesener, M. S.
• Balla, T.
• Baris, H. N.
• Tiosano, D.
• McDermott, B. M.
• Perkins, B. D.
• Ghigo, A.
• Martini, M.
• Haucke, V.
• Boura, E.
• Merlo, G. R.
• Buchner, D. A., &
• Hirsch, E.

Science 2021, 374, eabk0410

Liquid-like protein assemblies initiate endocytosis

• Witkowska, A., &
• Haucke, V.

Nature Cell Biology 2021, 23, 301-302

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

• Malek, M.
• Wawrzyniak, A. M.
• Koch, P.
• Lüchtenborg, C.
• Hessenberger, M.
• Sachsenheimer, T.
• Jang, W.
• Brügger, B., &
• Haucke, V.

Nature Communications 2021, 12, 2673

Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

• Guerrero-Valero, M.
• Grandi, F.
• Cipriani, S.
• Alberizzi, V.
• Di Guardo, R.
• Chicanne, G.
• Sawade, L.
• Bianchi, F.
• Del Carro, U.
• Curtis, I. D.
• Pareyson, D.
• Parman, Y.
• Schenone, A.
• Haucke, V.
• Payrastre, B., &
• Bolino, A.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

• Hostachy, S.
• Utesch, T.
• Franke, K.
• Dornan, G. L.
• Furkert, D.
• Turkaydin, B.
• Haucke, V.
• Sun, H., &
• Fiedler, D.

Chemical Science 2021, 12, 10696-10702

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

• Rizalar, F. S.
• Roosen, D. A., &
• Haucke, V.

Neuron 2021, 109, 27-41

A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

• Haucke, V.

Developmental Cell 2021, 56, 1557-1559

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

• Wang, H. B.
• Loerke, D.
• Bruns, C.
• Müller, R.
• Koch, P. A.
• Puchkov, D.
• Schultz, C., &
• Haucke, V.

Journal of Biological Chemistry 2020, 295, 1091-1104

Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes

• Bertovic, I.
• Kurelic, R.
• Milosevic, I.
• Bender, M.
• Krauss, M.
• Haucke, V., &
• Jurak Begonja, A.

Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

• Pechstein, A.
• Tomilin, N.
• Fredrich, K.
• Vorontsova, O.
• Sopova, E.
• Evergren, E.
• Haucke, V.
• Brodin, L., &
• Shupliakov, O.

Cell Reports 2020, 30, 2594-2602

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

• Liu, H.
• Paddock, M.
• Wang, H.
• Murphy, C.
• Geck, R.
• Navarro, A.
• Wulf, G.
• Elemento, O.
• Haucke, V.
• Cantley, L., &
• Toker, A.

Cancer Discovery 2020, 10, 1226-1239

The axonal endolysosomal and autophagic systems

• Kuijpers, M.
• Azarnia Tehran, D.
• Haucke, V., &
• Soykan, T.

Journal of Neurochemistry 2020, 158, 589-602

Ramping up the autophagy-lysosome system to cope with osmotic stress

• Lopez-Hernandez, T.
• Maritzen, T., &
• Haucke, V.

Autophagy 2020, 16, 1921-1922

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

• Sawade, L.
• Grandi, F.
• Mignanelli, M.
• Patino-Lopez, G.
• Klinkert, K.
• Langa-Vives, F.
• Di Guardo, R.
• Echard, A.
• Bolino, A., &
• Haucke, V.

Nature Communications 2020, 11, 2835

Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

• Lopez-Hernandez, T.
• Puchkov, D.
• Krause, E.
• Maritzen, T., &
• Haucke, V.

Nature Cell Biology 2020, 22, 815-827

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

• Kuijpers, M.
• Kochlamazashvili, G.
• Stumpf, A.
• Puchkov, D.
• Swaminathan, A.
• Lucht, M. T.
• Krause, E.
• Maritzen, T.
• Schmitz, D., &
• Haucke, V.

Neuron 2020, 109, 1-15

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

• Gowrisankaran, S.
• Houy, S.
• Castillo, J. G. P.
• Steubler, V.
• Gelker, M.
• Kroll, J.
• Pinheiro, P. S.
• Schwitters, D.
• Halbsgut, N.
• Pechstein, A.
• Weering, J. R. T.
• Maritzen, T.
• Haucke, V.
• Raimundo, N.
• Sorensen, J. B., &
• Milosevic, I.

Nature Communications 2020, 11, 1266

Endocytosis in the adaptation to cellular stress

• Lopez-Hernandez, T.
• Haucke, V., &
• Maritzen, T.

Cell Stress 2020, 4, 230-247

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

• Matthaeus, C.
• Lahmann, I.
• Kunz, S.
• Jonas, W.
• Melo, A. A.
• Lehmann, M.
• Larsson, E.
• Lundmark, R.
• Kern, M.
• Bluher, M.
• Olschowski, H.
• Kompa, J.
• Brügger, B.
• Müller, D. N.
• Haucke, V.
• Schürmann, A.
• Birchmeier, C., &
• Daumke, O.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

• Stanifer, M. L.
• Mukenhirn, M.
• Muenchau, S.
• Pervolaraki, K.
• Kanaya, T.
• Albrecht, D.
• Odendall, C.
• Hielscher, T.
• Haucke, V.
• Kagan, J. C.
• Bartfeld, S.
• Ohno, H., &
• Boulant, S.

Nature Microbiology 2020, 5, 181-191

A Golgi-associated lipid kinase controls peripheral nerve myelination

• Posor, Y., &
• Haucke, V.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875

Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

• Jäpel, M.
• Gerth, F.
• Sakaba, T.
• Bacetic, J.
• Yao, L. J.
• Koo, S. J.
• Maritzen, T.
• Freund, C., &
• Haucke, V.

Cell Reports 2020, 30, 409-420

Nanoscale coupling of endocytic pit growth and stability

• Lehmann, M.
• Lukonin, I.
• Noe, F.
• Schmoranzer, J.
• Clementi, C.
• Loerke, D., &
• Haucke, V.

Science Advances 2019, 5, eaax5775

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

• Maglione, M.
• Kochlamazashvili, G.
• Eisenberg, T.
• Racz, B.
• Michael, E.
• Toppe, D.
• Stumpf, A.
• Wirth, A.
• Zeug, A.
• Müller, F. E.
• Moreno-Velasquez, L.
• Sammons, R. P.
• Hofer, S. J.
• Madeo, F.
• Maritzen, T.
• Maier, N.
• Ponimaskin, E.
• Schmitz, D.
• Haucke, V., &
• Sigrist, S. J.

Scientific Reports 2019, 9, 19616

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

• Buntz, A.
• Killian, T.
• Schmid, D.
• Seul, H.
• Brinkmann, U.
• Ravn, J.
• Lindholm, M.
• Knoetgen, H.
• Haucke, V., &
• Mundigl, O.

Nucleic Acids Research 2019, 47, 953-969

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

• Wallroth, A.
• Koch, P. A.
• Marat, A. L.
• Krause, E., &
• Haucke, V.

Nature Cell Biology 2019, 21, 1093-1101

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

• Dejonghe, W.
• Sharma, I.
• Denoo, B.
• De Munck, S.
• Lu, Q.
• Mishev, K.
• Bulut, H.
• Mylle, E.
• De Rycke, R.
• Vasileva, M.
• Savatin, D. V.
• Nerinckx, W.
• Staes, A.
• Drozdzecki, A.
• Audenaert, D.
• Yperman, K.
• Madder, A.
• Friml, J.
• Van Damme, D.
• Gevaert, K.
• Haucke, V.
• Savvides, S. N.
• Winne, J., &
• Russinova, E.

Nature Chemical Biology 2019, 15, 641-649

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

• Tiosano, D.
• Baris, H. N.
• Chen, A.
• Hitzert, M. M.
• Schueler, M.
• Gulluni, F.
• Wiesener, A.
• Bergua, A.
• Mory, A.
• Copeland, B.
• Gleeson, J. G.
• Rump, P.
• Meer, H.
• Sival, D. A.
• Haucke, V.
• Kriwinsky, J.
• Knaup, K. X.
• Reis, A.
• Hauer, N. N.
• Hirsch, E.
• Roepman, R.
• Pfundt, R.
• Thiel, C. T.
• Wiesener, M. S.
• Aslanyan, M. G., &
• Buchner, D. A.

PLoS Genetics 2019, 15, e1008088

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

• Pascolutti, R.
• Algisi, V.
• Conte, A.
• Raimondi, A.
• Pasham, M.
• Upadhyayula, S.
• Gaudin, R.
• Maritzen, T.
• Barbieri, E.
• Caldieri, G.
• Tordonato, C.
• Confalonieri, S.
• Freddi, S.
• Malabarba, M. G.
• Maspero, E.
• Polo, S.
• Tacchetti, C.
• Haucke, V.
• Kirchhausen, T.
• Di Fiore, P. P., &
• Sigismund, S. (.

Cell Reports 2019, 27, 3049-3061

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

• Gerth, F.
• Jäpel, M.
• Sticht, J.
• Kuropka, B.
• Schmitt, X. J.
• Driller, J. H.
• Loll, B.
• Wahl, M. C.
• Pagel, K.
• Haucke, V., &
• Freund, C.

Structure 2019, 27, 977-987

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

• Helbig, I.
• Lopez-Hernandez, T.
• Shor, O.
• Galer, P.
• Ganesan, S.
• Pendziwiat, M.
• Rademacher, A.
• Ellis, C. A.
• Humpfer, N.
• Schwarz, N.
• Seiffert, S.
• Peeden, J.
• Shen, J.
• Sterbova, K.
• Hammer, T. B.
• Moller, R. S.
• Shinde, D. N.
• Tang, S.
• Smith, L.
• Poduri, A.
• Krause, R.
• Benninger, F.
• Helbig, K. L.
• Haucke, V.
• Weber, Y. G.
• Consortium, E., &
• Consortium, G.

American Journal of Human Genetics 2019, 104, 1060-1072

The cell adhesion protein CAR is a negative regulator of synaptic transmission

• Wrackmeyer, U.
• Kaldrack, J.
• Jüttner, R.
• Pannasch, U.
• Gimber, N.
• Freiberg, F.
• Purfürst, B.
• Kainmueller, D.
• Schmitz, D.
• Haucke, V.
• Rathjen, F. G., &
• Gotthardt, M.

Scientific Reports 2019, 9, 6768