Portrait Volker Haucke

Prof. Dr.

Volker Haucke

Volker Haucke hat Biochemie in Berlin und Basel studiert und an der Yale Universität, an der Universität Göttingen sowie an der Freien Universität Berlin geforscht. Seit 2012 ist er Direktor am Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Professor für Pharmakologie an der Freien Universität Berlin und Mitglied des Exzellenzclusters NeuroCure. Er nimmt eine international führende Stellung in der Molekularen Zell- und Neurobiologie ein und wurde mit zahlreichen wissenschaftlichen Preisen wie u.a. dem Feldberg Preis 2020 ausgezeichnet.

Publikationen

von 8

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

  • Lopez-Hernandez, T.
  • Takenaka, K. I.
  • Mori, Y.
  • Kongpracha, P.
  • Nagamori, S.
  • Haucke, V., &
  • Takamori, S.

Elife 2022, 11, e71198

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Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

  • Malek, M.
  • Wawrzyniak, A. M.
  • Ebner, M.
  • Puchkov, D., &
  • Haucke, V.

Journal of Biological Chemistry 2022, 298, 101740

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Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

  • Li, H. Y.
  • Prever, L.
  • Hsu, M. Y.
  • Lo, W.
  • Margaria, J. P.
  • De Santis, M. C.
  • Zanini, C.
  • Forni, M.
  • Novelli, F.
  • Pece, S.
  • Di Fiore, P. P.
  • Porporato, P. E.
  • Martini, M.
  • Belabed, H.
  • Nazaré, M.
  • Haucke, V.
  • Gulluni, F., &
  • Hirsch, E.

Advanced Science 2022, 9, e2103249

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Phosphoinositides as membrane organizers

  • Posor, Y.
  • Jang, W., &
  • Haucke, V.

Nature Reviews Molecular Cell Biology 2022, early access,

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Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity

  • Azarnia Tehran, D.
  • Kochlamazashvili, G.
  • Pampaloni, N. P.
  • Sposini, S.
  • Shergill, J. K.
  • Lehmann, M.
  • Pashkova, N.
  • Schmidt, C.
  • Löwe, D.
  • Napieczynska, H.
  • Heuser, A.
  • Plested, A. J. R.
  • Perrais, D.
  • Piper, R. C.
  • Haucke, V., &
  • Maritzen, T.

Science Advances 2022, 8, eabl5032

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Structural basis of phosphatidylinositol 3-kinase C2 alpha function

  • Lo, W.
  • Zhang, Y. Y.
  • Vadas, O.
  • Roske, Y.
  • Gulluni, F.
  • De Santis, M. C.
  • Zagar, A. V.
  • Stephanowitz, H.
  • Hirsch, E.
  • Liu, F.
  • Daumke, O.
  • Kudryashev, M., &
  • Haucke, V.

Nature Structural & Molecular Biology 2022, 29, 218-228

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Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

  • Birke, R.
  • Ast, J.
  • Roosen, D. A.
  • Lee, J.
  • Roßmann, K.
  • Huhn, C.
  • Mathes, B.
  • Lisurek, M.
  • Bushiri, D.
  • Sun, H.
  • Jones, B.
  • Lehmann, M.
  • Levitz, J.
  • Haucke, V.
  • Hodson, D. J., &
  • Broichhagen, J.

Organic & Biomolecular Chemistry 2022, Advance Article,

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

  • Liu, G. T.
  • Kochlamazashvili, G.
  • Puchkov, D.
  • Müller, R.
  • Schultz, C.
  • Mackintosh, A. I.
  • Vollweiter, D.
  • Haucke, V., &
  • Soykan, T.

EMBO Journal 2022, 41, e109352

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Publikationen

von 11

Mechanism of synaptic protein turnover and its regulation by neuronal activity

  • Soykan, T.
  • Haucke, V., &
  • Kuijpers, M.

Current Opinion in Neurobiology 2021, 69, 76-83

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The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

  • Koch, P. A.
  • Dornan, G. L.
  • Hessenberger, M., &
  • Haucke, V.

FEBS Journal 2021, 288, 7025-7042

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SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity

  • Schmied, C.
  • Soykan, T.
  • Bolz, S.
  • Haucke, V., &
  • Lehmann, M.

Frontiers in Computer Science 2021, 3, 777837

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Structural basis of PI3KC2alpha function

  • Lo, W.
  • Zhang, Y.
  • Vadas, O.
  • Belabed, H.
  • Roske, Y.
  • Gulluni, F.
  • De Santis, M.
  • Vujicic Zagar, A.
  • Stephanowitz, H.
  • Hirsch, E.
  • Liu, F.
  • Daumke, O.
  • Kudryashev, M., &
  • Haucke, V.

Nature Structural & Molecular Biology 2021, in press,

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

  • Gulluni, F.
  • Prever, L.
  • Li, H. Y.
  • Krafcikova, P.
  • Corrado, I.
  • Lo, W.
  • Margaria, J. P.
  • Chen, A. L.
  • De Santis, M. C.
  • Cnudde, S. J.
  • Fogerty, J.
  • Yuan, A.
  • Massarotti, A.
  • Sarijalo, N. T.
  • Vadas, O.
  • Williams, R. L.
  • Thelen, M.
  • Powell, D. R.
  • Schueler, M.
  • Wiesener, M. S.
  • Balla, T.
  • Baris, H. N.
  • Tiosano, D.
  • McDermott, B. M.
  • Perkins, B. D.
  • Ghigo, A.
  • Martini, M.
  • Haucke, V.
  • Boura, E.
  • Merlo, G. R.
  • Buchner, D. A., &
  • Hirsch, E.

Science 2021, 374, eabk0410

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Liquid-like protein assemblies initiate endocytosis

  • Witkowska, A., &
  • Haucke, V.

Nature Cell Biology 2021, 23, 301-302

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Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

  • Malek, M.
  • Wawrzyniak, A. M.
  • Koch, P.
  • Lüchtenborg, C.
  • Hessenberger, M.
  • Sachsenheimer, T.
  • Jang, W.
  • Brügger, B., &
  • Haucke, V.

Nature Communications 2021, 12, 2673

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Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy

  • Guerrero-Valero, M.
  • Grandi, F.
  • Cipriani, S.
  • Alberizzi, V.
  • Di Guardo, R.
  • Chicanne, G.
  • Sawade, L.
  • Bianchi, F.
  • Del Carro, U.
  • Curtis, I. D.
  • Pareyson, D.
  • Parman, Y.
  • Schenone, A.
  • Haucke, V.
  • Payrastre, B., &
  • Bolino, A.

Proceedings of the National Academy of Sciences of the United States of America 2021, 118, e2009469118

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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

  • Hostachy, S.
  • Utesch, T.
  • Franke, K.
  • Dornan, G. L.
  • Furkert, D.
  • Turkaydin, B.
  • Haucke, V.
  • Sun, H., &
  • Fiedler, D.

Chemical Science 2021, 12, 10696-10702

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A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

  • Rizalar, F. S.
  • Roosen, D. A., &
  • Haucke, V.

Neuron 2021, 109, 27-41

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A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

  • Haucke, V.

Developmental Cell 2021, 56, 1557-1559

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Publikationen

von 15

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

  • Wang, H. B.
  • Loerke, D.
  • Bruns, C.
  • Müller, R.
  • Koch, P. A.
  • Puchkov, D.
  • Schultz, C., &
  • Haucke, V.

Journal of Biological Chemistry 2020, 295, 1091-1104

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Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes

  • Bertovic, I.
  • Kurelic, R.
  • Milosevic, I.
  • Bender, M.
  • Krauss, M.
  • Haucke, V., &
  • Jurak Begonja, A.

Journal of Thrombosis and Haemostasis 2020, 18, 1756-1772

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Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

  • Pechstein, A.
  • Tomilin, N.
  • Fredrich, K.
  • Vorontsova, O.
  • Sopova, E.
  • Evergren, E.
  • Haucke, V.
  • Brodin, L., &
  • Shupliakov, O.

Cell Reports 2020, 30, 2594-2602

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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

  • Liu, H.
  • Paddock, M.
  • Wang, H.
  • Murphy, C.
  • Geck, R.
  • Navarro, A.
  • Wulf, G.
  • Elemento, O.
  • Haucke, V.
  • Cantley, L., &
  • Toker, A.

Cancer Discovery 2020, 10, 1226-1239

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The axonal endolysosomal and autophagic systems

  • Kuijpers, M.
  • Azarnia Tehran, D.
  • Haucke, V., &
  • Soykan, T.

Journal of Neurochemistry 2020, 158, 589-602

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Ramping up the autophagy-lysosome system to cope with osmotic stress

  • Lopez-Hernandez, T.
  • Maritzen, T., &
  • Haucke, V.

Autophagy 2020, 16, 1921-1922

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Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

  • Sawade, L.
  • Grandi, F.
  • Mignanelli, M.
  • Patino-Lopez, G.
  • Klinkert, K.
  • Langa-Vives, F.
  • Di Guardo, R.
  • Echard, A.
  • Bolino, A., &
  • Haucke, V.

Nature Communications 2020, 11, 2835

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Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

  • Lopez-Hernandez, T.
  • Puchkov, D.
  • Krause, E.
  • Maritzen, T., &
  • Haucke, V.

Nature Cell Biology 2020, 22, 815-827

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

  • Kuijpers, M.
  • Kochlamazashvili, G.
  • Stumpf, A.
  • Puchkov, D.
  • Swaminathan, A.
  • Lucht, M. T.
  • Krause, E.
  • Maritzen, T.
  • Schmitz, D., &
  • Haucke, V.

Neuron 2020, 109, 1-15

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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

  • Gowrisankaran, S.
  • Houy, S.
  • Castillo, J. G. P.
  • Steubler, V.
  • Gelker, M.
  • Kroll, J.
  • Pinheiro, P. S.
  • Schwitters, D.
  • Halbsgut, N.
  • Pechstein, A.
  • Weering, J. R. T.
  • Maritzen, T.
  • Haucke, V.
  • Raimundo, N.
  • Sorensen, J. B., &
  • Milosevic, I.

Nature Communications 2020, 11, 1266

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Endocytosis in the adaptation to cellular stress

  • Lopez-Hernandez, T.
  • Haucke, V., &
  • Maritzen, T.

Cell Stress 2020, 4, 230-247

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EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

  • Matthaeus, C.
  • Lahmann, I.
  • Kunz, S.
  • Jonas, W.
  • Melo, A. A.
  • Lehmann, M.
  • Larsson, E.
  • Lundmark, R.
  • Kern, M.
  • Bluher, M.
  • Olschowski, H.
  • Kompa, J.
  • Brügger, B.
  • Müller, D. N.
  • Haucke, V.
  • Schürmann, A.
  • Birchmeier, C., &
  • Daumke, O.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7471-7481

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Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

  • Stanifer, M. L.
  • Mukenhirn, M.
  • Muenchau, S.
  • Pervolaraki, K.
  • Kanaya, T.
  • Albrecht, D.
  • Odendall, C.
  • Hielscher, T.
  • Haucke, V.
  • Kagan, J. C.
  • Bartfeld, S.
  • Ohno, H., &
  • Boulant, S.

Nature Microbiology 2020, 5, 181-191

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A Golgi-associated lipid kinase controls peripheral nerve myelination

  • Posor, Y., &
  • Haucke, V.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 30873-30875

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Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

  • Jäpel, M.
  • Gerth, F.
  • Sakaba, T.
  • Bacetic, J.
  • Yao, L. J.
  • Koo, S. J.
  • Maritzen, T.
  • Freund, C., &
  • Haucke, V.

Cell Reports 2020, 30, 409-420

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Publikationen

von 10

Nanoscale coupling of endocytic pit growth and stability

  • Lehmann, M.
  • Lukonin, I.
  • Noe, F.
  • Schmoranzer, J.
  • Clementi, C.
  • Loerke, D., &
  • Haucke, V.

Science Advances 2019, 5, eaax5775

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Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

  • Maglione, M.
  • Kochlamazashvili, G.
  • Eisenberg, T.
  • Racz, B.
  • Michael, E.
  • Toppe, D.
  • Stumpf, A.
  • Wirth, A.
  • Zeug, A.
  • Müller, F. E.
  • Moreno-Velasquez, L.
  • Sammons, R. P.
  • Hofer, S. J.
  • Madeo, F.
  • Maritzen, T.
  • Maier, N.
  • Ponimaskin, E.
  • Schmitz, D.
  • Haucke, V., &
  • Sigrist, S. J.

Scientific Reports 2019, 9, 19616

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Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

  • Buntz, A.
  • Killian, T.
  • Schmid, D.
  • Seul, H.
  • Brinkmann, U.
  • Ravn, J.
  • Lindholm, M.
  • Knoetgen, H.
  • Haucke, V., &
  • Mundigl, O.

Nucleic Acids Research 2019, 47, 953-969

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Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

  • Wallroth, A.
  • Koch, P. A.
  • Marat, A. L.
  • Krause, E., &
  • Haucke, V.

Nature Cell Biology 2019, 21, 1093-1101

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Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

  • Dejonghe, W.
  • Sharma, I.
  • Denoo, B.
  • De Munck, S.
  • Lu, Q.
  • Mishev, K.
  • Bulut, H.
  • Mylle, E.
  • De Rycke, R.
  • Vasileva, M.
  • Savatin, D. V.
  • Nerinckx, W.
  • Staes, A.
  • Drozdzecki, A.
  • Audenaert, D.
  • Yperman, K.
  • Madder, A.
  • Friml, J.
  • Van Damme, D.
  • Gevaert, K.
  • Haucke, V.
  • Savvides, S. N.
  • Winne, J., &
  • Russinova, E.

Nature Chemical Biology 2019, 15, 641-649

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Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

  • Tiosano, D.
  • Baris, H. N.
  • Chen, A.
  • Hitzert, M. M.
  • Schueler, M.
  • Gulluni, F.
  • Wiesener, A.
  • Bergua, A.
  • Mory, A.
  • Copeland, B.
  • Gleeson, J. G.
  • Rump, P.
  • Meer, H.
  • Sival, D. A.
  • Haucke, V.
  • Kriwinsky, J.
  • Knaup, K. X.
  • Reis, A.
  • Hauer, N. N.
  • Hirsch, E.
  • Roepman, R.
  • Pfundt, R.
  • Thiel, C. T.
  • Wiesener, M. S.
  • Aslanyan, M. G., &
  • Buchner, D. A.

PLoS Genetics 2019, 15, e1008088

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

  • Pascolutti, R.
  • Algisi, V.
  • Conte, A.
  • Raimondi, A.
  • Pasham, M.
  • Upadhyayula, S.
  • Gaudin, R.
  • Maritzen, T.
  • Barbieri, E.
  • Caldieri, G.
  • Tordonato, C.
  • Confalonieri, S.
  • Freddi, S.
  • Malabarba, M. G.
  • Maspero, E.
  • Polo, S.
  • Tacchetti, C.
  • Haucke, V.
  • Kirchhausen, T.
  • Di Fiore, P. P., &
  • Sigismund, S. (.

Cell Reports 2019, 27, 3049-3061

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Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

  • Gerth, F.
  • Jäpel, M.
  • Sticht, J.
  • Kuropka, B.
  • Schmitt, X. J.
  • Driller, J. H.
  • Loll, B.
  • Wahl, M. C.
  • Pagel, K.
  • Haucke, V., &
  • Freund, C.

Structure 2019, 27, 977-987

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A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

  • Helbig, I.
  • Lopez-Hernandez, T.
  • Shor, O.
  • Galer, P.
  • Ganesan, S.
  • Pendziwiat, M.
  • Rademacher, A.
  • Ellis, C. A.
  • Humpfer, N.
  • Schwarz, N.
  • Seiffert, S.
  • Peeden, J.
  • Shen, J.
  • Sterbova, K.
  • Hammer, T. B.
  • Moller, R. S.
  • Shinde, D. N.
  • Tang, S.
  • Smith, L.
  • Poduri, A.
  • Krause, R.
  • Benninger, F.
  • Helbig, K. L.
  • Haucke, V.
  • Weber, Y. G.
  • Consortium, E., &
  • Consortium, G.

American Journal of Human Genetics 2019, 104, 1060-1072

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The cell adhesion protein CAR is a negative regulator of synaptic transmission

  • Wrackmeyer, U.
  • Kaldrack, J.
  • Jüttner, R.
  • Pannasch, U.
  • Gimber, N.
  • Freiberg, F.
  • Purfürst, B.
  • Kainmueller, D.
  • Schmitz, D.
  • Haucke, V.
  • Rathjen, F. G., &
  • Gotthardt, M.

Scientific Reports 2019, 9, 6768

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