[Translate to Deutsch:] Portrait

Prof. Dr.

Hartmut Oschkinat

Hartmut Oschinat ist der Gruppenleiter und NMR- Experte.
Er studierte in Göttingen und Heidelberg und so weiter


Strukturbiologie


Oschkinat Gruppe


FMP
FU Berlin

NMR quality control of fragment libraries for screening.

  • Hartmut Oschkinat

Journal of biomolecular NMR 2020

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MAS NMR detection of hydrogen bonds for protein secondary structure characterization.

  • Hartmut Oschkinat

Journal of biomolecular NMR 2020

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Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.

  • Hartmut Oschkinat

Journal of structural biology 2020

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Collective exchange processes reveal an active site proton cage in bacteriorhodopsin.

  • Hartmut Oschkinat

Communications biology 2020

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pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes.

  • Hartmut Oschkinat

Chembiochem : a European journal of chemical biology 2020

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Innentitelbild: Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose (Angew. Chem. 29/2020)

  • Wing Ying Chow; Brendan P. Norman; Norman B. Roberts; Lakshminarayan R. Ranganath; Christian Teutloff; Robert Bittl; Melinda J. Duer; James A. Gallagher; Hartmut Oschkinat

Angewandte Chemie 2020

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Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

  • Wing Ying Chow; Brendan P. Norman; Norman B. Roberts; Lakshminarayan R. Ranganath; Christian Teutloff; Robert Bittl; Melinda J. Duer; James A. Gallagher; Hartmut Oschkinat

Angewandte Chemie International Edition 2020

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Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose

  • Wing Ying Chow; Brendan P. Norman; Norman B. Roberts; Lakshminarayan R. Ranganath; Christian Teutloff; Robert Bittl; Melinda J. Duer; James A. Gallagher; Hartmut Oschkinat

Angewandte Chemie 2020

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Inside Cover: Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Angew. Chem. Int. Ed. 29/2020)

  • Wing Ying Chow; Brendan P. Norman; Norman B. Roberts; Lakshminarayan R. Ranganath; Christian Teutloff; Robert Bittl; Melinda J. Duer; James A. Gallagher; Hartmut Oschkinat

Angewandte Chemie International Edition 2020

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Structural changes of TasA in biofilm formation of Bacillus subtilis.

  • Hartmut Oschkinat

Proceedings of the National Academy of Sciences of the United States of America 2018

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Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR.

  • Hartmut Oschkinat

Chemical communications (Cambridge, England) 2018

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RIP2 filament formation is required for NOD2 dependent NF-κB signalling.

  • Hartmut Oschkinat

Nature communications 2018

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DNP NMR of biomolecular assemblies.

  • Hartmut Oschkinat

Journal of structural biology 2018

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iNEXT: a European facility network to stimulate translational structural biology.

  • Hartmut Oschkinat

FEBS letters 2018

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The protofilament architecture of a de novo designed coiled coil-based amyloidogenic peptide.

  • Hartmut Oschkinat

Journal of structural biology 2018

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Efficiency of Water-Soluble Nitroxide Biradicals for Dynamic Nuclear Polarization in Rotating Solids at 9.4 T: bcTol-M and cyolyl-TOTAPOL as New Polarizing Agents.

  • Hartmut Oschkinat

Chemistry (Weinheim an der Bergstrasse, Germany) 2018

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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.

  • Hartmut Oschkinat

PLoS biology 2018

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Understanding the roles of functional peptides in designing apatite and silica nanomaterials biomimetically using NMR techniques

  • Hartmut Oschkinat

Current Opinion in Colloid & Interface Science 2018

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Structural insight into protein-aided bacterial biofilm formation

  • Hartmut Oschkinat

Acta Crystallographica Section A Foundations and Advances 2018

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Dynamic Nuclear Polarization Enhanced MAS NMR Spectroscopy for Structural Analysis of HIV-1 Protein Assemblies.

  • Hartmut Oschkinat

The journal of physical chemistry. B 2016

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Studying the Conformation of a Silaffin-Derived Pentalysine Peptide Embedded in Bioinspired Silica using Solution and Dynamic Nuclear Polarization Magic-Angle Spinning NMR.

  • Hartmut Oschkinat

Journal of the American Chemical Society 2016

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bcTol : a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules.

  • Hartmut Oschkinat

Chemical communications (Cambridge, England) 2016

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Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core.

  • Hartmut Oschkinat

Scientific reports 2016

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Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors.

  • Hartmut Oschkinat

Angewandte Chemie (International ed. in English) 2016

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Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures.

  • Hartmut Oschkinat

Physical chemistry chemical physics : PCCP 2016

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Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR.

  • Hartmut Oschkinat

Science advances 2016

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Multifunctional Benzoxazines Feature Low Polymerization Temperature and Diverse Polymer Structures.

  • Hartmut Oschkinat

Polymers 2016

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On The Potential of Dynamic Nuclear Polarization Enhanced Diamonds in Solid-State and Dissolution (13) C NMR Spectroscopy.

  • Hartmut Oschkinat

Chemphyschem : a European journal of chemical physics and physical chemistry 2016

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Chemical shift assignments and secondary structure prediction for Q4DY78, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.

  • Hartmut Oschkinat

Biomolecular NMR assignments 2016

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Quantitative and Qualitative Analysis of Surface Modified Cellulose Utilizing TGA-MS.

  • Hartmut Oschkinat

Materials (Basel, Switzerland) 2016

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Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy.

  • Hartmut Oschkinat

Chembiochem : a European journal of chemical biology 2016

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Structural biology applications of solid state MAS DNP NMR.

  • Hartmut Oschkinat

Journal of magnetic resonance (San Diego, Calif. : 1997) 2016

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The mechanism of denaturation and the unfolded state of the α-helical membrane-associated protein Mistic.

  • Hartmut Oschkinat

Journal of the American Chemical Society 2013

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Dynamic nuclear polarization of spherical nanoparticles.

  • Hartmut Oschkinat

Physical chemistry chemical physics : PCCP 2013

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Preferential and specific binding of human αB-crystallin to a cataract-related variant of γS-crystallin.

  • Kingsley CN; Brubaker WD; Markovic S; Diehl A; Brindley AJ; Oschkinat H; Martin RW

Structure (London, England : 1993) 2013

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The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.

  • Fiebig JE; Weidauer SE; Qiu LY; Bauer M; Schmieder P; Beerbaum M; Zhang JL; Oschkinat H; Sebald W; Mueller TD

Molecules (Basel, Switzerland) 2013

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Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: biological effects on human tumor cells.

  • Kuznetsova NR; Svirshchevskaya EV; Sitnikov NS; Abodo L; Sutorius H; Zapke J; Velder J; Thomopoulou P; Oschkinat H; Prokop A; Schmalz HG; Fedorov AY; Vodovozova EL

Bioorganicheskaia khimiia 2013

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A well-defined Pd hybrid material for the Z-selective semihydrogenation of alkynes characterized at the molecular level by DNP SENS.

  • Conley MP; Drost RM; Baffert M; Gajan D; Elsevier C; Franks WT; Oschkinat H; Veyre L; Zagdoun A; Rossini A; Lelli M; Lesage A; Casano G; Ouari O; Thieuleux C

Chemistry (Weinheim an der Bergstrasse, Germany) 2013

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Reduced activity of alkaline phosphatase due to host-guest interactions with humic superstructures.

  • Mazzei P; Oschkinat H; Piccolo A

Chemosphere 2013

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Out-and-back 13C-13C scalar transfers in protein resonance assignment by proton-detected solid-state NMR under ultra-fast MAS.

  • Barbet-Massin E; Pell AJ; Jaudzems K; Franks WT; Retel JS; Kotelovica S; Akopjana I; Tars K; Emsley L; Oschkinat H; Lesage A; Pintacuda G

Journal of biomolecular NMR 2013

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A Floquet description of phase alternated sequences for efficient homonuclear recoupling in solid perdeuterated systems.

  • Jayanthi S; Akbey Ü; Uluca B; Oschkinat H; Vega S

Journal of magnetic resonance (San Diego, Calif. : 1997) 2013

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Improved dynamic nuclear polarization surface-enhanced NMR spectroscopy through controlled incorporation of deuterated functional groups.

  • Zagdoun A; Rossini AJ; Conley MP; Grüning WR; Schwarzwälder M; Lelli M; Franks WT; Oschkinat H; Copéret C; Emsley L; Lesage A

Angewandte Chemie (International ed. in English) 2013

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Dynamic nuclear polarization enhanced NMR in the solid-state.

  • Akbey U; Franks WT; Linden A; Orwick-Rydmark M; Lange S; Oschkinat H

Topics in current chemistry 2013

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Developing DNP/Solid-State NMR Spectroscopy of Oriented Membranes

  • Hartmut Oschkinat

Applied Magnetic Resonance 2012

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High-Temperature Dynamic Nuclear Polarization Enhanced Magic-Angle-Spinning NMR

  • Hartmut Oschkinat

Applied Magnetic Resonance 2012

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In support of the BMRB.

  • Markley JL; Akutsu H; Asakura T; Baldus M; Boelens R; Bonvin A; Kaptein R; Bax A; Bezsonova I; Gryk MR; Hoch JC; Korzhnev DM; Maciejewski MW; Case D; Yokoyama S

Nature structural & molecular biology 2012

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Fast passage dynamic nuclear polarization on rotating solids.

  • Mentink-Vigier F; Akbey U; Hovav Y; Vega S; Oschkinat H; Feintuch A

Journal of magnetic resonance (San Diego, Calif. : 1997) 2012

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Efficient modeling of symmetric protein aggregates from NMR data.

  • Bardiaux B; van Rossum BJ; Nilges M; Oschkinat H

Angewandte Chemie (International ed. in English) 2012

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Broadband excitation pulses for high-field solid-state nuclear magnetic resonance spectroscopy.

  • Loening NM; van Rossum BJ; Oschkinat H

Magnetic resonance in chemistry : MRC 2012

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Practical aspects of high-sensitivity multidimensional ¹³C MAS NMR spectroscopy of perdeuterated proteins.

  • Akbey U; Rossum BJ; Oschkinat H

Journal of magnetic resonance (San Diego, Calif. : 1997) 2012

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Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis.

  • Warrier T; Tropis M; Werngren J; Diehl A; Gengenbacher M; Schlegel B; Schade M; Oschkinat H; Daffe M; Hoffner S; Eddine AN; Kaufmann SH

Antimicrobial agents and chemotherapy 2012

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The effect of biradical concentration on the performance of DNP-MAS-NMR.

  • Lange S; Linden AH; Akbey U; Franks WT; Loening NM; van Rossum BJ; Oschkinat H

Journal of magnetic resonance (San Diego, Calif. : 1997) 2012

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Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution.

  • Jacso T; Franks WT; Rose H; Fink U; Broecker J; Keller S; Oschkinat H; Reif B

Angewandte Chemie (International ed. in English) 2012

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Rapid solid-state NMR of deuterated proteins by interleaved cross-polarization from ¹H and ²H nuclei.

  • Bjerring M; Paaske B; Oschkinat H; Akbey U; Nielsen NC

Journal of magnetic resonance (San Diego, Calif. : 1997) 2012

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A comparison of NCO and NCA transfer methods for biological solid-state NMR spectroscopy.

  • Loening NM; Bjerring M; Nielsen NC; Oschkinat H

Journal of magnetic resonance (San Diego, Calif. : 1997) 2012

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Solid-state magic-angle spinning NMR of membrane proteins and protein-ligand interactions.

  • Franks WT; Linden AH; Kunert B; van Rossum BJ; Oschkinat H

European journal of cell biology 2012

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Enhanced Resolution and Coherence Lifetimes in the Solid-State NMR Spectroscopy of Perdeuterated Proteins under Ultrafast Magic-Angle Spinning

  • Hartmut Oschkinat

The Journal of Physical Chemistry Letters 2011

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Neurotoxin II bound to acetylcholine receptors in native membranes studied by dynamic nuclear polarization NMR.

  • Linden AH; Lange S; Franks WT; Akbey U; Specker E; van Rossum BJ; Oschkinat H

Journal of the American Chemical Society 2011

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Three-dimensional deuterium-carbon correlation experiments for high-resolution solid-state MAS NMR spectroscopy of large proteins.

  • Lalli D; Schanda P; Chowdhury A; Retel J; Hiller M; Higman VA; Handel L; Agarwal V; Reif B; van Rossum B; Akbey U; Oschkinat H

Journal of biomolecular NMR 2011

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A software framework for analysing solid-state MAS NMR data.

  • Stevens TJ; Fogh RH; Boucher W; Higman VA; Eisenmenger F; Bardiaux B; van Rossum BJ; Oschkinat H; Laue ED

Journal of biomolecular NMR 2011

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Cryogenic temperature effects and resolution upon slow cooling of protein preparations in solid state NMR.

  • Linden AH; Franks WT; Akbey Ü; Lange S; van Rossum BJ; Oschkinat H

Journal of biomolecular NMR 2011

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SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

  • Koo SJ; Markovic S; Puchkov D; Mahrenholz CC; Beceren-Braun F; Maritzen T; Dernedde J; Volkmer R; Oschkinat H; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2011

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Triple resonance cross-polarization for more sensitive 13C MAS NMR spectroscopy of deuterated proteins.

  • Akbey U; Camponeschi F; van Rossum BJ; Oschkinat H

Chemphyschem : a European journal of chemical physics and physical chemistry 2011

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Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain.

  • Saupe J; Roske Y; Schillinger C; Kamdem N; Radetzki S; Diehl A; Oschkinat H; Krause G; Heinemann U; Rademann J

ChemMedChem 2011

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Optimal (2)H rf Pulses and (2)H-(13)C Cross-Polarization Methods for Solid-State (2)H MAS NMR of Perdeuterated Proteins.

  • Wei D; Akbey Ü; Paaske B; Oschkinat H; Reif B; Bjerring M; Nielsen NC

The journal of physical chemistry letters 2011

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Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins.

  • Linser R; Dasari M; Hiller M; Higman V; Fink U; Lopez del Amo JM; Markovic S; Handel L; Kessler B; Schmieder P; Oesterhelt D; Oschkinat H; Reif B

Angewandte Chemie (International ed. in English) 2011

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N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity.

  • Jehle S; Vollmar BS; Bardiaux B; Dove KK; Rajagopal P; Gonen T; Oschkinat H; Klevit RE

Proceedings of the National Academy of Sciences of the United States of America 2011

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The structure of MESD45-184 brings light into the mechanism of LDLR family folding.

  • Köhler C; Lighthouse JK; Werther T; Andersen OM; Diehl A; Schmieder P; Du J; Holdener BC; Oschkinat H

Structure (London, England : 1993) 2011

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Radio frequency assisted homonuclear recoupling - a Floquet description of homonuclear recoupling via surrounding heteronuclei in fully protonated to fully deuterated systems.

  • Leskes M; Akbey U; Oschkinat H; van Rossum BJ; Vega S

Journal of magnetic resonance (San Diego, Calif. : 1997) 2011

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Intermolecular protein-RNA interactions revealed by 2D 31P-15N magic angle spinning solid-state NMR spectroscopy.

  • Jehle S; Falb M; Kirkpatrick JP; Oschkinat H; van Rossum BJ; Althoff G; Carlomagno T

Journal of the American Chemical Society 2010

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Dynamic nuclear polarization of deuterated proteins.

  • Akbey Ü; Franks WT; Linden A; Lange S; Griffin RG; van Rossum BJ; Oschkinat H

Angewandte Chemie (International ed. in English) 2010

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Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.

  • Zaminer J; Brockmann C; Huy P; Opitz R; Reuter C; Beyermann M; Freund C; Müller M; Oschkinat H; Kühne R; Schmalz HG

Angewandte Chemie (International ed. in English) 2010

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Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers.

  • Jehle S; Rajagopal P; Bardiaux B; Markovic S; Kühne R; Stout JR; Higman VA; Klevit RE; van Rossum BJ; Oschkinat H

Nature structural & molecular biology 2010

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Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug.

  • Nicolaus N; Zapke J; Riesterer P; Neudörfl JM; Prokop A; Oschkinat H; Schmalz HG

ChemMedChem 2010

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A MAS NMR study of the bacterial ABC transporter ArtMP.

  • Lange V; Becker-Baldus J; Kunert B; van Rossum BJ; Casagrande F; Engel A; Roske Y; Scheffel FM; Schneider E; Oschkinat H

Chembiochem : a European journal of chemical biology 2010

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A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.

  • Maritzen T; Schmidt MR; Kukhtina V; Higman VA; Strauss H; Volkmer R; Oschkinat H; Dotti CG; Haucke V

The Journal of biological chemistry 2010

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Optimum levels of exchangeable protons in perdeuterated proteins for proton detection in MAS solid-state NMR spectroscopy.

  • Akbey U; Lange S; Trent Franks W; Linser R; Rehbein K; Diehl A; van Rossum BJ; Reif B; Oschkinat H

Journal of biomolecular NMR 2010

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Double-nucleus enhanced recoupling for efficient 13C MAS NMR correlation spectroscopy of perdeuterated proteins.

  • Akbey U; Oschkinat H; van Rossum BJ

Journal of the American Chemical Society 2009

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Large protein complexes with extreme rotational correlation times investigated in solution by magic-angle-spinning NMR spectroscopy.

  • Mainz A; Jehle S; van Rossum BJ; Oschkinat H; Reif B

Journal of the American Chemical Society 2009

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Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.

  • Schmidt MR; Maritzen T; Kukhtina V; Higman VA; Doglio L; Barak NN; Strauss H; Oschkinat H; Dotti CG; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2009

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Assigning large proteins in the solid state: a MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins.

  • Higman VA; Flinders J; Hiller M; Jehle S; Markovic S; Fiedler S; van Rossum BJ; Oschkinat H

Journal of biomolecular NMR 2009

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Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies.

  • Rutkowska A; Beerbaum M; Rajagopalan N; Fiaux J; Schmieder P; Kramer G; Oschkinat H; Bukau B

FEBS letters 2009

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Loop 3 of short neurotoxin II is an additional interaction site with membrane-bound nicotinic acetylcholine receptor as detected by solid-state NMR spectroscopy.

  • Krabben L; van Rossum BJ; Jehle S; Bocharov E; Lyukmanova EN; Schulga AA; Arseniev A; Hucho F; Oschkinat H

Journal of molecular biology 2009

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NMR structure of the Wnt modulator protein Sclerostin.

  • Weidauer SE; Schmieder P; Beerbaum M; Schmitz W; Oschkinat H; Mueller TD

Biochemical and biophysical research communications 2009

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alphaB-crystallin: a hybrid solid-state/solution-state NMR investigation reveals structural aspects of the heterogeneous oligomer.

  • Jehle S; van Rossum B; Stout JR; Noguchi SM; Falber K; Rehbein K; Oschkinat H; Klevit RE; Rajagopal P

Journal of molecular biology 2009

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Resonance assignment of the RGS domain of human RGS10.

  • Fedorov OY; Higman VA; Schmieder P; Leidert M; Diehl A; Elkins J; Soundararajan M; Oschkinat H; Ball LJ

Journal of biomolecular NMR 2007

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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.

  • Podust LM; von Kries JP; Eddine AN; Kim Y; Yermalitskaya LV; Kuehne R; Ouellet H; Warrier T; Alteköster M; Lee JS; Rademann J; Oschkinat H; Waterman MR

Antimicrobial agents and chemotherapy 2007

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Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains.

  • Ramirez-Espain X; Ruiz L; Martin-Malpartida P; Oschkinat H; Macias MJ

Journal of molecular biology 2007

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Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.

  • Dowler EF; Diehl A; Schmieder P; Brockmann C; Elkins J; Soundararajan M; Oschkinat H; Ball LJ

Biomolecular NMR assignments 2007

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J-deconvolution using maximum entropy reconstruction applied to 13C-13C solid-state cross-polarization magic-angle-spinning NMR of proteins.

  • Scholz I; Jehle S; Schmieder P; Hiller M; Eisenmenger F; Oschkinat H; van Rossum BJ

Journal of the American Chemical Society 2007

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Solid-state NMR of matrix metalloproteinase 12: an approach complementary to solution NMR.

  • Balayssac S; Bertini I; Fälber K; Fragai M; Jehle S; Lelli M; Luchinat C; Oschkinat H; Yeo KJ

Chembiochem : a European journal of chemical biology 2007

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The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.

  • Köhler C; Andersen OM; Diehl A; Krause G; Schmieder P; Oschkinat H

Journal of structural and functional genomics 2006

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General structural motifs of amyloid protofilaments.

  • Ferguson N; Becker J; Tidow H; Tremmel S; Sharpe TD; Krause G; Flinders J; Petrovich M; Berriman J; Oschkinat H; Fersht AR

Proceedings of the National Academy of Sciences of the United States of America 2006

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Spectral editing: selection of methyl groups in multidimensional solid-state magic-angle spinning NMR.

  • Jehle S; Hiller M; Rehbein K; Diehl A; Oschkinat H; van Rossum BJ

Journal of biomolecular NMR 2006

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NMR assignment of human RGS18.

  • Higman VA; Leidert M; Diehl A; Elkins J; Soundararajan M; Oschkinat H; Ball LJ

Journal of biomolecular NMR 2006

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Discovery of low-molecular-weight ligands for the AF6 PDZ domain.

  • Joshi M; Vargas C; Boisguerin P; Diehl A; Krause G; Schmieder P; Moelling K; Hagen V; Schade M; Oschkinat H

Angewandte Chemie (International ed. in English) 2006

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High yield expression and purification of isotopically labelled human endothelin-1 for use in NMR studies.

  • Mac TT; Beyermann M; Pires JR; Schmieder P; Oschkinat H

Protein expression and purification 2006

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Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.

  • Salmon D; do Aido-Machado R; Diehl A; Leidert M; Schmetzer O; de A Lima AP; Scharfstein J; Oschkinat H; Pires JR

Journal of molecular biology 2006

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1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi.

  • Aido-Machado Rd; Salmon D; Diehl A; Leidert M; Schmetzer O; de Lima AP; Scharfstein J; Oschkinat H; Pires JR

Journal of biomolecular NMR 2006

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Structural basis for APPTPPPLPP peptide recognition by the FBP11WW1 domain.

  • Pires JR; Parthier C; Aido-Machado Rd; Wiedemann U; Otte L; Böhm G; Rudolph R; Oschkinat H

Journal of molecular biology 2005

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A modified strategy for sequence specific assignment of protein NMR spectra based on amino acid type selective experiments.

  • Schubert M; Labudde D; Leitner D; Oschkinat H; Schmieder P

Journal of biomolecular NMR 2005

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Influence of chemical shift tolerances on NMR structure calculations using ARIA protocols for assigning NOE data.

  • Fossi M; Linge J; Labudde D; Leitner D; Nilges M; Oschkinat H

Journal of biomolecular NMR 2005

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13C-labeled tyrosine residues as local IR probes for monitoring conformational changes in peptides and proteins.

  • Tremmel S; Beyermann M; Oschkinat H; Bienert M; Naumann D; Fabian H

Angewandte Chemie (International ed. in English) 2005

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Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR.

  • Chevelkov V; Faelber K; Diehl A; Heinemann U; Oschkinat H; Reif B

Journal of biomolecular NMR 2005

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Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers.

  • Adam P; Gütlich M; Oschkinat H; Bacher A; Eisenreich W

BMC biochemistry 2005

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SOLARIA: a protocol for automated cross-peak assignment and structure calculation for solid-state magic-angle spinning NMR spectroscopy.

  • Fossi M; Castellani F; Nilges M; Oschkinat H; van Rossum BJ

Angewandte Chemie (International ed. in English) 2005

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Solid-state magic-angle spinning NMR of outer-membrane protein G from Escherichia coli.

  • Hiller M; Krabben L; Vinothkumar KR; Castellani F; van Rossum BJ; Kühlbrandt W; Oschkinat H

Chembiochem : a European journal of chemical biology 2005

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The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology.

  • Leitner D; Wahl M; Labudde D; Krause G; Diehl A; Schmieder P; Pires JR; Fossi M; Wiedemann U; Leidert M; Oschkinat H

FEBS letters 2005

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Quantitative study of the effects of chemical shift tolerances and rates of SA cooling on structure calculation from automatically assigned NOE data.

  • Fossi M; Oschkinat H; Nilges M; Ball LJ

Journal of magnetic resonance (San Diego, Calif. : 1997) 2005

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Recognition of proline-rich motifs by protein-protein-interaction domains.

  • Ball LJ; Kühne R; Schneider-Mergener J; Oschkinat H

Angewandte Chemie (International ed. in English) 2005

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NMR fragment screening: tackling protein-protein interaction targets.

  • Schade M; Oschkinat H

Current opinion in drug discovery & development 2005

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Letter to the Editor:1H,13C and15N Resonance Assignment of the Human Spred2 EVH1 Domain

  • Hartmut Oschkinat

Journal of Biomolecular NMR 2004

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Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.

  • Gaiser OJ; Ball LJ; Schmieder P; Leitner D; Strauss H; Wahl M; Kühne R; Oschkinat H; Heinemann U

Biochemistry 2004

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Comparative structural and energetic analysis of WW domain-peptide interactions.

  • Schleinkofer K; Wiedemann U; Otte L; Wang T; Krause G; Oschkinat H; Wade RC

Journal of molecular biology 2004

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1H, 13C and 15N resonance assignments of the C-terminal BRCT domain from human BRCA1.

  • Gaiser OJ; Oschkinat H; Heinemann U; Ball LJ

Journal of biomolecular NMR 2004

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The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L.

  • Soukenik M; Diehl A; Leidert M; Sievert V; Büssow K; Leitner D; Labudde D; Ball LJ; Lechner A; Nägler DK; Oschkinat H

FEBS letters 2004

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Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides.

  • Wiedemann U; Boisguerin P; Leben R; Leitner D; Krause G; Moelling K; Volkmer-Engert R; Oschkinat H

Journal of molecular biology 2004

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The oxidized subunit B8 from human complex I adopts a thioredoxin fold.

  • Brockmann C; Diehl A; Rehbein K; Strauss H; Schmieder P; Korn B; Kühne R; Oschkinat H

Structure (London, England : 1993) 2004

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Towards structure determination of neurotoxin II bound to nicotinic acetylcholine receptor: a solid-state NMR approach.

  • Krabben L; van Rossum BJ; Castellani F; Bocharov E; Schulga AA; Arseniev AS; Weise C; Hucho F; Oschkinat H

FEBS letters 2004

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The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.

  • Kahmann JD; Wecking DA; Putter V; Lowenhaupt K; Kim YG; Schmieder P; Oschkinat H; Rich A; Schade M

Proceedings of the National Academy of Sciences of the United States of America 2004

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Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.

  • Waldmann H; Karaguni IM; Carpintero M; Gourzoulidou E; Herrmann C; Brockmann C; Oschkinat H; Müller O

Angewandte Chemie (International ed. in English) 2004

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The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains.

  • Brockmann C; Leitner D; Labudde D; Diehl A; Sievert V; Büssow K; Kühne R; Oschkinat H

FEBS letters 2004

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Determination of solid-state NMR structures of proteins by means of three-dimensional 15N-13C-13C dipolar correlation spectroscopy and chemical shift analysis.

  • Castellani F; van Rossum BJ; Diehl A; Rehbein K; Oschkinat H

Biochemistry 2003

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Design of N-substituted peptomer ligands for EVH1 domains.

  • Zimmermann J; Kühne R; Volkmer-Engert R; Jarchau T; Walter U; Oschkinat H; Ball LJ

The Journal of biological chemistry 2003

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1H detection in MAS solid-state NMR spectroscopy of biomacromolecules employing pulsed field gradients for residual solvent suppression.

  • Chevelkov V; van Rossum BJ; Castellani F; Rehbein K; Diehl A; Hohwy M; Steuernagel S; Engelke F; Oschkinat H; Reif B

Journal of the American Chemical Society 2003

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Measurement of multiple psi torsion angles in uniformly 13C,15N-labeled alpha-spectrin SH3 domain using 3D 15N-13C-13C-15N MAS dipolar-chemical shift correlation spectroscopy.

  • Ladizhansky V; Jaroniec CP; Diehl A; Oschkinat H; Griffin RG

Journal of the American Chemical Society 2003

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Assignment of amide proton signals by combined evaluation of HN, NN and HNCA MAS-NMR correlation spectra.

  • van Rossum BJ; Castellani F; Pauli J; Rehbein K; Hollander J; de Groot HJ; Oschkinat H

Journal of biomolecular NMR 2003

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Combining SPOT synthesis and native peptide ligation to create large arrays of WW protein domains.

  • Toepert F; Knaute T; Guffler S; Pirés JR; Matzdorf T; Oschkinat H; Schneider-Mergener J

Angewandte Chemie (International ed. in English) 2003

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The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p.

  • Pires JR; Hong X; Brockmann C; Volkmer-Engert R; Schneider-Mergener J; Oschkinat H; Erdmann R

Journal of molecular biology 2003

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WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains.

  • Otte L; Wiedemann U; Schlegel B; Pires JR; Beyermann M; Schmieder P; Krause G; Volkmer-Engert R; Schneider-Mergener J; Oschkinat H

Protein science : a publication of the Protein Society 2003

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Characterization of (1)H-(1)H distances in a uniformly (2)H,(15)N-labeled SH3 domain by MAS solid-state NMR spectroscopy (section sign).

  • Reif B; Van Rossum BJ; Castellani F; Rehbein K; Diehl A; Oschkinat H

Journal of the American Chemical Society 2003

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Prediction algorithm for amino acid types with their secondary structure in proteins (PLATON) using chemical shifts.

  • Labudde D; Leitner D; Krüger M; Oschkinat H

Journal of biomolecular NMR 2003

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Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.

  • Fischer M; Romisch W; Schiffmann S; Kelly M; Oschkinat H; Steinbacher S; Huber R; Eisenreich W; Richter G; Bacher A

The Journal of biological chemistry 2002

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2D(13)C-(13)C MAS NMR correlation spectroscopy with mixing by true (1)H spin diffusion reveals long-range intermolecular distance restraints in ultra high magnetic field.

  • de Boer I; Bosman L; Raap J; Oschkinat H; de Groot HJ

Journal of magnetic resonance (San Diego, Calif. : 1997) 2002

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The structures of the active center in dark-adapted bacteriorhodopsin by solution-state NMR spectroscopy.

  • Patzelt H; Simon B; terLaak A; Kessler B; Kühne R; Schmieder P; Oesterhelt D; Oschkinat H

Proceedings of the National Academy of Sciences of the United States of America 2002

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Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy.

  • Castellani F; van Rossum B; Diehl A; Schubert M; Rehbein K; Oschkinat H

Nature 2002

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A software tool for the prediction of Xaa-Pro peptide bond conformations in proteins based on 13C chemical shift statistics.

  • Schubert M; Labudde D; Oschkinat H; Schmieder P

Journal of biomolecular NMR 2002

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Relaxation, equilibrium oligomerization, and molecular symmetry of the VASP (336-380) EVH2 tetramer.

  • Zimmermann J; Labudde D; Jarchau T; Walter U; Oschkinat H; Ball LJ

Biochemistry 2002

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A 3-D structural model of solid self-assembled chlorophyll a/H(2)O from multispin labeling and MAS NMR 2-D dipolar correlation spectroscopy in high magnetic field.

  • van Rossum BJ; Schulten EA; Raap J; Oschkinat H; de Groot HJ

Journal of magnetic resonance (San Diego, Calif. : 1997) 2002

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EVH1 domains: structure, function and interactions.

  • Ball LJ; Jarchau T; Oschkinat H; Walter U

FEBS letters 2002

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MUSIC and aromatic residues: amino acid type-selective (1)H-(15)N correlations, III.

  • Schubert M; Oschkinat H; Schmieder P

Journal of magnetic resonance (San Diego, Calif. : 1997) 2001

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Assignment of the nonexchanging protons of the alpha-spectrin SH3 domain by two- and three-dimensional 1H-13C solid-state magic-angle spinning NMR and comparison of solution and solid-state proton chemical shifts.

  • van Rossum BJ; Castellani F; Rehbein K; Pauli J; Oschkinat H

Chembiochem : a European journal of chemical biology 2001

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Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.

  • Pires JR; Taha-Nejad F; Toepert F; Ast T; Hoffmüller U; Schneider-Mergener J; Kühne R; Macias MJ; Oschkinat H

Journal of molecular biology 2001

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The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site.

  • Kelly MJ; Ball LJ; Krieger C; Yu Y; Fischer M; Schiffmann S; Schmieder P; Kühne R; Bermel W; Bacher A; Richter G; Oschkinat H

Proceedings of the National Academy of Sciences of the United States of America 2001

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Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions.

  • Ferguson N; Pires JR; Toepert F; Johnson CM; Pan YP; Volkmer-Engert R; Schneider-Mergener J; Daggett V; Oschkinat H; Fersht A

Proceedings of the National Academy of Sciences of the United States of America 2001

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Ultrafast folding of WW domains without structured aromatic clusters in the denatured state.

  • Ferguson N; Johnson CM; Macias M; Oschkinat H; Fersht A

Proceedings of the National Academy of Sciences of the United States of America 2001

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Amino acid type-selective backbone 1H-15N-correlations for Arg and Lys.

  • Schubert M; Oschkinat H; Schmieder P

Journal of biomolecular NMR 2001

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Secondary chemical shifts in immobilized peptides and proteins: a qualitative basis for structure refinement under magic angle spinning.

  • Luca S; Filippov DV; van Boom JH; Oschkinat H; de Groot HJ; Baldus M

Journal of biomolecular NMR 2001

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High-throughput three-dimensional protein structure determination.

  • Heinemann U; Illing G; Oschkinat H

Current opinion in biotechnology 2001

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Backbone and side-chain 13C and 15N signal assignments of the alpha-spectrin SH3 domain by magic angle spinning solid-state NMR at 17.6 Tesla.

  • Pauli J; Baldus M; van Rossum B; de Groot H; Oschkinat H

Chembiochem : a European journal of chemical biology 2001

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Synthesis of an Array Comprising 837 Variants of the hYAP WW Protein Domain This work was supported by the DFG (INK 16/B1-1), by the Fonds der Chemischen Industrie, and by the Universitätsklinikum Charité Berlin.

  • Toepert F; Pires JR; Landgraf C; Oschkinat H; Schneider-Mergener J

Angewandte Chemie (International ed. in English) 2001

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MUSIC, selective pulses, and tuned delays: amino acid type-selective (1)H-(15)N correlations, II.

  • Schubert M; Oschkinat H; Schmieder P

Journal of magnetic resonance (San Diego, Calif. : 1997) 2001

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Interaction of a PDZ Protein Domain with a Synthetic Library of All Human Protein C Termini

  • Hartmut Oschkinat

Angewandte Chemie International Edition 1999

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The entire metabolite spectrum of the green alga Scenedesmus obliquus in isotope-labelled form

  • Hartmut Oschkinat

Phytochemistry 1999

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A new type of PDZ domain recognition.

  • Oschkinat H

Nature structural biology 1999

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MUSIC in triple-resonance experiments: amino acid type-selective (1)H-(15)N correlations

  • Schubert M; Smalla M; Schmieder P; Oschkinat H

Journal of magnetic resonance (San Diego, Calif. : 1997) 1999

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Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites.

  • Smalla M; Schmieder P; Kelly M; Ter Laak A; Krause G; Ball L; Wahl M; Bork P; Oschkinat H

Protein science : a publication of the Protein Society 1999

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The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

  • Schade M; Turner CJ; Kühne R; Schmieder P; Lowenhaupt K; Herbert A; Rich A; Oschkinat H

Proceedings of the National Academy of Sciences of the United States of America 1999

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A 6 bp Z-DNA hairpin binds two Z alpha domains from the human RNA editing enzyme ADAR1.

  • Schade M; Behlke J; Lowenhaupt K; Herbert A; Rich A; Oschkinat H

FEBS letters 1999

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Rational design of a GCN4-derived mimetic of interleukin-4.

  • Domingues H; Cregut D; Sebald W; Oschkinat H; Serrano L

Nature structural biology 1999

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Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: potential for NMR structure determination of large proteins.

  • Kelly MJ; Krieger C; Ball LJ; Yu Y; Richter G; Schmieder P; Bacher A; Oschkinat H

Journal of biomolecular NMR 1999

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NMR studies on the 46-kDa dimeric protein, 3,4-dihydroxy-2-butanone 4-phosphate synthase, using 2H, 13C, and 15N-labelling.

  • Richter G; Kelly M; Krieger C; Yu Y; Bermel W; Karlsson G; Bacher A; Oschkinat H

European journal of biochemistry 1999

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Signal selection in high-resolution NMR by pulsed field gradients.

  • Thomas DJ; Mitschang L; Simon B; Oschkinat H

Journal of magnetic resonance (San Diego, Calif. : 1997) 1999

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Towards structural investigations on isotope labelled native bacteriorhodopsin in detergent micelles by solution-state NMR spectroscopy

  • Hartmut Oschkinat

Journal of Biomolecular NMR 1997

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NMR Investigations of the Role of the Sugar Moiety in Glycosylated Recombinant Human Granulocyte-Colony-Stimulating Factor

  • Hartmut Oschkinat

European Journal of Biochemistry 1997

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Constant-Time HQQC Experiment for Protein NMR Spectroscopy

  • Hartmut Oschkinat

Journal of Magnetic Resonance 1997

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Tools for the automated assignment of high-resolution three-dimensional protein NMR spectra based on pattern recognition techniques.

  • Croft D; Kemmink J; Neidig KP; Oschkinat H

Journal of biomolecular NMR 1997

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A small region in phosducin inhibits G-protein betagamma-subunit function.

  • Blüml K; Schnepp W; Schröder S; Beyermann M; Macias M; Oschkinat H; Lohse MJ

The EMBO journal 1997

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Characterization of pheophytin ground states in Rhodobacter sphaeroides R26 photosynthetic reaction centers from multispin pheophytin enrichment and 2-D 13C MAS NMR dipolar correlation spectroscopy.

  • Egorova-Zachernyuk TA; van Rossum B; Boender GJ; Franken E; Ashurst J; Raap J; Gast P; Hoff AJ; Oschkinat H; de Groot HJ

Biochemistry 1997

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Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrin.

  • Nilges M; Macias MJ; O'Donoghue SI; Oschkinat H

Journal of molecular biology 1997

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Rab7: NMR and kinetics analysis of intact and C-terminal truncated constructs.

  • Neu M; Brachvogel V; Oschkinat H; Zerial M; Metcalf P

Proteins 1997

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