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Prof. Dr.
Fan schloss ihr Studium der Biologie an der Fudan-Universität in Shanghai mit einem B.Sc. ab. Anschließend arbeitete sie im Labor von Prof. Dr. Mike Goshe an der North Carolina State University und promovierte 2013 in Biochemie. Danach arbeitet Fan als Postdoc im Labor von Prof. Dr. Albert Heck (Utrecht, Niederlande).
Seit 2017 arbeitet Fan am Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin als Gruppenleiterin für Strukturelle Interaktomik und Leiterin der Forschungsplattform Proteomik. Zusätzlich zu ihrer Position am FMP ist Fan auch zur Professorin für Strukturelle Interaktomik an der Charité - Universitätsmedizin Berlin berufen wurden.
Extensive protein pyrophosphorylation revealed in human cell lines
Nature Chemical Biology 2024
online lesenRawVegetable 2.0: Refining XL-MS Data Acquisition through Enhanced Quality Control
Journal of Proteome Research 2024
online lesenYeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase
The EMBO Journal 2024
online lesenCross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies
Nature Communications 2024
online lesenAn extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis
Nature Communications 2024
online lesenPROTEOME-SCALE RECOMBINANT STANDARDS AND A ROBUST HIGH-SPEED SEARCH ENGINE TO ADVANCE CROSS-LINKING MS-BASED INTERACTOMICS
Real-Time Library Search Increases Cross-Link Identification Depth across All Levels of Sample Complexity
Analytical Chemistry 2023
online lesenThe potential of cross-linking mass spectrometry in the development of protein–protein interaction modulators
Current Opinion in Structural Biology 2023
online lesenAn antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
eLife 2023
online lesenCaMKII autophosphorylation can occur between holoenzymes without subunit exchange
eLife 2023
online lesenSpatially resolved protein map of intact human cytomegalovirus virions
Nature Microbiology 2023
online lesenStructural Host-Virus Interactome Profiling of Intact Infected Cells
XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications
Journal of Proteome Research 2021
online lesenNovel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
Progress in Neurobiology 2021
online leseneIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
Cell Reports 2021
online lesenStitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Science Advances 2020
online lesenMITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex
EMBO reports 2020
online lesenRIM-binding protein couples synaptic vesicle recruitment to release sites
Journal of Cell Biology 2020
online lesenExpanding the depth and sensitivity of cross-link identification by differential ion mobility using FAIMS
Analytical Chemistry 2020
online lesenDeciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System.
MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis
Journal of Biological Chemistry 2016
online lesenHybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
Nature Communications 2016
online lesenInterrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry.
Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.
The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.
Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization.
Performing protein crosslinking using gas-phase cleavable chemical crosslinkers and liquid chromatography-tandem mass spectrometry.
Das Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) gehört zum Forschungsverbund Berlin e.V. (FVB), einem Zusammenschluss von sieben natur-, lebens- und umweltwissenschaftlichen Instituten in Berlin. Die Einrichtungen sind Mitglieder der Leibniz-Gemeinschaft.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Deutschland