Dorothea Fiedler

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

• Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn

The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

• Betül Haykir; Seraina Olivia Moser; Eva Maria Pastor-Arroyo; Udo Schnitzbauer; Zsuzsa Radvanyi; Isabel Prucker; Danye Qiu; Dorothea Fiedler; Adolfo Saiardi; Henning J. Jessen; Nati Hernando; Carsten A. Wagner

Journal of the American Society of Nephrology 2024

Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

• Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie 2024

Monodisperse Chemical Oligophosphorylation of Peptides via Protected Oligophosphorimidazolide Reagents

• Kevin Qian; Björn Hanf; Christopher Cummins; Dorothea Fiedler

Angewandte Chemie International Edition 2024

An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

• Arif Celik; Ida Beyer; Dorothea Fiedler

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

• Willem M. De Vos; Minh Nguyen Trung; Mark Davids; Guizhen Liu; Melany Rios-Morales; Henning Jessen; Dorothea Fiedler; Max Nieuwdorp; Thi Phuong Nam Bui

Nature Microbiology 2024

An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N-Acetylglucosamine Kinase

• Arif Celik; Ida Beyer; Dorothea Fiedler

Journal of the American Chemical Society 2024

Nucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation

• Arif Celik; Felix Schöpf; Christian E. Stieger; Jeremy A. M. Morgan; Sarah Lampe; Max Ruwolt; Fan Liu; Christian P. R. Hackenberger; Daniel Roderer; Dorothea Fiedler

Proteome-wide quantification of inositol pyrophosphate-protein interactions

• Annika Richter; Max Ruwolt; Sarah Lampe; Fan Liu; David Furkert; Dorothea Fiedler

Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

• Tim Aguirre; Ellen Teichmann; Florian Q. Römpp; Ruthey Vivier; Cole Bryant; Matthew A. Hulverson; Wesley C. Van Voorhis; Kayode K. Ojo; J. Stone Doggett; Dorothea Fiedler; Stefan Hecht

ACS Chemical Biology 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Sarah Hostachy; Gillian L. Dornan; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

Real-time monitoring of the sialic acid biosynthesis pathway by NMR

• Jacob L. Gorenflos López; Peter Schmieder; Kristin Kemnitz-Hassanin; Hatice Ceyda Asikoglu; Arif Celik; Christian E. Stieger; Dorothea Fiedler; Stephan Hinderlich; Christian P. R. Hackenberger

Chemical Science 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

• Joka Pipercevic; Bastian Kohl; Ruta Gerasimaite; Véronique Comte-Miserez; Sarah Hostachy; Thomas Müntener; Elia Agustoni; Henning Jacob Jessen; Dorothea Fiedler; Andreas Mayer; Sebastian Hiller

Nature Communications 2023

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

• Soumyadip Sahu; Jacob Gordon; Chunfang Gu; Mack Sobhany; Dorothea Fiedler; Robin E. Stanley; Stephen B. Shears

Biomolecules 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L. Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens P. von Kries; Dorothea Fiedler

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

• Tim Aguirre; Gillian L Dornan; Sarah Hostachy; Martin Neuenschwander; Carola Seyffarth; Volker Haucke; Anja Schütz; Jens Peter von Kries; Dorothea Fiedler

eLife 2023

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

• Sarah Hostachy; Huanchen Wang; Guangning Zong; Katy Franke; Andrew M. Riley; Peter Schmieder; Barry V. L. Potter; Stephen B. Shears; Dorothea Fiedler

Chemistry – A European Journal 2023

Pharmacological tools to investigate inositol polyphosphate kinases – Enzymes of increasing therapeutic relevance

• Tim Kröber; Simon M. Bartsch; Dorothea Fiedler

Advances in Biological Regulation 2022

Versatile signaling mechanisms of inositol pyrophosphates

• Minh Nguyen Trung; David Furkert; Dorothea Fiedler

Current Opinion in Chemical Biology 2022

Stable isotopomers of myo-inositol to uncover the complex MINPP1-dependent inositol phosphate network

• Minh Nguyen Trung; Stefanie Kieninger; Zeinab Fandi; Danye Qiu; Guizhen Liu; Adolfo Saiardi; Henning Jessen; Bettina Keller; Dorothea Fiedler

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in <i>S. pombe</i>

• Natascha Andrea Künzel; Abel R. Alcázar-Román; Adolfo Saiardi; Simon Maria Bartsch; Sarune Daunaraviciute; Dorothea Fiedler; ursula fleig

Journal of Fungi 2022

Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network

• Minh Nguyen Trung; Stefanie Kieninger; Zeinab Fandi; Danye Qiu; Guizhen Liu; Neelay K. Mehendale; Adolfo Saiardi; Henning Jessen; Bettina Keller; Dorothea Fiedler

ACS Central Science 2022

Investigation of a potential electrogenic transport-system for myo-inositol in the small intestine of laying hens

• K. Röhm; F. Gonzalez-Uarquin; R. K. Harmel; M. Nguyen Trung; M. Diener; D. Fiedler; K. Huber; J. Seifert

British Poultry Science 2022