[Translate to Deutsch:] Portrait

Prof. Dr.

Christian Hackenberger

Prof. Dr. Christian Hackenberger studierte Chemie an der Universität Freiburg, an der RWTH Aachen und an der University of Wisconsin/Madison (USA). Seit 2012 ist er Leibniz-Humboldt-Professor für Chemische Biologie an der Humboldt-Universität und Leiter der Abteilung Chemische Biologie II am FMP. Er ist Gründer der Tubulis GmbH, einem Unternehmen, das neue, besser verträgliche Therapeutika gegen Krebs entwickelt.

  • Leitung Peptide Chemistry
  • Humboldt-Leibniz Professor Chemical Biology Humboldt-Universität zu Berlin

Chemische Biologie


Hackenberger Gruppe
Peptide Chemistry


FMP

Kurzvita

Since 2012

Leibniz-Humboldt-Professor (W3) for Chemical Biology

FMP and HU Berlin

2011

Habilitation and venia legendi in Organic Chemistry

Freie Universität Berlin

2011 – 2012

Associate Professor (W2) for Bioorganic Chemistry

Freie Universität Berlin

2006 – 2011

Emmy-Noether-Group leader (DFG)

Freie Universität Berlin

2005 – 2006

Junior group leader as Liebig-Scholar (FCI)

Freie Universität Berlin

2003 – 2005

Postdoctoral work with Prof. Barbara Imperiali

Massachusetts Institute of Technology, USA

Auszeichnungen

Breakthrough of the Year-Award (Life Sciences) by the Falling Walls Foundation
2020

Novartis Lecturer and Visiting Professor New York University (NYU)
2019

Leonidas Zervas Award of the European Peptide Society
2018

JSPS Invitational Fellowship (Japan)
2018

Leibniz-Gründerpreis and m4 award for the biotech start-up Tubulis
2018

Visiting Professor at the Leopold-Franzens Universität Innsbruck
2018

Fellow of the Royal Society of Chemistry
2016

“The best 40 under 40 in Germany” (Welt am Sonntag)
2014

Harlan L. and Margaret L. Goering Visiting Professor of Chemistry (UW Madison/WI, USA)
2013

ORCHEM-Award of the GDCh
2012

Recognized as “Top 40 young German scientists under 40” (Capital)
2011/2012/2014

Heinz-Maier-Leibnitz-Award of the DFG
2011

ADUC-Award of the GDCh
2011

Dozentenstipendium of the Fonds der chemischen Industrie (FCI) and the Aventis Foundation
2011

Award in the competition “Junior investigator of the year 2010”
2010

Plus 3-Award of the Boehringer-Ingelheim Foundation
2010

Award of the GDCh section “Macromolecular Chemistry” (FG Makromolekulare Chemie)
2009

Award of the Otto-Röhm Memorial Foundation
2008

Emmy-Noether-Group leader
2006

Liebig-Scholarship of the FCI
2005

Thieme-Journal Award
2005

Postdoctoral fellowship of the DAAD and DFG
2003/2005

Borchers Medal and Friedrich-Wilhelm Preis (RWTH Aachen)
2003

Scholarship for scientific journalism of the FCI
2001

Kekulé-Ph.D.-Scholarship of the FCI and of the Studienstiftung des deutschen Volkes
2000/2001

Study-abroad Scholarship of the Universität Freiburg within the “Academic-Year-Programs”
1998

Scholarship of the Studienstiftung des deutschen Volkes
1997

Kooperationen

Tubulis GmbH

Publikationen

Publikationen

von 12

Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

  • Brandt, R.
  • Timm, S.
  • Gorenflos López, J. L.
  • Kwame Abledu, J.
  • Kuebler, W. M.
  • Hackenberger, C. P. R.
  • Ochs, M., &
  • Lopez-Rodriguez, E.

Frontiers in Bioengineering and Biotechnology 2021, 8, 614357

online lesen

The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

  • Park, Y.
  • Baumann, A. L.
  • Moon, H.
  • Byrne, S.
  • Kasper, M.
  • Hwang, S.
  • Sun, H.
  • Baik, M., &
  • Hackenberger, C. P. R.

Chemical Science 2021, 12, 8141-8148

online lesen

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates

  • Franz, L.
  • Schneider, A. F. L., &
  • Hackenberger, C. P. R.

Methods in Molecular Biology 2021, 2355, 287-299

online lesen

Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

  • Schwach, J.
  • Kolobynina, K.
  • Brandstetter, K.
  • Gerlach, M.
  • Ochtrop, P.
  • Helma, J.
  • Hackenberger, C. P. R.
  • Harz, H.
  • Cardoso, M. C.
  • Leonhardt, H., &
  • Stengl, A.

ChemBioChem 2021, 22, 1205-1209

online lesen

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

  • Cantrelle, F.
  • Loyens, A.
  • Trivelli, X.
  • Reimann, O.
  • Despres, C.
  • Gandhi, N. S.
  • Hackenberger, C. P. R.
  • Landrieu, I., &
  • Smet-Nocca, C.

Frontiers in Molecular Neuroscience 2021, 14, 661368

online lesen

Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses

  • Stadtmueller, M. N.
  • Bhatia, S.
  • Kiran, P.
  • Hilsch, M.
  • Reiter-Scherer, V.
  • Adam, L.
  • Parshad, B.
  • Budt, M.
  • Klenk, S.
  • Sellrie, K.
  • Lauster, D.
  • Seeberger, P. H.
  • Hackenberger, C. P. R.
  • Herrmann, A.
  • Haag, R., &
  • Wolff, T.

Journal of Medicinal Chemistry 2021, 64, 12774-12789

online lesen

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

  • Schneider, A. F. L.
  • Kallen, J.
  • Ottl, J.
  • Reid, P. C.
  • Ripoche, S.
  • Ruetz, S.
  • Stachyra, T.
  • Hintermann, S.
  • Dumelin, C. E.
  • Hackenberger, C. P. R., &
  • Marzinzik, A. L.

RSC Chemical Biology 2021, 2, 1661-1668

online lesen

Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging

  • Stieger, C. E.
  • Franz, L.
  • Körlin, F., &
  • Hackenberger, C. P. R.

Angewandte Chemie International Edition 2021, 60, 15359-15364

online lesen

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

  • Schneider, A. F. L.
  • Kithil, M.
  • Cardoso, M. C.
  • Lehmann, M., &
  • Hackenberger, C. P. R.

Nature Chemistry 2021, 13, 530-539

online lesen

Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells

  • Schneider, A. F. L.
  • Benz, L. S.
  • Lehmann, M., &
  • Hackenberger, C. P. R.

Angewandte Chemie International Edition 2021, 60, 22075-22080

online lesen

Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research

  • Hauser, A.
  • Stieger, C. E., &
  • Hackenberger, C. P. R.

Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552

online lesen

A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

  • Yan, B.
  • Li, W., &
  • Hackenberger, C. P. R.

Organic & Biomolecular Chemistry 2021, 19, 8014-8017

online lesen

Publikationen

von 8

N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

  • Kasper, M. A.
  • Gerlach, M.
  • Schneider, A. F. L.
  • Groneberg, C.
  • Ochtrop, P.
  • Boldt, S.
  • Schumacher, D.
  • Helma, J.
  • Leonhardt, H.
  • Christmann, M., &
  • Hackenberger, C. P. R.

ChemBioChem 2020, 21, 113-119

online lesen

Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics

  • Hauser, A.
  • Poulou, E.
  • Müller, F.
  • Schmieder, P., &
  • Hackenberger, C. P. R.

Chemistry 2020, Online ahead of print, 2326-2331

online lesen

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

  • Lauster, D.
  • Klenk, S.
  • Ludwig, K.
  • Nojoumi, S.
  • Behren, S.
  • Adam, L.
  • Stadtmüller, M.
  • Saenger, S.
  • Zimmler, S.
  • Honzke, K.
  • Yao, L.
  • Hoffmann, U.
  • Bardua, M.
  • Hamann, A.
  • Witzenrath, M.
  • Sander, L. E.
  • Wolff, T.
  • Hocke, A. C.
  • Hippenstiel, S.
  • De Carlo, S.
  • Neudecker, J.
  • Osterrieder, K.
  • Budisa, N.
  • Netz, R. R.
  • Böttcher, C.
  • Liese, S.
  • Herrmann, A., &
  • Hackenberger, C. P. R.

Nature Nanotechnology 2020, 15, 373-379

online lesen

Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations

  • Baumann, A. L.
  • Schwagerus, S.
  • Broi, K.
  • Kemnitz-Hassanin, K.
  • Stieger, C. E.
  • Trieloff, N.
  • Schmieder, P., &
  • Hackenberger, C. P. R.

Journal of the American Chemical Society 2020, 142, 9544-9552

online lesen

Modern Peptide and Protein Chemistry: Reaching New Heights

  • Hackenberger, C. P. R.
  • Dawson, P. E.
  • Chen, Y. X., &
  • Hojo, H.

Journal of Organic Chemistry 2020, 85, 1328-1330

online lesen

Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

  • Tu, Z. X.
  • Donskyi, E. G.
  • Qiao, H. S.
  • Zhu, Z. L.
  • Unger, W. E. S.
  • Hackenberger, C. P. R.
  • Chen, W.
  • Adeli, M., &
  • Haag, R.

Advanced Functional Materials 2020, 2000933

online lesen

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

  • Hauser, A.
  • Hwang, S.
  • Sun, H., &
  • Hackenberger, C. P. R.

Chemical Science 2020, 11, doi:10.1039/D0SC03930F

online lesen

Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives

  • Schneider, A. F. L.
  • Kithil, M.
  • Cardoso, M. C.
  • Lehmann, M., &
  • Hackenberger, C. P. R.

Nature Chemistry 2020, in press,

Publikationen

von 8

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations

  • Kasper, M. A.
  • Glanz, M.
  • Stengl, A.
  • Penkert, M.
  • Klenk, S.
  • Sauer, T.
  • Schumacher, D.
  • Helma, J.
  • Krause, E.
  • Cardoso, M. C.
  • Leonhardt, H., &
  • Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11625-11630

online lesen

Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

  • Penkert, M.
  • Hauser, A.
  • Harmel, R.
  • Fiedler, D.
  • Hackenberger, C. P. R., &
  • Krause, E.

Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585

online lesen

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

  • Kasper, M. A.
  • Stengl, A.
  • Ochtrop, P.
  • Gerlach, M.
  • Stoschek, T.
  • Schumacher, D.
  • Helma, J.
  • Penkert, M.
  • Krause, E.
  • Leonhardt, H., &
  • Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11631-11636

online lesen

In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation

  • Nojoumi, S.
  • Ma, Y.
  • Schwagerus, S.
  • Hackenberger, C. P. R., &
  • Budisa, N.

International Journal of Molecular Sciences 2019, 20, 2299

online lesen

Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

  • Apel, C.
  • Kasper, M. A.
  • Stieger, C. E.
  • Hackenberger, C. P. R., &
  • Christmann, M.

Organic Letters 2019, 21, 10043-10047

online lesen

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

  • Schneider, A. F. L.
  • Wallabregue, A. L. D.
  • Franz, L., &
  • Hackenberger, C. P. R.

Bioconjugate Chemistry 2019, 30, 400-404

online lesen

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles

  • Stengl, A.
  • Gerlach, M.
  • Kasper, M. A.
  • Hackenberger, C. P. R.
  • Leonhardt, H.
  • Schumacher, D., &
  • Helma, J.

Organic & Biomolecular Chemistry 2019, 17, 4964-4969

online lesen

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization

  • Kasper, M. A.
  • Glanz, M.
  • Oder, A.
  • Schmieder, P.
  • Kries, J. P., &
  • Hackenberger, C. P. R.

Chemical Science 2019, 10, 6322-6329

online lesen