Christian Hackenberger

Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

• Brandt, R.
• Timm, S.
• Gorenflos López, J. L.
• Kwame Abledu, J.
• Kuebler, W. M.
• Hackenberger, C. P. R.
• Ochs, M., &
• Lopez-Rodriguez, E.

Frontiers in Bioengineering and Biotechnology 2021, 8, 614357

The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

• Park, Y.
• Baumann, A. L.
• Moon, H.
• Byrne, S.
• Kasper, M.
• Hwang, S.
• Sun, H.
• Baik, M., &
• Hackenberger, C. P. R.

Chemical Science 2021, 12, 8141-8148

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptide-Conjugates

• Franz, L.
• Schneider, A. F. L., &
• Hackenberger, C. P. R.

Methods in Molecular Biology 2021, 2355, 287-299

Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

• Schwach, J.
• Kolobynina, K.
• Brandstetter, K.
• Gerlach, M.
• Ochtrop, P.
• Helma, J.
• Hackenberger, C. P. R.
• Harz, H.
• Cardoso, M. C.
• Leonhardt, H., &
• Stengl, A.

ChemBioChem 2021, 22, 1205-1209

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

• Cantrelle, F.
• Loyens, A.
• Trivelli, X.
• Reimann, O.
• Despres, C.
• Gandhi, N. S.
• Hackenberger, C. P. R.
• Landrieu, I., &
• Smet-Nocca, C.

Frontiers in Molecular Neuroscience 2021, 14, 661368

Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses

• Stadtmueller, M. N.
• Bhatia, S.
• Kiran, P.
• Hilsch, M.
• Reiter-Scherer, V.
• Adam, L.
• Parshad, B.
• Budt, M.
• Klenk, S.
• Sellrie, K.
• Lauster, D.
• Seeberger, P. H.
• Hackenberger, C. P. R.
• Herrmann, A.
• Haag, R., &
• Wolff, T.

Journal of Medicinal Chemistry 2021, 64, 12774-12789

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

• Schneider, A. F. L.
• Kallen, J.
• Ottl, J.
• Reid, P. C.
• Ripoche, S.
• Ruetz, S.
• Stachyra, T.
• Hintermann, S.
• Dumelin, C. E.
• Hackenberger, C. P. R., &
• Marzinzik, A. L.

RSC Chemical Biology 2021, 2, 1661-1668

Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging

• Stieger, C. E.
• Franz, L.
• Körlin, F., &
• Hackenberger, C. P. R.

Angewandte Chemie International Edition 2021, 60, 15359-15364

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

• Schneider, A. F. L.
• Kithil, M.
• Cardoso, M. C.
• Lehmann, M., &
• Hackenberger, C. P. R.

Nature Chemistry 2021, 13, 530-539

Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells

• Schneider, A. F. L.
• Benz, L. S.
• Lehmann, M., &
• Hackenberger, C. P. R.

Angewandte Chemie International Edition 2021, 60, 22075-22080

Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research

• Hauser, A.
• Stieger, C. E., &
• Hackenberger, C. P. R.

Total Chemical Synthesis of Proteins , Wiley VCh Verlag , 2021 533-552

A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

• Yan, B.
• Li, W., &
• Hackenberger, C. P. R.

Organic & Biomolecular Chemistry 2021, 19, 8014-8017

N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

• Kasper, M. A.
• Gerlach, M.
• Schneider, A. F. L.
• Groneberg, C.
• Ochtrop, P.
• Boldt, S.
• Schumacher, D.
• Helma, J.
• Leonhardt, H.
• Christmann, M., &
• Hackenberger, C. P. R.

ChemBioChem 2020, 21, 113-119

Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics

• Hauser, A.
• Poulou, E.
• Müller, F.
• Schmieder, P., &
• Hackenberger, C. P. R.

Chemistry 2020, Online ahead of print, 2326-2331

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

• Lauster, D.
• Klenk, S.
• Ludwig, K.
• Nojoumi, S.
• Behren, S.
• Adam, L.
• Stadtmüller, M.
• Saenger, S.
• Zimmler, S.
• Honzke, K.
• Yao, L.
• Hoffmann, U.
• Bardua, M.
• Hamann, A.
• Witzenrath, M.
• Sander, L. E.
• Wolff, T.
• Hocke, A. C.
• Hippenstiel, S.
• De Carlo, S.
• Neudecker, J.
• Osterrieder, K.
• Budisa, N.
• Netz, R. R.
• Böttcher, C.
• Liese, S.
• Herrmann, A., &
• Hackenberger, C. P. R.

Nature Nanotechnology 2020, 15, 373-379

Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations

• Baumann, A. L.
• Schwagerus, S.
• Broi, K.
• Kemnitz-Hassanin, K.
• Stieger, C. E.
• Trieloff, N.
• Schmieder, P., &
• Hackenberger, C. P. R.

Journal of the American Chemical Society 2020, 142, 9544-9552

Modern Peptide and Protein Chemistry: Reaching New Heights

• Hackenberger, C. P. R.
• Dawson, P. E.
• Chen, Y. X., &
• Hojo, H.

Journal of Organic Chemistry 2020, 85, 1328-1330

Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

• Tu, Z. X.
• Donskyi, E. G.
• Qiao, H. S.
• Zhu, Z. L.
• Unger, W. E. S.
• Hackenberger, C. P. R.
• Chen, W.
• Adeli, M., &
• Haag, R.

Advanced Functional Materials 2020, 2000933

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase

• Hauser, A.
• Hwang, S.
• Sun, H., &
• Hackenberger, C. P. R.

Chemical Science 2020, 11, doi:10.1039/D0SC03930F

Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives

• Schneider, A. F. L.
• Kithil, M.
• Cardoso, M. C.
• Lehmann, M., &
• Hackenberger, C. P. R.

Nature Chemistry 2020, in press,

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations

• Kasper, M. A.
• Glanz, M.
• Stengl, A.
• Penkert, M.
• Klenk, S.
• Sauer, T.
• Schumacher, D.
• Helma, J.
• Krause, E.
• Cardoso, M. C.
• Leonhardt, H., &
• Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11625-11630

Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

• Penkert, M.
• Hauser, A.
• Harmel, R.
• Fiedler, D.
• Hackenberger, C. P. R., &
• Krause, E.

Journal of the American Society for Mass Spectrometry 2019, 30, 1578-1585

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

• Kasper, M. A.
• Stengl, A.
• Ochtrop, P.
• Gerlach, M.
• Stoschek, T.
• Schumacher, D.
• Helma, J.
• Penkert, M.
• Krause, E.
• Leonhardt, H., &
• Hackenberger, C. P. R.

Angewandte Chemie-International Edition 2019, 58, 11631-11636

In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation

• Nojoumi, S.
• Ma, Y.
• Schwagerus, S.
• Hackenberger, C. P. R., &
• Budisa, N.

International Journal of Molecular Sciences 2019, 20, 2299

Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

• Apel, C.
• Kasper, M. A.
• Stieger, C. E.
• Hackenberger, C. P. R., &
• Christmann, M.

Organic Letters 2019, 21, 10043-10047

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

• Schneider, A. F. L.
• Wallabregue, A. L. D.
• Franz, L., &
• Hackenberger, C. P. R.

Bioconjugate Chemistry 2019, 30, 400-404

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles

• Stengl, A.
• Gerlach, M.
• Kasper, M. A.
• Hackenberger, C. P. R.
• Leonhardt, H.
• Schumacher, D., &
• Helma, J.

Organic & Biomolecular Chemistry 2019, 17, 4964-4969

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization

• Kasper, M. A.
• Glanz, M.
• Oder, A.
• Schmieder, P.
• Kries, J. P., &
• Hackenberger, C. P. R.

Chemical Science 2019, 10, 6322-6329